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The map label for this gene is trxA [C]

Identifier: 150397064

GI number: 150397064

Start: 1934795

End: 1935133

Strand: Direct

Name: trxA [C]

Synonym: Smed_1862

Alternate gene names: 150397064

Gene position: 1934795-1935133 (Clockwise)

Preceding gene: 150397059

Following gene: 150397065

Centisome position: 51.16

GC content: 59.29

Gene sequence:

>339_bases
ATGCCCACTGCTCCAAACGAGCACCCCACGGATGGGAAAGTCGACACTTGCACTTTCCCGGAAGAAGTTCTGAATTCGCC
CCTACCGGTCGTCGCCGCCTTCTCGGGAGATCGTTGCCTGCCGTGCGACGCGGTTGCATTCAGCCTCAAACAAATCGCCA
CCGAGCTTGCTGGCAAGGTCAAGGTGGTCAAGATCGACGTCGACGAGAACCTCGATCTCGCGGCGCAGTATGGCGTACGC
GAGGTTCCGACGCTTCTCATGTTCAAGGGTGGTGAAGTCGCCGACATCTACGTCGGAACCGGCTCACTCCGCTCATGGAT
TTCGGAGGCGCTGGCTTGA

Upstream 100 bases:

>100_bases
GACCAGGCACGACTTCGACGTTTACCCTGGTAGCGCATGTTGTTGGGCATTCGTGTGCCCCGAACAACCGAGTGCTTCAT
GAACTGAAGGCCAGAAAAAG

Downstream 100 bases:

>100_bases
GTCGCCGGTCTTCGCCTCCTTCGATACGCCGAGCGACCAACCCTTCTACCGGCGCATCTGAAACTGATCCGAATGCTCAC
CAACGTCCACCTCTGGAGGA

Product: thioredoxin domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 112; Mature: 111

Protein sequence:

>112_residues
MPTAPNEHPTDGKVDTCTFPEEVLNSPLPVVAAFSGDRCLPCDAVAFSLKQIATELAGKVKVVKIDVDENLDLAAQYGVR
EVPTLLMFKGGEVADIYVGTGSLRSWISEALA

Sequences:

>Translated_112_residues
MPTAPNEHPTDGKVDTCTFPEEVLNSPLPVVAAFSGDRCLPCDAVAFSLKQIATELAGKVKVVKIDVDENLDLAAQYGVR
EVPTLLMFKGGEVADIYVGTGSLRSWISEALA
>Mature_111_residues
PTAPNEHPTDGKVDTCTFPEEVLNSPLPVVAAFSGDRCLPCDAVAFSLKQIATELAGKVKVVKIDVDENLDLAAQYGVRE
VPTLLMFKGGEVADIYVGTGSLRSWISEALA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=81, Percent_Identity=40.7407407407407, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=38.8888888888889, Blast_Score=72, Evalue=7e-15,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=34.0425531914894, Blast_Score=69, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=36.4583333333333, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=39.7260273972603, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11921; Mature: 11790

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTAPNEHPTDGKVDTCTFPEEVLNSPLPVVAAFSGDRCLPCDAVAFSLKQIATELAGKV
CCCCCCCCCCCCCEECCCCCHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCE
KVVKIDVDENLDLAAQYGVREVPTLLMFKGGEVADIYVGTGSLRSWISEALA
EEEEEECCCCCCHHHHCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHCC
>Mature Secondary Structure 
PTAPNEHPTDGKVDTCTFPEEVLNSPLPVVAAFSGDRCLPCDAVAFSLKQIATELAGKV
CCCCCCCCCCCCEECCCCCHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCE
KVVKIDVDENLDLAAQYGVREVPTLLMFKGGEVADIYVGTGSLRSWISEALA
EEEEEECCCCCCHHHHCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]