Click here to switch to the map view.

The map label for this gene is cobW [H]

Identifier: 150396963

GI number: 150396963

Start: 1842139

End: 1843203

Strand: Reverse

Name: cobW [H]

Synonym: Smed_1760

Alternate gene names: 150396963

Gene position: 1843203-1842139 (Counterclockwise)

Preceding gene: 150396964

Following gene: 150396962

Centisome position: 48.74

GC content: 60.66

Gene sequence:

>1065_bases
ATGACACTCGCGAAGTCTCAGCAGGGCAAGATTCCCGCTACCGTCATCACCGGGTTTCTCGGTGCCGGCAAGACGACGAT
GATCCGCAATCTGCTGCAGAATGCCGACGGCAAGCGCATCGCGCTGATCATCAACGAGTTCGGCGACCTAGGCGTCGACG
GCGACGTGTTGAAGGGTTGCGGAGCTGAAGCCTGCACGGAGGATGATATCATCGAGCTGACCAATGGCTGCATTTGCTGC
ACTGTTGCCGACGACTTCATTCCGACCATGACGAAGCTGCTCGAAAGAGAGAACCGTCCGGACCATATCATCATCGAGAC
CTCGGGCCTGGCGCTGCCGCAGCCGCTCGTCGCGGCATTCAACTGGCCGGACATCCGCAGCGAGGTAACGGTCGACGGCG
TCGTTACCGTCGTCGATAGCGCCGCCGTTGCCGCGGGCCGCTTCGCAGACGATCATGACAAGGTGGACGCACTCCGCGCA
GGCGATGAAAATCTCGATCATGAGAGCCCGCTCGAAGAACTCTTCGAGGACCAGCTCACAGCTGCCGACCTCATCGTTCT
CAACAAGACGGATCTCATCGATGCCGCGGGGTTGAAGTCGGTGCGCGATGAAGTGGCCTCACGCATCAACCGCAAGCCCA
CCATGATCGAGGCGAAGAACGGTGAGGTAGCAGCTGCCATCCTGCTCGGGCTCGGGGTGGGTACGGAGGGCGACATCGTC
AACCGCAAGTCTCACCACGAGATGGAGCACGAGGCGGGCGAGGAGCATGATCACGACGAATTCGACAGCTTCGTCGTCGA
ACTGGGTGCCATAGCCGATCCTGCCGTTTTCGTGGAACGGCTCAGAAATGTGATCGCACAGCACGACGTGCTGCGCCTCA
AGGGTTTCGTCGACGTTCCCGGCAAATCGATGCGCCTCCTGATACAGGCGGTGGGCAGCCGCATCGACCAGTATTTCGAT
CGCGCATGGGCTCCGGGCGAAACGCGCAGCACACGGCTGGTCGTCATAGGCCTGCATGACATGGATGAGCCTGCCCTGCG
GGCGGCAATATCGGCACTTGTGTAA

Upstream 100 bases:

>100_bases
TCGCGATCACTCCGGCCGGCTCCACCAGATCGTGGCGGAGAAATCCGCAGAAGTTTACTTTGTCGCGGCCGGACTGCCGC
TGAAAATGAAGGGTTGATCC

Downstream 100 bases:

>100_bases
GGTGGTTTTGACCTTGCGCGCGGAAATCGAGGAGCATCCATGCATCTCCTCCTAGCCCAGAAAGGTACGATCGCCGACGG
CAACGAGGCGATCGACCTCG

Product: cobalamin biosynthesis protein CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTLAKSQQGKIPATVITGFLGAGKTTMIRNLLQNADGKRIALIINEFGDLGVDGDVLKGCGAEACTEDDIIELTNGCICC
TVADDFIPTMTKLLERENRPDHIIIETSGLALPQPLVAAFNWPDIRSEVTVDGVVTVVDSAAVAAGRFADDHDKVDALRA
GDENLDHESPLEELFEDQLTAADLIVLNKTDLIDAAGLKSVRDEVASRINRKPTMIEAKNGEVAAAILLGLGVGTEGDIV
NRKSHHEMEHEAGEEHDHDEFDSFVVELGAIADPAVFVERLRNVIAQHDVLRLKGFVDVPGKSMRLLIQAVGSRIDQYFD
RAWAPGETRSTRLVVIGLHDMDEPALRAAISALV

Sequences:

>Translated_354_residues
MTLAKSQQGKIPATVITGFLGAGKTTMIRNLLQNADGKRIALIINEFGDLGVDGDVLKGCGAEACTEDDIIELTNGCICC
TVADDFIPTMTKLLERENRPDHIIIETSGLALPQPLVAAFNWPDIRSEVTVDGVVTVVDSAAVAAGRFADDHDKVDALRA
GDENLDHESPLEELFEDQLTAADLIVLNKTDLIDAAGLKSVRDEVASRINRKPTMIEAKNGEVAAAILLGLGVGTEGDIV
NRKSHHEMEHEAGEEHDHDEFDSFVVELGAIADPAVFVERLRNVIAQHDVLRLKGFVDVPGKSMRLLIQAVGSRIDQYFD
RAWAPGETRSTRLVVIGLHDMDEPALRAAISALV
>Mature_353_residues
TLAKSQQGKIPATVITGFLGAGKTTMIRNLLQNADGKRIALIINEFGDLGVDGDVLKGCGAEACTEDDIIELTNGCICCT
VADDFIPTMTKLLERENRPDHIIIETSGLALPQPLVAAFNWPDIRSEVTVDGVVTVVDSAAVAAGRFADDHDKVDALRAG
DENLDHESPLEELFEDQLTAADLIVLNKTDLIDAAGLKSVRDEVASRINRKPTMIEAKNGEVAAAILLGLGVGTEGDIVN
RKSHHEMEHEAGEEHDHDEFDSFVVELGAIADPAVFVERLRNVIAQHDVLRLKGFVDVPGKSMRLLIQAVGSRIDQYFDR
AWAPGETRSTRLVVIGLHDMDEPALRAAISALV

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI223941779, Length=352, Percent_Identity=30.1136363636364, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI126722884, Length=372, Percent_Identity=29.5698924731183, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI33469141, Length=372, Percent_Identity=29.5698924731183, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI148727351, Length=372, Percent_Identity=29.5698924731183, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI146231952, Length=372, Percent_Identity=29.3010752688172, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI223941776, Length=360, Percent_Identity=28.3333333333333, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI119120938, Length=352, Percent_Identity=26.9886363636364, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI87082430, Length=351, Percent_Identity=29.3447293447293, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788499, Length=181, Percent_Identity=32.5966850828729, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=194, Percent_Identity=32.9896907216495, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 38254; Mature: 38123

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAKSQQGKIPATVITGFLGAGKTTMIRNLLQNADGKRIALIINEFGDLGVDGDVLKGC
CCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHCC
GAEACTEDDIIELTNGCICCTVADDFIPTMTKLLERENRPDHIIIETSGLALPQPLVAAF
CCCCCCCCCHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHC
NWPDIRSEVTVDGVVTVVDSAAVAAGRFADDHDKVDALRAGDENLDHESPLEELFEDQLT
CCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCC
AADLIVLNKTDLIDAAGLKSVRDEVASRINRKPTMIEAKNGEVAAAILLGLGVGTEGDIV
HHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCCCCC
NRKSHHEMEHEAGEEHDHDEFDSFVVELGAIADPAVFVERLRNVIAQHDVLRLKGFVDVP
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEECCC
GKSMRLLIQAVGSRIDQYFDRAWAPGETRSTRLVVIGLHDMDEPALRAAISALV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHC
>Mature Secondary Structure 
TLAKSQQGKIPATVITGFLGAGKTTMIRNLLQNADGKRIALIINEFGDLGVDGDVLKGC
CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHCC
GAEACTEDDIIELTNGCICCTVADDFIPTMTKLLERENRPDHIIIETSGLALPQPLVAAF
CCCCCCCCCHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHC
NWPDIRSEVTVDGVVTVVDSAAVAAGRFADDHDKVDALRAGDENLDHESPLEELFEDQLT
CCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCC
AADLIVLNKTDLIDAAGLKSVRDEVASRINRKPTMIEAKNGEVAAAILLGLGVGTEGDIV
HHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCCCCC
NRKSHHEMEHEAGEEHDHDEFDSFVVELGAIADPAVFVERLRNVIAQHDVLRLKGFVDVP
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEECCC
GKSMRLLIQAVGSRIDQYFDRAWAPGETRSTRLVVIGLHDMDEPALRAAISALV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]