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The map label for this gene is cobC [H]

Identifier: 150396947

GI number: 150396947

Start: 1823835

End: 1824836

Strand: Reverse

Name: cobC [H]

Synonym: Smed_1744

Alternate gene names: 150396947

Gene position: 1824836-1823835 (Counterclockwise)

Preceding gene: 150396948

Following gene: 150396946

Centisome position: 48.25

GC content: 63.67

Gene sequence:

>1002_bases
ATGCCCAATCCGATCACCCATGGCGGCGGAATCTCGGAAGCTGCAGCGCGCTTCGGCGGCAGGCCGGAGGACTGGCTTGA
CCTCTCGACGGGCATCAATCCCTGTCCCGCGGCGCTGCCGGAGATCGATGCCCGGGCCTGGCATCGGCTGCCGGACCGGC
ATGTGGAAGAGGCAGCGCGCGCGGCGGCCAGCCGCTATTACCGGACCGGCGGGCTGATGCCCTTGCCGGTGCCGGGAACG
CAGGCGGTCATTCAGTTGCTTCCGCGGATCGCGGATCCGGGGAAGAGGGCAGCCATCTTCGCTCCAACCTATGGGGAGTA
TGCACGCGTTCTGAGAGCCGCCGGCATTGCCGTCGATACTGTCGGATACGCCGATGATCTTCAGGCAGCGCACGGACTTT
CCGTCATCGTCAATCCCAACAATCCGACGGGTCGTTTTTTTCCGCCGGATGAAATTCTTGCGATGGCGGAGGCGATGAGA
ACTCATCGCGGACTCCTCGTGGTGGACGAAGCTTTCGGCGATCTGGAGCCGGCGGCAAGCGTGGCCGGACATGTAGCGGC
TCATGACAATCTTATCGTTTTCCGCTCCTTCGGTAAGTTCTTCGGTCTTGCGGGGCTTCGCCTCGGCTTTGTGGTCGCGA
ACCGCCCGATCGAGGAAGCGCTCCGCAACTGGCTCGGCCCATGGGCGGTCTCGGGGCCGGCACTCGCCATCTCGGCGAAG
CTGATGGAGGGTGATACGAACCGGATCAAAGCCGGTATCGCGGAGCGCAAAGCTGCGCTCGACGCCCTGCTTTTTGGCGC
GGGCCTTCACATCGTCGGCGGCACCGGCCTCTTCGCACTCGTCGATCACGAGCGGGCGCACGATATTCATACCGCACTCT
GCGAGGCGCACATCCTGACGCGCAAATTCGACTATGCTCCGCGCTGGCTGCGAATCGGGCTGTCACCGAACCCGGCAAGC
GACCGCCGGCTCGCAGAGGCGTTTAATCGAATGGGTTTTTAA

Upstream 100 bases:

>100_bases
CGGTAAGGGATGCGGCAGGCGTTGATCTTGGCCGCGCCGGGCTCAGACGCCGGAACGTCGCCGGATCCTTCATGCACCTA
ATCGATCTTTCGCAATGACC

Downstream 100 bases:

>100_bases
GTGTCGTCAGAAATACTTCTTCTTCTCGTCATGGCACTGCTTTTGGATCGCCTCATTGGCGATCCGGACTGGCTCTGGTC
GCGGATCACGCATCCCGTGG

Product: class I and II aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MPNPITHGGGISEAAARFGGRPEDWLDLSTGINPCPAALPEIDARAWHRLPDRHVEEAARAAASRYYRTGGLMPLPVPGT
QAVIQLLPRIADPGKRAAIFAPTYGEYARVLRAAGIAVDTVGYADDLQAAHGLSVIVNPNNPTGRFFPPDEILAMAEAMR
THRGLLVVDEAFGDLEPAASVAGHVAAHDNLIVFRSFGKFFGLAGLRLGFVVANRPIEEALRNWLGPWAVSGPALAISAK
LMEGDTNRIKAGIAERKAALDALLFGAGLHIVGGTGLFALVDHERAHDIHTALCEAHILTRKFDYAPRWLRIGLSPNPAS
DRRLAEAFNRMGF

Sequences:

>Translated_333_residues
MPNPITHGGGISEAAARFGGRPEDWLDLSTGINPCPAALPEIDARAWHRLPDRHVEEAARAAASRYYRTGGLMPLPVPGT
QAVIQLLPRIADPGKRAAIFAPTYGEYARVLRAAGIAVDTVGYADDLQAAHGLSVIVNPNNPTGRFFPPDEILAMAEAMR
THRGLLVVDEAFGDLEPAASVAGHVAAHDNLIVFRSFGKFFGLAGLRLGFVVANRPIEEALRNWLGPWAVSGPALAISAK
LMEGDTNRIKAGIAERKAALDALLFGAGLHIVGGTGLFALVDHERAHDIHTALCEAHILTRKFDYAPRWLRIGLSPNPAS
DRRLAEAFNRMGF
>Mature_332_residues
PNPITHGGGISEAAARFGGRPEDWLDLSTGINPCPAALPEIDARAWHRLPDRHVEEAARAAASRYYRTGGLMPLPVPGTQ
AVIQLLPRIADPGKRAAIFAPTYGEYARVLRAAGIAVDTVGYADDLQAAHGLSVIVNPNNPTGRFFPPDEILAMAEAMRT
HRGLLVVDEAFGDLEPAASVAGHVAAHDNLIVFRSFGKFFGLAGLRLGFVVANRPIEEALRNWLGPWAVSGPALAISAKL
MEGDTNRIKAGIAERKAALDALLFGAGLHIVGGTGLFALVDHERAHDIHTALCEAHILTRKFDYAPRWLRIGLSPNPASD
RRLAEAFNRMGF

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=271, Percent_Identity=30.2583025830258, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35741; Mature: 35610

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPITHGGGISEAAARFGGRPEDWLDLSTGINPCPAALPEIDARAWHRLPDRHVEEAAR
CCCCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHH
AAASRYYRTGGLMPLPVPGTQAVIQLLPRIADPGKRAAIFAPTYGEYARVLRAAGIAVDT
HHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCEEC
VGYADDLQAAHGLSVIVNPNNPTGRFFPPDEILAMAEAMRTHRGLLVVDEAFGDLEPAAS
CCCHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH
VAGHVAAHDNLIVFRSFGKFFGLAGLRLGFVVANRPIEEALRNWLGPWAVSGPALAISAK
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEEEH
LMEGDTNRIKAGIAERKAALDALLFGAGLHIVGGTGLFALVDHERAHDIHTALCEAHILT
HHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHH
RKFDYAPRWLRIGLSPNPASDRRLAEAFNRMGF
HHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PNPITHGGGISEAAARFGGRPEDWLDLSTGINPCPAALPEIDARAWHRLPDRHVEEAAR
CCCCCCCCCHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHH
AAASRYYRTGGLMPLPVPGTQAVIQLLPRIADPGKRAAIFAPTYGEYARVLRAAGIAVDT
HHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCEEC
VGYADDLQAAHGLSVIVNPNNPTGRFFPPDEILAMAEAMRTHRGLLVVDEAFGDLEPAAS
CCCHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH
VAGHVAAHDNLIVFRSFGKFFGLAGLRLGFVVANRPIEEALRNWLGPWAVSGPALAISAK
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCEEEEH
LMEGDTNRIKAGIAERKAALDALLFGAGLHIVGGTGLFALVDHERAHDIHTALCEAHILT
HHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHH
RKFDYAPRWLRIGLSPNPASDRRLAEAFNRMGF
HHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]