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The map label for this gene is znuA [H]

Identifier: 150396901

GI number: 150396901

Start: 1776166

End: 1777209

Strand: Direct

Name: znuA [H]

Synonym: Smed_1697

Alternate gene names: 150396901

Gene position: 1776166-1777209 (Clockwise)

Preceding gene: 150396897

Following gene: 150396911

Centisome position: 46.96

GC content: 62.64

Gene sequence:

>1044_bases
ATGAAATCGACGACTGCCCTTCTCTTCGCCTCGACGGTTCTTCTGGCCTCCCCAGCTCTTGCGGAGACGCCCAATGTGGT
CGTCTCGATCAAGCCGGTCCACTCGCTGGTCGCGTCGATCATGGAGGGAGTCGGCGAGCCGTCGCTCATCATGGAAGGCG
CCGCCTCCCCTCATACCTATACGATGAAACCTTCAAATGCGGCCGCACTGCAGGCCGCGAAGGTCGTATTCTGGGTAGGG
CCCGGCCTCGAGGCGTTTCTCGACACGCCGCTTGATGCGCTCAGCACAGGAGCCCGGGTGGTCGAACTCGGCGAAGCCCC
TGGGCTCGACAAGCTGAAATTCCGCGAGGGCGGCGCTTTCGAGGGGCATGATCATGGTGAAGAAGGTCACGCTGATGAGG
GTCACGCGGGCGAAGGTCACGCGGGGGAAGCCGACCATGACGGGCACGAGGATCACGGCGATGCCCATGCCGGCGAAGCG
GCGAGTGCCGAGAACGCAGCCGGCCATGAGCATCACGATCATGGCGAAGGCGAATTCGACATGCACATGTGGCTGGACCC
GATGAACGCCAAGGCCATGGCGGCCGAGATCGAGAAGACCCTGTCCTCGGCAGATCCGGACAACGCCGCCACTTACAAAG
CAAACCTGGAGAAGCTCAACGAGCGGATCGGCGCTCTCGACAAGAGCCTTGCCGAGACCGTGGCTGCCATCAAGGACAAG
CCGTTCGTCGTCTTCCACGACGCGTATCAATACTTCGAGCACCGCTACAAAGTGCGCGTGGCCGGTTCGATCACGGTCAG
CCCCGAAGTGCTGCCCGGCGCGGAACGACTCTCCGAAATCCGCGCAAAGATCAAGGAATTGGGCGCGACCTGCGTTTTCG
CCGAGCCGCAGTTCGAGCCTAAGCTCGTCGGCGTCGTGATCGAAGGCACGCCGGCGAAATCCGGCACGCTCGACCCGGAA
GGCGGCACCCTCGATGCAGGCCCCGACCTCTATTTCGAACTGATGGAAAGCATCGGCGCTTCGCTGAAGGAGTGCCTGTC
CTAG

Upstream 100 bases:

>100_bases
TATAGCATAACGCAATTGATGTAATAACATAACAGTGCCGTTTCAAGCAACGCCGGTGCGCAAGAACCGGCACAGCCCTC
CCGGACAACTGGAGAAAACA

Downstream 100 bases:

>100_bases
GCGACCTGATACGTCATCGCGCTCTGCCGGGCAGCAGGTCGTCGCCTCGAGTGACCGGGTAGGTTCTGAGAGAGCGGAAT
GCTTCGGCGGCTTCGGCATT

Product: periplasmic solute binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKSTTALLFASTVLLASPALAETPNVVVSIKPVHSLVASIMEGVGEPSLIMEGAASPHTYTMKPSNAAALQAAKVVFWVG
PGLEAFLDTPLDALSTGARVVELGEAPGLDKLKFREGGAFEGHDHGEEGHADEGHAGEGHAGEADHDGHEDHGDAHAGEA
ASAENAAGHEHHDHGEGEFDMHMWLDPMNAKAMAAEIEKTLSSADPDNAATYKANLEKLNERIGALDKSLAETVAAIKDK
PFVVFHDAYQYFEHRYKVRVAGSITVSPEVLPGAERLSEIRAKIKELGATCVFAEPQFEPKLVGVVIEGTPAKSGTLDPE
GGTLDAGPDLYFELMESIGASLKECLS

Sequences:

>Translated_347_residues
MKSTTALLFASTVLLASPALAETPNVVVSIKPVHSLVASIMEGVGEPSLIMEGAASPHTYTMKPSNAAALQAAKVVFWVG
PGLEAFLDTPLDALSTGARVVELGEAPGLDKLKFREGGAFEGHDHGEEGHADEGHAGEGHAGEADHDGHEDHGDAHAGEA
ASAENAAGHEHHDHGEGEFDMHMWLDPMNAKAMAAEIEKTLSSADPDNAATYKANLEKLNERIGALDKSLAETVAAIKDK
PFVVFHDAYQYFEHRYKVRVAGSITVSPEVLPGAERLSEIRAKIKELGATCVFAEPQFEPKLVGVVIEGTPAKSGTLDPE
GGTLDAGPDLYFELMESIGASLKECLS
>Mature_347_residues
MKSTTALLFASTVLLASPALAETPNVVVSIKPVHSLVASIMEGVGEPSLIMEGAASPHTYTMKPSNAAALQAAKVVFWVG
PGLEAFLDTPLDALSTGARVVELGEAPGLDKLKFREGGAFEGHDHGEEGHADEGHAGEGHAGEADHDGHEDHGDAHAGEA
ASAENAAGHEHHDHGEGEFDMHMWLDPMNAKAMAAEIEKTLSSADPDNAATYKANLEKLNERIGALDKSLAETVAAIKDK
PFVVFHDAYQYFEHRYKVRVAGSITVSPEVLPGAERLSEIRAKIKELGATCVFAEPQFEPKLVGVVIEGTPAKSGTLDPE
GGTLDAGPDLYFELMESIGASLKECLS

Specific function: Involved in the high-affinity zinc uptake transport system. Required for survival and normal growth under low Zn (2+) concentrations. Also required for virulence and intracellular growth in macrophages [H]

COG id: COG4531

COG function: function code P; ABC-type Zn2+ transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=321, Percent_Identity=33.6448598130841, Blast_Score=185, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 36600; Mature: 36600

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTTALLFASTVLLASPALAETPNVVVSIKPVHSLVASIMEGVGEPSLIMEGAASPHTY
CCCHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCEEEECCCCCCEE
TMKPSNAAALQAAKVVFWVGPGLEAFLDTPLDALSTGARVVELGEAPGLDKLKFREGGAF
EECCCCHHHHHHEEEEEEECCCHHHHHCCCHHHHHCCCEEEEECCCCCCCCEEECCCCCC
EGHDHGEEGHADEGHAGEGHAGEADHDGHEDHGDAHAGEAASAENAAGHEHHDHGEGEFD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
MHMWLDPMNAKAMAAEIEKTLSSADPDNAATYKANLEKLNERIGALDKSLAETVAAIKDK
EEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFVVFHDAYQYFEHRYKVRVAGSITVSPEVLPGAERLSEIRAKIKELGATCVFAEPQFEP
CEEEEHHHHHHHHHHEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCC
KLVGVVIEGTPAKSGTLDPEGGTLDAGPDLYFELMESIGASLKECLS
EEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKSTTALLFASTVLLASPALAETPNVVVSIKPVHSLVASIMEGVGEPSLIMEGAASPHTY
CCCHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCEEEECCCCCCEE
TMKPSNAAALQAAKVVFWVGPGLEAFLDTPLDALSTGARVVELGEAPGLDKLKFREGGAF
EECCCCHHHHHHEEEEEEECCCHHHHHCCCHHHHHCCCEEEEECCCCCCCCEEECCCCCC
EGHDHGEEGHADEGHAGEGHAGEADHDGHEDHGDAHAGEAASAENAAGHEHHDHGEGEFD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
MHMWLDPMNAKAMAAEIEKTLSSADPDNAATYKANLEKLNERIGALDKSLAETVAAIKDK
EEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFVVFHDAYQYFEHRYKVRVAGSITVSPEVLPGAERLSEIRAKIKELGATCVFAEPQFEP
CEEEEHHHHHHHHHHEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCC
KLVGVVIEGTPAKSGTLDPEGGTLDAGPDLYFELMESIGASLKECLS
EEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA