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The map label for this gene is gor [H]

Identifier: 150396780

GI number: 150396780

Start: 1668407

End: 1669798

Strand: Reverse

Name: gor [H]

Synonym: Smed_1571

Alternate gene names: 150396780

Gene position: 1669798-1668407 (Counterclockwise)

Preceding gene: 150396781

Following gene: 150396779

Centisome position: 44.15

GC content: 60.92

Gene sequence:

>1392_bases
ATGACCGCTTTCGACTATGACCTCTTCGTGATCGGCGGCGGTTCGGGCGGTGTGCGCAGCGGGCGGTTGGCCGCGGCGCT
CGGCAAAAAGGTGGCGATTGCCGAGGAGTTCCGCTATGGAGGGACATGCGTCATCCGTGGCTGCGTTCCCAAGAAGCTTT
ATGTTTATGCCTCGCAGTTTTCGGAGCATTTCGAAGATGCGGCGGGATTCGGCTGGAGCGTCGGCGAAAGCCGCTTCGAC
TGGGCTAAGCTCGTTGCCGCCAAGGAACAGGAAATCGCCAGACTGGAGGGCCTTTATCGCAAAGGCCTTGCGAATGCCGG
CGCCGAAATCCTCGATACACGGGCCGAGCTCGTCGGCCCCAACGCCGTGAAGCTGCTTGCAAGCGGCAAGACGGTGACGG
CGGAGCGTATCGTCGTCGCGGTCGGGGGGCATCCGAGCCCGCATGACGCTCTGCCGGGCAACGAGTTGTGCATCACGTCG
AACGAAGCCTTCGATCTCGCGGCACTGCCGGAAGCGATCCTTATTGCCGGCGGCGGTTACATCGCCGTGGAATTTGCGAA
CATTTTCCACGGCTTGGGTGTGAATACGACGCTGATCTACCGCGGAAAGGAAATTCTCTCCCGTTTCGATCAGGATATGC
GGCGCGGTCTTCACGCCGCAATGGAGGAGAAGGGAATCCGCATCCTCTGCGAGGACATCATCCAGGCCGTGTCGGCGAAC
TCGGACGGACGCCGTGTGGCGACGACGATGAAGCATGGGGATATTGTCGTGGACCAGGTGATGCTTGCGCTTGGACGCGT
GCCGAATACGAAAGACCTCGGGTTGGAGGCCGCCGGCGTCAAGACCGATGAACGGGGTGCTATCATCGTCGATGCCTTCT
CGCGTACGAGCACGCCGGGGATCTACGCCATCGGCGATGTGACCGATCGCGTGCAACTGACACCGGTTGCGATCCATGAG
GCCATGTGCTTCATCGAAACCGAATACAGGAACAACCCTACGTCGCCGGATCACGACCTGATCGCGACTGCGGTGTTCTC
TCAGCCCGAAATCGGCACGGTCGGCATCTCGGAAGAAGAAGCAGCGCGGAAGTTCGAAGAGATCGAGGTCTATCGCGCCG
AGTTCCGGCCGATGAAAGCAACGCTCTCCGGCCGGAAGGAAAAGACCATCATGAAGCTGATCGTCAATGCCGCGGACCGC
AAGGTGGTCGGCGTCCATATTCTCGGCCACGACGCCGGGGAAATGGCCCAGCTTTTGGGAATCTCGCTGAAGGCGGGCTG
CACGAAGGATGATTTCGACCGCACCATGGCGGTTCACCCGACTGCTGCGGAGGAACTCGTCACGATGTACCGGCCGAGCT
ACCGCGTGCGGGGCGGAGAGACGATCGTCTAA

Upstream 100 bases:

>100_bases
AATACTATATCAGGGGCGAAAGGCGACTTCGCTCGCATTTCCGAGCCGGCGGGCCTCCGCCGGCAACCCCTTCGACATTT
CGTTTCTTGCAGGAGTTCCC

Downstream 100 bases:

>100_bases
GGTCTTTCCGCCGGTGCTGTGGCCGTCCACGTTTTCTGGTAGGATGGCTTTCCAAGCTTCCTGTTAACGTTTATAAGCCC
GCATCCGCGGCAATGGCCCA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTAFDYDLFVIGGGSGGVRSGRLAAALGKKVAIAEEFRYGGTCVIRGCVPKKLYVYASQFSEHFEDAAGFGWSVGESRFD
WAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELVGPNAVKLLASGKTVTAERIVVAVGGHPSPHDALPGNELCITS
NEAFDLAALPEAILIAGGGYIAVEFANIFHGLGVNTTLIYRGKEILSRFDQDMRRGLHAAMEEKGIRILCEDIIQAVSAN
SDGRRVATTMKHGDIVVDQVMLALGRVPNTKDLGLEAAGVKTDERGAIIVDAFSRTSTPGIYAIGDVTDRVQLTPVAIHE
AMCFIETEYRNNPTSPDHDLIATAVFSQPEIGTVGISEEEAARKFEEIEVYRAEFRPMKATLSGRKEKTIMKLIVNAADR
KVVGVHILGHDAGEMAQLLGISLKAGCTKDDFDRTMAVHPTAAEELVTMYRPSYRVRGGETIV

Sequences:

>Translated_463_residues
MTAFDYDLFVIGGGSGGVRSGRLAAALGKKVAIAEEFRYGGTCVIRGCVPKKLYVYASQFSEHFEDAAGFGWSVGESRFD
WAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELVGPNAVKLLASGKTVTAERIVVAVGGHPSPHDALPGNELCITS
NEAFDLAALPEAILIAGGGYIAVEFANIFHGLGVNTTLIYRGKEILSRFDQDMRRGLHAAMEEKGIRILCEDIIQAVSAN
SDGRRVATTMKHGDIVVDQVMLALGRVPNTKDLGLEAAGVKTDERGAIIVDAFSRTSTPGIYAIGDVTDRVQLTPVAIHE
AMCFIETEYRNNPTSPDHDLIATAVFSQPEIGTVGISEEEAARKFEEIEVYRAEFRPMKATLSGRKEKTIMKLIVNAADR
KVVGVHILGHDAGEMAQLLGISLKAGCTKDDFDRTMAVHPTAAEELVTMYRPSYRVRGGETIV
>Mature_462_residues
TAFDYDLFVIGGGSGGVRSGRLAAALGKKVAIAEEFRYGGTCVIRGCVPKKLYVYASQFSEHFEDAAGFGWSVGESRFDW
AKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELVGPNAVKLLASGKTVTAERIVVAVGGHPSPHDALPGNELCITSN
EAFDLAALPEAILIAGGGYIAVEFANIFHGLGVNTTLIYRGKEILSRFDQDMRRGLHAAMEEKGIRILCEDIIQAVSANS
DGRRVATTMKHGDIVVDQVMLALGRVPNTKDLGLEAAGVKTDERGAIIVDAFSRTSTPGIYAIGDVTDRVQLTPVAIHEA
MCFIETEYRNNPTSPDHDLIATAVFSQPEIGTVGISEEEAARKFEEIEVYRAEFRPMKATLSGRKEKTIMKLIVNAADRK
VVGVHILGHDAGEMAQLLGISLKAGCTKDDFDRTMAVHPTAAEELVTMYRPSYRVRGGETIV

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=39.8692810457516, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI33519430, Length=489, Percent_Identity=35.7873210633947, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI33519428, Length=489, Percent_Identity=35.7873210633947, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI33519426, Length=489, Percent_Identity=35.7873210633947, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI148277065, Length=489, Percent_Identity=35.7873210633947, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI148277071, Length=489, Percent_Identity=35.7873210633947, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=34.2436974789916, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI22035672, Length=470, Percent_Identity=34.8936170212766, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI291045268, Length=474, Percent_Identity=32.7004219409283, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI91199540, Length=454, Percent_Identity=27.3127753303965, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1789915, Length=430, Percent_Identity=38.6046511627907, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=27.6548672566372, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=27.4122807017544, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=25.219298245614, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=453, Percent_Identity=39.514348785872, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71983429, Length=453, Percent_Identity=39.514348785872, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=31.9829424307036, Blast_Score=234, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=33.5416666666667, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32565766, Length=453, Percent_Identity=26.4900662251656, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17559934, Length=190, Percent_Identity=29.4736842105263, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=34.8484848484849, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=26.7515923566879, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=24.5119305856833, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=35.031847133758, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24640549, Length=473, Percent_Identity=33.8266384778013, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24640553, Length=473, Percent_Identity=33.8266384778013, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24640551, Length=473, Percent_Identity=33.8266384778013, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=28.448275862069, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49914; Mature: 49782

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFDYDLFVIGGGSGGVRSGRLAAALGKKVAIAEEFRYGGTCVIRGCVPKKLYVYASQF
CCEEEEEEEEEECCCCCCCCCHHHHHHCCHHEEHHHHCCCCEEEEECCCCCHHHHHHHHH
SEHFEDAAGFGWSVGESRFDWAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELVGP
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
NAVKLLASGKTVTAERIVVAVGGHPSPHDALPGNELCITSNEAFDLAALPEAILIAGGGY
CCEEEEECCCEEEEEEEEEEECCCCCCCCCCCCCCEEEECCCCEEHHHCCCEEEEECCCE
IAVEFANIFHGLGVNTTLIYRGKEILSRFDQDMRRGLHAAMEEKGIRILCEDIIQAVSAN
EEEEHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
SDGRRVATTMKHGDIVVDQVMLALGRVPNTKDLGLEAAGVKTDERGAIIVDAFSRTSTPG
CCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHCCCEECCCCCCCCCEEEEEECCCCCCCC
IYAIGDVTDRVQLTPVAIHEAMCFIETEYRNNPTSPDHDLIATAVFSQPEIGTVGISEEE
EEEECCCCCCEEEEHHHHHHHEEEEEECCCCCCCCCCHHHEEEEEECCCCCCEECCCHHH
AARKFEEIEVYRAEFRPMKATLSGRKEKTIMKLIVNAADRKVVGVHILGHDAGEMAQLLG
HHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHC
ISLKAGCTKDDFDRTMAVHPTAAEELVTMYRPSYRVRGGETIV
CHHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
TAFDYDLFVIGGGSGGVRSGRLAAALGKKVAIAEEFRYGGTCVIRGCVPKKLYVYASQF
CEEEEEEEEEECCCCCCCCCHHHHHHCCHHEEHHHHCCCCEEEEECCCCCHHHHHHHHH
SEHFEDAAGFGWSVGESRFDWAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELVGP
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
NAVKLLASGKTVTAERIVVAVGGHPSPHDALPGNELCITSNEAFDLAALPEAILIAGGGY
CCEEEEECCCEEEEEEEEEEECCCCCCCCCCCCCCEEEECCCCEEHHHCCCEEEEECCCE
IAVEFANIFHGLGVNTTLIYRGKEILSRFDQDMRRGLHAAMEEKGIRILCEDIIQAVSAN
EEEEHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
SDGRRVATTMKHGDIVVDQVMLALGRVPNTKDLGLEAAGVKTDERGAIIVDAFSRTSTPG
CCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHCCCEECCCCCCCCCEEEEEECCCCCCCC
IYAIGDVTDRVQLTPVAIHEAMCFIETEYRNNPTSPDHDLIATAVFSQPEIGTVGISEEE
EEEECCCCCCEEEEHHHHHHHEEEEEECCCCCCCCCCHHHEEEEEECCCCCCEECCCHHH
AARKFEEIEVYRAEFRPMKATLSGRKEKTIMKLIVNAADRKVVGVHILGHDAGEMAQLLG
HHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHC
ISLKAGCTKDDFDRTMAVHPTAAEELVTMYRPSYRVRGGETIV
CHHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]