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The map label for this gene is hemF [H]

Identifier: 150396759

GI number: 150396759

Start: 1641637

End: 1642548

Strand: Direct

Name: hemF [H]

Synonym: Smed_1549

Alternate gene names: 150396759

Gene position: 1641637-1642548 (Clockwise)

Preceding gene: 150396756

Following gene: 150396760

Centisome position: 43.41

GC content: 61.18

Gene sequence:

>912_bases
ATGGAAAGACCGCAATTGCCACAGGGCCTGCCGGCCGACATCGAACGCAAGAAAGCAGAGGCGAAAGCTTGGTTCGAAAG
CCTCCGCGACACGATCTGTGCTGACTTCGAGGCGATCGAGGATGATTTGGCTGGCCCTCTGTCGGATCGTCCGGCAGGCC
GTTTCGTCGCCAAGGACTGGCTGCGAGACGAAGGTAACGGCGGCGGCGGTCGCATGTCCATGATGGAGGGGCGCGTCTTC
GAAAAGGTGGGTGTCCACACCTCGACCGTCTTTGGCGAGTTCTCACCCGAGTTCCGCGACCAGATTCCCGGCGCGAGCGA
AGATCCTCGCTTCTGGGCCTCCGGCATTTCGCTGATCGCTCACCCGGTCAACCCCAATGTACCTGCCGTGCACATGAACA
CGCGCATGGTCGTGACAACCAGCAACTGGTTCGGCGGCGGTGCGGATCTTACGCCGGTCCTCGATCGCAGGCGCATCCCG
ACCGATGCGGACACCGTTCTCTTCCATCGCGCGATGGAGATCGCCTGCAATAGGCACAAGGTCGCGGATTATCCGAAATT
CAAGCAATGGTGCGACGAGTACTTCTATCTGAAACACCGGAACGAGCCGCGCGGCACCGGCGGCATCTTCTATGACTGGC
TGCGCTCTGACGAGGAAATTGGCGGCTGGGAAGCGGATTTCGCCTTCACGCGCGATGTCGGCAAAGCCTTCGCGATCGTC
TATCCGAGAATCGTCCGCACCAATTTCAACATGCCCTGGACCGAACAGGACCGCAGCGAACAGCTCGTGCGCCGTGGCCG
CTACGTCGAATTCAACCTCCTATACGACCGTGGCACGATCTTCGGACTCAAGACCGGCGGCAACGTCGAGTCGATCCTCT
CCTCCCTGCCCCCGCTCGTGCGCTGGCCCTGA

Upstream 100 bases:

>100_bases
CGCTGTGACACGGTTGCCAAGCAGCCGAAAATATGGCCTGTGACGGCCACATCGAATCGGCGGTTTTGATAGCGAAAGCC
GCAAACGGAAGCGCATTCCC

Downstream 100 bases:

>100_bases
AGCGAGAGCGCATCGACCGGCGGCCATCCGGCGAACAAATTCCCGGCGTTGGCGTTTCCCTCTCCAGGAGAGAAGGAGCG
CCGCATGATCTTTAAAAAAC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MERPQLPQGLPADIERKKAEAKAWFESLRDTICADFEAIEDDLAGPLSDRPAGRFVAKDWLRDEGNGGGGRMSMMEGRVF
EKVGVHTSTVFGEFSPEFRDQIPGASEDPRFWASGISLIAHPVNPNVPAVHMNTRMVVTTSNWFGGGADLTPVLDRRRIP
TDADTVLFHRAMEIACNRHKVADYPKFKQWCDEYFYLKHRNEPRGTGGIFYDWLRSDEEIGGWEADFAFTRDVGKAFAIV
YPRIVRTNFNMPWTEQDRSEQLVRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPLVRWP

Sequences:

>Translated_303_residues
MERPQLPQGLPADIERKKAEAKAWFESLRDTICADFEAIEDDLAGPLSDRPAGRFVAKDWLRDEGNGGGGRMSMMEGRVF
EKVGVHTSTVFGEFSPEFRDQIPGASEDPRFWASGISLIAHPVNPNVPAVHMNTRMVVTTSNWFGGGADLTPVLDRRRIP
TDADTVLFHRAMEIACNRHKVADYPKFKQWCDEYFYLKHRNEPRGTGGIFYDWLRSDEEIGGWEADFAFTRDVGKAFAIV
YPRIVRTNFNMPWTEQDRSEQLVRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPLVRWP
>Mature_303_residues
MERPQLPQGLPADIERKKAEAKAWFESLRDTICADFEAIEDDLAGPLSDRPAGRFVAKDWLRDEGNGGGGRMSMMEGRVF
EKVGVHTSTVFGEFSPEFRDQIPGASEDPRFWASGISLIAHPVNPNVPAVHMNTRMVVTTSNWFGGGADLTPVLDRRRIP
TDADTVLFHRAMEIACNRHKVADYPKFKQWCDEYFYLKHRNEPRGTGGIFYDWLRSDEEIGGWEADFAFTRDVGKAFAIV
YPRIVRTNFNMPWTEQDRSEQLVRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPLVRWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=262, Percent_Identity=42.7480916030534, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1788777, Length=293, Percent_Identity=42.320819112628, Blast_Score=211, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6320249, Length=334, Percent_Identity=39.5209580838323, Blast_Score=205, Evalue=7e-54,
Organism=Drosophila melanogaster, GI17864388, Length=308, Percent_Identity=39.2857142857143, Blast_Score=198, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34493; Mature: 34493

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERPQLPQGLPADIERKKAEAKAWFESLRDTICADFEAIEDDLAGPLSDRPAGRFVAKDW
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LRDEGNGGGGRMSMMEGRVFEKVGVHTSTVFGEFSPEFRDQIPGASEDPRFWASGISLIA
HHCCCCCCCCEEHHHHCHHHHHHCCCHHHHCCCCCHHHHHHCCCCCCCCHHHHCCHHEEE
HPVNPNVPAVHMNTRMVVTTSNWFGGGADLTPVLDRRRIPTDADTVLFHRAMEIACNRHK
ECCCCCCCEEEECCEEEEEECCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
VADYPKFKQWCDEYFYLKHRNEPRGTGGIFYDWLRSDEEIGGWEADFAFTRDVGKAFAIV
CCCCHHHHHHHHHHHEEHCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
YPRIVRTNFNMPWTEQDRSEQLVRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPLV
HHHHHEECCCCCCCCCHHHHHHHHCCCEEEEEEEEECCEEEEEECCCCHHHHHHHCCCCC
RWP
CCC
>Mature Secondary Structure
MERPQLPQGLPADIERKKAEAKAWFESLRDTICADFEAIEDDLAGPLSDRPAGRFVAKDW
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LRDEGNGGGGRMSMMEGRVFEKVGVHTSTVFGEFSPEFRDQIPGASEDPRFWASGISLIA
HHCCCCCCCCEEHHHHCHHHHHHCCCHHHHCCCCCHHHHHHCCCCCCCCHHHHCCHHEEE
HPVNPNVPAVHMNTRMVVTTSNWFGGGADLTPVLDRRRIPTDADTVLFHRAMEIACNRHK
ECCCCCCCEEEECCEEEEEECCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
VADYPKFKQWCDEYFYLKHRNEPRGTGGIFYDWLRSDEEIGGWEADFAFTRDVGKAFAIV
CCCCHHHHHHHHHHHEEHCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
YPRIVRTNFNMPWTEQDRSEQLVRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPLV
HHHHHEECCCCCCCCCHHHHHHHHCCCEEEEEEEEECCEEEEEECCCCHHHHHHHCCCCC
RWP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]