Click here to switch to the map view.

The map label for this gene is soxR [H]

Identifier: 150396756

GI number: 150396756

Start: 1639352

End: 1639837

Strand: Direct

Name: soxR [H]

Synonym: Smed_1546

Alternate gene names: 150396756

Gene position: 1639352-1639837 (Clockwise)

Preceding gene: 150396754

Following gene: 150396759

Centisome position: 43.35

GC content: 62.76

Gene sequence:

>486_bases
GTGAAAAAAGACAAAGCCAACGAATTCAAGCGCGAACTGACAGTTGGCGAAGTCGCCGAACGCAGCGGCCTCGCCGTGTC
GACGCTTCATTTCTACGAAAGCAAGGGGCTCATCCGCAGCAATCGAAGCCGTGGCAACCAGCGACGATACCCGCGCTCCG
TCCTGAGGCGCGTGGCCGTGATCAAGATCGCCCAGCGCACCGGTATCCCGCTTTCGGAAATACAGGCGGCTCTGTCGGTG
CTTCCCGACGACCGGCCGCTGACGGTTGAGGACTGGGGAAGGTTTTCGATGACCTGGCAGCGTCAGCTTGACGAACGAAT
CGCCAAGCTGACGGCGCTGCGCGATCAACTCACCGGCTGTATCGGCTGCGGTTGCCTGTCGATGCGTGACTGTCCCCTGC
GCAACCCATGGGACGTTCTCGCGGCAGAGGGCACCGGGCCGCGCCTCATCGATCCCGCCGACGGGTCGGAGCATGAGGCG
AGTTAG

Upstream 100 bases:

>100_bases
CAAGGGTCATCTTCTCAGTCATGCCGTACAGGCTCCTTATTGTCGTTAATAGAGAGCCCATGCTATAGAACCTCAACTAA
AGTTGAGGTCAATAGCCGCA

Downstream 100 bases:

>100_bases
CAGGCTAACCCGACTTCGCAGGCCTCATGCGCGCGAGCAGAGCCATGCTGGCCAATGCACCGAGGGAGCAGAGAAGCGCG
AAGGTCAGCGCCCACCTGTT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MKKDKANEFKRELTVGEVAERSGLAVSTLHFYESKGLIRSNRSRGNQRRYPRSVLRRVAVIKIAQRTGIPLSEIQAALSV
LPDDRPLTVEDWGRFSMTWQRQLDERIAKLTALRDQLTGCIGCGCLSMRDCPLRNPWDVLAAEGTGPRLIDPADGSEHEA
S

Sequences:

>Translated_161_residues
MKKDKANEFKRELTVGEVAERSGLAVSTLHFYESKGLIRSNRSRGNQRRYPRSVLRRVAVIKIAQRTGIPLSEIQAALSV
LPDDRPLTVEDWGRFSMTWQRQLDERIAKLTALRDQLTGCIGCGCLSMRDCPLRNPWDVLAAEGTGPRLIDPADGSEHEA
S
>Mature_161_residues
MKKDKANEFKRELTVGEVAERSGLAVSTLHFYESKGLIRSNRSRGNQRRYPRSVLRRVAVIKIAQRTGIPLSEIQAALSV
LPDDRPLTVEDWGRFSMTWQRQLDERIAKLTALRDQLTGCIGCGCLSMRDCPLRNPWDVLAAEGTGPRLIDPADGSEHEA
S

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=147, Percent_Identity=61.9047619047619, Blast_Score=182, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 18047; Mature: 18047

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDKANEFKRELTVGEVAERSGLAVSTLHFYESKGLIRSNRSRGNQRRYPRSVLRRVAV
CCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHH
IKIAQRTGIPLSEIQAALSVLPDDRPLTVEDWGRFSMTWQRQLDERIAKLTALRDQLTGC
HHHHHHCCCCHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IGCGCLSMRDCPLRNPWDVLAAEGTGPRLIDPADGSEHEAS
HHCCCCCCCCCCCCCCHHEEEECCCCCEEECCCCCCCCCCC
>Mature Secondary Structure
MKKDKANEFKRELTVGEVAERSGLAVSTLHFYESKGLIRSNRSRGNQRRYPRSVLRRVAV
CCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHH
IKIAQRTGIPLSEIQAALSVLPDDRPLTVEDWGRFSMTWQRQLDERIAKLTALRDQLTGC
HHHHHHCCCCHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IGCGCLSMRDCPLRNPWDVLAAEGTGPRLIDPADGSEHEAS
HHCCCCCCCCCCCCCCHHEEEECCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9045804; 10984043 [H]