Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 150396731

GI number: 150396731

Start: 1601963

End: 1603177

Strand: Direct

Name: icd [H]

Synonym: Smed_1519

Alternate gene names: 150396731

Gene position: 1601963-1603177 (Clockwise)

Preceding gene: 150396722

Following gene: 150396734

Centisome position: 42.36

GC content: 60.0

Gene sequence:

>1215_bases
ATGGCAAAGATCAAGGTCGCCAATCCGGTCGTCGAACTCGACGGCGACGAGATGACCCGCATCATATGGCAGTTCATCAA
GGACAAGCTGATCCATCCCTATCTCGACCTCGATCTCGAATATTATGACCTCGGCGTCGAGAACCGCGACGCAACCGACG
ATCAGGTGACGATCGACGCCGCGAACGCGATCAAGAAGCACGGCGTCGGCGTCAAATGCGCAACGATCACGCCGGACGAA
GGCCGCGTCGAGGAGTTCAAGCTGAAGAAGATGTGGAAGTCGCCCAACGGCACGATCCGCAACATCCTCGGCGGCGTCAT
TTTCCGCGAGCCGATCATCTGCAAGAACGTGCCTCGCCTCGTGCCCGGCTGGACAAAGCCGATCATCGTCGGCCGCCACG
CCTTTGGCGACCAGTATCGCGCGACCGATTTCAAGTTTCCGGGAAAGGGCAAGCTTTCAATCAAATTCGTCGGCGAAGAC
GGCCAGACGATCGAGCATGACGTTTACGACGCGCCGGGCGCCGGTGTGGCACTCGCCATGTACAATCTCGATGAGTCGAT
CACCGAATTTGCGCGCGCCTCGTTCAATTACGGCCTGCAGCGCAAGGTCCCCGTTTATCTCTCGACCAAGAACACCATTC
TCAAAGCCTATGACGGCCGCTTCAAGGACATTTTCCAGAAGGTGTTCGAGGAGGAGTTCGCCGACCAGTTCAGGGCCGAG
AAGCTCTGGTACGAACATCGTCTGATCGACGACATGGTCGCCTCGGCGCTGAAATGGTCCGGTGGCTATGTCTGGGCCTG
CAAAAACTATGACGGCGACGTCCAGTCCGATATCGTTGCGCAGGGCTTCGGCTCTCTCGGCCTGATGACTTCCGTTCTGA
TGACGCCGGACGGCAAGACGGTCGAGGCGGAAGCTGCGCACGGCACGGTCACCCGCCACTACCGGCAGCATCAGAAGGGC
GAGGAAACCTCGACCAACTCGATCGCCTCGATCTTCGCCTGGACCCGCGGCCTCGCGCACCGTGCCAAGCTCGACGGCAA
CACCGAACTTGCGAAGTTCTCGGAGACGCTGGAGCGCGTCTGCGTCGATACGGTCGAATCGGGCTTCATGACCAAGGATC
TGGCGCTGCTCATCGGTCCCGACCAACCCTGGCTGTCGACCACCGGCTTCCTCGACAAGATCGACGAGAACCTCCGGAAG
GCCATGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGAGCATGCTTTGCCTTGCCGGCTCACAGTGCTATAGGGCTCTGGATTTCTCCCACGGGGGGCATCGCGCCGATGTCCCG
CAAAGCTACGAGGCATATCA

Downstream 100 bases:

>100_bases
CGCCTGCTTCATCGCCGATATTCGGAAACCCGGCCTTGCGCCGGGTTTCTTTTTGGCCTGGGCCACTATACGACGCCGAT
GCTCCGAACATCATATCGCC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDAANAIKKHGVGVKCATITPDE
GRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGED
GQTIEHDVYDAPGAGVALAMYNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFEEEFADQFRAE
KLWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
EETSTNSIASIFAWTRGLAHRAKLDGNTELAKFSETLERVCVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLRK
AMAA

Sequences:

>Translated_404_residues
MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDAANAIKKHGVGVKCATITPDE
GRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGED
GQTIEHDVYDAPGAGVALAMYNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFEEEFADQFRAE
KLWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
EETSTNSIASIFAWTRGLAHRAKLDGNTELAKFSETLERVCVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLRK
AMAA
>Mature_403_residues
AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDAANAIKKHGVGVKCATITPDEG
RVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDG
QTIEHDVYDAPGAGVALAMYNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFEEEFADQFRAEK
LWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKGE
ETSTNSIASIFAWTRGLAHRAKLDGNTELAKFSETLERVCVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLRKA
MAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=68.6274509803922, Blast_Score=589, Evalue=1e-168,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=67.8048780487805, Blast_Score=580, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=69.4029850746269, Blast_Score=582, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=67.0761670761671, Blast_Score=569, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6323203, Length=409, Percent_Identity=62.5916870415648, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320137, Length=409, Percent_Identity=63.5696821515892, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6324319, Length=409, Percent_Identity=61.1246943765281, Blast_Score=531, Evalue=1e-152,
Organism=Drosophila melanogaster, GI21356561, Length=409, Percent_Identity=65.0366748166259, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330987, Length=409, Percent_Identity=65.0366748166259, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330985, Length=409, Percent_Identity=65.0366748166259, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI28574947, Length=409, Percent_Identity=65.0366748166259, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660849, Length=409, Percent_Identity=65.0366748166259, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660856, Length=409, Percent_Identity=65.0366748166259, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI221330983, Length=409, Percent_Identity=65.0366748166259, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24660868, Length=409, Percent_Identity=65.0366748166259, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660860, Length=409, Percent_Identity=65.0366748166259, Blast_Score=562, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45290; Mature: 45159

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDA
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCHHCCCEEEEECCCCCCCCCCCEEEEEH
ANAIKKHGVGVKCATITPDEGRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGQTIEHDVYDAPGAGVALAM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCCCEEEEE
YNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFEEEFADQFRAE
ECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHH
KLWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKT
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNTELAKFSETLERV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
CVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLRKAMAA
HHHHHHCCCCEECEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDA
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCHHCCCEEEEECCCCCCCCCCCEEEEEH
ANAIKKHGVGVKCATITPDEGRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGQTIEHDVYDAPGAGVALAM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCCCEEEEE
YNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFEEEFADQFRAE
ECCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHH
KLWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKT
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNTELAKFSETLERV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
CVDTVESGFMTKDLALLIGPDQPWLSTTGFLDKIDENLRKAMAA
HHHHHHCCCCEECEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]