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The map label for this gene is tetA [H]

Identifier: 150396480

GI number: 150396480

Start: 1355444

End: 1356709

Strand: Direct

Name: tetA [H]

Synonym: Smed_1262

Alternate gene names: 150396480

Gene position: 1355444-1356709 (Clockwise)

Preceding gene: 150396479

Following gene: 150396481

Centisome position: 35.84

GC content: 60.43

Gene sequence:

>1266_bases
ATGATCGACCAGAAATTTGTGAAGCGCGGTCTTTTCCTCGTCTTTATGATCCTCTTCCTCGATATTATGGGTATCGCCAT
CATTGTCCCTGTATTGCCGAGCTATCTCGAGGAATTGACGGGGGCGGATGTTGGTGAAGCGGCAATCGACGGCGGCTGGC
TGCTGCTCGTTTATTCGGCGATGCAGTTCTTCTTCGCGCCGCTCATCGGGAATCTGAGCGACCGATTCGGGCGCCGGCCG
ATCCTTTTGGCCTCCGTGCTGACCTTCGCTATCGACAACCTGATCTGCGCGCTTGCGACGAGCTACTGGATGCTTTTCAT
CGGGCGCAGCCTTGCCGGGATCAGCGGCGCGAGTTTCGGCACCGCGTCCGCTTACATCGCCGATGTCAGCAATGACGAAA
ACCGCGCCAAGAACTTCGGGCTGATCGGCATTGCCTTCGGAACCGGTTTTGCACTGGGCCCGGTCATAGGAGGTGTCCTT
GGGGAACTGGGACCAAGGGTGCCCTTTTATGGTGCCGCAGCGCTGTCGTTCCTCAATTTCGTCATGGGTGCCTTTCTCCT
GCCGGAAACGCTCGATCCGGCCAATCGGCGTCGCTTCGAATGGCGCCGGGCCAATCCGTTCGGCGCGCTCAAGCAGATGC
GTCATTACCCGGGTATCGGCTGGGTGGGCCTCGTCTTCTTCCTCTACTGGCTGGCGCACGCCGTCTACCCCGCCGTCTGG
TCCTTCGTCGCTTCCTATCGCTATGGGTGGAGCGAAGGGCAGATCGGGCTTTCATTGGGGATTTTCGGCGTCGGCGGCGC
AATCGTCATGGCGCTGGTACTGCCGCGCGTCGTCCCGGCATTGGGAGAAAGGCGAACGGCCGCGCTCGGGCTTACATTCA
CGGCTCTCGGAATGGCCGGCTATGCTGCTGCCTGGGAAGGCTGGATGGTATATGCTGTGATCGTCGCGACCGCGCTTGAA
AGCCTTGCCGATCCGCCGCTCCGCAGCATAGCGTCGGTCCATGTCCCGCCCTCCGCACAGGGCGAATTGCAAGGCGCGCT
CACCAGTATATCGAGCATGACGACGATCATCGGACCTCTGATGTTTACGCAGATTTTTGCCTATTTCACTAACCCCGCCG
CCACCTATGCCTTTTCCGGGGCTCCCTATGCGGTGGCCGGCTGCCTGATCATCGCCGCATTGCTGATATTCCTTGCCAAG
GTCCGCACCGGACGGGGTGGCACCTATCGGGATGGGGTGCCCGGCATAGCGGAGGCATCATCCTGA

Upstream 100 bases:

>100_bases
TGAGATGTTCACGTATTGTTTCGGCTCAGGCAAGTTGTTACACCTAAACTGGTAACTTTGTTCACGGTCTGTCTCCGCTC
CGGCAGACAGGGGGGAGCTC

Downstream 100 bases:

>100_bases
TTTCATGCCTTCAGATTGATCAATTATGTTGATCGATCGATGAAAAATTGAGCAGCCGCGCCATTACCGCTGGCGCAAGT
CCCGGTGGTGCTCTAATTCG

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MIDQKFVKRGLFLVFMILFLDIMGIAIIVPVLPSYLEELTGADVGEAAIDGGWLLLVYSAMQFFFAPLIGNLSDRFGRRP
ILLASVLTFAIDNLICALATSYWMLFIGRSLAGISGASFGTASAYIADVSNDENRAKNFGLIGIAFGTGFALGPVIGGVL
GELGPRVPFYGAAALSFLNFVMGAFLLPETLDPANRRRFEWRRANPFGALKQMRHYPGIGWVGLVFFLYWLAHAVYPAVW
SFVASYRYGWSEGQIGLSLGIFGVGGAIVMALVLPRVVPALGERRTAALGLTFTALGMAGYAAAWEGWMVYAVIVATALE
SLADPPLRSIASVHVPPSAQGELQGALTSISSMTTIIGPLMFTQIFAYFTNPAATYAFSGAPYAVAGCLIIAALLIFLAK
VRTGRGGTYRDGVPGIAEASS

Sequences:

>Translated_421_residues
MIDQKFVKRGLFLVFMILFLDIMGIAIIVPVLPSYLEELTGADVGEAAIDGGWLLLVYSAMQFFFAPLIGNLSDRFGRRP
ILLASVLTFAIDNLICALATSYWMLFIGRSLAGISGASFGTASAYIADVSNDENRAKNFGLIGIAFGTGFALGPVIGGVL
GELGPRVPFYGAAALSFLNFVMGAFLLPETLDPANRRRFEWRRANPFGALKQMRHYPGIGWVGLVFFLYWLAHAVYPAVW
SFVASYRYGWSEGQIGLSLGIFGVGGAIVMALVLPRVVPALGERRTAALGLTFTALGMAGYAAAWEGWMVYAVIVATALE
SLADPPLRSIASVHVPPSAQGELQGALTSISSMTTIIGPLMFTQIFAYFTNPAATYAFSGAPYAVAGCLIIAALLIFLAK
VRTGRGGTYRDGVPGIAEASS
>Mature_421_residues
MIDQKFVKRGLFLVFMILFLDIMGIAIIVPVLPSYLEELTGADVGEAAIDGGWLLLVYSAMQFFFAPLIGNLSDRFGRRP
ILLASVLTFAIDNLICALATSYWMLFIGRSLAGISGASFGTASAYIADVSNDENRAKNFGLIGIAFGTGFALGPVIGGVL
GELGPRVPFYGAAALSFLNFVMGAFLLPETLDPANRRRFEWRRANPFGALKQMRHYPGIGWVGLVFFLYWLAHAVYPAVW
SFVASYRYGWSEGQIGLSLGIFGVGGAIVMALVLPRVVPALGERRTAALGLTFTALGMAGYAAAWEGWMVYAVIVATALE
SLADPPLRSIASVHVPPSAQGELQGALTSISSMTTIIGPLMFTQIFAYFTNPAATYAFSGAPYAVAGCLIIAALLIFLAK
VRTGRGGTYRDGVPGIAEASS

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=315, Percent_Identity=28.2539682539683, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI94721311, Length=415, Percent_Identity=23.6144578313253, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI217416366, Length=199, Percent_Identity=34.1708542713568, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI225703104, Length=371, Percent_Identity=27.4932614555256, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI225703102, Length=371, Percent_Identity=27.4932614555256, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI87081738, Length=180, Percent_Identity=32.2222222222222, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71996331, Length=331, Percent_Identity=25.6797583081571, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17551570, Length=347, Percent_Identity=25.9365994236311, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221513297, Length=319, Percent_Identity=26.6457680250784, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357569, Length=317, Percent_Identity=26.1829652996845, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI161080926, Length=327, Percent_Identity=25.6880733944954, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161080924, Length=327, Percent_Identity=25.6880733944954, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24656463, Length=327, Percent_Identity=25.6880733944954, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24656468, Length=327, Percent_Identity=25.6880733944954, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17738085, Length=376, Percent_Identity=24.7340425531915, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24667561, Length=207, Percent_Identity=24.6376811594203, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44893; Mature: 44893

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00213 LIPOCALIN ; PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDQKFVKRGLFLVFMILFLDIMGIAIIVPVLPSYLEELTGADVGEAAIDGGWLLLVYSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHH
MQFFFAPLIGNLSDRFGRRPILLASVLTFAIDNLICALATSYWMLFIGRSLAGISGASFG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TASAYIADVSNDENRAKNFGLIGIAFGTGFALGPVIGGVLGELGPRVPFYGAAALSFLNF
CHHHHEEECCCCHHHHHHCCEEEEEHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VMGAFLLPETLDPANRRRFEWRRANPFGALKQMRHYPGIGWVGLVFFLYWLAHAVYPAVW
HHHHHHCCCCCCHHHHHHCHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SFVASYRYGWSEGQIGLSLGIFGVGGAIVMALVLPRVVPALGERRTAALGLTFTALGMAG
HHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YAAAWEGWMVYAVIVATALESLADPPLRSIASVHVPPSAQGELQGALTSISSMTTIIGPL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MFTQIFAYFTNPAATYAFSGAPYAVAGCLIIAALLIFLAKVRTGRGGTYRDGVPGIAEAS
HHHHHHHHHCCCHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
S
C
>Mature Secondary Structure
MIDQKFVKRGLFLVFMILFLDIMGIAIIVPVLPSYLEELTGADVGEAAIDGGWLLLVYSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHH
MQFFFAPLIGNLSDRFGRRPILLASVLTFAIDNLICALATSYWMLFIGRSLAGISGASFG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TASAYIADVSNDENRAKNFGLIGIAFGTGFALGPVIGGVLGELGPRVPFYGAAALSFLNF
CHHHHEEECCCCHHHHHHCCEEEEEHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VMGAFLLPETLDPANRRRFEWRRANPFGALKQMRHYPGIGWVGLVFFLYWLAHAVYPAVW
HHHHHHCCCCCCHHHHHHCHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
SFVASYRYGWSEGQIGLSLGIFGVGGAIVMALVLPRVVPALGERRTAALGLTFTALGMAG
HHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
YAAAWEGWMVYAVIVATALESLADPPLRSIASVHVPPSAQGELQGALTSISSMTTIIGPL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MFTQIFAYFTNPAATYAFSGAPYAVAGCLIIAALLIFLAKVRTGRGGTYRDGVPGIAEAS
HHHHHHHHHCCCHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]