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The map label for this gene is lrp [H]

Identifier: 150396467

GI number: 150396467

Start: 1340078

End: 1340548

Strand: Direct

Name: lrp [H]

Synonym: Smed_1249

Alternate gene names: 150396467

Gene position: 1340078-1340548 (Clockwise)

Preceding gene: 150396459

Following gene: 150396468

Centisome position: 35.43

GC content: 59.24

Gene sequence:

>471_bases
ATGGTCGTACGCGTCGAGCTCGATGCCATCGATATGAAAATACTGCGCGAACTGCAGGATAACGGCCGTATGACGAATGT
GGAACTGGCCGAGAGGGTGGGGATTTCGGCACCTCCCTGCCTGCGCCGGGTTCGCAAGCTCGAGGAGGCCGGCGTCATCC
GGGGCTATCGCGCGCTTCTGAATGCCGCCGCGCTTGGATATGATCTCGTTGCCTTCTGCATGGTCGGTCTGAAGCACCAG
TCCGACGCCAATCTGAAGGCCTTTGCCGCCCGCACCGCCTCATGGCCGCTTGTTCGCGAGGCCTGGATGGTGTCCGGAGA
GTCGGACTTTCTGCTGCAGTGCGTGGCCGAGAACCTTGCGAGCTTTCAGGATTTCGTTATTGAAGAACTGACCGCCACCG
AGAATGTCGATACGGTGCGGACGATGCTGACGATCCGGCAAGTGAAGGACGCATGTCAGGTAGAAATCTGA

Upstream 100 bases:

>100_bases
CGCGAAGGGATCGGCGCTACGGTATCGTACCGTCGTCCATCGATCGGCGGACAAAAGGCCTTTGCCGCAAGCAAGGCCGA
CATGATTGGGGATATGGGCA

Downstream 100 bases:

>100_bases
GGTGCAGAGCGGGTTCCCACCCGGCACCACAAGCCAAGGTCTTGCGGACTGCCGTTTCGACCGGCTTCCAGGACGAGAGC
GAATGCGGGACGGCCCTATG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MVVRVELDAIDMKILRELQDNGRMTNVELAERVGISAPPCLRRVRKLEEAGVIRGYRALLNAAALGYDLVAFCMVGLKHQ
SDANLKAFAARTASWPLVREAWMVSGESDFLLQCVAENLASFQDFVIEELTATENVDTVRTMLTIRQVKDACQVEI

Sequences:

>Translated_156_residues
MVVRVELDAIDMKILRELQDNGRMTNVELAERVGISAPPCLRRVRKLEEAGVIRGYRALLNAAALGYDLVAFCMVGLKHQ
SDANLKAFAARTASWPLVREAWMVSGESDFLLQCVAENLASFQDFVIEELTATENVDTVRTMLTIRQVKDACQVEI
>Mature_156_residues
MVVRVELDAIDMKILRELQDNGRMTNVELAERVGISAPPCLRRVRKLEEAGVIRGYRALLNAAALGYDLVAFCMVGLKHQ
SDANLKAFAARTASWPLVREAWMVSGESDFLLQCVAENLASFQDFVIEELTATENVDTVRTMLTIRQVKDACQVEI

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=151, Percent_Identity=36.4238410596026, Blast_Score=105, Evalue=1e-24,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=27.3333333333333, Blast_Score=77, Evalue=5e-16,
Organism=Escherichia coli, GI1790182, Length=140, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17414; Mature: 17414

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVRVELDAIDMKILRELQDNGRMTNVELAERVGISAPPCLRRVRKLEEAGVIRGYRALL
CEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NAAALGYDLVAFCMVGLKHQSDANLKAFAARTASWPLVREAWMVSGESDFLLQCVAENLA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SFQDFVIEELTATENVDTVRTMLTIRQVKDACQVEI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVVRVELDAIDMKILRELQDNGRMTNVELAERVGISAPPCLRRVRKLEEAGVIRGYRALL
CEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NAAALGYDLVAFCMVGLKHQSDANLKAFAARTASWPLVREAWMVSGESDFLLQCVAENLA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SFQDFVIEELTATENVDTVRTMLTIRQVKDACQVEI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]