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The map label for this gene is serS [H]

Identifier: 150396386

GI number: 150396386

Start: 1243773

End: 1245056

Strand: Direct

Name: serS [H]

Synonym: Smed_1167

Alternate gene names: 150396386

Gene position: 1243773-1245056 (Clockwise)

Preceding gene: 150396385

Following gene: 150396387

Centisome position: 32.89

GC content: 61.29

Gene sequence:

>1284_bases
ATGCTCGATATCAAATGGATCCGTGAGAATGCAGACGTCCTCGATAGCGCCCTGGCGAAACGGGGTGCGGGGCCATTGTC
GGCATCCCTGATCGCTCTTGACGAGCGCCGCCGGACAATTCTGCAGTCGCTGCAGGACATGCAGTCCCGCCGCAATGCCG
CGTCCAAGGAAATCGGCGCCGCAATGGCCCAGAAGAACAGCGAGTTGGCAGACAGGCTCAAGGCCGAAGTCGCCGAGCTC
AAGACCACGCTGCCGGCCGCCGAAGAGGAAAGCCGACGGATCGAAGCCGAGCTTACCGATGCGCTGTCGCGCATTCCCAA
TGCACCGCTCGACGATGTTCCCGTCGGAGCGGACGAAAGCGCAAACGTCGTAACACGTGTGGTCGGGGCCAAGCCCACAT
GGAACCACAAGCCGCTCGAGCATTTTGAGATCGGCGAAGCGCTGGGACTGATGGACTTCGAAGGAGCGGCGAGAATCGCC
GGGTCGCGCTTCACGATCCTCAAAGGTCAGCTCGCGCGCCTGGAACGCGCGCTCGGCCAGTTCATGCTCGACCTACACAC
AGGGGAACATGGGTACATCGAGGTTCAGCCTCCGTTGCTCGTCCGCGACGATGCGATGTATGGCACCGGCCAGCTGCCGA
AATTCACTGATGATCTCTTCCGCACGACTGATGGACGCTGGTTGATCCCGACGGCTGAAGTCCCGCTGACGAACATGGTC
CGGGAACAGATCCTCGACGGCGAAAAGCTGCCGCTGCGCTTTACGGCCTTGACCCCATGCTTCCGCTCCGAGGCCGGCTC
CGCCGGCCGTGACACCCGAGGTATGTTGCGCCAGCATCAGTTCAATAAAGTCGAACTGGTGTCGATCACGGATGCCGAGA
GCGCGCTCGACGAACACGAGCGGATGACTGCTTGTGCCGAGGAGGTACTTAAGCGTCTCGGCCTGCATTACCGTGTGATG
ACGCTTTGCACCGGCGACATGGGATTTAGCGCTCGCAAGACGTACGATCTCGAGGTCTGGCTGCCGGGACAGGACGCCTA
TCGCGAGATTTCTTCGTGCTCGGTCTGCGGCGATTTTCAAGGCCGCCGAATGAACGCGCGTTACCGCGGAAAAGAAGAAA
AGGGGACGAAGTTCGCCCACACGCTGAACGGTTCCGGCGTCGCCCTCGGCCGGGCGCTGATCGCCGTCATCGAGAATTAC
CTGAATGAGGACGGCTCTATCACCGTGCCAGACGCCCTCATAGCCTACATGGGCGGCCTGCGACGGATCGAGAAGGCTGC
TTAG

Upstream 100 bases:

>100_bases
CTCCGCTCCGAACGGGCAGGGCGCGCTGCGGCATTCTGAATGACTGTATGATCTCGTCGATCGACCCGAGGAAATGCAGT
AACCAACGCGTGGAACGACT

Downstream 100 bases:

>100_bases
GGCAGGCCCAGCTTTGTGAAATCGAGACCTGCCGGAGCAGAGAACCCGTTAGACGGTTTTCCGGGAAGTGCTCCGGCACC
ATAAATGGAAGAAGACCGGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDIKWIRENADVLDSALAKRGAGPLSASLIALDERRRTILQSLQDMQSRRNAASKEIGAAMAQKNSELADRLKAEVAEL
KTTLPAAEEESRRIEAELTDALSRIPNAPLDDVPVGADESANVVTRVVGAKPTWNHKPLEHFEIGEALGLMDFEGAARIA
GSRFTILKGQLARLERALGQFMLDLHTGEHGYIEVQPPLLVRDDAMYGTGQLPKFTDDLFRTTDGRWLIPTAEVPLTNMV
REQILDGEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFNKVELVSITDAESALDEHERMTACAEEVLKRLGLHYRVM
TLCTGDMGFSARKTYDLEVWLPGQDAYREISSCSVCGDFQGRRMNARYRGKEEKGTKFAHTLNGSGVALGRALIAVIENY
LNEDGSITVPDALIAYMGGLRRIEKAA

Sequences:

>Translated_427_residues
MLDIKWIRENADVLDSALAKRGAGPLSASLIALDERRRTILQSLQDMQSRRNAASKEIGAAMAQKNSELADRLKAEVAEL
KTTLPAAEEESRRIEAELTDALSRIPNAPLDDVPVGADESANVVTRVVGAKPTWNHKPLEHFEIGEALGLMDFEGAARIA
GSRFTILKGQLARLERALGQFMLDLHTGEHGYIEVQPPLLVRDDAMYGTGQLPKFTDDLFRTTDGRWLIPTAEVPLTNMV
REQILDGEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFNKVELVSITDAESALDEHERMTACAEEVLKRLGLHYRVM
TLCTGDMGFSARKTYDLEVWLPGQDAYREISSCSVCGDFQGRRMNARYRGKEEKGTKFAHTLNGSGVALGRALIAVIENY
LNEDGSITVPDALIAYMGGLRRIEKAA
>Mature_427_residues
MLDIKWIRENADVLDSALAKRGAGPLSASLIALDERRRTILQSLQDMQSRRNAASKEIGAAMAQKNSELADRLKAEVAEL
KTTLPAAEEESRRIEAELTDALSRIPNAPLDDVPVGADESANVVTRVVGAKPTWNHKPLEHFEIGEALGLMDFEGAARIA
GSRFTILKGQLARLERALGQFMLDLHTGEHGYIEVQPPLLVRDDAMYGTGQLPKFTDDLFRTTDGRWLIPTAEVPLTNMV
REQILDGEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFNKVELVSITDAESALDEHERMTACAEEVLKRLGLHYRVM
TLCTGDMGFSARKTYDLEVWLPGQDAYREISSCSVCGDFQGRRMNARYRGKEEKGTKFAHTLNGSGVALGRALIAVIENY
LNEDGSITVPDALIAYMGGLRRIEKAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=441, Percent_Identity=33.1065759637188, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI225579074, Length=399, Percent_Identity=31.077694235589, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI8923421, Length=403, Percent_Identity=29.5285359801489, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=51.2761020881671, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539260, Length=467, Percent_Identity=31.9057815845824, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=331, Percent_Identity=28.3987915407855, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=393, Percent_Identity=32.5699745547074, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6321799, Length=439, Percent_Identity=28.9293849658314, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24581334, Length=435, Percent_Identity=29.6551724137931, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17737985, Length=330, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47181; Mature: 47181

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKWIRENADVLDSALAKRGAGPLSASLIALDERRRTILQSLQDMQSRRNAASKEIGA
CCCCEEHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAQKNSELADRLKAEVAELKTTLPAAEEESRRIEAELTDALSRIPNAPLDDVPVGADES
HHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ANVVTRVVGAKPTWNHKPLEHFEIGEALGLMDFEGAARIAGSRFTILKGQLARLERALGQ
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCEEEEHHHHHHHHHHHHHH
FMLDLHTGEHGYIEVQPPLLVRDDAMYGTGQLPKFTDDLFRTTDGRWLIPTAEVPLTNMV
HHHHHCCCCCCEEEECCCEEEECCCCCCCCCCCCHHHHHHHCCCCCEEECCCCCCHHHHH
REQILDGEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFNKVELVSITDAESALDEHE
HHHHCCCCCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHH
RMTACAEEVLKRLGLHYRVMTLCTGDMGFSARKTYDLEVWLPGQDAYREISSCSVCGDFQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCC
GRRMNARYRGKEEKGTKFAHTLNGSGVALGRALIAVIENYLNEDGSITVPDALIAYMGGL
CCCCCCHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHH
RRIEKAA
HHHHHCC
>Mature Secondary Structure
MLDIKWIRENADVLDSALAKRGAGPLSASLIALDERRRTILQSLQDMQSRRNAASKEIGA
CCCCEEHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAQKNSELADRLKAEVAELKTTLPAAEEESRRIEAELTDALSRIPNAPLDDVPVGADES
HHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ANVVTRVVGAKPTWNHKPLEHFEIGEALGLMDFEGAARIAGSRFTILKGQLARLERALGQ
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCEEEEHHHHHHHHHHHHHH
FMLDLHTGEHGYIEVQPPLLVRDDAMYGTGQLPKFTDDLFRTTDGRWLIPTAEVPLTNMV
HHHHHCCCCCCEEEECCCEEEECCCCCCCCCCCCHHHHHHHCCCCCEEECCCCCCHHHHH
REQILDGEKLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFNKVELVSITDAESALDEHE
HHHHCCCCCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHH
RMTACAEEVLKRLGLHYRVMTLCTGDMGFSARKTYDLEVWLPGQDAYREISSCSVCGDFQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCCCCCC
GRRMNARYRGKEEKGTKFAHTLNGSGVALGRALIAVIENYLNEDGSITVPDALIAYMGGL
CCCCCCHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHH
RRIEKAA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]