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The map label for this gene is ctaB [H]

Identifier: 150395744

GI number: 150395744

Start: 564498

End: 565448

Strand: Direct

Name: ctaB [H]

Synonym: Smed_0520

Alternate gene names: 150395744

Gene position: 564498-565448 (Clockwise)

Preceding gene: 150395743

Following gene: 150395745

Centisome position: 14.93

GC content: 60.67

Gene sequence:

>951_bases
ATGACGGTCATCGACAATCACGAGGCAGTCGGCATGGAAGGCGCACCACGCCTGTCCGAGGCCTCTGCGCGCGATTATTT
CGAACTCCTGAAGCCGCGCGTCATGTCTCTCGTCGTCTTCACCGCCTTCGCGGGGCTCATCCTTGCTCCCGGGCATATCA
ATCCGTTCATCGGATTCACAGCGATTCTCTGTATCGCCATAGGAGCCGGCGCCTCGGGTGCGCTGAACATGTGGTACGAT
GCGGATATCGACGCGGTCATGAGCCGCACGGCCAAGCGCCCAATTCCGGCCGGAAAGATTTTGCCCCAGGAAGCGCTTGC
CTTCGGCCTGACGCTCTCGGCCTTCTCGGTGATCATCCTCGGGCTCGCCGTGCACTGGCTCGCAGCCGGGCTGCTCGCCT
TTACGATTTTCTTCTACGTGGCTGTATACACGATGTGGCTGAAGCGCTCGACGCCGCAGAACATCGTTATCGGCGGAGCT
GCCGGGGCCTTTCCTCCGATGATAGGCTGGGCCTGCGTGACCGGCGGCATATCGGTCGAGAGCATCGTGCTCTTCCTCAT
CATCTTCCTCTGGACGCCGGCGCATTTCTGGGCCCTGGCCCTTTTCAAGATGGGCGAATACGGCGCCGTCGGAGTGCCTA
TGATGCCGAATGTCTGCGGCGAGGCGACGACCAAGCGGCAAATCGTCATCTATGCCGTGCTCACTGCGATCAGCGGTATC
TGTCCCACCTTGCTCGGCTTCGCGAGCCTTGGTTATGGAGCCCTTGCGACGGCCTTGGGGCTTGGGTTCGTCGGGTATTC
GCTGGGCGTGCTGCGCATGCCTGAAGGCGACAAGCGAATGGTGCCGGCGAAGAAGCTTTTCGCCTTCTCCATCGTGTATC
TTTTCGCGATTTTCTCGGCGCTCCTGGTTGATTACGCAATCGCCCGGATCTGGTTCGGAGGCGTCATCTGA

Upstream 100 bases:

>100_bases
GACGGGAAACGAGCAGAAGCCGCCGGTTACGGCGGCTTCTCCCCGCCGGCAAGCCGGCGCGAAGCGGCTTTTCCTGCCGC
ATCAAGTTCAGGGTAAGGAC

Downstream 100 bases:

>100_bases
TGGAAACCGTTCAACTGAGCGAGGCTCAGAAGAAGTCCCGCCGCGGCCGCAACATCGCACTCGGTATCGTGCTGGCGTGC
CTTGTCGTCATTTTCTACGC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTVIDNHEAVGMEGAPRLSEASARDYFELLKPRVMSLVVFTAFAGLILAPGHINPFIGFTAILCIAIGAGASGALNMWYD
ADIDAVMSRTAKRPIPAGKILPQEALAFGLTLSAFSVIILGLAVHWLAAGLLAFTIFFYVAVYTMWLKRSTPQNIVIGGA
AGAFPPMIGWACVTGGISVESIVLFLIIFLWTPAHFWALALFKMGEYGAVGVPMMPNVCGEATTKRQIVIYAVLTAISGI
CPTLLGFASLGYGALATALGLGFVGYSLGVLRMPEGDKRMVPAKKLFAFSIVYLFAIFSALLVDYAIARIWFGGVI

Sequences:

>Translated_316_residues
MTVIDNHEAVGMEGAPRLSEASARDYFELLKPRVMSLVVFTAFAGLILAPGHINPFIGFTAILCIAIGAGASGALNMWYD
ADIDAVMSRTAKRPIPAGKILPQEALAFGLTLSAFSVIILGLAVHWLAAGLLAFTIFFYVAVYTMWLKRSTPQNIVIGGA
AGAFPPMIGWACVTGGISVESIVLFLIIFLWTPAHFWALALFKMGEYGAVGVPMMPNVCGEATTKRQIVIYAVLTAISGI
CPTLLGFASLGYGALATALGLGFVGYSLGVLRMPEGDKRMVPAKKLFAFSIVYLFAIFSALLVDYAIARIWFGGVI
>Mature_315_residues
TVIDNHEAVGMEGAPRLSEASARDYFELLKPRVMSLVVFTAFAGLILAPGHINPFIGFTAILCIAIGAGASGALNMWYDA
DIDAVMSRTAKRPIPAGKILPQEALAFGLTLSAFSVIILGLAVHWLAAGLLAFTIFFYVAVYTMWLKRSTPQNIVIGGAA
GAFPPMIGWACVTGGISVESIVLFLIIFLWTPAHFWALALFKMGEYGAVGVPMMPNVCGEATTKRQIVIYAVLTAISGIC
PTLLGFASLGYGALATALGLGFVGYSLGVLRMPEGDKRMVPAKKLFAFSIVYLFAIFSALLVDYAIARIWFGGVI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=200, Percent_Identity=34.5, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1786631, Length=285, Percent_Identity=28.4210526315789, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71998235, Length=269, Percent_Identity=27.1375464684015, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325085, Length=195, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921064, Length=299, Percent_Identity=27.4247491638796, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33657; Mature: 33525

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIDNHEAVGMEGAPRLSEASARDYFELLKPRVMSLVVFTAFAGLILAPGHINPFIGFT
CCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AILCIAIGAGASGALNMWYDADIDAVMSRTAKRPIPAGKILPQEALAFGLTLSAFSVIIL
HHHHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GLAVHWLAAGLLAFTIFFYVAVYTMWLKRSTPQNIVIGGAAGAFPPMIGWACVTGGISVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCCCHH
SIVLFLIIFLWTPAHFWALALFKMGEYGAVGVPMMPNVCGEATTKRQIVIYAVLTAISGI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CPTLLGFASLGYGALATALGLGFVGYSLGVLRMPEGDKRMVPAKKLFAFSIVYLFAIFSA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLVDYAIARIWFGGVI
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TVIDNHEAVGMEGAPRLSEASARDYFELLKPRVMSLVVFTAFAGLILAPGHINPFIGFT
CEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AILCIAIGAGASGALNMWYDADIDAVMSRTAKRPIPAGKILPQEALAFGLTLSAFSVIIL
HHHHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GLAVHWLAAGLLAFTIFFYVAVYTMWLKRSTPQNIVIGGAAGAFPPMIGWACVTGGISVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCCCHH
SIVLFLIIFLWTPAHFWALALFKMGEYGAVGVPMMPNVCGEATTKRQIVIYAVLTAISGI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CPTLLGFASLGYGALATALGLGFVGYSLGVLRMPEGDKRMVPAKKLFAFSIVYLFAIFSA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLVDYAIARIWFGGVI
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA