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The map label for this gene is hrcA [H]

Identifier: 150395239

GI number: 150395239

Start: 9671

End: 10750

Strand: Direct

Name: hrcA [H]

Synonym: Smed_0011

Alternate gene names: 150395239

Gene position: 9671-10750 (Clockwise)

Preceding gene: 150395234

Following gene: 150395240

Centisome position: 0.26

GC content: 62.13

Gene sequence:

>1080_bases
ATGGTACTGCGCAACCCTGACAAGAAGGGGATCGCATCGGCGCTGGATGAGCGCTCCGGCGAGATCTTCCGCCGTATTGT
CGAGAGCTATCTGGAAAGCGGAGAGCCGCTCGGCTCGCGCAATCTTTCGCGGCTTTTGCCGATATCGCTGTCGCCTGCCT
CGGTGCGCAACGTCATGAGCGACCTCGAGGATCTGGGCCTTATCTATTCGCCCCATGTCAGCGCCGGCCGGCTCCCGACG
CAGACGGGCCTGCGTTTTTTCGTCGATGCCTTTATGCAGGTGGGCAATCTTTCGCCCGAAGAGCGCGCCTCCATCGAAAG
GCAGGTGGGACCGGGAAATAGGGACCATTCGGTCGAGAACCTTCTTACCGAGGCGAGCCAGATGCTGTCGGGCATGTCGC
GCGGCGCCGGTCTCGTCATCACCACCAAGAGCGATCCCGTCCTCAAGCATGTCGAGTTTATCCGGCTGGCGCCGACAAAG
GCGCTTGCGGTGCTCGTCGGCGAACACGATCAGGTGGAGAACCGCATCATCGAGCTGCCGGCTGGGATCACGAGCGCGCA
GCTCACCGAAGCGGCCAATTTCGTCAACGCCCATCTTGCCGGGCAGACGATTCCCGAACTGCGGACGCAGCTGGAAAAGG
TGAAGGAGACCGTTCGCGGCGAACTCGATGCCCTCTCGCAGGATCTGGTCGAGCGCGGGCTGGCGATCTGGTCCGGAAGC
GAGGGCGACGGCCAGCCGGCGCGACTGATCGTGCGGGGCCGCGCCAATCTGCTCGAAGGACTGGAAGGGACTGAGGATAT
CGAGCGGCTGCGCATGCTCTTCGATGACCTCGAAAAGAAGGACAGCCTGATCGAGATACTCAACCTTGCCGAGAGCGGCC
CGGGCGTGCGTATCTTCATAGGCTCGGAAAACAAGCTGTTTTCGCTCTCCGGATCCTCTCTGATCGTCGCGCCCTATCGC
GACAGCGACGACCGCATTGTGGGCGCGGTCGGGGTTATCGGACCTACCCGGCTCAACTATTCCCGCATCGTTCCGATGGT
GGATTACACCGCGCAGCTCATGTCGAGGATGTCGCGCTGA

Upstream 100 bases:

>100_bases
CGCCGTAGCCCAAGCATCTCCTCGGCGTTTTTCCCTTTTGCCAATCCGCCTGTGGATCACTATATTCCTTCCTGACACCG
AACATTGATCACGGAGTGAC

Downstream 100 bases:

>100_bases
CGAATCCTTTTGGCCGATAACTCAATCGACCCTTGATTTTTCGGGCTCAAACATCGATATCGGGCTTCAAATCCAGGCAA
CAGAACGTTCAAGCAAAGCG

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MVLRNPDKKGIASALDERSGEIFRRIVESYLESGEPLGSRNLSRLLPISLSPASVRNVMSDLEDLGLIYSPHVSAGRLPT
QTGLRFFVDAFMQVGNLSPEERASIERQVGPGNRDHSVENLLTEASQMLSGMSRGAGLVITTKSDPVLKHVEFIRLAPTK
ALAVLVGEHDQVENRIIELPAGITSAQLTEAANFVNAHLAGQTIPELRTQLEKVKETVRGELDALSQDLVERGLAIWSGS
EGDGQPARLIVRGRANLLEGLEGTEDIERLRMLFDDLEKKDSLIEILNLAESGPGVRIFIGSENKLFSLSGSSLIVAPYR
DSDDRIVGAVGVIGPTRLNYSRIVPMVDYTAQLMSRMSR

Sequences:

>Translated_359_residues
MVLRNPDKKGIASALDERSGEIFRRIVESYLESGEPLGSRNLSRLLPISLSPASVRNVMSDLEDLGLIYSPHVSAGRLPT
QTGLRFFVDAFMQVGNLSPEERASIERQVGPGNRDHSVENLLTEASQMLSGMSRGAGLVITTKSDPVLKHVEFIRLAPTK
ALAVLVGEHDQVENRIIELPAGITSAQLTEAANFVNAHLAGQTIPELRTQLEKVKETVRGELDALSQDLVERGLAIWSGS
EGDGQPARLIVRGRANLLEGLEGTEDIERLRMLFDDLEKKDSLIEILNLAESGPGVRIFIGSENKLFSLSGSSLIVAPYR
DSDDRIVGAVGVIGPTRLNYSRIVPMVDYTAQLMSRMSR
>Mature_359_residues
MVLRNPDKKGIASALDERSGEIFRRIVESYLESGEPLGSRNLSRLLPISLSPASVRNVMSDLEDLGLIYSPHVSAGRLPT
QTGLRFFVDAFMQVGNLSPEERASIERQVGPGNRDHSVENLLTEASQMLSGMSRGAGLVITTKSDPVLKHVEFIRLAPTK
ALAVLVGEHDQVENRIIELPAGITSAQLTEAANFVNAHLAGQTIPELRTQLEKVKETVRGELDALSQDLVERGLAIWSGS
EGDGQPARLIVRGRANLLEGLEGTEDIERLRMLFDDLEKKDSLIEILNLAESGPGVRIFIGSENKLFSLSGSSLIVAPYR
DSDDRIVGAVGVIGPTRLNYSRIVPMVDYTAQLMSRMSR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 39189; Mature: 39189

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLRNPDKKGIASALDERSGEIFRRIVESYLESGEPLGSRNLSRLLPISLSPASVRNVMS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHH
DLEDLGLIYSPHVSAGRLPTQTGLRFFVDAFMQVGNLSPEERASIERQVGPGNRDHSVEN
HHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHH
LLTEASQMLSGMSRGAGLVITTKSDPVLKHVEFIRLAPTKALAVLVGEHDQVENRIIELP
HHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHEECC
AGITSAQLTEAANFVNAHLAGQTIPELRTQLEKVKETVRGELDALSQDLVERGLAIWSGS
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
EGDGQPARLIVRGRANLLEGLEGTEDIERLRMLFDDLEKKDSLIEILNLAESGPGVRIFI
CCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
GSENKLFSLSGSSLIVAPYRDSDDRIVGAVGVIGPTRLNYSRIVPMVDYTAQLMSRMSR
CCCCCEEEECCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLRNPDKKGIASALDERSGEIFRRIVESYLESGEPLGSRNLSRLLPISLSPASVRNVMS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHH
DLEDLGLIYSPHVSAGRLPTQTGLRFFVDAFMQVGNLSPEERASIERQVGPGNRDHSVEN
HHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHH
LLTEASQMLSGMSRGAGLVITTKSDPVLKHVEFIRLAPTKALAVLVGEHDQVENRIIELP
HHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHEECC
AGITSAQLTEAANFVNAHLAGQTIPELRTQLEKVKETVRGELDALSQDLVERGLAIWSGS
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
EGDGQPARLIVRGRANLLEGLEGTEDIERLRMLFDDLEKKDSLIEILNLAESGPGVRIFI
CCCCCCEEEEEECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
GSENKLFSLSGSSLIVAPYRDSDDRIVGAVGVIGPTRLNYSRIVPMVDYTAQLMSRMSR
CCCCCEEEECCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]