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The map label for this gene is guaB [H]

Identifier: 150401620

GI number: 150401620

Start: 1264189

End: 1265664

Strand: Reverse

Name: guaB [H]

Synonym: Maeo_1197

Alternate gene names: 150401620

Gene position: 1265664-1264189 (Counterclockwise)

Preceding gene: 150401632

Following gene: 150401614

Centisome position: 80.64

GC content: 35.84

Gene sequence:

>1476_bases
TTGTTTTTAAATAAATTAGAAAAAGCCAAAAAAGCTTATACATTTGATGATGTTTTATTAATTCCTAATGCTTCGTTTGT
AGAGCCAAAAGACACAGATTTATCTGTAAATTTATGTGGATTAAAATTAAATATTCCAGTGGTATCTGCTGCAATGGATA
CAGTATCTGAAAAAGATATGGCTGTTGCAATTGCTAGAAAAGGTGGAATAGGAGTAATTCACAGAAATATGACTGTGGAA
GAACAGGTAAATCAGATAAAGGCAGTTAAAAAAGCAGAAGATTTAATTGTTAGAGATGTTTATACAATATCGCCAGATTC
AACCGTGGCAGATGCTCAAAGATTGATGGAACAGGTATCAATTAGTGGATTGCCTGTTGTAAATGAAAACGATGAATTGG
TTGGCATAATCACGACACGAGATATAAAATATATTAAAAATAAAAAAACAGTTTTAAAGGACTGTATGACTAAAAAGTTA
ATTGTGGGCGATGAAGATACAACCCATGAAAAGGCCACGGAAATTATGTATAATTACAAAATAGAGAGATTACCTATTGT
AAAAAATAAAAAATTAATAGGTATGATGACATTACGAGATATTTTAAAAAGAAAACAATATCCGAATGCAGCACGAGACG
AAAAAGGAAGGTTAATTGTAGCAGGAGCATGTGGTCCAAGTGATTTAAATAGGGCTCATGCACTAATAGATGCCGAAGTT
GATGCCATAGCTATTGACTGTGCTCATGCCCACAATATGACTGTTGTAAATAATGTTAAAATACTTAAAAAAGAATTAGA
AGGAACAAACATAAAATTAATTGTAGGTAATATAGCTACAAAAGAAGCAGCTATTGACTTAATAAACGCGGGAGCCGATG
CCTTAAAAGTAGGAATTGGTCCGGGAAGTATTTGTACCACAAGAATAGTTGCAGGAGTTGGAGTTCCCCAGCTAACAGCA
GTTGCCGAAGTTGCCAGTGTTGCAAAAGAGCATGGTGTTCCAGTGATTGCAGATGGTGGAATTAAATTCAGTGGAGATAT
AGCAAAGGCAATTGCAGCAGGTGCTGATGCCGTAATGTTAGGAAGTCTATTGGCAGGAACGGACGAAGCTCCAGGACAGT
TAATTACAATTAACGGAAGAAGATACAAACAATATAGAGGAATGGGCTCTGTTGGAGCTATGACAACCAATGCAGGCGGT
GGAGCAGATAGATACTTCCAAAGCGAAATGAAGCATGTTAAAATGGTTCCCGAAGGTATAGAAGGAGCTGTCCCATACAA
AGGAGCCGTTAAAGATACAATATACCAATTAATGGGCGGTTTAAGGTCGTCTATGGGATACTGTGGAGCAAAGAATATAA
AAGAAATGCATGAAAAAGCAAGATTTGTAATAATCACTCAAAGCGGTCAGAAAGAAAGCCACCCTCATGATGTGATTATT
ACAAATGAAGCTCCAAATTATCCAATGAATAAATAA

Upstream 100 bases:

>100_bases
CTTTATAATTTTATATATTTACATTATATATTATTCTATTAACTGTAAAGTATATATATTATTTTAAATAACATATATAA
AAGGATATATGGGTGAGATT

Downstream 100 bases:

>100_bases
AATTATAGGCAATCTTCAATAATTGTCCCTTATCCGGCTTATTATTAAACAAAATCTCTTCGAGATTTTATACAAAATCG
AAGATTTTGTAAACAAAATC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MFLNKLEKAKKAYTFDDVLLIPNASFVEPKDTDLSVNLCGLKLNIPVVSAAMDTVSEKDMAVAIARKGGIGVIHRNMTVE
EQVNQIKAVKKAEDLIVRDVYTISPDSTVADAQRLMEQVSISGLPVVNENDELVGIITTRDIKYIKNKKTVLKDCMTKKL
IVGDEDTTHEKATEIMYNYKIERLPIVKNKKLIGMMTLRDILKRKQYPNAARDEKGRLIVAGACGPSDLNRAHALIDAEV
DAIAIDCAHAHNMTVVNNVKILKKELEGTNIKLIVGNIATKEAAIDLINAGADALKVGIGPGSICTTRIVAGVGVPQLTA
VAEVASVAKEHGVPVIADGGIKFSGDIAKAIAAGADAVMLGSLLAGTDEAPGQLITINGRRYKQYRGMGSVGAMTTNAGG
GADRYFQSEMKHVKMVPEGIEGAVPYKGAVKDTIYQLMGGLRSSMGYCGAKNIKEMHEKARFVIITQSGQKESHPHDVII
TNEAPNYPMNK

Sequences:

>Translated_491_residues
MFLNKLEKAKKAYTFDDVLLIPNASFVEPKDTDLSVNLCGLKLNIPVVSAAMDTVSEKDMAVAIARKGGIGVIHRNMTVE
EQVNQIKAVKKAEDLIVRDVYTISPDSTVADAQRLMEQVSISGLPVVNENDELVGIITTRDIKYIKNKKTVLKDCMTKKL
IVGDEDTTHEKATEIMYNYKIERLPIVKNKKLIGMMTLRDILKRKQYPNAARDEKGRLIVAGACGPSDLNRAHALIDAEV
DAIAIDCAHAHNMTVVNNVKILKKELEGTNIKLIVGNIATKEAAIDLINAGADALKVGIGPGSICTTRIVAGVGVPQLTA
VAEVASVAKEHGVPVIADGGIKFSGDIAKAIAAGADAVMLGSLLAGTDEAPGQLITINGRRYKQYRGMGSVGAMTTNAGG
GADRYFQSEMKHVKMVPEGIEGAVPYKGAVKDTIYQLMGGLRSSMGYCGAKNIKEMHEKARFVIITQSGQKESHPHDVII
TNEAPNYPMNK
>Mature_491_residues
MFLNKLEKAKKAYTFDDVLLIPNASFVEPKDTDLSVNLCGLKLNIPVVSAAMDTVSEKDMAVAIARKGGIGVIHRNMTVE
EQVNQIKAVKKAEDLIVRDVYTISPDSTVADAQRLMEQVSISGLPVVNENDELVGIITTRDIKYIKNKKTVLKDCMTKKL
IVGDEDTTHEKATEIMYNYKIERLPIVKNKKLIGMMTLRDILKRKQYPNAARDEKGRLIVAGACGPSDLNRAHALIDAEV
DAIAIDCAHAHNMTVVNNVKILKKELEGTNIKLIVGNIATKEAAIDLINAGADALKVGIGPGSICTTRIVAGVGVPQLTA
VAEVASVAKEHGVPVIADGGIKFSGDIAKAIAAGADAVMLGSLLAGTDEAPGQLITINGRRYKQYRGMGSVGAMTTNAGG
GADRYFQSEMKHVKMVPEGIEGAVPYKGAVKDTIYQLMGGLRSSMGYCGAKNIKEMHEKARFVIITQSGQKESHPHDVII
TNEAPNYPMNK

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=481, Percent_Identity=38.045738045738, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI217035146, Length=489, Percent_Identity=36.1963190184049, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI34328930, Length=489, Percent_Identity=36.1963190184049, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI34328928, Length=489, Percent_Identity=36.1963190184049, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI156616279, Length=489, Percent_Identity=36.1963190184049, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI217035152, Length=488, Percent_Identity=36.0655737704918, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI217035148, Length=489, Percent_Identity=35.7873210633947, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI217035150, Length=489, Percent_Identity=33.5378323108384, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI156104880, Length=252, Percent_Identity=42.0634920634921, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI50541954, Length=271, Percent_Identity=40.2214022140221, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI50541952, Length=271, Percent_Identity=40.2214022140221, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI50541948, Length=271, Percent_Identity=40.2214022140221, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI50541956, Length=271, Percent_Identity=40.2214022140221, Blast_Score=178, Evalue=1e-44,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=49.1836734693878, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1786293, Length=262, Percent_Identity=36.6412213740458, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=489, Percent_Identity=32.719836400818, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71994389, Length=440, Percent_Identity=33.6363636363636, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17560440, Length=282, Percent_Identity=36.8794326241135, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=36.2704918032787, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6323464, Length=487, Percent_Identity=36.5503080082135, Blast_Score=296, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=36.5904365904366, Blast_Score=293, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6319352, Length=344, Percent_Identity=34.593023255814, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319353, Length=134, Percent_Identity=41.044776119403, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24641071, Length=490, Percent_Identity=38.1632653061225, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24641073, Length=490, Percent_Identity=38.1632653061225, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=39.1402714932127, Blast_Score=276, Evalue=3e-74,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52859; Mature: 52859

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLNKLEKAKKAYTFDDVLLIPNASFVEPKDTDLSVNLCGLKLNIPVVSAAMDTVSEKDM
CCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHCCCCCE
AVAIARKGGIGVIHRNMTVEEQVNQIKAVKKAEDLIVRDVYTISPDSTVADAQRLMEQVS
EEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHC
ISGLPVVNENDELVGIITTRDIKYIKNKKTVLKDCMTKKLIVGDEDTTHEKATEIMYNYK
CCCCEEECCCCCEEEEEEECCHHHHHCHHHHHHHHHHCEEEECCCCCCHHHHHHHHHEEE
IERLPIVKNKKLIGMMTLRDILKRKQYPNAARDEKGRLIVAGACGPSDLNRAHALIDAEV
EEEECEECCCCEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHEEECCC
DAIAIDCAHAHNMTVVNNVKILKKELEGTNIKLIVGNIATKEAAIDLINAGADALKVGIG
CEEEEEECCCCCEEEECCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEECCC
PGSICTTRIVAGVGVPQLTAVAEVASVAKEHGVPVIADGGIKFSGDIAKAIAAGADAVML
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCHHHH
GSLLAGTDEAPGQLITINGRRYKQYRGMGSVGAMTTNAGGGADRYFQSEMKHVKMVPEGI
HHHHCCCCCCCCEEEEECCCHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCC
EGAVPYKGAVKDTIYQLMGGLRSSMGYCGAKNIKEMHEKARFVIITQSGQKESHPHDVII
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCEEE
TNEAPNYPMNK
ECCCCCCCCCC
>Mature Secondary Structure
MFLNKLEKAKKAYTFDDVLLIPNASFVEPKDTDLSVNLCGLKLNIPVVSAAMDTVSEKDM
CCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHCCCCCE
AVAIARKGGIGVIHRNMTVEEQVNQIKAVKKAEDLIVRDVYTISPDSTVADAQRLMEQVS
EEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHC
ISGLPVVNENDELVGIITTRDIKYIKNKKTVLKDCMTKKLIVGDEDTTHEKATEIMYNYK
CCCCEEECCCCCEEEEEEECCHHHHHCHHHHHHHHHHCEEEECCCCCCHHHHHHHHHEEE
IERLPIVKNKKLIGMMTLRDILKRKQYPNAARDEKGRLIVAGACGPSDLNRAHALIDAEV
EEEECEECCCCEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHEEECCC
DAIAIDCAHAHNMTVVNNVKILKKELEGTNIKLIVGNIATKEAAIDLINAGADALKVGIG
CEEEEEECCCCCEEEECCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEECCC
PGSICTTRIVAGVGVPQLTAVAEVASVAKEHGVPVIADGGIKFSGDIAKAIAAGADAVML
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCCHHHH
GSLLAGTDEAPGQLITINGRRYKQYRGMGSVGAMTTNAGGGADRYFQSEMKHVKMVPEGI
HHHHCCCCCCCCEEEEECCCHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCC
EGAVPYKGAVKDTIYQLMGGLRSSMGYCGAKNIKEMHEKARFVIITQSGQKESHPHDVII
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCEEE
TNEAPNYPMNK
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]