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The map label for this gene is hom [H]

Identifier: 150401632

GI number: 150401632

Start: 1277620

End: 1278642

Strand: Reverse

Name: hom [H]

Synonym: Maeo_1209

Alternate gene names: 150401632

Gene position: 1278642-1277620 (Counterclockwise)

Preceding gene: 150401633

Following gene: 150401620

Centisome position: 81.47

GC content: 33.24

Gene sequence:

>1023_bases
ATGAAAATTATATTGGTAGGTTTTGGAGTAATTGGAAAAGGAGTTCTTAAAGCCATAACTTCAAAAAAGGATTATTTAAA
AGATAAATATGGAATGGATTTAAAGGTTGTAGCAATTTGCGATAGAAGTGGTTCAGCAATAGATGACAACGGGCTAAATT
TAGAAACTGCATTAAAAATTAAAGAAGAAACTGGAAAAATAGCAAATTATCCAGAAAAAGGAACTGATTTATCAATTATT
GAAACAATACAGACCGTTGAAGCCGATGCGATTATTGAAATTACACCAACAAATATTGAAACAGGAGCTCCGGCAAATAC
CTATATGTTGGAGGCATTTAAAAATGGAAAGCATGTAATAACTGCCAATAAAGGACCACTTGCCGTAAATTTCAAAGAAT
TAATTGATTGTGCAAATGAAAATAGCAAATTATTTAGGTTTGAAGCATCAGTTGGAGGAGCTATGCCAATTATTAATTTA
GCAAATGATGCCCTTGCAGGAAACGAGATATTTGAAATAAAAGGAATATTAAATGGAACTACAAACTACATACTTTCAAA
GATGGAAACCGAAGGACTTGATTTTGATACAGTTTTAAAAGAGGCACAAGAATTAGGTATAGCTGAAACTAACCCGCACC
AAGATATAAGCGGACTTGATACAGCCGCAAAAATAGTAATACTTGCCAACTCTTTAATGAATAAAAATGTCTCCATTAAA
GATGTTAAACTTGAAGGAATTACAAGAATTACTCCCGAAGCAATTGCCATGGCCAATAAAAGTGGATATACCATAAAATT
AATTGGCGAAGTGAGCAATGATAAATTAGAGGTGGGCCCCAAATTAATACCAATTGACGACCCCATGAATGTAAAAGGCT
CCCTCAATGTTGCCATGCTTAACACTGATTTGGCAAAAGAAGTTGCTGTTGTTGGTAGAGGAGCAGGAGACATAGAAACT
GCATCGGCAATATTAAGCGATATAATATATATTTATGAAAATAATATAAAATGGAATAGATAA

Upstream 100 bases:

>100_bases
ATAAAATATCAGAAGAAAAAAATCTATTGTTTATAAAATCGTTTTAATTTATTTAATTTATTTTATTTAATTACTAATTA
TGTAATACAGAGGAGAAATA

Downstream 100 bases:

>100_bases
AAAATATTAAAAATAATATGTGGGGGAGCTCCGAACATATATATTAGAACGAAGCTAAGAAAAGAAAAATAATCCCTTCA
ATCAACCTAAAATCATAAAT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKIILVGFGVIGKGVLKAITSKKDYLKDKYGMDLKVVAICDRSGSAIDDNGLNLETALKIKEETGKIANYPEKGTDLSII
ETIQTVEADAIIEITPTNIETGAPANTYMLEAFKNGKHVITANKGPLAVNFKELIDCANENSKLFRFEASVGGAMPIINL
ANDALAGNEIFEIKGILNGTTNYILSKMETEGLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSLMNKNVSIK
DVKLEGITRITPEAIAMANKSGYTIKLIGEVSNDKLEVGPKLIPIDDPMNVKGSLNVAMLNTDLAKEVAVVGRGAGDIET
ASAILSDIIYIYENNIKWNR

Sequences:

>Translated_340_residues
MKIILVGFGVIGKGVLKAITSKKDYLKDKYGMDLKVVAICDRSGSAIDDNGLNLETALKIKEETGKIANYPEKGTDLSII
ETIQTVEADAIIEITPTNIETGAPANTYMLEAFKNGKHVITANKGPLAVNFKELIDCANENSKLFRFEASVGGAMPIINL
ANDALAGNEIFEIKGILNGTTNYILSKMETEGLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSLMNKNVSIK
DVKLEGITRITPEAIAMANKSGYTIKLIGEVSNDKLEVGPKLIPIDDPMNVKGSLNVAMLNTDLAKEVAVVGRGAGDIET
ASAILSDIIYIYENNIKWNR
>Mature_340_residues
MKIILVGFGVIGKGVLKAITSKKDYLKDKYGMDLKVVAICDRSGSAIDDNGLNLETALKIKEETGKIANYPEKGTDLSII
ETIQTVEADAIIEITPTNIETGAPANTYMLEAFKNGKHVITANKGPLAVNFKELIDCANENSKLFRFEASVGGAMPIINL
ANDALAGNEIFEIKGILNGTTNYILSKMETEGLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSLMNKNVSIK
DVKLEGITRITPEAIAMANKSGYTIKLIGEVSNDKLEVGPKLIPIDDPMNVKGSLNVAMLNTDLAKEVAVVGRGAGDIET
ASAILSDIIYIYENNIKWNR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=355, Percent_Identity=24.5070422535211, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790376, Length=354, Percent_Identity=22.5988700564972, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322599, Length=122, Percent_Identity=32.7868852459016, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 36586; Mature: 36586

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIILVGFGVIGKGVLKAITSKKDYLKDKYGMDLKVVAICDRSGSAIDDNGLNLETALKI
CEEEEEECCHHHHHHHHHHHCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
KEETGKIANYPEKGTDLSIIETIQTVEADAIIEITPTNIETGAPANTYMLEAFKNGKHVI
EHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCEEE
TANKGPLAVNFKELIDCANENSKLFRFEASVGGAMPIINLANDALAGNEIFEIKGILNGT
EECCCCEEEEHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCEEEEEEEEECCC
TNYILSKMETEGLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSLMNKNVSIK
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEHHHHCCCCEEE
DVKLEGITRITPEAIAMANKSGYTIKLIGEVSNDKLEVGPKLIPIDDPMNVKGSLNVAML
EEEECCCEECCHHHHHEECCCCCEEEEEEECCCCEEECCCEEEECCCCCCCCCCEEEEEE
NTDLAKEVAVVGRGAGDIETASAILSDIIYIYENNIKWNR
CCHHHHHHHHCCCCCCCHHHHHHHHHHEEEEEECCEEECC
>Mature Secondary Structure
MKIILVGFGVIGKGVLKAITSKKDYLKDKYGMDLKVVAICDRSGSAIDDNGLNLETALKI
CEEEEEECCHHHHHHHHHHHCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
KEETGKIANYPEKGTDLSIIETIQTVEADAIIEITPTNIETGAPANTYMLEAFKNGKHVI
EHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCEEE
TANKGPLAVNFKELIDCANENSKLFRFEASVGGAMPIINLANDALAGNEIFEIKGILNGT
EECCCCEEEEHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCEEEEEEEEECCC
TNYILSKMETEGLDFDTVLKEAQELGIAETNPHQDISGLDTAAKIVILANSLMNKNVSIK
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEHHHHCCCCEEE
DVKLEGITRITPEAIAMANKSGYTIKLIGEVSNDKLEVGPKLIPIDDPMNVKGSLNVAML
EEEECCCEECCHHHHHEECCCCCEEEEEEECCCCEEECCCEEEECCCCCCCCCCEEEEEE
NTDLAKEVAVVGRGAGDIETASAILSDIIYIYENNIKWNR
CCHHHHHHHHCCCCCCCHHHHHHHHHHEEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]