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The map label for this gene is glyA

Identifier: 150401470

GI number: 150401470

Start: 1078869

End: 1080158

Strand: Reverse

Name: glyA

Synonym: Maeo_1046

Alternate gene names: 150401470

Gene position: 1080158-1078869 (Counterclockwise)

Preceding gene: 150401471

Following gene: 150401469

Centisome position: 68.82

GC content: 37.29

Gene sequence:

>1290_bases
ATGAATCCATCAGAAGTTCAACAATTTGTAAGAGAAACGGCTCTAAAACAACACAACTGGATGAGAGAATGTATTAAATT
AATTGCAAGTGAAAATATAACCAGTATTCCAGTAAGAGAAGCATGTGCTACTGACTTTATGCACAGATATGCAGAAGGAT
TACCAAATAACAGGTTATACCAGGGTTGCGAATATATAGACGACATTGAAAATTTATGTATTGAATTATCGGAAGATATT
TTTAAAGCAGAACATGCAAATGTGCAACCAACAAGTGGTGTGGTGGCAAATCTTGCCGTATTTTTCGCAGAGGCAAAACC
GGGCGATAAATTAATGGCTATGGATGTTCCAAATGGGGGACATATAAGCCACTGGAAAGTAAGTGCCGCAGGTATTAGAG
GATTAAGAGCATCAGCTCACCCATTCGATGCCGAAGAGATGAACATCGATGTAGATAAAATGGTTAAACAAATTTTGGAA
GAAAAACCAAGATTGGTATTATTTGGTGGTAGTTTATTCCCATTCCCACACCCAGTAAAAGATGCCGTAGATGCTGCAAA
TGAAGTTGGGGCAACTATTGCCTATGATGGAGCTCATGTATTGGGATTAATTGCGGGAGGACAATTCCAAGACCCACTCA
GAGAAGGGGCTGAATATATGATGGGAAGCACCCACAAAACATTATTTGGAACCCAAGGTGGAGTGGTATTAACAGAGAAA
AAGAATGCTAAGAAAATCGATGATAAAATATTCCCTGGAGTTGTATCAAACCATCATTTACACCATAAGGCAGGTCTTGC
TATTGCACTGGCAGAAACAAAAGAATTTGGAGAAGCTTATGCTAAACAAGTTGTTAAAAATGCTAAGGCACTTGGACAGG
CTTTATATGAAAGAGGCTGTAATGTGTTGTGTGAGCACAAAGGATTTACAGAAAGCCACCAAGTTATACTTGACATAGAA
AAATCAGAATGCATTGAGTTTTCAGCAAGAGAATTGGCAACAATGTTTGAAGAAGCCAATATAATATTAAATAAAAACCT
ATTGCCGTGGGACGATGTGAGCAATTCCGATAATCCAAGCGGTATAAGATTGGGAAGTCAAGAATGTACTCGGTTAGGAA
TGAAGGAAAGCGAAATGGACGAAATTGCTGAATTTATGAAAAGAATAGCAATTGATGGAGAGGACATTAAAAAAGTTAAA
GAAGATATTGTAGAATTTGCTAAAAGCTATTCGGAAATACATTATGCTTTTGAGGGCGGAGATGCTTTTAAATATCTTAA
ATTCTATTAA

Upstream 100 bases:

>100_bases
ATTTTAAATAGTAGAAATATGACAAAAACAAAATACTACTTAAAATAAACAATAATTATAACAACTAACATAACAATAAA
TAATAAAAAAGAGGAAAAAT

Downstream 100 bases:

>100_bases
TTAATTATTTATCTATTTTTATTTATGGGGAGCTCCCGGAGCTCCAAGCCATATATATTTTATATTGCCCCTATTTGTTT
ATTAAATACCTATTATCATA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNPSEVQQFVRETALKQHNWMRECIKLIASENITSIPVREACATDFMHRYAEGLPNNRLYQGCEYIDDIENLCIELSEDI
FKAEHANVQPTSGVVANLAVFFAEAKPGDKLMAMDVPNGGHISHWKVSAAGIRGLRASAHPFDAEEMNIDVDKMVKQILE
EKPRLVLFGGSLFPFPHPVKDAVDAANEVGATIAYDGAHVLGLIAGGQFQDPLREGAEYMMGSTHKTLFGTQGGVVLTEK
KNAKKIDDKIFPGVVSNHHLHHKAGLAIALAETKEFGEAYAKQVVKNAKALGQALYERGCNVLCEHKGFTESHQVILDIE
KSECIEFSARELATMFEEANIILNKNLLPWDDVSNSDNPSGIRLGSQECTRLGMKESEMDEIAEFMKRIAIDGEDIKKVK
EDIVEFAKSYSEIHYAFEGGDAFKYLKFY

Sequences:

>Translated_429_residues
MNPSEVQQFVRETALKQHNWMRECIKLIASENITSIPVREACATDFMHRYAEGLPNNRLYQGCEYIDDIENLCIELSEDI
FKAEHANVQPTSGVVANLAVFFAEAKPGDKLMAMDVPNGGHISHWKVSAAGIRGLRASAHPFDAEEMNIDVDKMVKQILE
EKPRLVLFGGSLFPFPHPVKDAVDAANEVGATIAYDGAHVLGLIAGGQFQDPLREGAEYMMGSTHKTLFGTQGGVVLTEK
KNAKKIDDKIFPGVVSNHHLHHKAGLAIALAETKEFGEAYAKQVVKNAKALGQALYERGCNVLCEHKGFTESHQVILDIE
KSECIEFSARELATMFEEANIILNKNLLPWDDVSNSDNPSGIRLGSQECTRLGMKESEMDEIAEFMKRIAIDGEDIKKVK
EDIVEFAKSYSEIHYAFEGGDAFKYLKFY
>Mature_429_residues
MNPSEVQQFVRETALKQHNWMRECIKLIASENITSIPVREACATDFMHRYAEGLPNNRLYQGCEYIDDIENLCIELSEDI
FKAEHANVQPTSGVVANLAVFFAEAKPGDKLMAMDVPNGGHISHWKVSAAGIRGLRASAHPFDAEEMNIDVDKMVKQILE
EKPRLVLFGGSLFPFPHPVKDAVDAANEVGATIAYDGAHVLGLIAGGQFQDPLREGAEYMMGSTHKTLFGTQGGVVLTEK
KNAKKIDDKIFPGVVSNHHLHHKAGLAIALAETKEFGEAYAKQVVKNAKALGQALYERGCNVLCEHKGFTESHQVILDIE
KSECIEFSARELATMFEEANIILNKNLLPWDDVSNSDNPSGIRLGSQECTRLGMKESEMDEIAEFMKRIAIDGEDIKKVK
EDIVEFAKSYSEIHYAFEGGDAFKYLKFY

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=426, Percent_Identity=30.5164319248826, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI261862346, Length=420, Percent_Identity=30.4761904761905, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI261862352, Length=426, Percent_Identity=30.5164319248826, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI261862350, Length=426, Percent_Identity=30.5164319248826, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI261862348, Length=426, Percent_Identity=30.5164319248826, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=32.1695760598504, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI22547189, Length=385, Percent_Identity=30.9090909090909, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=34.6153846153846, Blast_Score=204, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI25144732, Length=442, Percent_Identity=30.0904977375566, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI25144729, Length=442, Percent_Identity=30.0904977375566, Blast_Score=174, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323087, Length=411, Percent_Identity=31.8734793187348, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319739, Length=407, Percent_Identity=28.5012285012285, Blast_Score=159, Evalue=7e-40,
Organism=Drosophila melanogaster, GI221329721, Length=397, Percent_Identity=33.7531486146096, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24640005, Length=397, Percent_Identity=33.7531486146096, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_META3 (A6UVV2)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325236.1
- ProteinModelPortal:   A6UVV2
- STRING:   A6UVV2
- GeneID:   5327142
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_1046
- eggNOG:   arNOG04649
- HOGENOM:   HBG301263
- OMA:   IMTASTH
- ProtClustDB:   PRK00011
- BioCyc:   MAEO419665:MAEO_1046-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_A
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 47670; Mature: 47670

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSEVQQFVRETALKQHNWMRECIKLIASENITSIPVREACATDFMHRYAEGLPNNRLY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
QGCEYIDDIENLCIELSEDIFKAEHANVQPTSGVVANLAVFFAEAKPGDKLMAMDVPNGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCC
HISHWKVSAAGIRGLRASAHPFDAEEMNIDVDKMVKQILEEKPRLVLFGGSLFPFPHPVK
CCCEEEEHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHH
DAVDAANEVGATIAYDGAHVLGLIAGGQFQDPLREGAEYMMGSTHKTLFGTQGGVVLTEK
HHHHHHHHCCCEEEECCHHEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCEEEECC
KNAKKIDDKIFPGVVSNHHLHHKAGLAIALAETKEFGEAYAKQVVKNAKALGQALYERGC
CCCHHHHHHHCCCHHCCCCEEHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVLCEHKGFTESHQVILDIEKSECIEFSARELATMFEEANIILNKNLLPWDDVSNSDNPS
CEEECCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCC
GIRLGSQECTRLGMKESEMDEIAEFMKRIAIDGEDIKKVKEDIVEFAKSYSEIHYAFEGG
CEEECHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEECCC
DAFKYLKFY
CCCHHEECC
>Mature Secondary Structure
MNPSEVQQFVRETALKQHNWMRECIKLIASENITSIPVREACATDFMHRYAEGLPNNRLY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
QGCEYIDDIENLCIELSEDIFKAEHANVQPTSGVVANLAVFFAEAKPGDKLMAMDVPNGG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCC
HISHWKVSAAGIRGLRASAHPFDAEEMNIDVDKMVKQILEEKPRLVLFGGSLFPFPHPVK
CCCEEEEHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHH
DAVDAANEVGATIAYDGAHVLGLIAGGQFQDPLREGAEYMMGSTHKTLFGTQGGVVLTEK
HHHHHHHHCCCEEEECCHHEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCEEEECC
KNAKKIDDKIFPGVVSNHHLHHKAGLAIALAETKEFGEAYAKQVVKNAKALGQALYERGC
CCCHHHHHHHCCCHHCCCCEEHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVLCEHKGFTESHQVILDIEKSECIEFSARELATMFEEANIILNKNLLPWDDVSNSDNPS
CEEECCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCC
GIRLGSQECTRLGMKESEMDEIAEFMKRIAIDGEDIKKVKEDIVEFAKSYSEIHYAFEGG
CEEECHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEECCC
DAFKYLKFY
CCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA