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The map label for this gene is eIF5A

Identifier: 150401342

GI number: 150401342

Start: 938799

End: 939194

Strand: Reverse

Name: eIF5A

Synonym: Maeo_0915

Alternate gene names: 150401342

Gene position: 939194-938799 (Counterclockwise)

Preceding gene: 150401343

Following gene: 150401340

Centisome position: 59.84

GC content: 34.09

Gene sequence:

>396_bases
ATGCCAGGAACAAAACCAGTAGAATTGGGTTCATTAAAAGTAGGACAATACATCGTAATTGATGAAGTGCCATGTAGAAT
TGTAGATATGACAAAGTCAAAACCGGGAAAACACGGAGGAGCTAAAATAAGATTAACAGCAATGGGACTATTCGAAAATG
TTAAAAAAGAGCATGTTGGACCAACCTCATCAAGAGCAGATGTTCCATTAATTGACAAAAGAAAAGGACAAGTTTTATCA
ATTATGGGAGATTTAGTTCAAATAATGGATTTAGAAACATTTGATACATTAGAAATCCCAATGCCTGAGGATGTTGAGGA
AATAGACAGCGGTATGGAAGTAGAATACTTCGAAGCTGTTGGAAGATATAAAATAACAAGAGTAATAAGTAAATAA

Upstream 100 bases:

>100_bases
ATATAGTTTTTTCATGTAAATATTTATATACTATATATGACAATCAATAATAAAACAATTCAATAAACAATAAAAAACGA
AACATATATTAGGTGATTAA

Downstream 100 bases:

>100_bases
TTAAATAATAATTTATTTTTAATATTTCTATTTTTTTAATATTTTTTGTATTGTTTGGAGCTCCGAGCACACCATATTAT
ATTTTTAATCATTAGTTTTA

Product: translation initiation factor IF-5A

Products: NA

Alternate protein names: Hypusine-containing protein; eIF-5A

Number of amino acids: Translated: 131; Mature: 130

Protein sequence:

>131_residues
MPGTKPVELGSLKVGQYIVIDEVPCRIVDMTKSKPGKHGGAKIRLTAMGLFENVKKEHVGPTSSRADVPLIDKRKGQVLS
IMGDLVQIMDLETFDTLEIPMPEDVEEIDSGMEVEYFEAVGRYKITRVISK

Sequences:

>Translated_131_residues
MPGTKPVELGSLKVGQYIVIDEVPCRIVDMTKSKPGKHGGAKIRLTAMGLFENVKKEHVGPTSSRADVPLIDKRKGQVLS
IMGDLVQIMDLETFDTLEIPMPEDVEEIDSGMEVEYFEAVGRYKITRVISK
>Mature_130_residues
PGTKPVELGSLKVGQYIVIDEVPCRIVDMTKSKPGKHGGAKIRLTAMGLFENVKKEHVGPTSSRADVPLIDKRKGQVLSI
MGDLVQIMDLETFDTLEIPMPEDVEEIDSGMEVEYFEAVGRYKITRVISK

Specific function: Functions by promoting the formation of the first peptide bond

COG id: COG0231

COG function: function code J; Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-5A family

Homologues:

Organism=Homo sapiens, GI153791632, Length=128, Percent_Identity=30.46875, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI219555707, Length=128, Percent_Identity=29.6875, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI219555712, Length=128, Percent_Identity=29.6875, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI219555710, Length=128, Percent_Identity=29.6875, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI4503545, Length=128, Percent_Identity=29.6875, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI9966867, Length=108, Percent_Identity=31.4814814814815, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71990399, Length=102, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534327, Length=133, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320801, Length=101, Percent_Identity=32.6732673267327, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322507, Length=100, Percent_Identity=35, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922878, Length=101, Percent_Identity=31.6831683168317, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24762531, Length=101, Percent_Identity=31.6831683168317, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF5A_META3 (A6UVH4)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325108.1
- ProteinModelPortal:   A6UVH4
- SMR:   A6UVH4
- STRING:   A6UVH4
- GeneID:   5327472
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0915
- eggNOG:   arNOG10602
- HOGENOM:   HBG497107
- OMA:   CRIVEMS
- ProtClustDB:   PRK03999
- BioCyc:   MAEO419665:MAEO_0915-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00085
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR019769
- InterPro:   IPR001884
- InterPro:   IPR022847
- InterPro:   IPR020189
- InterPro:   IPR013185
- InterPro:   IPR014722
- InterPro:   IPR008991
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:2.30.30.30
- PANTHER:   PTHR11673
- PIRSF:   PIRSF003025
- TIGRFAMs:   TIGR00037

Pfam domain/function: PF08207 EFP_N; PF01287 eIF-5a; SSF50249 Nucleic_acid_OB; SSF50104 Transl_SH3_like

EC number: NA

Molecular weight: Translated: 14518; Mature: 14387

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00302 IF5A_HYPUSINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGTKPVELGSLKVGQYIVIDEVPCRIVDMTKSKPGKHGGAKIRLTAMGLFENVKKEHVG
CCCCCCCEECCEECCCEEEEECCCEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHCC
PTSSRADVPLIDKRKGQVLSIMGDLVQIMDLETFDTLEIPMPEDVEEIDSGMEVEYFEAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHCCCCCHHHHHH
GRYKITRVISK
HHHHHHHHHCC
>Mature Secondary Structure 
PGTKPVELGSLKVGQYIVIDEVPCRIVDMTKSKPGKHGGAKIRLTAMGLFENVKKEHVG
CCCCCCEECCEECCCEEEEECCCEEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHHHCC
PTSSRADVPLIDKRKGQVLSIMGDLVQIMDLETFDTLEIPMPEDVEEIDSGMEVEYFEAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHCCCCCHHHHHH
GRYKITRVISK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA