Click here to switch to the map view.

The map label for this gene is hemB [H]

Identifier: 150401343

GI number: 150401343

Start: 939326

End: 940306

Strand: Reverse

Name: hemB [H]

Synonym: Maeo_0916

Alternate gene names: 150401343

Gene position: 940306-939326 (Counterclockwise)

Preceding gene: 150401350

Following gene: 150401342

Centisome position: 59.91

GC content: 33.03

Gene sequence:

>981_bases
ATGATAAAAAGACCAAGAAGATTAAGAAACACCAAAAAAATTAGAGATTTAGTCGGTGAAACTACCCTTATAAAAAATGA
TTTAATAATGCCTTTATTTATTGACGAAACCCTAAAAGGAAGTGAAAAAAAAGAAATAACTTCAATGCCAAATCAATATA
GATTTAGCACAGAGGGCGTAGTTGAAGAATGTAAGGAAATAGCAGATTTAGGGGTTCCAGCTGTAATATTATTTGGAATA
CCAAAATATAAAGATGAAATTGCATCATCAGCATATGATGAAAATGGAGTTATCCAAAAAGCCATAAGAAACATAAAGGC
AGAGCTGGGAAATGATTTATTAGTTATTGCTGACACATGTTTATGCGAATATACTTCACATGGGCATTGTGGTTTAATTG
ATTATAAAAATAATAAAGTTTTAAATGATGAAACGCTACCCATACTTTCAAAAATAGCCATATCTTATGCAAATAGTGGC
GTGGATATAATTGCTCCTTCGGATATGATGGACGGTAGGGTTGGAGCTCTGCGAAAAGCCCTCGACGAAAACAATCACAC
GGATATACCCATAATGAGCTACGGTGCAAAATATGCTTCCTCATTTTATGGTCCATTTAGGGATGCCGCAGAAAGTGCTC
CAAAATCAGAGATAAAAGACAGGAAAACATATCAAATGGATTATAGGAACTCCAATGAGGCAATTCGTGAAATTGAATTA
GATATTGAAGAAGGAGCCGATTTAATATTGGTAAAACCTGCACTTCCTTATTTGGATATTATAAAAATTGCCAATGATAA
TTTTAATATACCAATTGGAGCATACTGTGTAAGTGGAGAATATTCTATGATTGAAGCGGCTTCAATAAATGGTTGGATAA
ATAGGACTGATGCTATTATAGAAACACTACATGGCATAAAAAGAGCAGGGGCAAGTTTTATTATAAATTATTGGGCAAAA
GAAATTGCAAAATATTTATAA

Upstream 100 bases:

>100_bases
ATATATTTTATTATTAATATTATTATATACTTTATATTATATATTACAATATACCATATATTTTATTATTATTGCGAATA
ATAGATAGAGATGCAATACC

Downstream 100 bases:

>100_bases
TTAGTTATAAATATTAATAAAAATATTAAAGATATAGTTTTTTCATGTAAATATTTATATACTATATATGACAATCAATA
ATAAAACAATTCAATAAACA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MIKRPRRLRNTKKIRDLVGETTLIKNDLIMPLFIDETLKGSEKKEITSMPNQYRFSTEGVVEECKEIADLGVPAVILFGI
PKYKDEIASSAYDENGVIQKAIRNIKAELGNDLLVIADTCLCEYTSHGHCGLIDYKNNKVLNDETLPILSKIAISYANSG
VDIIAPSDMMDGRVGALRKALDENNHTDIPIMSYGAKYASSFYGPFRDAAESAPKSEIKDRKTYQMDYRNSNEAIREIEL
DIEEGADLILVKPALPYLDIIKIANDNFNIPIGAYCVSGEYSMIEAASINGWINRTDAIIETLHGIKRAGASFIINYWAK
EIAKYL

Sequences:

>Translated_326_residues
MIKRPRRLRNTKKIRDLVGETTLIKNDLIMPLFIDETLKGSEKKEITSMPNQYRFSTEGVVEECKEIADLGVPAVILFGI
PKYKDEIASSAYDENGVIQKAIRNIKAELGNDLLVIADTCLCEYTSHGHCGLIDYKNNKVLNDETLPILSKIAISYANSG
VDIIAPSDMMDGRVGALRKALDENNHTDIPIMSYGAKYASSFYGPFRDAAESAPKSEIKDRKTYQMDYRNSNEAIREIEL
DIEEGADLILVKPALPYLDIIKIANDNFNIPIGAYCVSGEYSMIEAASINGWINRTDAIIETLHGIKRAGASFIINYWAK
EIAKYL
>Mature_326_residues
MIKRPRRLRNTKKIRDLVGETTLIKNDLIMPLFIDETLKGSEKKEITSMPNQYRFSTEGVVEECKEIADLGVPAVILFGI
PKYKDEIASSAYDENGVIQKAIRNIKAELGNDLLVIADTCLCEYTSHGHCGLIDYKNNKVLNDETLPILSKIAISYANSG
VDIIAPSDMMDGRVGALRKALDENNHTDIPIMSYGAKYASSFYGPFRDAAESAPKSEIKDRKTYQMDYRNSNEAIREIEL
DIEEGADLILVKPALPYLDIIKIANDNFNIPIGAYCVSGEYSMIEAASINGWINRTDAIIETLHGIKRAGASFIINYWAK
EIAKYL

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=310, Percent_Identity=38.3870967741935, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI87081728, Length=324, Percent_Identity=45.679012345679, Blast_Score=276, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6321398, Length=323, Percent_Identity=39.938080495356, Blast_Score=216, Evalue=6e-57,
Organism=Drosophila melanogaster, GI21358291, Length=296, Percent_Identity=38.5135135135135, Blast_Score=217, Evalue=9e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36413; Mature: 36413

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRPRRLRNTKKIRDLVGETTLIKNDLIMPLFIDETLKGSEKKEITSMPNQYRFSTEGV
CCCCCHHHHHHHHHHHHHCCHHEECCCCEEEEEECHHHCCCCHHHHHCCCCCEECCHHHH
VEECKEIADLGVPAVILFGIPKYKDEIASSAYDENGVIQKAIRNIKAELGNDLLVIADTC
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEHHH
LCEYTSHGHCGLIDYKNNKVLNDETLPILSKIAISYANSGVDIIAPSDMMDGRVGALRKA
HHHCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHCCCCEEEEECCHHCCCHHHHHHHH
LDENNHTDIPIMSYGAKYASSFYGPFRDAAESAPKSEIKDRKTYQMDYRNSNEAIREIEL
HCCCCCCCCCHHHHCHHHHHHHCCHHHHHHHCCCHHHHCCCHHEEECCCCCCHHHHHHEE
DIEEGADLILVKPALPYLDIIKIANDNFNIPIGAYCVSGEYSMIEAASINGWINRTDAII
ECCCCCCEEEECCCCCHHHHEEECCCCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHH
ETLHGIKRAGASFIINYWAKEIAKYL
HHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MIKRPRRLRNTKKIRDLVGETTLIKNDLIMPLFIDETLKGSEKKEITSMPNQYRFSTEGV
CCCCCHHHHHHHHHHHHHCCHHEECCCCEEEEEECHHHCCCCHHHHHCCCCCEECCHHHH
VEECKEIADLGVPAVILFGIPKYKDEIASSAYDENGVIQKAIRNIKAELGNDLLVIADTC
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEHHH
LCEYTSHGHCGLIDYKNNKVLNDETLPILSKIAISYANSGVDIIAPSDMMDGRVGALRKA
HHHCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHCCCCEEEEECCHHCCCHHHHHHHH
LDENNHTDIPIMSYGAKYASSFYGPFRDAAESAPKSEIKDRKTYQMDYRNSNEAIREIEL
HCCCCCCCCCHHHHCHHHHHHHCCHHHHHHHCCCHHHHCCCHHEEECCCCCCHHHHHHEE
DIEEGADLILVKPALPYLDIIKIANDNFNIPIGAYCVSGEYSMIEAASINGWINRTDAII
ECCCCCCEEEECCCCCHHHHEEECCCCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHH
ETLHGIKRAGASFIINYWAKEIAKYL
HHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]