Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 150401341

GI number: 150401341

Start: 937848

End: 938714

Strand: Direct

Name: nadC [H]

Synonym: Maeo_0914

Alternate gene names: 150401341

Gene position: 937848-938714 (Clockwise)

Preceding gene: 150401332

Following gene: 150401344

Centisome position: 59.75

GC content: 28.72

Gene sequence:

>867_bases
GTGATAACAGATTATGCAAAAAAGATATTAAATGAAACCCTATCCTACGATGTCGGATTTGGAGATTTAACCACAGAATT
AATTATTCCCGATAGCCACACTTCAAAAGGAATTATAAAAGTTAAAGAAAATGGTGTTGTGGCATGTGGGCTAAATTTTG
TAGTAGAATATATAAAAGAACATAATTTAAAGGTAAAAACATTTGTAAATGATGGAGATGTTGTATCAGAAAATACAAAT
ATTTTGGAAATAGAAGGAAATACCAAAAAAATATTGACAATTGAAAGAACAATTTTAAATTTTTTGATGCATTTATCAGG
CATAGCCACAAAAACCCATAATGTTGTGGAAATGGTGAAAAAAGTAAATAACAATGTAAAAATTGCCTGCACACGAAAAA
CTCTTCCGATGTTGTCTCCTTTGGAAAAATATGCCGTATTTGTAGGAGGCGGGGATACTCACAGATTTAGATTAGATGAT
ATGATAATGATAAAAGACAACCACATAGAGGCTGTTGGTATTGAAAATTGTTTTAAAATAGTAAAAAAATTAAGTTTTTC
CAAAAAAATAGAAATAGAAGTAGATAATATTGAGCAATTAAAAGAAGTGTTACAATATAAGCCTGATATTGTGCTTTTAG
ATAATTTTAAACCCGAGGATATTGGCGGAGCTCTTGAAATTATTGAGGAAAATTATAATAAAAATAAATACACCTATAAG
CCATTAATCGAAGTTAGTGGAGGAATTAACGATAAAACAGTATTAAATTATGCAAAATATCCTATTGATATAATTTCTAT
GGGCTGTTTAATTCATTCAGCAATTGCTGTTGATATGGGGCTTGATTTAAATAAAACTAATGATTAA

Upstream 100 bases:

>100_bases
TCGTTTAGGGCGGATAAGGGACAGTAATTGAACTTACTATATTGTTATTTTATTTTTTCTTATTCTATTTATTGTTATTA
ATACTATAAACGGTGATTTC

Downstream 100 bases:

>100_bases
AAATATAATATGGTGTGCTCGGAGCTCCAAACAATACAAAAAATATTAAAAAAATAGAAATATTAAAAATAAATTATTAT
TTAATTATTTACTTATTACT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MITDYAKKILNETLSYDVGFGDLTTELIIPDSHTSKGIIKVKENGVVACGLNFVVEYIKEHNLKVKTFVNDGDVVSENTN
ILEIEGNTKKILTIERTILNFLMHLSGIATKTHNVVEMVKKVNNNVKIACTRKTLPMLSPLEKYAVFVGGGDTHRFRLDD
MIMIKDNHIEAVGIENCFKIVKKLSFSKKIEIEVDNIEQLKEVLQYKPDIVLLDNFKPEDIGGALEIIEENYNKNKYTYK
PLIEVSGGINDKTVLNYAKYPIDIISMGCLIHSAIAVDMGLDLNKTND

Sequences:

>Translated_288_residues
MITDYAKKILNETLSYDVGFGDLTTELIIPDSHTSKGIIKVKENGVVACGLNFVVEYIKEHNLKVKTFVNDGDVVSENTN
ILEIEGNTKKILTIERTILNFLMHLSGIATKTHNVVEMVKKVNNNVKIACTRKTLPMLSPLEKYAVFVGGGDTHRFRLDD
MIMIKDNHIEAVGIENCFKIVKKLSFSKKIEIEVDNIEQLKEVLQYKPDIVLLDNFKPEDIGGALEIIEENYNKNKYTYK
PLIEVSGGINDKTVLNYAKYPIDIISMGCLIHSAIAVDMGLDLNKTND
>Mature_288_residues
MITDYAKKILNETLSYDVGFGDLTTELIIPDSHTSKGIIKVKENGVVACGLNFVVEYIKEHNLKVKTFVNDGDVVSENTN
ILEIEGNTKKILTIERTILNFLMHLSGIATKTHNVVEMVKKVNNNVKIACTRKTLPMLSPLEKYAVFVGGGDTHRFRLDD
MIMIKDNHIEAVGIENCFKIVKKLSFSKKIEIEVDNIEQLKEVLQYKPDIVLLDNFKPEDIGGALEIIEENYNKNKYTYK
PLIEVSGGINDKTVLNYAKYPIDIISMGCLIHSAIAVDMGLDLNKTND

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=258, Percent_Identity=30.6201550387597, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786299, Length=280, Percent_Identity=36.0714285714286, Blast_Score=146, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321162, Length=251, Percent_Identity=34.6613545816733, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32367; Mature: 32367

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITDYAKKILNETLSYDVGFGDLTTELIIPDSHTSKGIIKVKENGVVACGLNFVVEYIKE
CCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEECHHHHHHHHHH
HNLKVKTFVNDGDVVSENTNILEIEGNTKKILTIERTILNFLMHLSGIATKTHNVVEMVK
CCCEEEEEECCCCEEECCCCEEEEECCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHH
KVNNNVKIACTRKTLPMLSPLEKYAVFVGGGDTHRFRLDDMIMIKDNHIEAVGIENCFKI
HHCCCEEEEEECCCCCHHCCCCCEEEEEECCCCEEEEECCEEEEECCCEEEECHHHHHHH
VKKLSFSKKIEIEVDNIEQLKEVLQYKPDIVLLDNFKPEDIGGALEIIEENYNKNKYTYK
HHHCCCCCEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEE
PLIEVSGGINDKTVLNYAKYPIDIISMGCLIHSAIAVDMGLDLNKTND
EEEEECCCCCCHHEEEHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MITDYAKKILNETLSYDVGFGDLTTELIIPDSHTSKGIIKVKENGVVACGLNFVVEYIKE
CCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEECHHHHHHHHHH
HNLKVKTFVNDGDVVSENTNILEIEGNTKKILTIERTILNFLMHLSGIATKTHNVVEMVK
CCCEEEEEECCCCEEECCCCEEEEECCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHH
KVNNNVKIACTRKTLPMLSPLEKYAVFVGGGDTHRFRLDDMIMIKDNHIEAVGIENCFKI
HHCCCEEEEEECCCCCHHCCCCCEEEEEECCCCEEEEECCEEEEECCCEEEECHHHHHHH
VKKLSFSKKIEIEVDNIEQLKEVLQYKPDIVLLDNFKPEDIGGALEIIEENYNKNKYTYK
HHHCCCCCEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEE
PLIEVSGGINDKTVLNYAKYPIDIISMGCLIHSAIAVDMGLDLNKTND
EEEEECCCCCCHHEEEHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]