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The map label for this gene is 150401332

Identifier: 150401332

GI number: 150401332

Start: 931513

End: 932508

Strand: Direct

Name: 150401332

Synonym: Maeo_0905

Alternate gene names: NA

Gene position: 931513-932508 (Clockwise)

Preceding gene: 150401331

Following gene: 150401341

Centisome position: 59.35

GC content: 25.8

Gene sequence:

>996_bases
ATGTGGAATTTAGAAACCGACAGAGTAATAAAAGAAATAGAAAAATCAAATGGGAAAAATATAGTATTTCATGCACCAGA
AGGTTTAAAATTAGCCGTTGAAAAAGAAATAGAAAAAATAAATGATTATTTTAACAGCACTAAAAATTTAATAATGTGGG
GAGCTCCATGCTATGGTGCATGTGATTTATGCGACCATGAATTAAAATATAATAATATTGATTTAATAATTCACTATGGG
CATGAGGAGCTCCCATATGCAAAACCAGACATACCAACAATTTTCATACATTGCTACTATATTTATGATGAAATTGAACA
AAACAATATATTAAATAAAATAGATGAATATTTACAAAATAATCCAAACACCATAATTACAACCACAATACAATTTAAAG
AATTGTTAAAAAAATATAATCCAAATATAATTCTTGGTTGTAGGGCAAATATATCCAATAAACCAAAATCAGAATTAGAA
CAGGGAACAGAGAAAGAAACAGAAAACAGCAAAATATTATATATTGGAACGGGGCGATTTCACCCATTAATGTTATGTTA
TAAATTTAAAAAATCTGTGAATTTATTTAATCCGACATCCAAAGAGTTTTCTGCCATATCAGAAGAGGAAGTAAATAAAT
TTATTAAAAAAAGAATTGGGGCCATTTCAAAATTATTAATAAATCCACCTAAAAAAATTGGAGTTGTTTTATCCACTAAA
AAAGGGCAAAATAGAATAAATGTATACAATAAAATAATAAATTTATTAAAAGACAATAATATTGAATATATGCCGATTAT
ATTAAATAATGCCTCACCAGATAATTTATTTTATGATGTGTCTGCATATATTATATGTGCCTGTCCTAGAATTGTGTTAG
ATGATTATTTAAATTACAATAAAACATTATTAACCCCTAAAGAGTTTGAAATGTATATTAAAAAAGATTTTGAATATGTT
TTTGACGAAATATTATTTGATGATTTCGAACCCTAG

Upstream 100 bases:

>100_bases
TTAGTAATAATAATGAGTTAGCTTTATTAATATACCCAACTGAAAAAGACCGAAGATTGACTATACTCCATTATTAAAAT
ACAGATCGAGTAGGATATTT

Downstream 100 bases:

>100_bases
GTTCAATTAACAAAATTATAAAATAATTTTGTCCAATTATAGTCAATCTTCAAAAACTGTCCTATGATAGTCCAAAATAA
TTAAATAATTATAGGTTTAA

Product: diphthamide biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MWNLETDRVIKEIEKSNGKNIVFHAPEGLKLAVEKEIEKINDYFNSTKNLIMWGAPCYGACDLCDHELKYNNIDLIIHYG
HEELPYAKPDIPTIFIHCYYIYDEIEQNNILNKIDEYLQNNPNTIITTTIQFKELLKKYNPNIILGCRANISNKPKSELE
QGTEKETENSKILYIGTGRFHPLMLCYKFKKSVNLFNPTSKEFSAISEEEVNKFIKKRIGAISKLLINPPKKIGVVLSTK
KGQNRINVYNKIINLLKDNNIEYMPIILNNASPDNLFYDVSAYIICACPRIVLDDYLNYNKTLLTPKEFEMYIKKDFEYV
FDEILFDDFEP

Sequences:

>Translated_331_residues
MWNLETDRVIKEIEKSNGKNIVFHAPEGLKLAVEKEIEKINDYFNSTKNLIMWGAPCYGACDLCDHELKYNNIDLIIHYG
HEELPYAKPDIPTIFIHCYYIYDEIEQNNILNKIDEYLQNNPNTIITTTIQFKELLKKYNPNIILGCRANISNKPKSELE
QGTEKETENSKILYIGTGRFHPLMLCYKFKKSVNLFNPTSKEFSAISEEEVNKFIKKRIGAISKLLINPPKKIGVVLSTK
KGQNRINVYNKIINLLKDNNIEYMPIILNNASPDNLFYDVSAYIICACPRIVLDDYLNYNKTLLTPKEFEMYIKKDFEYV
FDEILFDDFEP
>Mature_331_residues
MWNLETDRVIKEIEKSNGKNIVFHAPEGLKLAVEKEIEKINDYFNSTKNLIMWGAPCYGACDLCDHELKYNNIDLIIHYG
HEELPYAKPDIPTIFIHCYYIYDEIEQNNILNKIDEYLQNNPNTIITTTIQFKELLKKYNPNIILGCRANISNKPKSELE
QGTEKETENSKILYIGTGRFHPLMLCYKFKKSVNLFNPTSKEFSAISEEEVNKFIKKRIGAISKLLINPPKKIGVVLSTK
KGQNRINVYNKIINLLKDNNIEYMPIILNNASPDNLFYDVSAYIICACPRIVLDDYLNYNKTLLTPKEFEMYIKKDFEYV
FDEILFDDFEP

Specific function: Unknown

COG id: COG1736

COG function: function code J; Diphthamide synthase subunit DPH2

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI116686106, Length=344, Percent_Identity=22.9651162790698, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17552166, Length=337, Percent_Identity=26.1127596439169, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322088, Length=350, Percent_Identity=24, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24662841, Length=351, Percent_Identity=26.4957264957265, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21356957, Length=351, Percent_Identity=26.4957264957265, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016435
- InterPro:   IPR002728
- InterPro:   IPR022428 [H]

Pfam domain/function: PF01866 Diphthamide_syn [H]

EC number: NA

Molecular weight: Translated: 38600; Mature: 38600

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWNLETDRVIKEIEKSNGKNIVFHAPEGLKLAVEKEIEKINDYFNSTKNLIMWGAPCYGA
CCCCCHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHHCCCCCEEEECCCCCCC
CDLCDHELKYNNIDLIIHYGHEELPYAKPDIPTIFIHCYYIYDEIEQNNILNKIDEYLQN
HHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEEEEEHHHCCHHHHHHHHHHHC
NPNTIITTTIQFKELLKKYNPNIILGCRANISNKPKSELEQGTEKETENSKILYIGTGRF
CCCEEEEEEHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEEECCCC
HPLMLCYKFKKSVNLFNPTSKEFSAISEEEVNKFIKKRIGAISKLLINPPKKIGVVLSTK
CHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECC
KGQNRINVYNKIINLLKDNNIEYMPIILNNASPDNLFYDVSAYIICACPRIVLDDYLNYN
CCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEHHHHHHHHCHHHHHHHHCCCC
KTLLTPKEFEMYIKKDFEYVFDEILFDDFEP
CEECCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MWNLETDRVIKEIEKSNGKNIVFHAPEGLKLAVEKEIEKINDYFNSTKNLIMWGAPCYGA
CCCCCHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHHCCCCCEEEECCCCCCC
CDLCDHELKYNNIDLIIHYGHEELPYAKPDIPTIFIHCYYIYDEIEQNNILNKIDEYLQN
HHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEEEEEHHHCCHHHHHHHHHHHC
NPNTIITTTIQFKELLKKYNPNIILGCRANISNKPKSELEQGTEKETENSKILYIGTGRF
CCCEEEEEEHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEEECCCC
HPLMLCYKFKKSVNLFNPTSKEFSAISEEEVNKFIKKRIGAISKLLINPPKKIGVVLSTK
CHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECC
KGQNRINVYNKIINLLKDNNIEYMPIILNNASPDNLFYDVSAYIICACPRIVLDDYLNYN
CCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEHHHHHHHHCHHHHHHHHCCCC
KTLLTPKEFEMYIKKDFEYVFDEILFDDFEP
CEECCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]