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The map label for this gene is hisD [H]

Identifier: 150401291

GI number: 150401291

Start: 890110

End: 891390

Strand: Direct

Name: hisD [H]

Synonym: Maeo_0863

Alternate gene names: 150401291

Gene position: 890110-891390 (Clockwise)

Preceding gene: 150401290

Following gene: 150401292

Centisome position: 56.71

GC content: 33.18

Gene sequence:

>1281_bases
ATGATTATTAAAAATATCAATAATTTAACAGAATCTGACCAAAACATAATATTTAACAGAAATAAAACAAATATAGAGGA
AGTTTATCCAATCGTTAAAGAAATATTGGACAATGTGAAAAATAACGGAGATAGTGCTTTAAAATACTACACTGAAAAGT
TTGATAAAGCAAATATTGATAATTTTAGAATAAGTAACGAGGAAATCGAAGAGGCATACAATTCAATAGATTATAAGATA
ATAGAGGCATTAGAAAAAGCAAACGAAAGAATAATAGAATTCCACAAAATTCAATTAGATAACTTAAAAGAATGGGATAT
TGAAAACAACGGCATAAAAACGGGGCAAATAATAAGGCCAATAGAAAAAGCTGGTTGTTATGTCCCAGGAGGTAGGGCTT
TTTATCCTTCTACGGTTTTAATGACCGTAACACCTGCAAAAGTGGCAGGAGTGGAGAAAGTAGTTGTAGTCTCACCACCA
GATGGAACAAAGGGAGCTCCTGCTACATTGGTGGCATCAGATATAGCCAAAGCTGACGAAATATATAAAGTTGGAGGGGC
CCATGCAATAGGAGCTTTGGCTTATGGAACAGAAACAATACCAAAAGTAGATATTATCGTTGGTCCAGGAAATGTATTTG
TAACTACGGCCAAAATGATGGTTTATGGAAATACTTCAATAGATTTTCCAGCAGGACCTTCTGAGGTTTTAATTTTATGC
GATAATACGGCAAATAGTAAATTTGTGGCTTTGGATTTCATAGCTCAGGCGGAACATGACCCCAACGCATCATGCATAAT
TACCACCACATCTAAGGAACATGCTGAAAAAATTAAAAATAACATTGTAGAAATCATAAATAATAAAGCTACAAAAAGAA
CGGAAATAATAAATAAAGCACTAAATAATTGTGCAATAATCTATGGAAGTATGGAAGATTGTATAAACCTATCAAATGAA
TATGCACCAGAACATTTGGAAATAATTACGGAAAATCCAAGGGAAACACTAAAATATATTAAAAATGCGGGAAGCATCTT
TTTGGGAAGTTATGCTCCTGTTCCTGTTGGAGATTATGCAAGTGGAACAAATCATGTTTTACCAACTAGTGGTTGTGCTA
AAATGTATTCTGGTTTAAGTGTAGATACATTTATAAAAAAGCCAACGGTGCAAGAATTTACAAAAGAAGGACTAAAAAAT
ATATCCGATATAGCCATAACCATAGCAGAGGCAGAAGGGCTTTACAATCATGCTGAATCCATTAAAAAGAGATTAATTTA
A

Upstream 100 bases:

>100_bases
GAAAACGACAAAGAATATATAATTAAAAGAGTTTGCGAAAAAATAAGTATTATTGAAGTGTCATAATCAAAAATAAAAAA
ATAAAAAATAGGGCGAAAAA

Downstream 100 bases:

>100_bases
TAATTTATTAATAATTTATTATTTTTTCTTTTTTTATATTCTAAATATTTTAAATATTAATATTTATTTAATAATTTCTC
AAAACTCCGAAGGAGTTTTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MIIKNINNLTESDQNIIFNRNKTNIEEVYPIVKEILDNVKNNGDSALKYYTEKFDKANIDNFRISNEEIEEAYNSIDYKI
IEALEKANERIIEFHKIQLDNLKEWDIENNGIKTGQIIRPIEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVEKVVVVSPP
DGTKGAPATLVASDIAKADEIYKVGGAHAIGALAYGTETIPKVDIIVGPGNVFVTTAKMMVYGNTSIDFPAGPSEVLILC
DNTANSKFVALDFIAQAEHDPNASCIITTTSKEHAEKIKNNIVEIINNKATKRTEIINKALNNCAIIYGSMEDCINLSNE
YAPEHLEIITENPRETLKYIKNAGSIFLGSYAPVPVGDYASGTNHVLPTSGCAKMYSGLSVDTFIKKPTVQEFTKEGLKN
ISDIAITIAEAEGLYNHAESIKKRLI

Sequences:

>Translated_426_residues
MIIKNINNLTESDQNIIFNRNKTNIEEVYPIVKEILDNVKNNGDSALKYYTEKFDKANIDNFRISNEEIEEAYNSIDYKI
IEALEKANERIIEFHKIQLDNLKEWDIENNGIKTGQIIRPIEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVEKVVVVSPP
DGTKGAPATLVASDIAKADEIYKVGGAHAIGALAYGTETIPKVDIIVGPGNVFVTTAKMMVYGNTSIDFPAGPSEVLILC
DNTANSKFVALDFIAQAEHDPNASCIITTTSKEHAEKIKNNIVEIINNKATKRTEIINKALNNCAIIYGSMEDCINLSNE
YAPEHLEIITENPRETLKYIKNAGSIFLGSYAPVPVGDYASGTNHVLPTSGCAKMYSGLSVDTFIKKPTVQEFTKEGLKN
ISDIAITIAEAEGLYNHAESIKKRLI
>Mature_426_residues
MIIKNINNLTESDQNIIFNRNKTNIEEVYPIVKEILDNVKNNGDSALKYYTEKFDKANIDNFRISNEEIEEAYNSIDYKI
IEALEKANERIIEFHKIQLDNLKEWDIENNGIKTGQIIRPIEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVEKVVVVSPP
DGTKGAPATLVASDIAKADEIYKVGGAHAIGALAYGTETIPKVDIIVGPGNVFVTTAKMMVYGNTSIDFPAGPSEVLILC
DNTANSKFVALDFIAQAEHDPNASCIITTTSKEHAEKIKNNIVEIINNKATKRTEIINKALNNCAIIYGSMEDCINLSNE
YAPEHLEIITENPRETLKYIKNAGSIFLGSYAPVPVGDYASGTNHVLPTSGCAKMYSGLSVDTFIKKPTVQEFTKEGLKN
ISDIAITIAEAEGLYNHAESIKKRLI

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=429, Percent_Identity=40.7925407925408, Blast_Score=314, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6319819, Length=418, Percent_Identity=40.6698564593301, Blast_Score=301, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46727; Mature: 46727

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00611 HISOL_DEHYDROGENASE ; PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKNINNLTESDQNIIFNRNKTNIEEVYPIVKEILDNVKNNGDSALKYYTEKFDKANID
CEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
NFRISNEEIEEAYNSIDYKIIEALEKANERIIEFHKIQLDNLKEWDIENNGIKTGQIIRP
CEEECHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHCC
IEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVEKVVVVSPPDGTKGAPATLVASDIAKADE
HHHCCCCCCCCCEECCCEEEEEECCHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
IYKVGGAHAIGALAYGTETIPKVDIIVGPGNVFVTTAKMMVYGNTSIDFPAGPSEVLILC
HHHCCCCHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCEEEEE
DNTANSKFVALDFIAQAEHDPNASCIITTTSKEHAEKIKNNIVEIINNKATKRTEIINKA
ECCCCCEEEEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LNNCAIIYGSMEDCINLSNEYAPEHLEIITENPRETLKYIKNAGSIFLGSYAPVPVGDYA
HCCEEEEEECHHHHHCCCCCCCCCHHHEEECCHHHHHHHHHCCCCEEECCCCCCCCCCCC
SGTNHVLPTSGCAKMYSGLSVDTFIKKPTVQEFTKEGLKNISDIAITIAEAEGLYNHAES
CCCCCCCCCCCHHHHHCCCCHHHHHCCCCHHHHHHHHHCCHHHHEEEEEHHHHHHHHHHH
IKKRLI
HHHHCC
>Mature Secondary Structure
MIIKNINNLTESDQNIIFNRNKTNIEEVYPIVKEILDNVKNNGDSALKYYTEKFDKANID
CEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
NFRISNEEIEEAYNSIDYKIIEALEKANERIIEFHKIQLDNLKEWDIENNGIKTGQIIRP
CEEECHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCHHHCC
IEKAGCYVPGGRAFYPSTVLMTVTPAKVAGVEKVVVVSPPDGTKGAPATLVASDIAKADE
HHHCCCCCCCCCEECCCEEEEEECCHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
IYKVGGAHAIGALAYGTETIPKVDIIVGPGNVFVTTAKMMVYGNTSIDFPAGPSEVLILC
HHHCCCCHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCEEEEE
DNTANSKFVALDFIAQAEHDPNASCIITTTSKEHAEKIKNNIVEIINNKATKRTEIINKA
ECCCCCEEEEEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LNNCAIIYGSMEDCINLSNEYAPEHLEIITENPRETLKYIKNAGSIFLGSYAPVPVGDYA
HCCEEEEEECHHHHHCCCCCCCCCHHHEEECCHHHHHHHHHCCCCEEECCCCCCCCCCCC
SGTNHVLPTSGCAKMYSGLSVDTFIKKPTVQEFTKEGLKNISDIAITIAEAEGLYNHAES
CCCCCCCCCCCHHHHHCCCCHHHHHCCCCHHHHHHHHHCCHHHHEEEEEHHHHHHHHHHH
IKKRLI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA