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The map label for this gene is rnz

Identifier: 150401156

GI number: 150401156

Start: 745851

End: 746819

Strand: Reverse

Name: rnz

Synonym: Maeo_0727

Alternate gene names: 150401156

Gene position: 746819-745851 (Counterclockwise)

Preceding gene: 150401157

Following gene: 150401155

Centisome position: 47.58

GC content: 30.13

Gene sequence:

>969_bases
ATGAAAATTATTTTTTTAGGCACTGGTGCGGCTATTCCAACAAAACATAGAAATCATTCTTCAGTAGGAATTAAATACGA
TGGCGAGGTTTTTTTATTCGATTGTGGGGAGGGAACTCAGCGACAAATGATATACACAGACATATCACCCATGAAAATAA
ATAATATATTCATATCTCATCTTCATGGTGACCATATATTAGGACTTGCAGGGCTTCTTCAATCAATTGGATTTAATGGA
CGAACAGAACCAATAAATATATATGGTCCGCCTGAAATAAAAAATACAATTGAAAATATTTTAAAAATTGGATATCATTC
CATTAATTTTAAAATAACTGTCCATGAGATAAATTCCAAAAAACCAATGAAAATAATAGATAGTGAAAAATATATGGCAT
ATGCCTATCCAGTAAATCATTCTATACCTTGTTATGCATATATTCTTAAAGAGAAAAAGAAACCACAATTAAATTTAAAG
AAAGCCATGGAATTAGGCGTAGAAGTTGGACCAGATTTAAAATCATTAAAAGATGGCAACGAAGTAAAATTGAAAAATGG
AAAAATCATATACCCAAATGATGTGCTTTTACCTCCAAAAGATAGCATGTGCGTAGCATATAGTGGAGACACCATGCCAA
TTGAAGATTTTGGGGAGTTTTTAAACTCAATTGGTTGTACAGTATTAATTCATGAGGCAACATTTGGGAGCTCCAAGAAA
AATAATGCAGTTGAAACCATGCACTCCACCATAGAAGATGCTGTAAATATCGGAAAAATTGCCTGTGTGGATACGGTGAT
ATTGACCCATATCTCGGCGAGATATGATGACAATATTGAAATATATTATAATGAAATAGAAAATATTATTAAAAATAATA
ATGAATATAATGACAATAATTTCAAAATTATTGTAGCAGAAGATTTAATGGAATATGATTTAAAAAATAAAGAAACCATA
AAAAAATAA

Upstream 100 bases:

>100_bases
AAAATCTAACCTATTACCAATATATGAAGAAATTTATTAATAATTGGACGGATAAGGAACAGTTATTGAACTTACTATAA
TAAACCATCTGGGCGATATT

Downstream 100 bases:

>100_bases
AATAAAAAAATCGGTGATATTATATGCTAAAAATCACAGATTTTTAGACTAATATCACCTAAAAATAAAAAAATCGGTGA
TATTATGGAAAAATCCATTA

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKIIFLGTGAAIPTKHRNHSSVGIKYDGEVFLFDCGEGTQRQMIYTDISPMKINNIFISHLHGDHILGLAGLLQSIGFNG
RTEPINIYGPPEIKNTIENILKIGYHSINFKITVHEINSKKPMKIIDSEKYMAYAYPVNHSIPCYAYILKEKKKPQLNLK
KAMELGVEVGPDLKSLKDGNEVKLKNGKIIYPNDVLLPPKDSMCVAYSGDTMPIEDFGEFLNSIGCTVLIHEATFGSSKK
NNAVETMHSTIEDAVNIGKIACVDTVILTHISARYDDNIEIYYNEIENIIKNNNEYNDNNFKIIVAEDLMEYDLKNKETI
KK

Sequences:

>Translated_322_residues
MKIIFLGTGAAIPTKHRNHSSVGIKYDGEVFLFDCGEGTQRQMIYTDISPMKINNIFISHLHGDHILGLAGLLQSIGFNG
RTEPINIYGPPEIKNTIENILKIGYHSINFKITVHEINSKKPMKIIDSEKYMAYAYPVNHSIPCYAYILKEKKKPQLNLK
KAMELGVEVGPDLKSLKDGNEVKLKNGKIIYPNDVLLPPKDSMCVAYSGDTMPIEDFGEFLNSIGCTVLIHEATFGSSKK
NNAVETMHSTIEDAVNIGKIACVDTVILTHISARYDDNIEIYYNEIENIIKNNNEYNDNNFKIIVAEDLMEYDLKNKETI
KK
>Mature_322_residues
MKIIFLGTGAAIPTKHRNHSSVGIKYDGEVFLFDCGEGTQRQMIYTDISPMKINNIFISHLHGDHILGLAGLLQSIGFNG
RTEPINIYGPPEIKNTIENILKIGYHSINFKITVHEINSKKPMKIIDSEKYMAYAYPVNHSIPCYAYILKEKKKPQLNLK
KAMELGVEVGPDLKSLKDGNEVKLKNGKIIYPNDVLLPPKDSMCVAYSGDTMPIEDFGEFLNSIGCTVLIHEATFGSSKK
NNAVETMHSTIEDAVNIGKIACVDTVILTHISARYDDNIEIYYNEIENIIKNNNEYNDNNFKIIVAEDLMEYDLKNKETI
KK

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=353, Percent_Identity=32.2946175637394, Blast_Score=181, Evalue=6e-46,
Organism=Escherichia coli, GI87082078, Length=304, Percent_Identity=35.5263157894737, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71985808, Length=290, Percent_Identity=27.9310344827586, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71985814, Length=290, Percent_Identity=27.9310344827586, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24652403, Length=105, Percent_Identity=39.0476190476191, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_META3 (A6UUY8)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324922.1
- ProteinModelPortal:   A6UUY8
- SMR:   A6UUY8
- STRING:   A6UUY8
- GeneID:   5327423
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0727
- eggNOG:   arNOG04942
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   CLSK876601
- BioCyc:   MAEO419665:MAEO_0727-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 36248; Mature: 36248

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIFLGTGAAIPTKHRNHSSVGIKYDGEVFLFDCGEGTQRQMIYTDISPMKINNIFISH
CEEEEEECCCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCEEEEECCCCEEEEEEEEEE
LHGDHILGLAGLLQSIGFNGRTEPINIYGPPEIKNTIENILKIGYHSINFKITVHEINSK
ECCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCEEEEEEEEEEEECCCC
KPMKIIDSEKYMAYAYPVNHSIPCYAYILKEKKKPQLNLKKAMELGVEVGPDLKSLKDGN
CCEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHCCCCC
EVKLKNGKIIYPNDVLLPPKDSMCVAYSGDTMPIEDFGEFLNSIGCTVLIHEATFGSSKK
EEEEECCEEECCCCEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
NNAVETMHSTIEDAVNIGKIACVDTVILTHISARYDDNIEIYYNEIENIIKNNNEYNDNN
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCC
FKIIVAEDLMEYDLKNKETIKK
EEEEEECHHHHHCCCCHHHCCC
>Mature Secondary Structure
MKIIFLGTGAAIPTKHRNHSSVGIKYDGEVFLFDCGEGTQRQMIYTDISPMKINNIFISH
CEEEEEECCCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCEEEEECCCCEEEEEEEEEE
LHGDHILGLAGLLQSIGFNGRTEPINIYGPPEIKNTIENILKIGYHSINFKITVHEINSK
ECCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCEEEEEEEEEEEECCCC
KPMKIIDSEKYMAYAYPVNHSIPCYAYILKEKKKPQLNLKKAMELGVEVGPDLKSLKDGN
CCEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHCCCCC
EVKLKNGKIIYPNDVLLPPKDSMCVAYSGDTMPIEDFGEFLNSIGCTVLIHEATFGSSKK
EEEEECCEEECCCCEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
NNAVETMHSTIEDAVNIGKIACVDTVILTHISARYDDNIEIYYNEIENIIKNNNEYNDNN
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCC
FKIIVAEDLMEYDLKNKETIKK
EEEEEECHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA