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The map label for this gene is 150401103

Identifier: 150401103

GI number: 150401103

Start: 688910

End: 689851

Strand: Direct

Name: 150401103

Synonym: Maeo_0673

Alternate gene names: NA

Gene position: 688910-689851 (Clockwise)

Preceding gene: 150401102

Following gene: 150401104

Centisome position: 43.89

GC content: 33.76

Gene sequence:

>942_bases
ATGAAGCATAATAATAATAATAACTCAAATACTATAATAGACGCCCACAAAAAAATAAAAAATATGGAAATAAGGGGGGC
GGGAAGGATCGGGAGAGCCGTAGCAAGTGCTTTAAAAGAATATTCTTTAACAATTCAAAATATAGAGAATAACGAATTTA
AAGAAAAAATGATTGAAGCAGGAGACATATTAAAATCAGCACGACCAACTGCGGTATCCCTCCCAAATGCTGTAAATTAT
GTGTTAAGTGGATTAAATACCAATAATCCAAAGGAAAACATAATATTGAATGCCGAAGAATTTATAAAATCCTCCTCAGA
AGCTACTTCAAAAATTGGAAAAATTGGCTCCAACAGAATAAAAGATGGATGGACAATATTAACTCATTGTAATTCGGAAG
CCGCAATTAGTGTAATAAAAACAGCACATAACAGCGGGAAAAATATAAAAGTTATATGCACAGAGACACGACCAAGAAAC
CAAGGATATTTAACAGCAAAGGCGTTGGCGGACGAAGGTATTGACACCACATTAATAGTGGATAGTGCTGTAAGATACCA
CATTAAAGATGTGGATATTGTGGTGGTGGGTGCCGATGCCATAACCTCAAATGGTTGCCTTGTAAATAAAATAGGGAGCT
CCCAAATAGCTTTAATGGCATATGAAAGAAAAATACCATTTTTAACAGCCGCAGAAACTTATAAATTTCACCCTAAAACA
ATAATCGGGGAAACAATAGAGATTGAGGAAAGGGCAGTTGGTGAAATACATGAATTTGAGGAAAAATATAAAGATAAAAT
AAAATTAAGAAATCCAGCTTTTGACATTACTCCTTCTCAATATATTGACGGAATAATAACAGAAATAGGAATTATTCCGC
CACAGGGAGCTTGGCATATAATAGAAAAATATTTTGGAAATGTATTTAAGGAAACACTTTAA

Upstream 100 bases:

>100_bases
AGTGCAGGCGACATTATAAAAATGATGCATGAATCATTGGAATAATTTATTAATTTATTGTATTTTTTTTATTAATTCAT
ATTTGCAGGGGGTGATATTT

Downstream 100 bases:

>100_bases
TATTAAAATGATAATTAATATAATTAAAAAATATCCATATGAACTACGGTGAAATTGTGAGTAAAGTTAAAGATATAAAT
TTAGCTCCTGAGGGAGATTT

Product: translation initiation factor IF-2B subunit delta

Products: NA

Alternate protein names: eIF-2B GDP-GTP exchange factor [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MKHNNNNNSNTIIDAHKKIKNMEIRGAGRIGRAVASALKEYSLTIQNIENNEFKEKMIEAGDILKSARPTAVSLPNAVNY
VLSGLNTNNPKENIILNAEEFIKSSSEATSKIGKIGSNRIKDGWTILTHCNSEAAISVIKTAHNSGKNIKVICTETRPRN
QGYLTAKALADEGIDTTLIVDSAVRYHIKDVDIVVVGADAITSNGCLVNKIGSSQIALMAYERKIPFLTAAETYKFHPKT
IIGETIEIEERAVGEIHEFEEKYKDKIKLRNPAFDITPSQYIDGIITEIGIIPPQGAWHIIEKYFGNVFKETL

Sequences:

>Translated_313_residues
MKHNNNNNSNTIIDAHKKIKNMEIRGAGRIGRAVASALKEYSLTIQNIENNEFKEKMIEAGDILKSARPTAVSLPNAVNY
VLSGLNTNNPKENIILNAEEFIKSSSEATSKIGKIGSNRIKDGWTILTHCNSEAAISVIKTAHNSGKNIKVICTETRPRN
QGYLTAKALADEGIDTTLIVDSAVRYHIKDVDIVVVGADAITSNGCLVNKIGSSQIALMAYERKIPFLTAAETYKFHPKT
IIGETIEIEERAVGEIHEFEEKYKDKIKLRNPAFDITPSQYIDGIITEIGIIPPQGAWHIIEKYFGNVFKETL
>Mature_313_residues
MKHNNNNNSNTIIDAHKKIKNMEIRGAGRIGRAVASALKEYSLTIQNIENNEFKEKMIEAGDILKSARPTAVSLPNAVNY
VLSGLNTNNPKENIILNAEEFIKSSSEATSKIGKIGSNRIKDGWTILTHCNSEAAISVIKTAHNSGKNIKVICTETRPRN
QGYLTAKALADEGIDTTLIVDSAVRYHIKDVDIVVVGADAITSNGCLVNKIGSSQIALMAYERKIPFLTAAETYKFHPKT
IIGETIEIEERAVGEIHEFEEKYKDKIKLRNPAFDITPSQYIDGIITEIGIIPPQGAWHIIEKYFGNVFKETL

Specific function: Catalyzes the exchange of initiation factor 2-bound GDP for GTP [H]

COG id: COG1184

COG function: function code J; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=329, Percent_Identity=31.306990881459, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI4503503, Length=212, Percent_Identity=29.7169811320755, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI78000158, Length=284, Percent_Identity=22.5352112676056, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI78000156, Length=284, Percent_Identity=22.5352112676056, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI187607323, Length=284, Percent_Identity=22.5352112676056, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI23943880, Length=147, Percent_Identity=42.1768707482993, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI7657058, Length=160, Percent_Identity=27.5, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=310, Percent_Identity=30.3225806451613, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17557123, Length=200, Percent_Identity=30.5, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322878, Length=272, Percent_Identity=29.7794117647059, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6325375, Length=362, Percent_Identity=30.3867403314917, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321520, Length=188, Percent_Identity=31.9148936170213, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357667, Length=319, Percent_Identity=33.5423197492163, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24651647, Length=319, Percent_Identity=33.5423197492163, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21358605, Length=204, Percent_Identity=31.3725490196078, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281364091, Length=252, Percent_Identity=26.984126984127, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24659399, Length=252, Percent_Identity=26.984126984127, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24659407, Length=252, Percent_Identity=26.984126984127, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922816, Length=252, Percent_Identity=26.984126984127, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005250
- InterPro:   IPR000649
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: NA

Molecular weight: Translated: 34593; Mature: 34593

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHNNNNNSNTIIDAHKKIKNMEIRGAGRIGRAVASALKEYSLTIQNIENNEFKEKMIEA
CCCCCCCCCCEEEECHHHHHCCEEECCCHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHH
GDILKSARPTAVSLPNAVNYVLSGLNTNNPKENIILNAEEFIKSSSEATSKIGKIGSNRI
HHHHHHCCCCEEECCHHHHHHHHCCCCCCCCCCEEECHHHHHCCCHHHHHHHHHCCCCCC
KDGWTILTHCNSEAAISVIKTAHNSGKNIKVICTETRPRNQGYLTAKALADEGIDTTLIV
CCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEHHHHCCCCCEEEEE
DSAVRYHIKDVDIVVVGADAITSNGCLVNKIGSSQIALMAYERKIPFLTAAETYKFHPKT
EHHHEEEEEEEEEEEECCCEECCCCEEEEECCCCEEEEEEEECCCCEEEECCCEEECCHH
IIGETIEIEERAVGEIHEFEEKYKDKIKLRNPAFDITPSQYIDGIITEIGIIPPQGAWHI
HCCCEEEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
IEKYFGNVFKETL
HHHHHHHHHHHCC
>Mature Secondary Structure
MKHNNNNNSNTIIDAHKKIKNMEIRGAGRIGRAVASALKEYSLTIQNIENNEFKEKMIEA
CCCCCCCCCCEEEECHHHHHCCEEECCCHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHH
GDILKSARPTAVSLPNAVNYVLSGLNTNNPKENIILNAEEFIKSSSEATSKIGKIGSNRI
HHHHHHCCCCEEECCHHHHHHHHCCCCCCCCCCEEECHHHHHCCCHHHHHHHHHCCCCCC
KDGWTILTHCNSEAAISVIKTAHNSGKNIKVICTETRPRNQGYLTAKALADEGIDTTLIV
CCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEHHHHCCCCCEEEEE
DSAVRYHIKDVDIVVVGADAITSNGCLVNKIGSSQIALMAYERKIPFLTAAETYKFHPKT
EHHHEEEEEEEEEEEECCCEECCCCEEEEECCCCEEEEEEEECCCCEEEECCCEEECCHH
IIGETIEIEERAVGEIHEFEEKYKDKIKLRNPAFDITPSQYIDGIITEIGIIPPQGAWHI
HCCCEEEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHH
IEKYFGNVFKETL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]