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The map label for this gene is ahcY [H]

Identifier: 150401104

GI number: 150401104

Start: 689890

End: 691155

Strand: Direct

Name: ahcY [H]

Synonym: Maeo_0674

Alternate gene names: 150401104

Gene position: 689890-691155 (Clockwise)

Preceding gene: 150401103

Following gene: 150401106

Centisome position: 43.96

GC content: 35.23

Gene sequence:

>1266_bases
ATGAACTACGGTGAAATTGTGAGTAAAGTTAAAGATATAAATTTAGCTCCTGAGGGAGATTTAAAAATGGAATGGGCTAA
AAACTATATGCCTGTATTAAATTCCATAAGGGAAGAATATTCAGCAGACAAACCATTCGAAGGCATCACAATAGGAATGG
CACTTCATTTGGAGGCAAAAACTGCAATACTTGCCGAAACTCTAATGAATGGAGGGGCAAAAATTGTAATTACTGGCTGT
AATCCATTATCTACACAAGACGATGTTGCTGCAAATTGTGTAAAAAAAGGAATGGAAGTTTATGCTTGGAGAGGAGAAAC
TGACGAAGAATATTATGAAAATTTAAATAAAGTTCTTGATGCCAAACCTGACATTGTAATTGATGATGGTGCAGATTTAA
TATTTTTACTTCACACTCAAAGACAGGAGCTCCTTGATAGCATCATGGGAGGTTGTGAGGAAACCACCACAGGAATAATA
AGATTAAAAGCTATGGCAGACGAAGGGGCTTTAAAATTCCCTGTTGTAAATGTAAATGATGCCTACACAAAACATTTATT
TGACAATAGATATGGAACAGGCCAAAGTGCTATTGATGGAATATTGAGAACAACAAATTTACTTATTGCCGGCAAAAATG
TTGTAGTAGGAGGCTACGGCTGGTGCGGTAAAGGAGTAGCTATGAGAGCCGCAGGAATGGGGGCAAGTGTGATAATTACG
GAAGTAGATGCCATTAGAGCATTAGAAGCTAAAATGGATGGATTTAGAGTAATGACAATGAACGAAGCTTCAAAAATCGG
AGATATATTTATAACTACAACAGGATGTAAAAATATTATCGGAGCTCCACACTTTTTGGTAATGAAAGATGGTGCAGTTC
TTGCAAATGCTGGACATTTCGACAATGAAATAAACAAAGAAGAATTGAGTTCATTGGCAAAATCAGTTAAAACAGTTAGA
TACAATATTGAAGAATATGATTTAGGAAATAAAAAAATATATCTTCTTGGAGAAGGTAGGCTGGTAAATCTCGCCTGTGG
AGATGGACACCCATGCGAAGTAATGGACATGAGCTTTGCGAATCAGGCACTTAGTGCAAAATTCATATTAGAAAATAATG
GAAAACTTGAAAATAATGTATATGAAATACCTTATGAACAAGATTTAAGAATAGCTTCATTAAAATTAAAGTCAATGGAT
GTTGAAATAGATGAATTATCCCCAGAACAGAGAAAATATTTAGCTGACTGGAAAGAAGGAACTTAA

Upstream 100 bases:

>100_bases
CACAGGGAGCTTGGCATATAATAGAAAAATATTTTGGAAATGTATTTAAGGAAACACTTTAATATTAAAATGATAATTAA
TATAATTAAAAAATATCCAT

Downstream 100 bases:

>100_bases
TTAAAATAATATTTCTTTTTATTTCTATTTTTTTAATGTTTCCCTCCTTGTTTTAATCTCAAAATCAAAGGATTTTTTCT
GATTTCTTCGCTTTGCTCAG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MNYGEIVSKVKDINLAPEGDLKMEWAKNYMPVLNSIREEYSADKPFEGITIGMALHLEAKTAILAETLMNGGAKIVITGC
NPLSTQDDVAANCVKKGMEVYAWRGETDEEYYENLNKVLDAKPDIVIDDGADLIFLLHTQRQELLDSIMGGCEETTTGII
RLKAMADEGALKFPVVNVNDAYTKHLFDNRYGTGQSAIDGILRTTNLLIAGKNVVVGGYGWCGKGVAMRAAGMGASVIIT
EVDAIRALEAKMDGFRVMTMNEASKIGDIFITTTGCKNIIGAPHFLVMKDGAVLANAGHFDNEINKEELSSLAKSVKTVR
YNIEEYDLGNKKIYLLGEGRLVNLACGDGHPCEVMDMSFANQALSAKFILENNGKLENNVYEIPYEQDLRIASLKLKSMD
VEIDELSPEQRKYLADWKEGT

Sequences:

>Translated_421_residues
MNYGEIVSKVKDINLAPEGDLKMEWAKNYMPVLNSIREEYSADKPFEGITIGMALHLEAKTAILAETLMNGGAKIVITGC
NPLSTQDDVAANCVKKGMEVYAWRGETDEEYYENLNKVLDAKPDIVIDDGADLIFLLHTQRQELLDSIMGGCEETTTGII
RLKAMADEGALKFPVVNVNDAYTKHLFDNRYGTGQSAIDGILRTTNLLIAGKNVVVGGYGWCGKGVAMRAAGMGASVIIT
EVDAIRALEAKMDGFRVMTMNEASKIGDIFITTTGCKNIIGAPHFLVMKDGAVLANAGHFDNEINKEELSSLAKSVKTVR
YNIEEYDLGNKKIYLLGEGRLVNLACGDGHPCEVMDMSFANQALSAKFILENNGKLENNVYEIPYEQDLRIASLKLKSMD
VEIDELSPEQRKYLADWKEGT
>Mature_421_residues
MNYGEIVSKVKDINLAPEGDLKMEWAKNYMPVLNSIREEYSADKPFEGITIGMALHLEAKTAILAETLMNGGAKIVITGC
NPLSTQDDVAANCVKKGMEVYAWRGETDEEYYENLNKVLDAKPDIVIDDGADLIFLLHTQRQELLDSIMGGCEETTTGII
RLKAMADEGALKFPVVNVNDAYTKHLFDNRYGTGQSAIDGILRTTNLLIAGKNVVVGGYGWCGKGVAMRAAGMGASVIIT
EVDAIRALEAKMDGFRVMTMNEASKIGDIFITTTGCKNIIGAPHFLVMKDGAVLANAGHFDNEINKEELSSLAKSVKTVR
YNIEEYDLGNKKIYLLGEGRLVNLACGDGHPCEVMDMSFANQALSAKFILENNGKLENNVYEIPYEQDLRIASLKLKSMD
VEIDELSPEQRKYLADWKEGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=410, Percent_Identity=45.8536585365854, Blast_Score=335, Evalue=6e-92,
Organism=Homo sapiens, GI239937451, Length=389, Percent_Identity=46.0154241645244, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI298286489, Length=416, Percent_Identity=36.7788461538462, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI195539349, Length=410, Percent_Identity=36.8292682926829, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI195539337, Length=416, Percent_Identity=36.7788461538462, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI24308043, Length=416, Percent_Identity=36.7788461538462, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI21361647, Length=416, Percent_Identity=36.7788461538462, Blast_Score=255, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17506425, Length=416, Percent_Identity=42.5480769230769, Blast_Score=318, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6320882, Length=432, Percent_Identity=41.4351851851852, Blast_Score=323, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24642172, Length=411, Percent_Identity=44.7688564476886, Blast_Score=326, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24656245, Length=407, Percent_Identity=37.3464373464373, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI45553385, Length=415, Percent_Identity=36.8674698795181, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI45553387, Length=415, Percent_Identity=36.8674698795181, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46249; Mature: 46249

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00739 ADOHCYASE_2 ; PS00697 DNA_LIGASE_A1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYGEIVSKVKDINLAPEGDLKMEWAKNYMPVLNSIREEYSADKPFEGITIGMALHLEAK
CCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECHH
TAILAETLMNGGAKIVITGCNPLSTQDDVAANCVKKGMEVYAWRGETDEEYYENLNKVLD
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHC
AKPDIVIDDGADLIFLLHTQRQELLDSIMGGCEETTTGIIRLKAMADEGALKFPVVNVND
CCCCEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEEEECCH
AYTKHLFDNRYGTGQSAIDGILRTTNLLIAGKNVVVGGYGWCGKGVAMRAAGMGASVIIT
HHHHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEECCCCCCCCCEEEECCCCCEEEEE
EVDAIRALEAKMDGFRVMTMNEASKIGDIFITTTGCKNIIGAPHFLVMKDGAVLANAGHF
EHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCHHHCCCCEEEEEECCEEEEECCCC
DNEINKEELSSLAKSVKTVRYNIEEYDLGNKKIYLLGEGRLVNLACGDGHPCEVMDMSFA
CCCCCHHHHHHHHHHHHHHEECCHHEECCCCEEEEEECCEEEEEEECCCCCCEEEECHHH
NQALSAKFILENNGKLENNVYEIPYEQDLRIASLKLKSMDVEIDELSPEQRKYLADWKEG
HHHHEEEEEEECCCCCCCCEEECCCCCCCEEEEEEEEECCEEHHHCCHHHHHHHCCCCCC
T
C
>Mature Secondary Structure
MNYGEIVSKVKDINLAPEGDLKMEWAKNYMPVLNSIREEYSADKPFEGITIGMALHLEAK
CCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECHH
TAILAETLMNGGAKIVITGCNPLSTQDDVAANCVKKGMEVYAWRGETDEEYYENLNKVLD
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHC
AKPDIVIDDGADLIFLLHTQRQELLDSIMGGCEETTTGIIRLKAMADEGALKFPVVNVND
CCCCEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEEEECCH
AYTKHLFDNRYGTGQSAIDGILRTTNLLIAGKNVVVGGYGWCGKGVAMRAAGMGASVIIT
HHHHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEECCCCCCCCCEEEECCCCCEEEEE
EVDAIRALEAKMDGFRVMTMNEASKIGDIFITTTGCKNIIGAPHFLVMKDGAVLANAGHF
EHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCHHHCCCCEEEEEECCEEEEECCCC
DNEINKEELSSLAKSVKTVRYNIEEYDLGNKKIYLLGEGRLVNLACGDGHPCEVMDMSFA
CCCCCHHHHHHHHHHHHHHEECCHHEECCCCEEEEEECCEEEEEEECCCCCCEEEECHHH
NQALSAKFILENNGKLENNVYEIPYEQDLRIASLKLKSMDVEIDELSPEQRKYLADWKEG
HHHHEEEEEEECCCCCCCCEEECCCCCCCEEEEEEEEECCEEHHHCCHHHHHHHCCCCCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA