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The map label for this gene is rnhB

Identifier: 150401039

GI number: 150401039

Start: 622920

End: 623753

Strand: Reverse

Name: rnhB

Synonym: Maeo_0608

Alternate gene names: 150401039

Gene position: 623753-622920 (Counterclockwise)

Preceding gene: 150401041

Following gene: 150401038

Centisome position: 39.74

GC content: 25.66

Gene sequence:

>834_bases
ATGAATGATAATGATAATATTGATAAGGATAATATTGATACAATGAATGATAATAATAAACTAATAATTGGATTAGATGA
AGCTGGTAGGGGTCCTGTTTTGGGACCTATGGTTATTGCATTGGTAAAAATTAAAGGGCAAGACCTAAAAAACTTTGAAA
AGTTGGATATTAAAGATAGTAAAAAACATAGTAAAAATAGACGAGAAGAGCTATTTGAGATGATTATAAATAATTATGAT
GTAAGATATGAAATTCTTGAAGCAAAAACTATTGATAAATTAATGAATACCATAAATTTAAATAAAATAGAATTAATGGC
TTTCACTAAATTAATAAATTCTGTTTTAAAGGAAGAATATCCGAATTATAAGGAAAATAGTAAAATTCAAACAGCCACTC
CGCAAATAGAAATATATATTGATGCTTGTAGTAGCAATGAAAAGGCATTTGCAAATCAAATAAAATCTAAATTAATAGTA
AATGACGAAAATAATATTAAAATTATAGCCGAACATAAGGCCGACGAAAATTATAAAATTGTTTCAGCTGCATCGATAAT
TGCGAAAGTAATAAGAGATAGAAAAATAGAAGAATATAAAAAGATATATGGTGAGATTGGTAGTGGCTATCCAAGTGATA
AAATAACACAAAAATATTTGGCAAATTATGTTGAAAAAAACAGGGAGCTCCCTGAAATTGCAAGAAAAAGTTGGAATACT
TCAAAAAAATTATTAAAAAAAATTGAAGATAAAAATACCGTAGATAAAATTAAAGATTCAAAACGCATTAAAACCAATAT
AGAATTAAAACAAACTAAACTGGTGGAATTTTGA

Upstream 100 bases:

>100_bases
CAATACGGTCGCCTTATAGGTGGGACTGTCTCCACAGTATCATATAATCAACTGCAAATATAATAAGTAGTTTAAAGTAT
ATATAATATTCCGTGATACA

Downstream 100 bases:

>100_bases
AAACTAAAAAATTAATAATTGACGAAAGAGAAAAAAAATATTTATTAAAAAACAAAGTAAATGAGTTTGGAAATGATTTG
GGCGTAATTAATATATCGGA

Product: ribonuclease HII

Products: NA

Alternate protein names: RNase HII

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNDNDNIDKDNIDTMNDNNKLIIGLDEAGRGPVLGPMVIALVKIKGQDLKNFEKLDIKDSKKHSKNRREELFEMIINNYD
VRYEILEAKTIDKLMNTINLNKIELMAFTKLINSVLKEEYPNYKENSKIQTATPQIEIYIDACSSNEKAFANQIKSKLIV
NDENNIKIIAEHKADENYKIVSAASIIAKVIRDRKIEEYKKIYGEIGSGYPSDKITQKYLANYVEKNRELPEIARKSWNT
SKKLLKKIEDKNTVDKIKDSKRIKTNIELKQTKLVEF

Sequences:

>Translated_277_residues
MNDNDNIDKDNIDTMNDNNKLIIGLDEAGRGPVLGPMVIALVKIKGQDLKNFEKLDIKDSKKHSKNRREELFEMIINNYD
VRYEILEAKTIDKLMNTINLNKIELMAFTKLINSVLKEEYPNYKENSKIQTATPQIEIYIDACSSNEKAFANQIKSKLIV
NDENNIKIIAEHKADENYKIVSAASIIAKVIRDRKIEEYKKIYGEIGSGYPSDKITQKYLANYVEKNRELPEIARKSWNT
SKKLLKKIEDKNTVDKIKDSKRIKTNIELKQTKLVEF
>Mature_277_residues
MNDNDNIDKDNIDTMNDNNKLIIGLDEAGRGPVLGPMVIALVKIKGQDLKNFEKLDIKDSKKHSKNRREELFEMIINNYD
VRYEILEAKTIDKLMNTINLNKIELMAFTKLINSVLKEEYPNYKENSKIQTATPQIEIYIDACSSNEKAFANQIKSKLIV
NDENNIKIIAEHKADENYKIVSAASIIAKVIRDRKIEEYKKIYGEIGSGYPSDKITQKYLANYVEKNRELPEIARKSWNT
SKKLLKKIEDKNTVDKIKDSKRIKTNIELKQTKLVEF

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0164

COG function: function code L; Ribonuclease HII

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase HII family

Homologues:

Organism=Homo sapiens, GI38455391, Length=238, Percent_Identity=30.672268907563, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324257, Length=246, Percent_Identity=31.3008130081301, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24580635, Length=243, Percent_Identity=30.0411522633745, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH2_META3 (A6UUM1)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324805.1
- ProteinModelPortal:   A6UUM1
- SMR:   A6UUM1
- STRING:   A6UUM1
- GeneID:   5327382
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0608
- eggNOG:   arNOG07713
- HOGENOM:   HBG584843
- OMA:   AEHKADE
- ProtClustDB:   PRK00015
- BioCyc:   MAEO419665:MAEO_0608-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00052_A
- InterPro:   IPR004649
- InterPro:   IPR001352
- InterPro:   IPR020787
- InterPro:   IPR023160
- InterPro:   IPR012337
- Gene3D:   G3DSA:1.10.10.460
- PANTHER:   PTHR10954
- TIGRFAMs:   TIGR00729

Pfam domain/function: PF01351 RNase_HII; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 32046; Mature: 32046

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDNDNIDKDNIDTMNDNNKLIIGLDEAGRGPVLGPMVIALVKIKGQDLKNFEKLDIKDS
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCC
KKHSKNRREELFEMIINNYDVRYEILEAKTIDKLMNTINLNKIELMAFTKLINSVLKEEY
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
PNYKENSKIQTATPQIEIYIDACSSNEKAFANQIKSKLIVNDENNIKIIAEHKADENYKI
CCCCCCCEEEECCCEEEEEEEECCCCHHHHHHHHHHHEEEECCCCEEEEEECCCCCCEEE
VSAASIIAKVIRDRKIEEYKKIYGEIGSGYPSDKITQKYLANYVEKNRELPEIARKSWNT
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCH
SKKLLKKIEDKNTVDKIKDSKRIKTNIELKQTKLVEF
HHHHHHHHHCCCHHHHHHCCHHHHCCCEEHHHHCCCC
>Mature Secondary Structure
MNDNDNIDKDNIDTMNDNNKLIIGLDEAGRGPVLGPMVIALVKIKGQDLKNFEKLDIKDS
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCC
KKHSKNRREELFEMIINNYDVRYEILEAKTIDKLMNTINLNKIELMAFTKLINSVLKEEY
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
PNYKENSKIQTATPQIEIYIDACSSNEKAFANQIKSKLIVNDENNIKIIAEHKADENYKI
CCCCCCCEEEECCCEEEEEEEECCCCHHHHHHHHHHHEEEECCCCEEEEEECCCCCCEEE
VSAASIIAKVIRDRKIEEYKKIYGEIGSGYPSDKITQKYLANYVEKNRELPEIARKSWNT
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCH
SKKLLKKIEDKNTVDKIKDSKRIKTNIELKQTKLVEF
HHHHHHHHHCCCHHHHHHCCHHHHCCCEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA