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The map label for this gene is mtbA [H]

Identifier: 150401031

GI number: 150401031

Start: 614560

End: 615504

Strand: Direct

Name: mtbA [H]

Synonym: Maeo_0600

Alternate gene names: 150401031

Gene position: 614560-615504 (Clockwise)

Preceding gene: 150401030

Following gene: 150401032

Centisome position: 39.16

GC content: 33.76

Gene sequence:

>945_bases
ATGATTGACATTGAAGAAGAAGTTAAAAATAGAACTTTGATAGCACCAATGGGTGGGTGTTATATTGCAAAACTTTATGG
ATGCGGTAAGAAGCACCATTTTTGTAGAAATGGGGAAATTTTTGGTAAAGCACTTTGTAAGGCAAAGGAACATTTTGGCC
ATGATATTATCCATCTTTCCTCAGATATATATGTTGAAGTGGAAGCCATGGGATTGTACGATTGGAGCTGTATATCTGAG
GGCTATGGGAAGATGGATGAAGATTTTGATTTGGATAGTTTAACGATTGATTTAGATGGTGGGAGAATTCCCGAATACAG
AAAGGCAATTGAATACTGCAACTCAAAAAATAATACGGCATTTGTAAGCGTAAGTGCCCCATTTACTCTTGCAGCAATTC
TGAGAGGCATTGATAGATTTATGATAGATTTAATAAAAAATGAAAAATTTGCTAAGGATTTGATTAAAAAAACTACAGAG
ATATCCAAAATTGTTATAGAAGATATAAATGAGATTGCACACCCTTTTGTTGTTGATGCGGTGTCATCTTCCTCCCTTAT
TAGTCCAGAATTTTATAGAAAATTTGCTTTTAAACCGATAAAAAAAGTAATGAAGGCATGTGATTTTCCCATCTTACACA
TGTGTGGAGACATAAACCCAATATTAGATGATGTTAAAAAAACAGGAACAAAAATTATAAGCTTTGATGATAATTTAGAT
ATTTCTAAAGCCTTTGAGGCATTTAAAGACTTAATTGTTTTTGGAAATATTGACCCTTCAATGATGTATTATTCAAAAGT
AGATAAAGTAGAAATGGAAGTAAAGAAATGTATGGAAGCTAAGGGTGGTGATTTCATATTGTCCACTGGATGTAGCCTCC
CAGTGGGAGCTCCAAAGAAAAATTTAGAGGCGTTAGTGCATTATGGGGGGTGTTATGATGTATAA

Upstream 100 bases:

>100_bases
AAAAATAAGGGAAAACAGCACATAATAGCGACAGGTTGTGAGTTGCTTCCCAATACTCCCGAAAAAAACATTATTAAATT
AATTAACTCGAGGGTGGATT

Downstream 100 bases:

>100_bases
TATTACATACATAAAAGAGGATGGAACTAAAAAATCAATTAAAGTTAAAGAAGGAACCACAATACTTGAAGGAGCGATAA
AAGCGGGAGTTTATATTGAT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: MT2-A; Methylcobamide:CoM methyltransferase II isozyme A [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MIDIEEEVKNRTLIAPMGGCYIAKLYGCGKKHHFCRNGEIFGKALCKAKEHFGHDIIHLSSDIYVEVEAMGLYDWSCISE
GYGKMDEDFDLDSLTIDLDGGRIPEYRKAIEYCNSKNNTAFVSVSAPFTLAAILRGIDRFMIDLIKNEKFAKDLIKKTTE
ISKIVIEDINEIAHPFVVDAVSSSSLISPEFYRKFAFKPIKKVMKACDFPILHMCGDINPILDDVKKTGTKIISFDDNLD
ISKAFEAFKDLIVFGNIDPSMMYYSKVDKVEMEVKKCMEAKGGDFILSTGCSLPVGAPKKNLEALVHYGGCYDV

Sequences:

>Translated_314_residues
MIDIEEEVKNRTLIAPMGGCYIAKLYGCGKKHHFCRNGEIFGKALCKAKEHFGHDIIHLSSDIYVEVEAMGLYDWSCISE
GYGKMDEDFDLDSLTIDLDGGRIPEYRKAIEYCNSKNNTAFVSVSAPFTLAAILRGIDRFMIDLIKNEKFAKDLIKKTTE
ISKIVIEDINEIAHPFVVDAVSSSSLISPEFYRKFAFKPIKKVMKACDFPILHMCGDINPILDDVKKTGTKIISFDDNLD
ISKAFEAFKDLIVFGNIDPSMMYYSKVDKVEMEVKKCMEAKGGDFILSTGCSLPVGAPKKNLEALVHYGGCYDV
>Mature_314_residues
MIDIEEEVKNRTLIAPMGGCYIAKLYGCGKKHHFCRNGEIFGKALCKAKEHFGHDIIHLSSDIYVEVEAMGLYDWSCISE
GYGKMDEDFDLDSLTIDLDGGRIPEYRKAIEYCNSKNNTAFVSVSAPFTLAAILRGIDRFMIDLIKNEKFAKDLIKKTTE
ISKIVIEDINEIAHPFVVDAVSSSSLISPEFYRKFAFKPIKKVMKACDFPILHMCGDINPILDDVKKTGTKIISFDDNLD
ISKAFEAFKDLIVFGNIDPSMMYYSKVDKVEMEVKKCMEAKGGDFILSTGCSLPVGAPKKNLEALVHYGGCYDV

Specific function: Catalyzes the transfer of the methyl group from the methylated corrinoid cofactor of mtmC, mtbC and mttC to coenzyme M [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006360
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: NA

Molecular weight: Translated: 35175; Mature: 35175

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIEEEVKNRTLIAPMGGCYIAKLYGCGKKHHFCRNGEIFGKALCKAKEHFGHDIIHLS
CCCCHHHHCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEC
SDIYVEVEAMGLYDWSCISEGYGKMDEDFDLDSLTIDLDGGRIPEYRKAIEYCNSKNNTA
CCEEEEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEE
FVSVSAPFTLAAILRGIDRFMIDLIKNEKFAKDLIKKTTEISKIVIEDINEIAHPFVVDA
EEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
VSSSSLISPEFYRKFAFKPIKKVMKACDFPILHMCGDINPILDDVKKTGTKIISFDDNLD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCEEEEECCCCC
ISKAFEAFKDLIVFGNIDPSMMYYSKVDKVEMEVKKCMEAKGGDFILSTGCSLPVGAPKK
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHH
NLEALVHYGGCYDV
HHHHHHHCCCCCCC
>Mature Secondary Structure
MIDIEEEVKNRTLIAPMGGCYIAKLYGCGKKHHFCRNGEIFGKALCKAKEHFGHDIIHLS
CCCCHHHHCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEC
SDIYVEVEAMGLYDWSCISEGYGKMDEDFDLDSLTIDLDGGRIPEYRKAIEYCNSKNNTA
CCEEEEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEE
FVSVSAPFTLAAILRGIDRFMIDLIKNEKFAKDLIKKTTEISKIVIEDINEIAHPFVVDA
EEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
VSSSSLISPEFYRKFAFKPIKKVMKACDFPILHMCGDINPILDDVKKTGTKIISFDDNLD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCEEEEECCCCC
ISKAFEAFKDLIVFGNIDPSMMYYSKVDKVEMEVKKCMEAKGGDFILSTGCSLPVGAPKK
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHH
NLEALVHYGGCYDV
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8702528; 9642198; 7635826; 8617801; 9006042; 9195968; 10852929 [H]