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The map label for this gene is pyrE [H]

Identifier: 150400992

GI number: 150400992

Start: 577166

End: 577705

Strand: Reverse

Name: pyrE [H]

Synonym: Maeo_0561

Alternate gene names: 150400992

Gene position: 577705-577166 (Counterclockwise)

Preceding gene: 150400994

Following gene: 150400990

Centisome position: 36.81

GC content: 29.26

Gene sequence:

>540_bases
ATGAAAAATAAATTAAAAGATAAACTAATAAAATTATTAAAAGAAGTCGAATGTGTGCAGTTTGGGGATTTTACCTTAGC
ATCTGGAAAAAAAAGTAATTATTATGTAAATATCAAAAAGGCAACCACAAATCCAAAGATTTTAAAGACTGTTGCACAAT
TAATAAATATTTACATCGAAGAAGACAAAAAAAATCCAAATTTAAAAATAGCAGGAGTAGAGTTGGGCTCTGTTTCAATA
GCCACAGCAGTATCTCTTGAAACTGAAAAAGATTTAATAATTATAAGAAAAAAAGCAAAAGACTACGGAACTAAATCTAA
AATAGAAGGGACATTAAATAATGGAGATACCGTAATTATGGTGGAGGATGTTACTACAACGGGTGGAAGTGTTATAAAAG
CAATACAGGAGGTTAGAGAAAATGGTGGCATTGTGGATAAAGTATTTGTAATTGTGGATAGAAATGAAGGGGCAAAAGAA
AATTTAAAAGAAATTGGAGTAGAATTAATTGCCCTTGTAAATGTTGAAGAGTTAAAATAA

Upstream 100 bases:

>100_bases
TTGGTATAGAATATTTATTTAATATATTATATACGATATTATATACAATATAATAATTTATATATTTATATATTATTTTA
GATATTTTTTGGGTGAAATT

Downstream 100 bases:

>100_bases
TATCTATATATTTATAGTTATTATAAATATATTTTATTATAAATATATTATAAAGAGCCCTATAAAATTAATTATCTAGC
TCCTCCATCAATTACACTTA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MKNKLKDKLIKLLKEVECVQFGDFTLASGKKSNYYVNIKKATTNPKILKTVAQLINIYIEEDKKNPNLKIAGVELGSVSI
ATAVSLETEKDLIIIRKKAKDYGTKSKIEGTLNNGDTVIMVEDVTTTGGSVIKAIQEVRENGGIVDKVFVIVDRNEGAKE
NLKEIGVELIALVNVEELK

Sequences:

>Translated_179_residues
MKNKLKDKLIKLLKEVECVQFGDFTLASGKKSNYYVNIKKATTNPKILKTVAQLINIYIEEDKKNPNLKIAGVELGSVSI
ATAVSLETEKDLIIIRKKAKDYGTKSKIEGTLNNGDTVIMVEDVTTTGGSVIKAIQEVRENGGIVDKVFVIVDRNEGAKE
NLKEIGVELIALVNVEELK
>Mature_179_residues
MKNKLKDKLIKLLKEVECVQFGDFTLASGKKSNYYVNIKKATTNPKILKTVAQLINIYIEEDKKNPNLKIAGVELGSVSI
ATAVSLETEKDLIIIRKKAKDYGTKSKIEGTLNNGDTVIMVEDVTTTGGSVIKAIQEVRENGGIVDKVFVIVDRNEGAKE
NLKEIGVELIALVNVEELK

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=174, Percent_Identity=30.4597701149425, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1790073, Length=172, Percent_Identity=27.3255813953488, Blast_Score=61, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17554964, Length=174, Percent_Identity=32.7586206896552, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508631, Length=169, Percent_Identity=31.9526627218935, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17933654, Length=176, Percent_Identity=32.3863636363636, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 19691; Mature: 19691

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKLKDKLIKLLKEVECVQFGDFTLASGKKSNYYVNIKKATTNPKILKTVAQLINIYIE
CCCHHHHHHHHHHHHHHHEEECCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHEEEE
EDKKNPNLKIAGVELGSVSIATAVSLETEKDLIIIRKKAKDYGTKSKIEGTLNNGDTVIM
CCCCCCCEEEEEEEECCEEEEEEEEECCCCCEEEEEECCCCCCCCHHEEEEECCCCEEEE
VEDVTTTGGSVIKAIQEVRENGGIVDKVFVIVDRNEGAKENLKEIGVELIALVNVEELK
EEECCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHEEEEHHHCC
>Mature Secondary Structure
MKNKLKDKLIKLLKEVECVQFGDFTLASGKKSNYYVNIKKATTNPKILKTVAQLINIYIE
CCCHHHHHHHHHHHHHHHEEECCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHEEEE
EDKKNPNLKIAGVELGSVSIATAVSLETEKDLIIIRKKAKDYGTKSKIEGTLNNGDTVIM
CCCCCCCEEEEEEEECCEEEEEEEEECCCCCEEEEEECCCCCCCCHHEEEEECCCCEEEE
VEDVTTTGGSVIKAIQEVRENGGIVDKVFVIVDRNEGAKENLKEIGVELIALVNVEELK
EEECCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHEEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA