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The map label for this gene is gmd [H]

Identifier: 150400829

GI number: 150400829

Start: 412357

End: 413385

Strand: Reverse

Name: gmd [H]

Synonym: Maeo_0397

Alternate gene names: 150400829

Gene position: 413385-412357 (Counterclockwise)

Preceding gene: 150400830

Following gene: 150400828

Centisome position: 26.34

GC content: 35.28

Gene sequence:

>1029_bases
ATGAAAAAGGCAATTATTACGGGAATAACCGGACAGGATGGATACTATTTAACAAAATTACTTTTGGAAAAAGGATATGA
AGTTCATGGAATTGTTAGAAGAAATAGCCAAAATTCCTTGGGAAACTTGGAACACCTACCAAAGGAAGAATTGGAACAAA
TAAATATTCACTGGGGGGATATTACAGACAATTTATTCATGGATAATGTTGTTAAAGCGGTGCAACCTGATGAAGTTTAT
CATTTAGCTGCTCAAAGTTTTGTTGGATTCTCTTTTGAAAATCCAAGATTTACCTATGATGTTAATATTGGTGGAACTTT
AAATGTAACTAATGCAGTAAAGGAATATGCACCATCTTCAAAACTCTATTTTGCTGCAACATCTGAATTGTATGGAAAGG
TTCAGGAAATTCCGCAGAAGGAAACTACACCATTTTACCCAAGGAGCCCTTATGGGGTTTCCAAGTTGGCAGGATTTTGG
ACTATTAAGAATTATAGGGAAAGCTATGACTTATTTATGAGCAATGGTATCCTGTTCAATCACGAGAGCCCCATGCGTGG
CCCAGAATTCGTAACAAGAAAAATAACAATGGCTGTTGCTAAAATATCTCATGGATTACAGGATTTTGTTGAATTAGGAA
ATTTAAGTGCTAAAAGGGATTGGGGTTATGCTGGAGATTATGTTTATGGCATGTGGAAAATATTACAGCACGATAAGCCA
GATGACTTTGTTTTAGCAACAAATGAAACCCATACAGTTAGGGAATTTGTTGAAAATGCCTTTAAGGTTGTTGGAATCGA
CATAGAATGGGAAGGGGAAGGAGTTAATGAAATTGGTAAAGATGCTAACAATGGAAAGGTTTTGGTAAAAGTTAATCCTG
AATTTTTCAGACCTGCGGAAGTTGATATATTAATTGGTGATTATTCAAAGGCTAAGAAGGAGCTCGGATGGGAACCAAAA
GTTAAATTTGAAGAATTAGTTAAGATGATGGTTGAAAAGGATTTGGAAAGAATTGGGAAATTGAAATAA

Upstream 100 bases:

>100_bases
AGATTATGAACCCAAATGGAATTTTGAAGATGGGGTTAAAGATTATGTTGAATGGTTAAAGGAAAATAGGTATATTTAAA
AATATTATTGGGTGATATGT

Downstream 100 bases:

>100_bases
ATTTAAATATATAGTTTATTTAGTTCAGATTTAAAATGAATTATGTGAGCTCCGATATATATTTTTTAATTTTTAAAAAT
TTTAAGATGATACTATGGAT

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKKAIITGITGQDGYYLTKLLLEKGYEVHGIVRRNSQNSLGNLEHLPKEELEQINIHWGDITDNLFMDNVVKAVQPDEVY
HLAAQSFVGFSFENPRFTYDVNIGGTLNVTNAVKEYAPSSKLYFAATSELYGKVQEIPQKETTPFYPRSPYGVSKLAGFW
TIKNYRESYDLFMSNGILFNHESPMRGPEFVTRKITMAVAKISHGLQDFVELGNLSAKRDWGYAGDYVYGMWKILQHDKP
DDFVLATNETHTVREFVENAFKVVGIDIEWEGEGVNEIGKDANNGKVLVKVNPEFFRPAEVDILIGDYSKAKKELGWEPK
VKFEELVKMMVEKDLERIGKLK

Sequences:

>Translated_342_residues
MKKAIITGITGQDGYYLTKLLLEKGYEVHGIVRRNSQNSLGNLEHLPKEELEQINIHWGDITDNLFMDNVVKAVQPDEVY
HLAAQSFVGFSFENPRFTYDVNIGGTLNVTNAVKEYAPSSKLYFAATSELYGKVQEIPQKETTPFYPRSPYGVSKLAGFW
TIKNYRESYDLFMSNGILFNHESPMRGPEFVTRKITMAVAKISHGLQDFVELGNLSAKRDWGYAGDYVYGMWKILQHDKP
DDFVLATNETHTVREFVENAFKVVGIDIEWEGEGVNEIGKDANNGKVLVKVNPEFFRPAEVDILIGDYSKAKKELGWEPK
VKFEELVKMMVEKDLERIGKLK
>Mature_342_residues
MKKAIITGITGQDGYYLTKLLLEKGYEVHGIVRRNSQNSLGNLEHLPKEELEQINIHWGDITDNLFMDNVVKAVQPDEVY
HLAAQSFVGFSFENPRFTYDVNIGGTLNVTNAVKEYAPSSKLYFAATSELYGKVQEIPQKETTPFYPRSPYGVSKLAGFW
TIKNYRESYDLFMSNGILFNHESPMRGPEFVTRKITMAVAKISHGLQDFVELGNLSAKRDWGYAGDYVYGMWKILQHDKP
DDFVLATNETHTVREFVENAFKVVGIDIEWEGEGVNEIGKDANNGKVLVKVNPEFFRPAEVDILIGDYSKAKKELGWEPK
VKFEELVKMMVEKDLERIGKLK

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=339, Percent_Identity=56.047197640118, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI42516563, Length=335, Percent_Identity=26.865671641791, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI7657641, Length=336, Percent_Identity=26.4880952380952, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788366, Length=354, Percent_Identity=50, Blast_Score=356, Evalue=1e-99,
Organism=Escherichia coli, GI48994969, Length=346, Percent_Identity=26.3005780346821, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786974, Length=344, Percent_Identity=27.0348837209302, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788353, Length=349, Percent_Identity=23.7822349570201, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=341, Percent_Identity=54.8387096774194, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17539424, Length=341, Percent_Identity=54.8387096774194, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI133901790, Length=341, Percent_Identity=54.8387096774194, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17539422, Length=341, Percent_Identity=54.8387096774194, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI133901786, Length=341, Percent_Identity=54.8387096774194, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17507723, Length=341, Percent_Identity=54.2521994134897, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24158427, Length=345, Percent_Identity=52.7536231884058, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI21356223, Length=332, Percent_Identity=27.710843373494, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 38969; Mature: 38969

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAIITGITGQDGYYLTKLLLEKGYEVHGIVRRNSQNSLGNLEHLPKEELEQINIHWGD
CCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHEEEEEECC
ITDNLFMDNVVKAVQPDEVYHLAAQSFVGFSFENPRFTYDVNIGGTLNVTNAVKEYAPSS
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCEECCCEEEEEEECCCEEEHHHHHHHHCCCC
KLYFAATSELYGKVQEIPQKETTPFYPRSPYGVSKLAGFWTIKNYRESYDLFMSNGILFN
CEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
HESPMRGPEFVTRKITMAVAKISHGLQDFVELGNLSAKRDWGYAGDYVYGMWKILQHDKP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCC
DDFVLATNETHTVREFVENAFKVVGIDIEWEGEGVNEIGKDANNGKVLVKVNPEFFRPAE
CCEEEECCCCHHHHHHHHCCCEEEEEEEEECCCCHHHHCCCCCCCEEEEEECCCCCCCCE
VDILIGDYSKAKKELGWEPKVKFEELVKMMVEKDLERIGKLK
EEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKAIITGITGQDGYYLTKLLLEKGYEVHGIVRRNSQNSLGNLEHLPKEELEQINIHWGD
CCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHEEEEEECC
ITDNLFMDNVVKAVQPDEVYHLAAQSFVGFSFENPRFTYDVNIGGTLNVTNAVKEYAPSS
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCEECCCEEEEEEECCCEEEHHHHHHHHCCCC
KLYFAATSELYGKVQEIPQKETTPFYPRSPYGVSKLAGFWTIKNYRESYDLFMSNGILFN
CEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
HESPMRGPEFVTRKITMAVAKISHGLQDFVELGNLSAKRDWGYAGDYVYGMWKILQHDKP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCC
DDFVLATNETHTVREFVENAFKVVGIDIEWEGEGVNEIGKDANNGKVLVKVNPEFFRPAE
CCEEEECCCCHHHHHHHHCCCEEEEEEEEECCCCHHHHCCCCCCCEEEEEECCCCCCCCE
VDILIGDYSKAKKELGWEPKVKFEELVKMMVEKDLERIGKLK
EEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]