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The map label for this gene is ziaA [H]

Identifier: 150400770

GI number: 150400770

Start: 356584

End: 358656

Strand: Direct

Name: ziaA [H]

Synonym: Maeo_0336

Alternate gene names: 150400770

Gene position: 356584-358656 (Clockwise)

Preceding gene: 150400769

Following gene: 150400776

Centisome position: 22.72

GC content: 37.67

Gene sequence:

>2073_bases
ATGTCAAAAAAACTTAAATTGAAAGGTTTAGATTGTGCAAACTGTGCATATAAGATTGAAAATGCCTTAAAAAAAGAGGG
GTTTGAGTCTGCATCAGTTAACTTCGCTACCGGTGAGCTCACCATTGAAGGGGATATAGAAAAAGCCAAAAATATAGTGA
AGAAAGTTGATTCAGGGGTTGAAGTAATAGAAAAAGAAGAACATCACCATGACTGCCATGATCACGGTGAAGATCCAAAG
AAAATGCTTTACTTCATAGTTCCATCGTTAATTCTTTTTGTAATTGGGGTACTACTTAGGTACTACTACAACTACGACAA
TATTTTTGTATTTGGAATATTTGTCGTAGGCTATATGTTAGTAGGGTGGAAAGTTCTAAGGAACGCTGTTGTAAACTCCA
TCCACGGAAATGTCTTTGATGAGAACTTTCTTATGACAATAGCCACTTTAGGAGCCTTTGCTATTGGAGAATATCCTGAA
GCCGTAGGTGTTATGCTCTTCTATATGGTGGGTGAGTTCTTCCAGAACTTATCAATAAATCGTTCTAGAAAATCAATTAA
AGGGTTGTTAGCATTAAAGGCAGACTACGCAAACTTAAAGATTGGAGATAAGACAATTAAAGTTAAACCTGAGGATGTTA
AAGTTGGTGATCTAATCTTAGTAAAACCTGGAGAACGGGTACCATTGGACGGATTGGTGATTGAAGGTTCATCAACTGTT
GACTCTTCAGCACTAACTGGTGAAAGTATACCTAGGGTAGTCAAAGAAGGAGATGAGCTCCTATCAGGAATATTAAACTT
AAATGGTCTTTTAACAGTTAAGGTTGCAAAGGAGCTCAAAGAATCGACGATTTCAAGAATCTTTGAACTAGTTGAGAATG
CAAGTGCAAGAAAAGCAAAAACAGAGCGTTTTATTACCAGATTTTCCAGATATTATACTCCAATAGTCGTAGGTTTAGCA
GTACTGATAGCCACAATCCCACCCCTGGTTTTTGGAGAACCTTTATCCAATTGGGTATATAGGGCATTGGTACTATTGGT
TATATCCTGCCCCTGTGCATTGATGCTTTCAATTCCTTTAGTCTACTTCGGAGGAATTGGAAAGTCTGCCAGAGAGGGGA
TACTCGTCAAAGGTTCAAACTTTCTCGATGCACTGGGCAAAGCTAGAATTGTGGCATTTGATAAAACAGGGACTTTAACA
AAAGGAGTATTTAAGACGGTACAGATAGTCGCAAAGAACAGCTTTAACAAAGATGAAATCTTAAAATTTATGGCACTGGC
TGAAGCTCATTCAAGTCATCCAATTGCAAATGCACTAAAAGAGGCTTATGGAAAAGAAATTAATGAAAACGAGATTAAAG
AACATGAGGAAATACCAGGGTATGGAGTTAGAGCCAAAATTAATGGAAAAGAAATAATGGTTGGAAATGATAGGCTTTTG
CATAAATTTAACATCGAACATGACACCTGCCATGTAAAAGGTACGGTTGTCCATGTGGTTGTTGATGGAGAGTATGCAGG
TTACATAATAATATCCGACGAGATAAAAAAAGATGCTTTAGAAACCATACAGGAGCTCAGAAAACTTGGAGTTAAAAAGA
TTGTAATGCTTACCGGTGACAGCAAGGATGTTGCAGAAGAGATAGCAAAAAAAATCGGCTTAGATGAGTTTTACGCTGAA
CTGCTACCTGAGGATAAGGTAAATATTATCGAAAAGCTTGGGGCAGAGAAAGAAAATGGTACCGTTGTTTTCGTTGGAGA
CGGAATAAACGATGCCCCAGTTATTGCAAGGTCAGATTTAGGTGTTGCAATGGGAGCTCTGGGAAGTGACGTTGCCATAG
AAACAGCAGATATAGTTATAATGGACGATAAACCTTCGAAGCTACCTTTAGGAATTAAAATATCAAAGAAGGTACAGAAT
ATAGTTATGGAAAACATAATCTTAATTTTAATCGTTAAACTGTCATTTGTACTACTCGGAGCTCTTGGACAGGTCACAAT
ATGGGGGGCCATATTTGCAGATGTTGGAGTTGCACTACTCGCAGTTTTTAACTCGATGAGGATATTAAAATAG

Upstream 100 bases:

>100_bases
ATACAATAATTATAAATAACATTTGAACAAATGTTCAATTGAACTGGTGATATAATGTCTTATATTTGTGAAGTTTACAA
AGAACATTTAGGTGAGTAAA

Downstream 100 bases:

>100_bases
AGAAACTTAAAGTATTTATATAACTATTTTTATTCTATTATTCTTATTCACTACTACTGCATAATTATTAATTAGAATAT
ACTCATGTTACTTATGAGAA

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 690; Mature: 689

Protein sequence:

>690_residues
MSKKLKLKGLDCANCAYKIENALKKEGFESASVNFATGELTIEGDIEKAKNIVKKVDSGVEVIEKEEHHHDCHDHGEDPK
KMLYFIVPSLILFVIGVLLRYYYNYDNIFVFGIFVVGYMLVGWKVLRNAVVNSIHGNVFDENFLMTIATLGAFAIGEYPE
AVGVMLFYMVGEFFQNLSINRSRKSIKGLLALKADYANLKIGDKTIKVKPEDVKVGDLILVKPGERVPLDGLVIEGSSTV
DSSALTGESIPRVVKEGDELLSGILNLNGLLTVKVAKELKESTISRIFELVENASARKAKTERFITRFSRYYTPIVVGLA
VLIATIPPLVFGEPLSNWVYRALVLLVISCPCALMLSIPLVYFGGIGKSAREGILVKGSNFLDALGKARIVAFDKTGTLT
KGVFKTVQIVAKNSFNKDEILKFMALAEAHSSHPIANALKEAYGKEINENEIKEHEEIPGYGVRAKINGKEIMVGNDRLL
HKFNIEHDTCHVKGTVVHVVVDGEYAGYIIISDEIKKDALETIQELRKLGVKKIVMLTGDSKDVAEEIAKKIGLDEFYAE
LLPEDKVNIIEKLGAEKENGTVVFVGDGINDAPVIARSDLGVAMGALGSDVAIETADIVIMDDKPSKLPLGIKISKKVQN
IVMENIILILIVKLSFVLLGALGQVTIWGAIFADVGVALLAVFNSMRILK

Sequences:

>Translated_690_residues
MSKKLKLKGLDCANCAYKIENALKKEGFESASVNFATGELTIEGDIEKAKNIVKKVDSGVEVIEKEEHHHDCHDHGEDPK
KMLYFIVPSLILFVIGVLLRYYYNYDNIFVFGIFVVGYMLVGWKVLRNAVVNSIHGNVFDENFLMTIATLGAFAIGEYPE
AVGVMLFYMVGEFFQNLSINRSRKSIKGLLALKADYANLKIGDKTIKVKPEDVKVGDLILVKPGERVPLDGLVIEGSSTV
DSSALTGESIPRVVKEGDELLSGILNLNGLLTVKVAKELKESTISRIFELVENASARKAKTERFITRFSRYYTPIVVGLA
VLIATIPPLVFGEPLSNWVYRALVLLVISCPCALMLSIPLVYFGGIGKSAREGILVKGSNFLDALGKARIVAFDKTGTLT
KGVFKTVQIVAKNSFNKDEILKFMALAEAHSSHPIANALKEAYGKEINENEIKEHEEIPGYGVRAKINGKEIMVGNDRLL
HKFNIEHDTCHVKGTVVHVVVDGEYAGYIIISDEIKKDALETIQELRKLGVKKIVMLTGDSKDVAEEIAKKIGLDEFYAE
LLPEDKVNIIEKLGAEKENGTVVFVGDGINDAPVIARSDLGVAMGALGSDVAIETADIVIMDDKPSKLPLGIKISKKVQN
IVMENIILILIVKLSFVLLGALGQVTIWGAIFADVGVALLAVFNSMRILK
>Mature_689_residues
SKKLKLKGLDCANCAYKIENALKKEGFESASVNFATGELTIEGDIEKAKNIVKKVDSGVEVIEKEEHHHDCHDHGEDPKK
MLYFIVPSLILFVIGVLLRYYYNYDNIFVFGIFVVGYMLVGWKVLRNAVVNSIHGNVFDENFLMTIATLGAFAIGEYPEA
VGVMLFYMVGEFFQNLSINRSRKSIKGLLALKADYANLKIGDKTIKVKPEDVKVGDLILVKPGERVPLDGLVIEGSSTVD
SSALTGESIPRVVKEGDELLSGILNLNGLLTVKVAKELKESTISRIFELVENASARKAKTERFITRFSRYYTPIVVGLAV
LIATIPPLVFGEPLSNWVYRALVLLVISCPCALMLSIPLVYFGGIGKSAREGILVKGSNFLDALGKARIVAFDKTGTLTK
GVFKTVQIVAKNSFNKDEILKFMALAEAHSSHPIANALKEAYGKEINENEIKEHEEIPGYGVRAKINGKEIMVGNDRLLH
KFNIEHDTCHVKGTVVHVVVDGEYAGYIIISDEIKKDALETIQELRKLGVKKIVMLTGDSKDVAEEIAKKIGLDEFYAEL
LPEDKVNIIEKLGAEKENGTVVFVGDGINDAPVIARSDLGVAMGALGSDVAIETADIVIMDDKPSKLPLGIKISKKVQNI
VMENIILILIVKLSFVLLGALGQVTIWGAIFADVGVALLAVFNSMRILK

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=800, Percent_Identity=26.375, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI55743073, Length=743, Percent_Identity=27.0524899057873, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI115529486, Length=583, Percent_Identity=26.0720411663808, Blast_Score=176, Evalue=8e-44,
Organism=Homo sapiens, GI297374799, Length=119, Percent_Identity=31.0924369747899, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI83700225, Length=119, Percent_Identity=31.0924369747899, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI153946397, Length=120, Percent_Identity=30.8333333333333, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1789879, Length=692, Percent_Identity=34.2485549132948, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1786691, Length=695, Percent_Identity=28.7769784172662, Blast_Score=255, Evalue=8e-69,
Organism=Escherichia coli, GI1786914, Length=504, Percent_Identity=28.1746031746032, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI2367363, Length=586, Percent_Identity=23.2081911262799, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17556548, Length=790, Percent_Identity=28.2278481012658, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17557486, Length=179, Percent_Identity=29.608938547486, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557770, Length=179, Percent_Identity=27.9329608938547, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32566766, Length=179, Percent_Identity=27.9329608938547, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559224, Length=158, Percent_Identity=29.1139240506329, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320475, Length=679, Percent_Identity=27.3932253313697, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6319772, Length=551, Percent_Identity=27.7676950998185, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321271, Length=220, Percent_Identity=32.7272727272727, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6325221, Length=221, Percent_Identity=25.3393665158371, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321432, Length=192, Percent_Identity=29.6875, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321430, Length=221, Percent_Identity=24.4343891402715, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221329854, Length=592, Percent_Identity=25.8445945945946, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24668704, Length=146, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161085803, Length=146, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281366617, Length=146, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668708, Length=146, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24668696, Length=146, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553435, Length=294, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553439, Length=294, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553437, Length=294, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553441, Length=294, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24648580, Length=294, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24648578, Length=294, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24648576, Length=294, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281362164, Length=294, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24648582, Length=309, Percent_Identity=23.3009708737864, Blast_Score=66, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 75611; Mature: 75479

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKLKLKGLDCANCAYKIENALKKEGFESASVNFATGELTIEGDIEKAKNIVKKVDSGV
CCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEECEEEEECCHHHHHHHHHHHHCCH
EVIEKEEHHHDCHDHGEDPKKMLYFIVPSLILFVIGVLLRYYYNYDNIFVFGIFVVGYML
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VGWKVLRNAVVNSIHGNVFDENFLMTIATLGAFAIGEYPEAVGVMLFYMVGEFFQNLSIN
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
RSRKSIKGLLALKADYANLKIGDKTIKVKPEDVKVGDLILVKPGERVPLDGLVIEGSSTV
CHHHHHHHHHHEEECCCCEEECCEEEEECCCCEEECCEEEECCCCCCCCCCEEEECCCCC
DSSALTGESIPRVVKEGDELLSGILNLNGLLTVKVAKELKESTISRIFELVENASARKAK
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TERFITRFSRYYTPIVVGLAVLIATIPPLVFGEPLSNWVYRALVLLVISCPCALMLSIPL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYFGGIGKSAREGILVKGSNFLDALGKARIVAFDKTGTLTKGVFKTVQIVAKNSFNKDEI
HHCCCCCCCCCCCEEEECCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
LKFMALAEAHSSHPIANALKEAYGKEINENEIKEHEEIPGYGVRAKINGKEIMVGNDRLL
HHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCEEEECCCCEE
HKFNIEHDTCHVKGTVVHVVVDGEYAGYIIISDEIKKDALETIQELRKLGVKKIVMLTGD
EEECCCCCEEEEEEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECC
SKDVAEEIAKKIGLDEFYAELLPEDKVNIIEKLGAEKENGTVVFVGDGINDAPVIARSDL
CHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCC
GVAMGALGSDVAIETADIVIMDDKPSKLPLGIKISKKVQNIVMENIILILIVKLSFVLLG
CHHHHCCCCCCEEEEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGQVTIWGAIFADVGVALLAVFNSMRILK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKKLKLKGLDCANCAYKIENALKKEGFESASVNFATGELTIEGDIEKAKNIVKKVDSGV
CCCEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEECEEEEECCHHHHHHHHHHHHCCH
EVIEKEEHHHDCHDHGEDPKKMLYFIVPSLILFVIGVLLRYYYNYDNIFVFGIFVVGYML
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VGWKVLRNAVVNSIHGNVFDENFLMTIATLGAFAIGEYPEAVGVMLFYMVGEFFQNLSIN
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
RSRKSIKGLLALKADYANLKIGDKTIKVKPEDVKVGDLILVKPGERVPLDGLVIEGSSTV
CHHHHHHHHHHEEECCCCEEECCEEEEECCCCEEECCEEEECCCCCCCCCCEEEECCCCC
DSSALTGESIPRVVKEGDELLSGILNLNGLLTVKVAKELKESTISRIFELVENASARKAK
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TERFITRFSRYYTPIVVGLAVLIATIPPLVFGEPLSNWVYRALVLLVISCPCALMLSIPL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYFGGIGKSAREGILVKGSNFLDALGKARIVAFDKTGTLTKGVFKTVQIVAKNSFNKDEI
HHCCCCCCCCCCCEEEECCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
LKFMALAEAHSSHPIANALKEAYGKEINENEIKEHEEIPGYGVRAKINGKEIMVGNDRLL
HHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCEEEECCCCEE
HKFNIEHDTCHVKGTVVHVVVDGEYAGYIIISDEIKKDALETIQELRKLGVKKIVMLTGD
EEECCCCCEEEEEEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECC
SKDVAEEIAKKIGLDEFYAELLPEDKVNIIEKLGAEKENGTVVFVGDGINDAPVIARSDL
CHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCC
GVAMGALGSDVAIETADIVIMDDKPSKLPLGIKISKKVQNIVMENIILILIVKLSFVLLG
CHHHHCCCCCCEEEEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGQVTIWGAIFADVGVALLAVFNSMRILK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]