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The map label for this gene is hisH [H]

Identifier: 150400623

GI number: 150400623

Start: 202853

End: 203470

Strand: Reverse

Name: hisH [H]

Synonym: Maeo_0185

Alternate gene names: 150400623

Gene position: 203470-202853 (Counterclockwise)

Preceding gene: 150400624

Following gene: 150400619

Centisome position: 12.96

GC content: 32.69

Gene sequence:

>618_bases
GTGATTGCTATAATTGACTACAATGCAGGGAATTTAAGAAGCATAAAAAAGGCCGTTGAATTATATTCTAATAACATAGT
AATTACCAACGACCCTGAAACCATTTTCAGTGCAGATAAAATAATACTACCAGGAGTTGGAAATTTCGGAAGTGTGATGC
AAAATTTATCCATTAAGAATGGAGAATATTCTTTAAAAGAAGTGATAGGTAAAGCGGTAGAGAATGTTCCATTTTTAGGC
ATTTGTTTAGGTATGCAACTGTTAATGGAACAAAGTGAAGAATGTGGGGATTCAAAAGATGGAGGATTGGGAATTATAAA
AGGAGATGTTTTAAAATTTAAAGGCGTAGAAAAAATCCCCCATATGGGCTGGAATAATGTCGAACAAGTTAAAGATATTC
CCCTATTTGAGGGCATAAAAAATAATGAGTATTTTTATTTTGTTCATTCATATTTCGTAAATCCATCAAATGCCGATGTC
ATAGCAGGAGTTAGTGATTATGGCAATAAATTTGCCTGCGTATTAAATAAGGATAACATATATGCCACCCAGTTTCACCC
TGAAAAAAGTGGTAATGCAGGATTAAAAATGATTGAGAATTTCGTTGAATTGATTTAA

Upstream 100 bases:

>100_bases
TTATAACGGGATTAAAAAATAAAGAAGATGCATACATTGCCCTTGAAAAAATAAAAAATACAGTGAAAGAACTTGAAGAA
GAATATTTTTAAGTGATATT

Downstream 100 bases:

>100_bases
TTATTTATTATTTTTTAGTTATTTTTCAATAAGTTCAAAACAGCATTTTGTAAATCCTAATTTTTTAAATTCGTTGTTAA
TCTGTTTAATATTTTTAATA

Product: imidazole glycerol phosphate synthase subunit HisH

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit 1; IGP synthase subunit hisH 1; ImGP synthase subunit hisH 1; IGPS subunit hisH 1 [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MIAIIDYNAGNLRSIKKAVELYSNNIVITNDPETIFSADKIILPGVGNFGSVMQNLSIKNGEYSLKEVIGKAVENVPFLG
ICLGMQLLMEQSEECGDSKDGGLGIIKGDVLKFKGVEKIPHMGWNNVEQVKDIPLFEGIKNNEYFYFVHSYFVNPSNADV
IAGVSDYGNKFACVLNKDNIYATQFHPEKSGNAGLKMIENFVELI

Sequences:

>Translated_205_residues
MIAIIDYNAGNLRSIKKAVELYSNNIVITNDPETIFSADKIILPGVGNFGSVMQNLSIKNGEYSLKEVIGKAVENVPFLG
ICLGMQLLMEQSEECGDSKDGGLGIIKGDVLKFKGVEKIPHMGWNNVEQVKDIPLFEGIKNNEYFYFVHSYFVNPSNADV
IAGVSDYGNKFACVLNKDNIYATQFHPEKSGNAGLKMIENFVELI
>Mature_205_residues
MIAIIDYNAGNLRSIKKAVELYSNNIVITNDPETIFSADKIILPGVGNFGSVMQNLSIKNGEYSLKEVIGKAVENVPFLG
ICLGMQLLMEQSEECGDSKDGGLGIIKGDVLKFKGVEKIPHMGWNNVEQVKDIPLFEGIKNNEYFYFVHSYFVNPSNADV
IAGVSDYGNKFACVLNKDNIYATQFHPEKSGNAGLKMIENFVELI

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR [H]

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788334, Length=204, Percent_Identity=41.6666666666667, Blast_Score=146, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6319725, Length=218, Percent_Identity=36.2385321100917, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 22621; Mature: 22621

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIIDYNAGNLRSIKKAVELYSNNIVITNDPETIFSADKIILPGVGNFGSVMQNLSIKN
CEEEEECCCCCHHHHHHHHHHHCCCEEEECCCHHHHCCCEEEECCCCCHHHHHHHCCCCC
GEYSLKEVIGKAVENVPFLGICLGMQLLMEQSEECGDSKDGGLGIIKGDVLKFKGVEKIP
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEECCCCCCC
HMGWNNVEQVKDIPLFEGIKNNEYFYFVHSYFVNPSNADVIAGVSDYGNKFACVLNKDNI
CCCCCCHHHHHCCHHHCCCCCCCEEEEEEEEEECCCCCEEEEEHHHCCCEEEEEEECCCE
YATQFHPEKSGNAGLKMIENFVELI
EEEEECCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MIAIIDYNAGNLRSIKKAVELYSNNIVITNDPETIFSADKIILPGVGNFGSVMQNLSIKN
CEEEEECCCCCHHHHHHHHHHHCCCEEEECCCHHHHCCCEEEECCCCCHHHHHHHCCCCC
GEYSLKEVIGKAVENVPFLGICLGMQLLMEQSEECGDSKDGGLGIIKGDVLKFKGVEKIP
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEECCCCCCC
HMGWNNVEQVKDIPLFEGIKNNEYFYFVHSYFVNPSNADVIAGVSDYGNKFACVLNKDNI
CCCCCCHHHHHCCHHHCCCCCCCEEEEEEEEEECCCCCEEEEEHHHCCCEEEEEEECCCE
YATQFHPEKSGNAGLKMIENFVELI
EEEEECCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA