BacMap

Definition	Methanococcus aeolicus Nankai-3, complete genome.
Accession	NC_009635
Length	1,569,500

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The map label for this gene is psmA [H]

Identifier: 150400619

GI number: 150400619

Start: 197725

End: 198540

Strand: Reverse

Name: psmA [H]

Synonym: Maeo_0181

Alternate gene names: 150400619

Gene position: 198540-197725 (Counterclockwise)

Preceding gene: 150400623

Following gene: 150400618

Centisome position: 12.65

GC content: 34.07

Gene sequence:

>816_bases
ATGCAAATGAATCCAATACAAGGTGGATACGATAGGGCAATTACAGTATTTAGCCCAGAAGGAAGATTATATCAGGTTGA
ATATGCAAGAGAAGCTGTTAGAAGAGGAACAACTGCAATAGGCATAAAATACAGCGGAGGAGTTATTTTAGCAGTCGATA
GAAGAATAATGAGTAAATTGATAGAAAAATATTCAGTCGAAAAAATATTCCATATAGATGAGCACATAATGGCTGCAAGT
TCCGGTTTAATTGCAGATGCAAGAATTTTAGTGGATAGGGCAAGAGTAGAAGCTCAAATAAATAAAATTACATACGGAGA
ACCCATGACCGTTGAAGCTCTTTCAAAGAAAATTTGTGATATTAAACAGGCATATACACAGCATGGAGGTTCAAGACCTT
TTGGTATTTCATTACTAATTGCAGGAATAGATAGACATAATTCAAAATTATTCGAAACTGACCCAAGCGGTGCTTTAATT
GAATATAAGGCAACTGCAATAGGATTTGGAAGACCTTCGGCAATGGAAATACTTGAAGAAAAATATGATGAAAACATAAG
CAGAGAGGAAGCTCTTGAACTTGCTTTATATGCCCTTAGTAAGTCATCAAACATGGCATTATTGCCTGAAAATATAGATA
TGGCAATTATTACAGATGACGAAAAAGTTGTAAAAAAATTACAATTTGAGGAAATTAAGGAGCTCCTAAAAAAAGTGTCC
GATAAAATAGAAGATGAAAAAGAAAAGGAAGAAAAGGAAGAGGAACATGCTGAGGAAAATGGAGATAATAACGAGATGGG
TAAAATTGACAATTAA

Upstream 100 bases:

>100_bases
ATAAAACATCATAACGATGTATTTAATAAAAAAAATAAGATAATATAAATATTATTATAATATTATTATATGAGAATATA
AATTATATGAGAGGGACAAT

Downstream 100 bases:

>100_bases
TACATATAGGATAGATAAATTAGATAATAAATAAATTAAAATATCAATGTCATTTATTAAAATGTATCATATAAAATCAT
ATATCAAAATGATTATATAA

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MQMNPIQGGYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIKYSGGVILAVDRRIMSKLIEKYSVEKIFHIDEHIMAAS
SGLIADARILVDRARVEAQINKITYGEPMTVEALSKKICDIKQAYTQHGGSRPFGISLLIAGIDRHNSKLFETDPSGALI
EYKATAIGFGRPSAMEILEEKYDENISREEALELALYALSKSSNMALLPENIDMAIITDDEKVVKKLQFEEIKELLKKVS
DKIEDEKEKEEKEEEHAEENGDNNEMGKIDN

Sequences:

>Translated_271_residues
MQMNPIQGGYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIKYSGGVILAVDRRIMSKLIEKYSVEKIFHIDEHIMAAS
SGLIADARILVDRARVEAQINKITYGEPMTVEALSKKICDIKQAYTQHGGSRPFGISLLIAGIDRHNSKLFETDPSGALI
EYKATAIGFGRPSAMEILEEKYDENISREEALELALYALSKSSNMALLPENIDMAIITDDEKVVKKLQFEEIKELLKKVS
DKIEDEKEKEEKEEEHAEENGDNNEMGKIDN
>Mature_271_residues
MQMNPIQGGYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIKYSGGVILAVDRRIMSKLIEKYSVEKIFHIDEHIMAAS
SGLIADARILVDRARVEAQINKITYGEPMTVEALSKKICDIKQAYTQHGGSRPFGISLLIAGIDRHNSKLFETDPSGALI
EYKATAIGFGRPSAMEILEEKYDENISREEALELALYALSKSSNMALLPENIDMAIITDDEKVVKKLQFEEIKELLKKVS
DKIEDEKEKEEKEEEHAEENGDNNEMGKIDN

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation [H]

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family [H]

Homologues:

Organism=Homo sapiens, GI68303563, Length=211, Percent_Identity=47.39336492891, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI23110942, Length=235, Percent_Identity=42.1276595744681, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI68303561, Length=217, Percent_Identity=46.0829493087558, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI4506189, Length=230, Percent_Identity=43.9130434782609, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI156713442, Length=233, Percent_Identity=40.7725321888412, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4506185, Length=233, Percent_Identity=40.7725321888412, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4506181, Length=232, Percent_Identity=38.3620689655172, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI68303565, Length=215, Percent_Identity=41.3953488372093, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI23110944, Length=215, Percent_Identity=35.3488372093023, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI4506183, Length=173, Percent_Identity=38.728323699422, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI23110939, Length=172, Percent_Identity=38.953488372093, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI23110935, Length=271, Percent_Identity=31.7343173431734, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4506179, Length=260, Percent_Identity=32.3076923076923, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI156713444, Length=166, Percent_Identity=38.5542168674699, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI221316716, Length=109, Percent_Identity=37.6146788990826, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4506191, Length=200, Percent_Identity=26, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI73747875, Length=207, Percent_Identity=25.6038647342995, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4758970, Length=173, Percent_Identity=27.1676300578035, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508491, Length=233, Percent_Identity=45.0643776824034, Blast_Score=197, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI25143215, Length=231, Percent_Identity=40.2597402597403, Blast_Score=176, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17508493, Length=212, Percent_Identity=41.9811320754717, Blast_Score=174, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17562790, Length=210, Percent_Identity=38.0952380952381, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17562788, Length=239, Percent_Identity=31.7991631799163, Blast_Score=133, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17562792, Length=190, Percent_Identity=34.2105263157895, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71998965, Length=173, Percent_Identity=34.6820809248555, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321574, Length=237, Percent_Identity=42.6160337552743, Blast_Score=186, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324535, Length=237, Percent_Identity=40.084388185654, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321692, Length=240, Percent_Identity=39.5833333333333, Blast_Score=165, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6324938, Length=196, Percent_Identity=42.3469387755102, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323547, Length=213, Percent_Identity=38.9671361502347, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323974, Length=216, Percent_Identity=33.7962962962963, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6321427, Length=245, Percent_Identity=30.6122448979592, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324731, Length=167, Percent_Identity=28.1437125748503, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356137, Length=246, Percent_Identity=40.2439024390244, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17933602, Length=211, Percent_Identity=43.6018957345972, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24654391, Length=238, Percent_Identity=38.2352941176471, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24654389, Length=238, Percent_Identity=38.2352941176471, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19922898, Length=245, Percent_Identity=36.734693877551, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI17136420, Length=240, Percent_Identity=38.3333333333333, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI17737927, Length=230, Percent_Identity=37.3913043478261, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24651571, Length=237, Percent_Identity=37.5527426160338, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281360341, Length=237, Percent_Identity=35.8649789029536, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24586406, Length=237, Percent_Identity=35.8649789029536, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24586400, Length=237, Percent_Identity=35.8649789029536, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24586402, Length=237, Percent_Identity=35.8649789029536, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24652204, Length=167, Percent_Identity=36.5269461077844, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17737405, Length=192, Percent_Identity=34.375, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19921232, Length=195, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24584895, Length=171, Percent_Identity=32.1637426900585, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130281, Length=171, Percent_Identity=29.8245614035088, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573221, Length=166, Percent_Identity=28.3132530120482, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639979, Length=190, Percent_Identity=25.7894736842105, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355573, Length=174, Percent_Identity=28.735632183908, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24652553, Length=174, Percent_Identity=28.735632183908, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353 [H]

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N [H]

EC number: =3.4.25.1 [H]

Molecular weight: Translated: 30444; Mature: 30444

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00388 PROTEASOME_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMNPIQGGYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIKYSGGVILAVDRRIMSKL
CCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCEEEEEEECCCEEEEECHHHHHHH
IEKYSVEKIFHIDEHIMAASSGLIADARILVDRARVEAQINKITYGEPMTVEALSKKICD
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
IKQAYTQHGGSRPFGISLLIAGIDRHNSKLFETDPSGALIEYKATAIGFGRPSAMEILEE
HHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEEEECCCCHHHHHHHH
KYDENISREEALELALYALSKSSNMALLPENIDMAIITDDEKVVKKLQFEEIKELLKKVS
HHCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
DKIEDEKEKEEKEEEHAEENGDNNEMGKIDN
HHHCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQMNPIQGGYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIKYSGGVILAVDRRIMSKL
CCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCEEEEEEECCCEEEEECHHHHHHH
IEKYSVEKIFHIDEHIMAASSGLIADARILVDRARVEAQINKITYGEPMTVEALSKKICD
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
IKQAYTQHGGSRPFGISLLIAGIDRHNSKLFETDPSGALIEYKATAIGFGRPSAMEILEE
HHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEEEECCCCHHHHHHHH
KYDENISREEALELALYALSKSSNMALLPENIDMAIITDDEKVVKKLQFEEIKELLKKVS
HHCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
DKIEDEKEKEEKEEEHAEENGDNNEMGKIDN
HHHCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA