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The map label for this gene is pyrG

Identifier: 150400612

GI number: 150400612

Start: 192855

End: 194483

Strand: Reverse

Name: pyrG

Synonym: Maeo_0174

Alternate gene names: 150400612

Gene position: 194483-192855 (Counterclockwise)

Preceding gene: 150400613

Following gene: 150400611

Centisome position: 12.39

GC content: 34.32

Gene sequence:

>1629_bases
ATGAAATTTATATTCATAACTGGCGGAGTGGTTTCATCACTTGGAAAAGGAATCACGGCGTCATCAATAGGAAGATTATT
AAAAGCAAGAGGATTTAAAATAAATATGGTAAAAATAGACCCATATTTACAAATAGATGCTGGAACAATGTCCCCCTATG
AACATGGAGAGGTGTTTGTTACAGACGACGGCGGAGAAACAGATTTAGACCTTGGAAACTATGAAAGGTTTGTAGATATA
AAATTAAGTGCAAATAATAATATTACCACAGGTAAAGTATATTGGAGTGTCCTTTCAAAAGAAAGAAGAGGAGACTATTT
GGGTAAAACCGTTCAAGTTATACCCCACATAACCAACGAAATAAAAGAACTGATAAAATCAACTGGAACTAACTGCGATA
TAACTATTGTAGAAATTGGAGGAACTGTTGGGGATATAGAGAGCCTTCCATTTTTAGAGGCAATAAGGCAGTTTAAAAAA
GATGTTGGAGATAATAATGTTTTATATGTCCATGTGTCATTACTTCCATATATAAAGACAGCAGGAGAGATAAAAACAAA
ACCAACCCAGCATAGTGTAAAAGAATTAAGAGGAATAGGCATTCAACCAAATATATTGGTTTGTAGGACAGAAATACCCA
TAAGCGAAAAAACTAGGGAAAAATTGGCTTTATTCTGTGATGTCGAAAAAGATGCCGTAATTGAGGCAAAAGATGCCAGA
ACAATTTACGAGGTGCCATTAAATCTCGAAAGAGAGGGCATAGCAAAATTAATAATAAATAAATTAAAACTTAATACAAA
TAATTCTAAGCCAGATTTAAAAGAATGGCGGGCAATGGTGGATAGAATAGTAAATCCATTGAATGAAATTACAATAGGTA
TTGTTGGAAAATATATAATGTTAAAAGATGCCTACACAAGTATTACAGAGTCCTTAGTTCATGCGGGAGCCAAACATGAT
ACAAAAGTAAATATTGAATGGATCAGCTCCGAAGAATTAAGAGACGAAACATATAAAGAAACAATGGATAAACTTGTAGA
AGATGAAAAACTCGATGGAATACTTATTCCCGGAGGATTTGGGGAAAGAGGTATTGACGGAAAAGTAAATGCTTCAAAAT
ATGCTAGAGAAAATAATATCCCATATCTTGGAATATGTCTTGGTATGCAATGTGCAGTAATAGATTTCGCCAGAAATGTA
TGTAATTTAAAAGGTGCAAATTCCACAGAGTTTGATGAGGGAGCTCCCTTCCCAGTAATAGATTATTTGCCAGAGCAAAG
AGATATTGAGGACAAAGGGGGAACGATGCGACTTGGAGAATATAAAGCAATCTTAAAAGAAGGAAGCCTTGCACAAAAGC
TATACAATGAAAAGGAAGCTTTTGAAAGACACAGACATAGATATGAAGTAAATCCCGAATATCACGACATACTTACCGAA
AATGGACTAATTATTTCAGGAACTTCTCCAGATGGAAAACTTGCGGAATTTATAGAATTAGATACTTTAACCCATCCATA
TTTTATAGCTACCCAGGCACACCCCGAATTTAAATCAAGACCAAATAAACCACACCCATTATTTGATGGACTTGTAAAAT
CGGCACTTGATAAGAAATTAAAAAAATAA

Upstream 100 bases:

>100_bases
TTGCCCAATGGTTATAAATTATGGCATATATTATTTATATAACTAGAAATTTATTATCTTATAAATATTATTATTTTATT
TTAATAACAGAGGAGCTACT

Downstream 100 bases:

>100_bases
TTTAAAAATATACAGTCTGTTGTTGAAATTTGACATTCCAAACAATATATGGCCGAAAATAAATTAATATAAATTAAAAA
ATAAAATAAAGGTGTAATTA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MKFIFITGGVVSSLGKGITASSIGRLLKARGFKINMVKIDPYLQIDAGTMSPYEHGEVFVTDDGGETDLDLGNYERFVDI
KLSANNNITTGKVYWSVLSKERRGDYLGKTVQVIPHITNEIKELIKSTGTNCDITIVEIGGTVGDIESLPFLEAIRQFKK
DVGDNNVLYVHVSLLPYIKTAGEIKTKPTQHSVKELRGIGIQPNILVCRTEIPISEKTREKLALFCDVEKDAVIEAKDAR
TIYEVPLNLEREGIAKLIINKLKLNTNNSKPDLKEWRAMVDRIVNPLNEITIGIVGKYIMLKDAYTSITESLVHAGAKHD
TKVNIEWISSEELRDETYKETMDKLVEDEKLDGILIPGGFGERGIDGKVNASKYARENNIPYLGICLGMQCAVIDFARNV
CNLKGANSTEFDEGAPFPVIDYLPEQRDIEDKGGTMRLGEYKAILKEGSLAQKLYNEKEAFERHRHRYEVNPEYHDILTE
NGLIISGTSPDGKLAEFIELDTLTHPYFIATQAHPEFKSRPNKPHPLFDGLVKSALDKKLKK

Sequences:

>Translated_542_residues
MKFIFITGGVVSSLGKGITASSIGRLLKARGFKINMVKIDPYLQIDAGTMSPYEHGEVFVTDDGGETDLDLGNYERFVDI
KLSANNNITTGKVYWSVLSKERRGDYLGKTVQVIPHITNEIKELIKSTGTNCDITIVEIGGTVGDIESLPFLEAIRQFKK
DVGDNNVLYVHVSLLPYIKTAGEIKTKPTQHSVKELRGIGIQPNILVCRTEIPISEKTREKLALFCDVEKDAVIEAKDAR
TIYEVPLNLEREGIAKLIINKLKLNTNNSKPDLKEWRAMVDRIVNPLNEITIGIVGKYIMLKDAYTSITESLVHAGAKHD
TKVNIEWISSEELRDETYKETMDKLVEDEKLDGILIPGGFGERGIDGKVNASKYARENNIPYLGICLGMQCAVIDFARNV
CNLKGANSTEFDEGAPFPVIDYLPEQRDIEDKGGTMRLGEYKAILKEGSLAQKLYNEKEAFERHRHRYEVNPEYHDILTE
NGLIISGTSPDGKLAEFIELDTLTHPYFIATQAHPEFKSRPNKPHPLFDGLVKSALDKKLKK
>Mature_542_residues
MKFIFITGGVVSSLGKGITASSIGRLLKARGFKINMVKIDPYLQIDAGTMSPYEHGEVFVTDDGGETDLDLGNYERFVDI
KLSANNNITTGKVYWSVLSKERRGDYLGKTVQVIPHITNEIKELIKSTGTNCDITIVEIGGTVGDIESLPFLEAIRQFKK
DVGDNNVLYVHVSLLPYIKTAGEIKTKPTQHSVKELRGIGIQPNILVCRTEIPISEKTREKLALFCDVEKDAVIEAKDAR
TIYEVPLNLEREGIAKLIINKLKLNTNNSKPDLKEWRAMVDRIVNPLNEITIGIVGKYIMLKDAYTSITESLVHAGAKHD
TKVNIEWISSEELRDETYKETMDKLVEDEKLDGILIPGGFGERGIDGKVNASKYARENNIPYLGICLGMQCAVIDFARNV
CNLKGANSTEFDEGAPFPVIDYLPEQRDIEDKGGTMRLGEYKAILKEGSLAQKLYNEKEAFERHRHRYEVNPEYHDILTE
NGLIISGTSPDGKLAEFIELDTLTHPYFIATQAHPEFKSRPNKPHPLFDGLVKSALDKKLKK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=556, Percent_Identity=46.5827338129496, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI28559085, Length=553, Percent_Identity=48.2820976491863, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI28559083, Length=553, Percent_Identity=48.2820976491863, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI221316689, Length=553, Percent_Identity=48.2820976491863, Blast_Score=514, Evalue=1e-146,
Organism=Escherichia coli, GI1789142, Length=543, Percent_Identity=52.3020257826888, Blast_Score=556, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI25148299, Length=604, Percent_Identity=41.0596026490066, Blast_Score=455, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=46.113074204947, Blast_Score=487, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6319432, Length=566, Percent_Identity=45.4063604240283, Blast_Score=480, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24664469, Length=556, Percent_Identity=48.5611510791367, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI21357815, Length=500, Percent_Identity=47, Blast_Score=442, Evalue=1e-124,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_META3 (A6UTE4)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324378.1
- ProteinModelPortal:   A6UTE4
- SMR:   A6UTE4
- STRING:   A6UTE4
- GeneID:   5326750
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0174
- eggNOG:   arNOG04675
- HOGENOM:   HBG597806
- OMA:   NIKIDPY
- ProtClustDB:   PRK05380
- BioCyc:   MAEO419665:MAEO_0174-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60644; Mature: 60644

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 386-386 ACT_SITE 514-514 ACT_SITE 516-516

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFIFITGGVVSSLGKGITASSIGRLLKARGFKINMVKIDPYLQIDAGTMSPYEHGEVFV
CEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEECCCCCCCCCCEEEE
TDDGGETDLDLGNYERFVDIKLSANNNITTGKVYWSVLSKERRGDYLGKTVQVIPHITNE
ECCCCCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHHCCCHHCHHHHHHHHHHHH
IKELIKSTGTNCDITIVEIGGTVGDIESLPFLEAIRQFKKDVGDNNVLYVHVSLLPYIKT
HHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHC
AGEIKTKPTQHSVKELRGIGIQPNILVCRTEIPISEKTREKLALFCDVEKDAVIEAKDAR
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHEEEEEECCCCCEEEECCCC
TIYEVPLNLEREGIAKLIINKLKLNTNNSKPDLKEWRAMVDRIVNPLNEITIGIVGKYIM
EEEECCCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCEEE
LKDAYTSITESLVHAGAKHDTKVNIEWISSEELRDETYKETMDKLVEDEKLDGILIPGGF
EHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GERGIDGKVNASKYARENNIPYLGICLGMQCAVIDFARNVCNLKGANSTEFDEGAPFPVI
CCCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
DYLPEQRDIEDKGGTMRLGEYKAILKEGSLAQKLYNEKEAFERHRHRYEVNPEYHDILTE
HCCCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEECCCCHHHHHCC
NGLIISGTSPDGKLAEFIELDTLTHPYFIATQAHPEFKSRPNKPHPLFDGLVKSALDKKL
CCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHH
KK
CC
>Mature Secondary Structure
MKFIFITGGVVSSLGKGITASSIGRLLKARGFKINMVKIDPYLQIDAGTMSPYEHGEVFV
CEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCEEEEECCCCCCCCCCEEEE
TDDGGETDLDLGNYERFVDIKLSANNNITTGKVYWSVLSKERRGDYLGKTVQVIPHITNE
ECCCCCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHHCCCHHCHHHHHHHHHHHH
IKELIKSTGTNCDITIVEIGGTVGDIESLPFLEAIRQFKKDVGDNNVLYVHVSLLPYIKT
HHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHC
AGEIKTKPTQHSVKELRGIGIQPNILVCRTEIPISEKTREKLALFCDVEKDAVIEAKDAR
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHEEEEEECCCCCEEEECCCC
TIYEVPLNLEREGIAKLIINKLKLNTNNSKPDLKEWRAMVDRIVNPLNEITIGIVGKYIM
EEEECCCCCCHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCEEE
LKDAYTSITESLVHAGAKHDTKVNIEWISSEELRDETYKETMDKLVEDEKLDGILIPGGF
EHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GERGIDGKVNASKYARENNIPYLGICLGMQCAVIDFARNVCNLKGANSTEFDEGAPFPVI
CCCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
DYLPEQRDIEDKGGTMRLGEYKAILKEGSLAQKLYNEKEAFERHRHRYEVNPEYHDILTE
HCCCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEECCCCHHHHHCC
NGLIISGTSPDGKLAEFIELDTLTHPYFIATQAHPEFKSRPNKPHPLFDGLVKSALDKKL
CCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHH
KK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA