Click here to switch to the map view.

The map label for this gene is guaAB [H]

Identifier: 150400611

GI number: 150400611

Start: 191823

End: 192755

Strand: Reverse

Name: guaAB [H]

Synonym: Maeo_0173

Alternate gene names: 150400611

Gene position: 192755-191823 (Counterclockwise)

Preceding gene: 150400612

Following gene: 150400610

Centisome position: 12.28

GC content: 35.26

Gene sequence:

>933_bases
ATGATGAATACCAAAGAATTCATAGAAGAATCAATTGCGGAAATAAAGGAACAAATAGGAGATAAAAAAACAATAATTGC
CCTTAGTGGTGGTGTAGATAGTGCTGTTGCTGCTGTTCTCACAGCTAGGGCGATTGGAGACCAGCTTTTGGCTGTTTTTG
TAGATACAGGATTAATGAGAAAAAACGAAGCTCAGGAAATATACAAAATATTTAAAGAAGACATGGGGCTTAATTTAAGA
ATAATTGAGGCAAAAGAGCAATTTTTAAAAGAATTAGATGGAGTAGATGACCCAGAGGAAAAAAGAAAAATAATAGGAAG
AATATTTATTGAAATATTTGAAGAAGTTGCAAAAGAAAATGGGGAAGAAGTTTTAGTTCAGGGAACCATAGCTCCGGACT
GGATAGAAAGTGAAGGAGAGATAAAAACTCACCATAACATAGCGCTTCCTAGTGGAATGGTGCTTGAATTAGTAGAGCCT
TTGAGAGATTTATATAAGGATGAAGTAAGATTATTGGCGAAAGACTTGGGGCTTCCAGATGAAATAGCATATAGACAGCC
ATTCCCAGGTCCAGGTCTTGCCGTTAGGATATTGGGAAAAATTACCGAAGAAAAATTGGAAATATGTAAAGAGGCCAATG
CAATTGTAGAAGAAGAAATTGAGAAAGAAGGATTAAATAAAGATTTATGGCAATATTTCGCTGCTGTTCTAGATACCAAG
GCAACGGGAGTTAAAGGAGACATAAGAGAATACAACTGGGTTGTAGTTATTCGATTTGTTGAATCCCTTGATGCTATGAC
TGCCAGTGTTCCAGAATTGCCATTTAATATAATAAAAAGAATAAGTAAAAGAATTACCTCAGAAGTTCCAAATGTTGCAA
GAGTTGTTTTAGATGTATCCGATAAACCACCTGCAACAATTGAATTTGAATAA

Upstream 100 bases:

>100_bases
ATTTAAAAATATACAGTCTGTTGTTGAAATTTGACATTCCAAACAATATATGGCCGAAAATAAATTAATATAAATTAAAA
AATAAAATAAAGGTGTAATT

Downstream 100 bases:

>100_bases
TATTAAGAATAAAATAATTTATTATTTTTTCTATTTTTATCACTTATAGTCAATCTTCGGTCTTTTTCAATTAAATACAT
TAATGAAGCTAAATCAGTAT

Product: GMP synthase subunit B

Products: NA

Alternate protein names: GMP synthetase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MMNTKEFIEESIAEIKEQIGDKKTIIALSGGVDSAVAAVLTARAIGDQLLAVFVDTGLMRKNEAQEIYKIFKEDMGLNLR
IIEAKEQFLKELDGVDDPEEKRKIIGRIFIEIFEEVAKENGEEVLVQGTIAPDWIESEGEIKTHHNIALPSGMVLELVEP
LRDLYKDEVRLLAKDLGLPDEIAYRQPFPGPGLAVRILGKITEEKLEICKEANAIVEEEIEKEGLNKDLWQYFAAVLDTK
ATGVKGDIREYNWVVVIRFVESLDAMTASVPELPFNIIKRISKRITSEVPNVARVVLDVSDKPPATIEFE

Sequences:

>Translated_310_residues
MMNTKEFIEESIAEIKEQIGDKKTIIALSGGVDSAVAAVLTARAIGDQLLAVFVDTGLMRKNEAQEIYKIFKEDMGLNLR
IIEAKEQFLKELDGVDDPEEKRKIIGRIFIEIFEEVAKENGEEVLVQGTIAPDWIESEGEIKTHHNIALPSGMVLELVEP
LRDLYKDEVRLLAKDLGLPDEIAYRQPFPGPGLAVRILGKITEEKLEICKEANAIVEEEIEKEGLNKDLWQYFAAVLDTK
ATGVKGDIREYNWVVVIRFVESLDAMTASVPELPFNIIKRISKRITSEVPNVARVVLDVSDKPPATIEFE
>Mature_310_residues
MMNTKEFIEESIAEIKEQIGDKKTIIALSGGVDSAVAAVLTARAIGDQLLAVFVDTGLMRKNEAQEIYKIFKEDMGLNLR
IIEAKEQFLKELDGVDDPEEKRKIIGRIFIEIFEEVAKENGEEVLVQGTIAPDWIESEGEIKTHHNIALPSGMVLELVEP
LRDLYKDEVRLLAKDLGLPDEIAYRQPFPGPGLAVRILGKITEEKLEICKEANAIVEEEIEKEGLNKDLWQYFAAVLDTK
ATGVKGDIREYNWVVVIRFVESLDAMTASVPELPFNIIKRISKRITSEVPNVARVVLDVSDKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=340, Percent_Identity=36.4705882352941, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1788854, Length=312, Percent_Identity=49.0384615384615, Blast_Score=301, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI71992710, Length=358, Percent_Identity=33.5195530726257, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71992717, Length=358, Percent_Identity=33.5195530726257, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI133901714, Length=358, Percent_Identity=33.5195530726257, Blast_Score=160, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6323873, Length=318, Percent_Identity=45.9119496855346, Blast_Score=279, Evalue=5e-76,
Organism=Drosophila melanogaster, GI281365319, Length=310, Percent_Identity=37.741935483871, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 34774; Mature: 34774

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNTKEFIEESIAEIKEQIGDKKTIIALSGGVDSAVAAVLTARAIGDQLLAVFVDTGLMR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNEAQEIYKIFKEDMGLNLRIIEAKEQFLKELDGVDDPEEKRKIIGRIFIEIFEEVAKEN
CCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GEEVLVQGTIAPDWIESEGEIKTHHNIALPSGMVLELVEPLRDLYKDEVRLLAKDLGLPD
CCEEEEECCCCCHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EIAYRQPFPGPGLAVRILGKITEEKLEICKEANAIVEEEIEKEGLNKDLWQYFAAVLDTK
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
ATGVKGDIREYNWVVVIRFVESLDAMTASVPELPFNIIKRISKRITSEVPNVARVVLDVS
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHEECC
DKPPATIEFE
CCCCCEEECC
>Mature Secondary Structure
MMNTKEFIEESIAEIKEQIGDKKTIIALSGGVDSAVAAVLTARAIGDQLLAVFVDTGLMR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNEAQEIYKIFKEDMGLNLRIIEAKEQFLKELDGVDDPEEKRKIIGRIFIEIFEEVAKEN
CCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GEEVLVQGTIAPDWIESEGEIKTHHNIALPSGMVLELVEPLRDLYKDEVRLLAKDLGLPD
CCEEEEECCCCCHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EIAYRQPFPGPGLAVRILGKITEEKLEICKEANAIVEEEIEKEGLNKDLWQYFAAVLDTK
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
ATGVKGDIREYNWVVVIRFVESLDAMTASVPELPFNIIKRISKRITSEVPNVARVVLDVS
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHEECC
DKPPATIEFE
CCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA