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The map label for this gene is moeA [C]

Identifier: 150400524

GI number: 150400524

Start: 89713

End: 90861

Strand: Reverse

Name: moeA [C]

Synonym: Maeo_0086

Alternate gene names: 150400524

Gene position: 90861-89713 (Counterclockwise)

Preceding gene: 150400526

Following gene: 150400519

Centisome position: 5.79

GC content: 29.42

Gene sequence:

>1149_bases
ATGATTTCATTGAACGAAGCACTCAACATATTAAATAATTATTCATTAAATAAAAAATATCCTGCTGAATATGTGGATAT
ATATAACTCACAGGGTAGGATTATAGCAGAAGATATTATTTCAAAAGTGGATATTCCACTATATAATCGGTCGAATATGG
ACGGTTATGCCGTTGTAGATTTAAATTTAAAACAGTATAAAATAATAGATGAGATTTTTGCGGGAGATATGAGAGATTTG
ATAATTAAACAAAATGAATGTGTTTATGTTGCCACGGGTTCAAAAATTCCAAATAATGCAAATTTCGTAATACCTATTGA
ATTGGTCAATATAATAGACAATGAAATTATAGAACCAATTGAGAAAATCACCGAAAAATATATTTCAAAAATAGGAACAG
ATATAAAATATGGAGAAAAGGTTTTGAAGAGAGGAGCAAAATTAAATGAAAGAACTATTGGATTACTTGCATCGGTGGGG
ATTGAAAAGGTAAAAGTTAATTATGTTCCTAAAATAGGCATAATATCCACAGGTAATGAGCTATCGGTTATCAATGAGGT
AAATTCAAAAACTTTGTATTCCATTATAAAAATGGCAAATTGTATTCCTGTGCATATTGGAAATGCCCGAGATAATATGG
AAGATATTGAAAACATGATAAATAAAGCAATTAAATTAAATTGTGATATTATTATAACTTCGGGAGGGGTATCAGAAGGG
AAGAAAGATTTAATTCCAAATATTGTATTAAATAGGGGAAATATATTATTCCATAAAGTTAAAATGAGACCGGGGAAACC
TATGCTATTTGGGGAAATAGATAGTATTCCTATATTTGGTATGCCCGGTAATGTGGTATCCTGTATAGTGTGTAGTTATG
TTTATTTGCTTCCATTTTTGGAAAACATAACTAAAAAAATGCAAACCACAAAAAAAATAGTTAAAGCAAAATTGGGGGGA
AAAGTATGTTCTGAGCCTGATTTTGTATATTATCGTCCCGTTAAATTAGAAAATGGGATAGCACATCTAACATTTAAAGG
CTCTGGTTTAATTACTTCCATTGTATATGCTGATGGGTTTATTAAATTAAATGAAAATGAATTGCAAAAAAATAAAGACG
ATGTTGTAGATGTTTGGCTGTTTGAATAA

Upstream 100 bases:

>100_bases
GTTAATTAATAATAGTAATTACATATAATTATAAATATATTATATCAATAACACCATAATAATTATTTAATTATATACAA
TAAAAAATATTGGGGAAATT

Downstream 100 bases:

>100_bases
TTTATTATAAAATTATTTTTTTAATTTAATTTTAGTTGGAATATAGTTAATCTTCAAAAACTGTCCCTAATCTGTCCCAA
TGCATTTTATAATATTATTT

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MISLNEALNILNNYSLNKKYPAEYVDIYNSQGRIIAEDIISKVDIPLYNRSNMDGYAVVDLNLKQYKIIDEIFAGDMRDL
IIKQNECVYVATGSKIPNNANFVIPIELVNIIDNEIIEPIEKITEKYISKIGTDIKYGEKVLKRGAKLNERTIGLLASVG
IEKVKVNYVPKIGIISTGNELSVINEVNSKTLYSIIKMANCIPVHIGNARDNMEDIENMINKAIKLNCDIIITSGGVSEG
KKDLIPNIVLNRGNILFHKVKMRPGKPMLFGEIDSIPIFGMPGNVVSCIVCSYVYLLPFLENITKKMQTTKKIVKAKLGG
KVCSEPDFVYYRPVKLENGIAHLTFKGSGLITSIVYADGFIKLNENELQKNKDDVVDVWLFE

Sequences:

>Translated_382_residues
MISLNEALNILNNYSLNKKYPAEYVDIYNSQGRIIAEDIISKVDIPLYNRSNMDGYAVVDLNLKQYKIIDEIFAGDMRDL
IIKQNECVYVATGSKIPNNANFVIPIELVNIIDNEIIEPIEKITEKYISKIGTDIKYGEKVLKRGAKLNERTIGLLASVG
IEKVKVNYVPKIGIISTGNELSVINEVNSKTLYSIIKMANCIPVHIGNARDNMEDIENMINKAIKLNCDIIITSGGVSEG
KKDLIPNIVLNRGNILFHKVKMRPGKPMLFGEIDSIPIFGMPGNVVSCIVCSYVYLLPFLENITKKMQTTKKIVKAKLGG
KVCSEPDFVYYRPVKLENGIAHLTFKGSGLITSIVYADGFIKLNENELQKNKDDVVDVWLFE
>Mature_382_residues
MISLNEALNILNNYSLNKKYPAEYVDIYNSQGRIIAEDIISKVDIPLYNRSNMDGYAVVDLNLKQYKIIDEIFAGDMRDL
IIKQNECVYVATGSKIPNNANFVIPIELVNIIDNEIIEPIEKITEKYISKIGTDIKYGEKVLKRGAKLNERTIGLLASVG
IEKVKVNYVPKIGIISTGNELSVINEVNSKTLYSIIKMANCIPVHIGNARDNMEDIENMINKAIKLNCDIIITSGGVSEG
KKDLIPNIVLNRGNILFHKVKMRPGKPMLFGEIDSIPIFGMPGNVVSCIVCSYVYLLPFLENITKKMQTTKKIVKAKLGG
KVCSEPDFVYYRPVKLENGIAHLTFKGSGLITSIVYADGFIKLNENELQKNKDDVVDVWLFE

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=398, Percent_Identity=30.9045226130653, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI66932975, Length=398, Percent_Identity=30.9045226130653, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1787049, Length=389, Percent_Identity=27.2493573264781, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147659, Length=404, Percent_Identity=26.4851485148515, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562606, Length=315, Percent_Identity=27.6190476190476, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17136978, Length=354, Percent_Identity=25.7062146892655, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24638841, Length=354, Percent_Identity=25.7062146892655, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42773; Mature: 42773

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLNEALNILNNYSLNKKYPAEYVDIYNSQGRIIAEDIISKVDIPLYNRSNMDGYAVVD
CCCHHHHHHHHHCCCCCCCCCHHHHEEECCCCCEEHHHHHHHCCCCCCCCCCCCCEEEEE
LNLKQYKIIDEIFAGDMRDLIIKQNECVYVATGSKIPNNANFVIPIELVNIIDNEIIEPI
ECCHHHHHHHHHHCCCHHHHEEECCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHH
EKITEKYISKIGTDIKYGEKVLKRGAKLNERTIGLLASVGIEKVKVNYVPKIGIISTGNE
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEECCCC
LSVINEVNSKTLYSIIKMANCIPVHIGNARDNMEDIENMINKAIKLNCDIIITSGGVSEG
EEEEHHCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHEEEEEEEEEECCCCCCC
KKDLIPNIVLNRGNILFHKVKMRPGKPMLFGEIDSIPIFGMPGNVVSCIVCSYVYLLPFL
CHHCCCCEEECCCCEEEEEEECCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHH
ENITKKMQTTKKIVKAKLGGKVCSEPDFVYYRPVKLENGIAHLTFKGSGLITSIVYADGF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCEEEEEEECCCCEEEEEEECCE
IKLNENELQKNKDDVVDVWLFE
EEECHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure
MISLNEALNILNNYSLNKKYPAEYVDIYNSQGRIIAEDIISKVDIPLYNRSNMDGYAVVD
CCCHHHHHHHHHCCCCCCCCCHHHHEEECCCCCEEHHHHHHHCCCCCCCCCCCCCEEEEE
LNLKQYKIIDEIFAGDMRDLIIKQNECVYVATGSKIPNNANFVIPIELVNIIDNEIIEPI
ECCHHHHHHHHHHCCCHHHHEEECCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHH
EKITEKYISKIGTDIKYGEKVLKRGAKLNERTIGLLASVGIEKVKVNYVPKIGIISTGNE
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEECCCC
LSVINEVNSKTLYSIIKMANCIPVHIGNARDNMEDIENMINKAIKLNCDIIITSGGVSEG
EEEEHHCCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHEEEEEEEEEECCCCCCC
KKDLIPNIVLNRGNILFHKVKMRPGKPMLFGEIDSIPIFGMPGNVVSCIVCSYVYLLPFL
CHHCCCCEEECCCCEEEEEEECCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHH
ENITKKMQTTKKIVKAKLGGKVCSEPDFVYYRPVKLENGIAHLTFKGSGLITSIVYADGF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCEEEEEEECCCCEEEEEEECCE
IKLNENELQKNKDDVVDVWLFE
EEECHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]