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The map label for this gene is panE [C]

Identifier: 150400258

GI number: 150400258

Start: 1537123

End: 1538052

Strand: Reverse

Name: panE [C]

Synonym: Mevan_1519

Alternate gene names: 150400258

Gene position: 1538052-1537123 (Counterclockwise)

Preceding gene: 150400259

Following gene: 150400253

Centisome position: 89.42

GC content: 30.97

Gene sequence:

>930_bases
ATGAATGTATTAATTATAGGCGCAGGAGCTGTTGGATTATGTTTAGCAGCCAAATTATCACGTGTTTGTAACGTTTTTGC
AGTAACTAGGGAAAAAAATGCCAAAATAATTCGTGAATCCGGCTTTAAAATGACAGGAATTTGGGGAAACGGAATTTTTA
AATTTGGAGCTTCTGAAGAGGTTCCAAAAATAGATTTTGATTATATCATTATTGCTTCAAAAGGGATTTCAACCGAATCA
ATCTGTAAACAATTTAAAGATGATATAAAGAATAAAAACGTTGTAAGCATTCAAAACGGTGTTGGAAACGAGGAAATAAT
TTCAAAGTATACTGATAAGGTAATTGGTGGAACAATAATTACTGGTTTTGAATGGAAAGGTAATGCAGAAGTCCATGTTT
CAGTAGAAGGTGGCCCAATGACCGTTGGAAGATACCCTGATGGAACAGATGAAGAAGTAATTGACTTTGTAAAGTTAATA
AAAAGTTCAGGAATACCAATTACTGAATCAAAAAATATTCAGGGTGCAATCTGGTCAAAAACAATTTATAATTGTGCATT
AAATCCACTTGGTGCGATTATGAATGTTAATTATGGAAAACTTTCAAATAATCATTCTTTAAATATTATTGAAAATATAG
TATCTGAAATTTTTGAAATAACGTCTAAAAAAGGAGTAATTCTTCCTTGGAAGACTCCAAAAGAATATTTAAAATATTTA
ACGGAATTTCAATTGCCAAATACTGCTGCACATCATTCTTCAATGTTACAAGATATTTTAAAAGGAAAAATGACTGAGAT
AGATTTTTTAAACGGTGCAGTAGTTTCAAATGGGAAAAAATTGGGGGTAAAAACCCCTTATAATGAATTTATTACAGAGC
AAGTGAAATTCCTTGAGTTTTTAAAGTCTGAAACAAAGTCGAGTGAATGA

Upstream 100 bases:

>100_bases
ACTTGAAGATGGAAGCGTTGGAAGAGTTCAAGAAATTTTAAAGTGAATTAACTAAATATTTATAGCTAATTTGAATATTA
TCTTAAAAAGGGGTTTTTAA

Downstream 100 bases:

>100_bases
CACTTCATTAATATTTAATCTAAAAGTATCATTTTGCTTTTTTTAGGTTCTTCATATAATGAATCAAGTTTTATGGCATT
ATCATAACATTTTAAAGCTT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNVLIIGAGAVGLCLAAKLSRVCNVFAVTREKNAKIIRESGFKMTGIWGNGIFKFGASEEVPKIDFDYIIIASKGISTES
ICKQFKDDIKNKNVVSIQNGVGNEEIISKYTDKVIGGTIITGFEWKGNAEVHVSVEGGPMTVGRYPDGTDEEVIDFVKLI
KSSGIPITESKNIQGAIWSKTIYNCALNPLGAIMNVNYGKLSNNHSLNIIENIVSEIFEITSKKGVILPWKTPKEYLKYL
TEFQLPNTAAHHSSMLQDILKGKMTEIDFLNGAVVSNGKKLGVKTPYNEFITEQVKFLEFLKSETKSSE

Sequences:

>Translated_309_residues
MNVLIIGAGAVGLCLAAKLSRVCNVFAVTREKNAKIIRESGFKMTGIWGNGIFKFGASEEVPKIDFDYIIIASKGISTES
ICKQFKDDIKNKNVVSIQNGVGNEEIISKYTDKVIGGTIITGFEWKGNAEVHVSVEGGPMTVGRYPDGTDEEVIDFVKLI
KSSGIPITESKNIQGAIWSKTIYNCALNPLGAIMNVNYGKLSNNHSLNIIENIVSEIFEITSKKGVILPWKTPKEYLKYL
TEFQLPNTAAHHSSMLQDILKGKMTEIDFLNGAVVSNGKKLGVKTPYNEFITEQVKFLEFLKSETKSSE
>Mature_309_residues
MNVLIIGAGAVGLCLAAKLSRVCNVFAVTREKNAKIIRESGFKMTGIWGNGIFKFGASEEVPKIDFDYIIIASKGISTES
ICKQFKDDIKNKNVVSIQNGVGNEEIISKYTDKVIGGTIITGFEWKGNAEVHVSVEGGPMTVGRYPDGTDEEVIDFVKLI
KSSGIPITESKNIQGAIWSKTIYNCALNPLGAIMNVNYGKLSNNHSLNIIENIVSEIFEITSKKGVILPWKTPKEYLKYL
TEFQLPNTAAHHSSMLQDILKGKMTEIDFLNGAVVSNGKKLGVKTPYNEFITEQVKFLEFLKSETKSSE

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=234, Percent_Identity=26.9230769230769, Blast_Score=81, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33997; Mature: 33997

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLIIGAGAVGLCLAAKLSRVCNVFAVTREKNAKIIRESGFKMTGIWGNGIFKFGASEE
CCEEEEECCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHCCCEEEEEECCCEEECCCCCC
VPKIDFDYIIIASKGISTESICKQFKDDIKNKNVVSIQNGVGNEEIISKYTDKVIGGTII
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCEEE
TGFEWKGNAEVHVSVEGGPMTVGRYPDGTDEEVIDFVKLIKSSGIPITESKNIQGAIWSK
EEEEECCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
TIYNCALNPLGAIMNVNYGKLSNNHSLNIIENIVSEIFEITSKKGVILPWKTPKEYLKYL
HHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHH
TEFQLPNTAAHHSSMLQDILKGKMTEIDFLNGAVVSNGKKLGVKTPYNEFITEQVKFLEF
HHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCEECCCCCHHHHHHHHHHHHHH
LKSETKSSE
HHHHCCCCC
>Mature Secondary Structure
MNVLIIGAGAVGLCLAAKLSRVCNVFAVTREKNAKIIRESGFKMTGIWGNGIFKFGASEE
CCEEEEECCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHCCCEEEEEECCCEEECCCCCC
VPKIDFDYIIIASKGISTESICKQFKDDIKNKNVVSIQNGVGNEEIISKYTDKVIGGTII
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCEEE
TGFEWKGNAEVHVSVEGGPMTVGRYPDGTDEEVIDFVKLIKSSGIPITESKNIQGAIWSK
EEEEECCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
TIYNCALNPLGAIMNVNYGKLSNNHSLNIIENIVSEIFEITSKKGVILPWKTPKEYLKYL
HHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHH
TEFQLPNTAAHHSSMLQDILKGKMTEIDFLNGAVVSNGKKLGVKTPYNEFITEQVKFLEF
HHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEECCCCEECCCCCHHHHHHHHHHHHHH
LKSETKSSE
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]