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The map label for this gene is yggV [C]

Identifier: 150399972

GI number: 150399972

Start: 1260715

End: 1261275

Strand: Reverse

Name: yggV [C]

Synonym: Mevan_1229

Alternate gene names: 150399972

Gene position: 1261275-1260715 (Counterclockwise)

Preceding gene: 150399974

Following gene: 150399971

Centisome position: 73.33

GC content: 28.88

Gene sequence:

>561_bases
ATGAAGATTTATTTTGCAACTGGAAACCAGAACAAAGTAAATGAGGCCAATATTATTCTAAAAGGCCTTGAAGGTTACGA
ATTAGAACATTTGAAAATTCCATATGCTGAAATTCAAGGCACTCTTGAAGAAGTTTCTAAAGTTGGAGTAAAAGAAATAT
ATAATAAAATTAAAAAACCCGTAATTGTAGAAGATAGTGGTTTTTTTATAGAATCATTAAACGGATTTCCTGGAACATAC
TCAAAGTACGTTCAGGAAACACTTGGAAATGAAAAAATTTTAAAACTCCTAAAAGACGAAGAAAACCGAAAAGCATATTT
TAAAACTATAATTGGTTATTTTGACGGTATAGATTTAAAATTATTCAGGGGTGAAATTTTTGGAAGCGTTTCTAAGGAGA
TAAAAACTTCTGGTTTTGGATTTGCATATGACAGCATATTTATCCCAGAAGGGCAGAATAAAACTTTTGCAGAAATGACT
ACAAAAGAAAAAAGTGATATTTCACACAGAAAACTTGCATTTTACAAATTTAAAAGTTATTTAGAATCAAAAGTAAAATA
G

Upstream 100 bases:

>100_bases
CCCGTTAATTTAAATTCCTGTTAAAAATTATTTTTATAAGAATATAAATAGTTGCAAGTTAGAATTAGTGTTAAAATCCA
AAATTAATTCTGGTGGTTTT

Downstream 100 bases:

>100_bases
TGAAAAATATGAAACCGTTTGAAATCATGAAAGCATCTCAAATTGCTTGCTGTTTTGAAGTAGGAAGTTTTAAACCTGGA
AACGTCCATAAAAACAGGGA

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MKIYFATGNQNKVNEANIILKGLEGYELEHLKIPYAEIQGTLEEVSKVGVKEIYNKIKKPVIVEDSGFFIESLNGFPGTY
SKYVQETLGNEKILKLLKDEENRKAYFKTIIGYFDGIDLKLFRGEIFGSVSKEIKTSGFGFAYDSIFIPEGQNKTFAEMT
TKEKSDISHRKLAFYKFKSYLESKVK

Sequences:

>Translated_186_residues
MKIYFATGNQNKVNEANIILKGLEGYELEHLKIPYAEIQGTLEEVSKVGVKEIYNKIKKPVIVEDSGFFIESLNGFPGTY
SKYVQETLGNEKILKLLKDEENRKAYFKTIIGYFDGIDLKLFRGEIFGSVSKEIKTSGFGFAYDSIFIPEGQNKTFAEMT
TKEKSDISHRKLAFYKFKSYLESKVK
>Mature_186_residues
MKIYFATGNQNKVNEANIILKGLEGYELEHLKIPYAEIQGTLEEVSKVGVKEIYNKIKKPVIVEDSGFFIESLNGFPGTY
SKYVQETLGNEKILKLLKDEENRKAYFKTIIGYFDGIDLKLFRGEIFGSVSKEIKTSGFGFAYDSIFIPEGQNKTFAEMT
TKEKSDISHRKLAFYKFKSYLESKVK

Specific function: Hydrolyzes non-standard nucleotides such as XTP and ITP to nucleotide monophosphate and pyrophosphate. Probably excludes non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=185, Percent_Identity=33.5135135135135, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI31657144, Length=155, Percent_Identity=32.9032258064516, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17556833, Length=184, Percent_Identity=30.9782608695652, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322529, Length=190, Percent_Identity=34.2105263157895, Blast_Score=85, Evalue=8e-18,
Organism=Drosophila melanogaster, GI19920712, Length=186, Percent_Identity=33.8709677419355, Blast_Score=103, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 21291; Mature: 21291

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYFATGNQNKVNEANIILKGLEGYELEHLKIPYAEIQGTLEEVSKVGVKEIYNKIKKP
CEEEEECCCCCCCCCHHEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCC
VIVEDSGFFIESLNGFPGTYSKYVQETLGNEKILKLLKDEENRKAYFKTIIGYFDGIDLK
EEEECCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEE
LFRGEIFGSVSKEIKTSGFGFAYDSIFIPEGQNKTFAEMTTKEKSDISHRKLAFYKFKSY
EEHHHHHHHHHHHHHHCCCCEEECEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
LESKVK
HHHHCC
>Mature Secondary Structure
MKIYFATGNQNKVNEANIILKGLEGYELEHLKIPYAEIQGTLEEVSKVGVKEIYNKIKKP
CEEEEECCCCCCCCCHHEEEECCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCC
VIVEDSGFFIESLNGFPGTYSKYVQETLGNEKILKLLKDEENRKAYFKTIIGYFDGIDLK
EEEECCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEE
LFRGEIFGSVSKEIKTSGFGFAYDSIFIPEGQNKTFAEMTTKEKSDISHRKLAFYKFKSY
EEHHHHHHHHHHHHHHCCCCEEECEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
LESKVK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10404228 [H]