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The map label for this gene is 150399851

Identifier: 150399851

GI number: 150399851

Start: 1118871

End: 1120295

Strand: Reverse

Name: 150399851

Synonym: Mevan_1106

Alternate gene names: NA

Gene position: 1120295-1118871 (Counterclockwise)

Preceding gene: 150399853

Following gene: 150399850

Centisome position: 65.13

GC content: 33.4

Gene sequence:

>1425_bases
ATGAATATAGACTATTCTATTTTAAAAAAATACCCATTTTGCAACAGGTGTTTTGGAAGACTTTATGGAAAACTCATAAG
AACTGATAACTTTGATAGAGGGCGTGCATTAAAACTTTCAAAGGCAATTGAGCTTGAACAGTTGCTTAGGATTGCTCTTG
AAAATTTAAATAATGATAATTTGGAATTTGAAAGCGATTTAAAATTAACCCCTGATGAAATTGACGAAATAAAGAGATTA
ATGTATTCGATACATAGATCAGGTCTTTTTGAAATAAAACTTGATTTAATAGATAATATCGAAAAATATGAAGCAGAATA
TAAACTCCTTGAGGAAACTAATGGTGAAAAAGCCTTAGAAGAATTAGAAATTAAATGTCCTTGGTGTAAGGACATTTTTG
CACCTGAAAACCTACAAAAAATTTCTGAAAATATCGCTGAGACCTTAAAGAATTATGAATTTGAAAGCTTTTTGATTGGA
ACTAAACTTCCAAAACGATTTAAAGAACTAGAAAAAGAGATTGAAACACCATTCATGGAAAGTATAAGGCAGGAATTTGG
TCGGGAACTTGGAAAAATTGTAACACCCATTCTTAAAAGAAGAGTTGATAAGGAAAACCCTGACATTGTTATAATGGTTA
ATCCATATAACCAAAAAGTTACGCTTCAGGTAAATCCTATTTTTATTAAGGGCAGGTATAAAAAACTCGTCAGGGGAATT
CCACAAAGTCACTGGCACTGCAGGACCTGTAAAGGAAGAGGCTGTGAAAAATGTAACTTCACTGGAAAACAGTACCAAAC
TTCAGTCGAAGAAATTATTGCAGAACCGTTCATGGAAATTATGAAAGGAAGTTCTGAAGCACTTCACGGCGCTGGAAGGG
AAGATATCGATGTTAGAATGCTTGGAAATGGAAGGCCCTTTGTAATTGAAATAAAAGAACCAAAAGTTAGAACAGTAAAT
TTAAAAAAAATGTCTGAAAAAGTAAATTCTTCCAAAATGGTTGAAATAACTGATTTAGAGTATGGGAATAAAAAAGATGT
TCACTTTTTTAAAAATGAACCGCATAAAAAAACATACCTTGCAAAAGTTGAGTGTGATGAAAAGGTTTCCAAAGAAGAAG
TCTTAAACCTCGTTCAAAAGCTTGAAAATTTAGTAATTGACCAAAGAACGCCTGATAGGGTAGCCCATAGAAGGGCCGAC
CTTGTACGTGTACGTAAGGTATATAAAGCTTGGCCACATATACTTGATGATTATAACTTCGAACTTAAGATCTTCTGCGA
TGGCGGATTATACATCAAAGAGCTCATAAGTAGTGACGAAGGAAGAACTTCGCCTTCTGTTTCGGAATTACTCGATAAAA
AGTGCATCTGTAAGTTTTTAGACGTTTTGGATGTTCACGATTATGAGGATGTAGAAAATATCTAA

Upstream 100 bases:

>100_bases
TATATGTTCAATATCCATATACTTAGAAGTTCCTTTTGAATACTTTGAATGAATGTGTAAATCAGCATTTATTATCATTA
AATCACCCAGGTGAGATTAT

Downstream 100 bases:

>100_bases
AACAGAAATAGTTATATATTGGTAGTGGAAAATAAGATAGACACTATGCCAATTATTTTTGTGAAACACATTAGGAGGAA
TAATTATGCAAAAAAGTGAA

Product: putative pseudouridylate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNIDYSILKKYPFCNRCFGRLYGKLIRTDNFDRGRALKLSKAIELEQLLRIALENLNNDNLEFESDLKLTPDEIDEIKRL
MYSIHRSGLFEIKLDLIDNIEKYEAEYKLLEETNGEKALEELEIKCPWCKDIFAPENLQKISENIAETLKNYEFESFLIG
TKLPKRFKELEKEIETPFMESIRQEFGRELGKIVTPILKRRVDKENPDIVIMVNPYNQKVTLQVNPIFIKGRYKKLVRGI
PQSHWHCRTCKGRGCEKCNFTGKQYQTSVEEIIAEPFMEIMKGSSEALHGAGREDIDVRMLGNGRPFVIEIKEPKVRTVN
LKKMSEKVNSSKMVEITDLEYGNKKDVHFFKNEPHKKTYLAKVECDEKVSKEEVLNLVQKLENLVIDQRTPDRVAHRRAD
LVRVRKVYKAWPHILDDYNFELKIFCDGGLYIKELISSDEGRTSPSVSELLDKKCICKFLDVLDVHDYEDVENI

Sequences:

>Translated_474_residues
MNIDYSILKKYPFCNRCFGRLYGKLIRTDNFDRGRALKLSKAIELEQLLRIALENLNNDNLEFESDLKLTPDEIDEIKRL
MYSIHRSGLFEIKLDLIDNIEKYEAEYKLLEETNGEKALEELEIKCPWCKDIFAPENLQKISENIAETLKNYEFESFLIG
TKLPKRFKELEKEIETPFMESIRQEFGRELGKIVTPILKRRVDKENPDIVIMVNPYNQKVTLQVNPIFIKGRYKKLVRGI
PQSHWHCRTCKGRGCEKCNFTGKQYQTSVEEIIAEPFMEIMKGSSEALHGAGREDIDVRMLGNGRPFVIEIKEPKVRTVN
LKKMSEKVNSSKMVEITDLEYGNKKDVHFFKNEPHKKTYLAKVECDEKVSKEEVLNLVQKLENLVIDQRTPDRVAHRRAD
LVRVRKVYKAWPHILDDYNFELKIFCDGGLYIKELISSDEGRTSPSVSELLDKKCICKFLDVLDVHDYEDVENI
>Mature_474_residues
MNIDYSILKKYPFCNRCFGRLYGKLIRTDNFDRGRALKLSKAIELEQLLRIALENLNNDNLEFESDLKLTPDEIDEIKRL
MYSIHRSGLFEIKLDLIDNIEKYEAEYKLLEETNGEKALEELEIKCPWCKDIFAPENLQKISENIAETLKNYEFESFLIG
TKLPKRFKELEKEIETPFMESIRQEFGRELGKIVTPILKRRVDKENPDIVIMVNPYNQKVTLQVNPIFIKGRYKKLVRGI
PQSHWHCRTCKGRGCEKCNFTGKQYQTSVEEIIAEPFMEIMKGSSEALHGAGREDIDVRMLGNGRPFVIEIKEPKVRTVN
LKKMSEKVNSSKMVEITDLEYGNKKDVHFFKNEPHKKTYLAKVECDEKVSKEEVLNLVQKLENLVIDQRTPDRVAHRRAD
LVRVRKVYKAWPHILDDYNFELKIFCDGGLYIKELISSDEGRTSPSVSELLDKKCICKFLDVLDVHDYEDVENI

Specific function: Unknown

COG id: COG1258

COG function: function code J; Predicted pseudouridylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 THUMP domain [H]

Homologues:

Organism=Homo sapiens, GI207113130, Length=245, Percent_Identity=32.6530612244898, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17537241, Length=251, Percent_Identity=34.2629482071713, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI19920442, Length=259, Percent_Identity=33.5907335907336, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005912
- InterPro:   IPR020103
- InterPro:   IPR004114 [H]

Pfam domain/function: PF02926 THUMP [H]

EC number: NA

Molecular weight: Translated: 55446; Mature: 55446

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS51165 THUMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDYSILKKYPFCNRCFGRLYGKLIRTDNFDRGRALKLSKAIELEQLLRIALENLNNDN
CCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCC
LEFESDLKLTPDEIDEIKRLMYSIHRSGLFEIKLDLIDNIEKYEAEYKLLEETNGEKALE
CCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHCHHHHHHHHHHHHHCCCHHHHH
ELEIKCPWCKDIFAPENLQKISENIAETLKNYEFESFLIGTKLPKRFKELEKEIETPFME
HHHCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHEECCCCCHHHHHHHHHHHCCHHHH
SIRQEFGRELGKIVTPILKRRVDKENPDIVIMVNPYNQKVTLQVNPIFIKGRYKKLVRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEEEEECCHHHHHHHCC
PQSHWHCRTCKGRGCEKCNFTGKQYQTSVEEIIAEPFMEIMKGSSEALHGAGREDIDVRM
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEE
LGNGRPFVIEIKEPKVRTVNLKKMSEKVNSSKMVEITDLEYGNKKDVHFFKNEPHKKTYL
ECCCCEEEEEECCCCEEEEHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCCCCCEEE
AKVECDEKVSKEEVLNLVQKLENLVIDQRTPDRVAHRRADLVRVRKVYKAWPHILDDYNF
EEECCHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELKIFCDGGLYIKELISSDEGRTSPSVSELLDKKCICKFLDVLDVHDYEDVENI
EEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MNIDYSILKKYPFCNRCFGRLYGKLIRTDNFDRGRALKLSKAIELEQLLRIALENLNNDN
CCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCC
LEFESDLKLTPDEIDEIKRLMYSIHRSGLFEIKLDLIDNIEKYEAEYKLLEETNGEKALE
CCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHHHHHCHHHHHHHHHHHHHCCCHHHHH
ELEIKCPWCKDIFAPENLQKISENIAETLKNYEFESFLIGTKLPKRFKELEKEIETPFME
HHHCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHEECCCCCHHHHHHHHHHHCCHHHH
SIRQEFGRELGKIVTPILKRRVDKENPDIVIMVNPYNQKVTLQVNPIFIKGRYKKLVRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEEEEECCHHHHHHHCC
PQSHWHCRTCKGRGCEKCNFTGKQYQTSVEEIIAEPFMEIMKGSSEALHGAGREDIDVRM
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEE
LGNGRPFVIEIKEPKVRTVNLKKMSEKVNSSKMVEITDLEYGNKKDVHFFKNEPHKKTYL
ECCCCEEEEEECCCCEEEEHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCCCCCEEE
AKVECDEKVSKEEVLNLVQKLENLVIDQRTPDRVAHRRADLVRVRKVYKAWPHILDDYNF
EEECCHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELKIFCDGGLYIKELISSDEGRTSPSVSELLDKKCICKFLDVLDVHDYEDVENI
EEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]