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The map label for this gene is lysN [H]

Identifier: 150399853

GI number: 150399853

Start: 1121542

End: 1122729

Strand: Reverse

Name: lysN [H]

Synonym: Mevan_1108

Alternate gene names: 150399853

Gene position: 1122729-1121542 (Counterclockwise)

Preceding gene: 150399855

Following gene: 150399851

Centisome position: 65.27

GC content: 31.48

Gene sequence:

>1188_bases
ATGAATGTAAAGTTTTCAAATAGAATGGAAAAGTTAAAAACATCAGAAATAAGAGAAATATTAAAAGTTACACAGAATCC
TGAAGTAATTTCTTTTGCAGGCGGACTTCCCGCACCAGAATTATTTCCGGTTCATGAAATAAAAAAGATTTCTTCGCTAG
TTTTAGATGAAATGGGCCCAGAATCATTACAGTACGATTTAACTGAAGGGTATGTTCCCCTTAGAAAGCAGATTTCCGAA
AGAATGAATAGAGTATATAAAACAGAGCTTTCAGAAAAAAACATTTTAATCGTTTGCGGTTCCCAACAAGGCCTTGATTT
CTCCGGAAAAGTATTTATTGATAAAGGAGATGTTATATTATGCGAAAGTCCAACATATTTGGGCGCAATTAATGCATTTA
AAGCATATGAACCTGAATTTATTGAAGTTCCAACCGATGACTTTGGAATGATTCCAGAAGAACTTGAAAAAATATTAAAT
CAGAGACATGATGTAAAAATGATTTACGTAATTCCAGATTTTCAAAATCCTACTGGTAAAACATGGTCTTTTGAAAGAAG
AAAAAAATTCATGGAAGTTATTGAAAAATATAAAATTCCAGTAATTGAGGATAATCCTTACGGAGAACTAAGGTTTTCAG
GTGAAATTCTTCCTTCATTAAAATCTCTCGATAATTTAGGACTTGTGGTTCATCTTGGAACTTTTTCAAAAACGTTCTGC
CCCGGTTTAAGGGTTGGTTGGATTTGTGCATCTGAACATATCCTTGAAAAATATATTTTAATAAAACAGGGTGCAGATTT
ACACACTTCTTCGTTTTCCCAGCGAATAATTTCAAAAATGCTTGAAAATTACGATTTCGAAGAAAGACTATCAAAATTAA
AAGAACTTTATAAAAAAAGAAGAGATTTAATGATTTTTGAAATGAAAAAAAAATTCCCTAAAAATTTAAAATACACAAAT
CCTGATGGGGGCCTTTTTACATGGGTTGAACTTCCAGAAGGGTTTGATGGAAGGAAATTTTTAGAAGAATGTCTAAAAAA
TAATGTTGCAATTGTTCCAGGAGGTTCATTTTTCCCAAACGGAGGCCATGAAAATACGTTTAGGTTAAATTATTCAAACA
TGTCTGAAGAAAAAATAATTGAAGGGATAAACCGGCTTTCAAAGGTTTTGAATGAATTTGAATATTAA

Upstream 100 bases:

>100_bases
AGATATTTTTAATAATTCTCTAAACCGTATATCGTATATATGTACGGTATATATACTTAGCATATATCATTATCAATCTT
AACAAAATTGGGGCATTAAA

Downstream 100 bases:

>100_bases
ATATTTTCTAATTAAATATTTTCAGCCCTATTTCATAAATTTTTATTTTACCCAAGAATCAAGTGTTACTTTTGGATGAA
ACCACTTAACTGTCGGCATG

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNVKFSNRMEKLKTSEIREILKVTQNPEVISFAGGLPAPELFPVHEIKKISSLVLDEMGPESLQYDLTEGYVPLRKQISE
RMNRVYKTELSEKNILIVCGSQQGLDFSGKVFIDKGDVILCESPTYLGAINAFKAYEPEFIEVPTDDFGMIPEELEKILN
QRHDVKMIYVIPDFQNPTGKTWSFERRKKFMEVIEKYKIPVIEDNPYGELRFSGEILPSLKSLDNLGLVVHLGTFSKTFC
PGLRVGWICASEHILEKYILIKQGADLHTSSFSQRIISKMLENYDFEERLSKLKELYKKRRDLMIFEMKKKFPKNLKYTN
PDGGLFTWVELPEGFDGRKFLEECLKNNVAIVPGGSFFPNGGHENTFRLNYSNMSEEKIIEGINRLSKVLNEFEY

Sequences:

>Translated_395_residues
MNVKFSNRMEKLKTSEIREILKVTQNPEVISFAGGLPAPELFPVHEIKKISSLVLDEMGPESLQYDLTEGYVPLRKQISE
RMNRVYKTELSEKNILIVCGSQQGLDFSGKVFIDKGDVILCESPTYLGAINAFKAYEPEFIEVPTDDFGMIPEELEKILN
QRHDVKMIYVIPDFQNPTGKTWSFERRKKFMEVIEKYKIPVIEDNPYGELRFSGEILPSLKSLDNLGLVVHLGTFSKTFC
PGLRVGWICASEHILEKYILIKQGADLHTSSFSQRIISKMLENYDFEERLSKLKELYKKRRDLMIFEMKKKFPKNLKYTN
PDGGLFTWVELPEGFDGRKFLEECLKNNVAIVPGGSFFPNGGHENTFRLNYSNMSEEKIIEGINRLSKVLNEFEY
>Mature_395_residues
MNVKFSNRMEKLKTSEIREILKVTQNPEVISFAGGLPAPELFPVHEIKKISSLVLDEMGPESLQYDLTEGYVPLRKQISE
RMNRVYKTELSEKNILIVCGSQQGLDFSGKVFIDKGDVILCESPTYLGAINAFKAYEPEFIEVPTDDFGMIPEELEKILN
QRHDVKMIYVIPDFQNPTGKTWSFERRKKFMEVIEKYKIPVIEDNPYGELRFSGEILPSLKSLDNLGLVVHLGTFSKTFC
PGLRVGWICASEHILEKYILIKQGADLHTSSFSQRIISKMLENYDFEERLSKLKELYKKRRDLMIFEMKKKFPKNLKYTN
PDGGLFTWVELPEGFDGRKFLEECLKNNVAIVPGGSFFPNGGHENTFRLNYSNMSEEKIIEGINRLSKVLNEFEY

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=407, Percent_Identity=27.7641277641278, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI33469970, Length=407, Percent_Identity=27.7641277641278, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787710, Length=377, Percent_Identity=27.3209549071618, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1790797, Length=386, Percent_Identity=24.0932642487047, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1788722, Length=366, Percent_Identity=22.6775956284153, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI48994949, Length=389, Percent_Identity=23.6503856041131, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321236, Length=482, Percent_Identity=24.896265560166, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321000, Length=246, Percent_Identity=28.8617886178862, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356535, Length=403, Percent_Identity=25.3101736972705, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 45577; Mature: 45577

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVKFSNRMEKLKTSEIREILKVTQNPEVISFAGGLPAPELFPVHEIKKISSLVLDEMGP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
ESLQYDLTEGYVPLRKQISERMNRVYKTELSEKNILIVCGSQQGLDFSGKVFIDKGDVIL
HHHEECHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCEEE
CESPTYLGAINAFKAYEPEFIEVPTDDFGMIPEELEKILNQRHDVKMIYVIPDFQNPTGK
ECCCCHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCC
TWSFERRKKFMEVIEKYKIPVIEDNPYGELRFSGEILPSLKSLDNLGLVVHLGTFSKTFC
CCCHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCHHHHHHHHCCCEEEEEECCCCHHHC
PGLRVGWICASEHILEKYILIKQGADLHTSSFSQRIISKMLENYDFEERLSKLKELYKKR
CCCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RDLMIFEMKKKFPKNLKYTNPDGGLFTWVELPEGFDGRKFLEECLKNNVAIVPGGSFFPN
HCEEEEHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCC
GGHENTFRLNYSNMSEEKIIEGINRLSKVLNEFEY
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNVKFSNRMEKLKTSEIREILKVTQNPEVISFAGGLPAPELFPVHEIKKISSLVLDEMGP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
ESLQYDLTEGYVPLRKQISERMNRVYKTELSEKNILIVCGSQQGLDFSGKVFIDKGDVIL
HHHEECHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCEEE
CESPTYLGAINAFKAYEPEFIEVPTDDFGMIPEELEKILNQRHDVKMIYVIPDFQNPTGK
ECCCCHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCC
TWSFERRKKFMEVIEKYKIPVIEDNPYGELRFSGEILPSLKSLDNLGLVVHLGTFSKTFC
CCCHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCHHHHHHHHCCCEEEEEECCCCHHHC
PGLRVGWICASEHILEKYILIKQGADLHTSSFSQRIISKMLENYDFEERLSKLKELYKKR
CCCEEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RDLMIFEMKKKFPKNLKYTNPDGGLFTWVELPEGFDGRKFLEECLKNNVAIVPGGSFFPN
HCEEEEHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCC
GGHENTFRLNYSNMSEEKIIEGINRLSKVLNEFEY
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA