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The map label for this gene is bioF [C]

Identifier: 150399636

GI number: 150399636

Start: 906927

End: 908039

Strand: Reverse

Name: bioF [C]

Synonym: Mevan_0886

Alternate gene names: 150399636

Gene position: 908039-906927 (Counterclockwise)

Preceding gene: 150399637

Following gene: 150399635

Centisome position: 52.79

GC content: 29.56

Gene sequence:

>1113_bases
ATGTTTAGGGAAAAGTTAAAAAGAGAACTTCAGGGAATAAAAGATGAAAATTTATATAGGAAATTAAGAAATCAAGATGA
TTTTATTTTAAATTTTTCTACAAATGACTACTTAGGCCTTTCAAAAAATGAAGAAGTAATTTTAGCATATAATGAAGGTT
TAAAAGATGGCGCTGGTTCAACCGGTTCAAGACTTACTTCTGGAAACTTTAAACTTCATGAAAAATTAGAAGGAGTTATT
TCAGAATTTAAAGAAACTGAAAAATCACTAGTTTATTCCTCAGGTTATGCTGCAAACGTTGGCGTAATAAGTGCACTTGC
TAAAAAAGGAGACCTTGTTTTAAGCGATGAATTAAATCATGCATCAATTATTGATGGGATACGACTTTCAAGAGCGGATA
AATTAATTTATCGACATTCTGATGTACAAAACTTGATTGAAATTCTTGAAAAAAATAAGTACTATGAAAATATAATTGTA
GTTACGGACTCGGTTTTTAGTATGGATGGTGATGTATCTCCAATTGATAAAATTGCAAAGATTATTGATGAATATAACGC
AGTTTTAATTATTGATGATGCACACGGTACCGGAGTTTTAGGGCAGGGAAAAGGTACCCTAAAACATTTTAAGGTAAAGG
CAAGTGACAATATTATACAAATTGGAACCCTTTCAAAAGCTATTGGAACTTCAGGTGGATTTGTATCTGGAATTGAAGAA
TTAATTGATTACTTAATAAATAATTCTCGAAGTTTTATATATTCAACATCACTTCCACCGGCCGTAATTTCTGCAAGCAT
AAAATCATTTGAATTAGTTGAAAAAGAAAGACTTTCTAAAAACCTTGAAAAAAATATAATTTGTGCAAATAAACTTTTTA
AAAACCATGGATTTATTAAATGTGAAAGTATTACTCCAATATATCCATTTGTATTCGGTGAAAAGTCAATAGATATATCA
AAAGGTCTTATAAATCATGGAATATTTGGGGTCCCAATAAGGTATCCCACGGTAAAAAAAGGCATGGAGAGAATACGAAT
TAGTATAACTTCAAAACACGAAAAAAACGATTTTAAATACCTTTGCGAAAAAATAGACAAATTAACAATTTAA

Upstream 100 bases:

>100_bases
AATTTGGTGGAAGGGTGTTTTTTATAGAAAATTCAGCAAATATTGAAGAAATTTTTGAAAAAATCGAAAAAACTCCAGTA
ATTGTTTATTAGGTGTTTTC

Downstream 100 bases:

>100_bases
ATATGGCAAATTTTCGAGGGTTAAAATGATATTTGTTACTGGAACTGATACGGGAATTGGAAAAACATACGTTTCAGCCA
TTTTAGGGAAAATTTTAAAA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MFREKLKRELQGIKDENLYRKLRNQDDFILNFSTNDYLGLSKNEEVILAYNEGLKDGAGSTGSRLTSGNFKLHEKLEGVI
SEFKETEKSLVYSSGYAANVGVISALAKKGDLVLSDELNHASIIDGIRLSRADKLIYRHSDVQNLIEILEKNKYYENIIV
VTDSVFSMDGDVSPIDKIAKIIDEYNAVLIIDDAHGTGVLGQGKGTLKHFKVKASDNIIQIGTLSKAIGTSGGFVSGIEE
LIDYLINNSRSFIYSTSLPPAVISASIKSFELVEKERLSKNLEKNIICANKLFKNHGFIKCESITPIYPFVFGEKSIDIS
KGLINHGIFGVPIRYPTVKKGMERIRISITSKHEKNDFKYLCEKIDKLTI

Sequences:

>Translated_370_residues
MFREKLKRELQGIKDENLYRKLRNQDDFILNFSTNDYLGLSKNEEVILAYNEGLKDGAGSTGSRLTSGNFKLHEKLEGVI
SEFKETEKSLVYSSGYAANVGVISALAKKGDLVLSDELNHASIIDGIRLSRADKLIYRHSDVQNLIEILEKNKYYENIIV
VTDSVFSMDGDVSPIDKIAKIIDEYNAVLIIDDAHGTGVLGQGKGTLKHFKVKASDNIIQIGTLSKAIGTSGGFVSGIEE
LIDYLINNSRSFIYSTSLPPAVISASIKSFELVEKERLSKNLEKNIICANKLFKNHGFIKCESITPIYPFVFGEKSIDIS
KGLINHGIFGVPIRYPTVKKGMERIRISITSKHEKNDFKYLCEKIDKLTI
>Mature_370_residues
MFREKLKRELQGIKDENLYRKLRNQDDFILNFSTNDYLGLSKNEEVILAYNEGLKDGAGSTGSRLTSGNFKLHEKLEGVI
SEFKETEKSLVYSSGYAANVGVISALAKKGDLVLSDELNHASIIDGIRLSRADKLIYRHSDVQNLIEILEKNKYYENIIV
VTDSVFSMDGDVSPIDKIAKIIDEYNAVLIIDDAHGTGVLGQGKGTLKHFKVKASDNIIQIGTLSKAIGTSGGFVSGIEE
LIDYLINNSRSFIYSTSLPPAVISASIKSFELVEKERLSKNLEKNIICANKLFKNHGFIKCESITPIYPFVFGEKSIDIS
KGLINHGIFGVPIRYPTVKKGMERIRISITSKHEKNDFKYLCEKIDKLTI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=384, Percent_Identity=35.4166666666667, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI284448556, Length=344, Percent_Identity=37.5, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI83977442, Length=344, Percent_Identity=32.8488372093023, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI83977440, Length=344, Percent_Identity=32.8488372093023, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI83977444, Length=344, Percent_Identity=32.8488372093023, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4502025, Length=344, Percent_Identity=32.5581395348837, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI40316939, Length=344, Percent_Identity=32.5581395348837, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4758668, Length=362, Percent_Identity=29.5580110497238, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=26.8292682926829, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI5454084, Length=244, Percent_Identity=28.6885245901639, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1786993, Length=351, Percent_Identity=35.042735042735, Blast_Score=200, Evalue=9e-53,
Organism=Escherichia coli, GI1790046, Length=387, Percent_Identity=31.266149870801, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71994529, Length=383, Percent_Identity=36.2924281984334, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI32566772, Length=376, Percent_Identity=25.531914893617, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=24.8618784530387, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=24.8618784530387, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=280, Percent_Identity=27.8571428571429, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=280, Percent_Identity=27.8571428571429, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=373, Percent_Identity=31.3672922252011, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=28.5326086956522, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=290, Percent_Identity=27.5862068965517, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24662918, Length=375, Percent_Identity=35.2, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI17137420, Length=352, Percent_Identity=34.0909090909091, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI17136286, Length=403, Percent_Identity=24.5657568238213, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653280, Length=259, Percent_Identity=28.1853281853282, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653276, Length=259, Percent_Identity=28.1853281853282, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24653278, Length=259, Percent_Identity=28.1853281853282, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_METVS (A6UQL9)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323403.1
- ProteinModelPortal:   A6UQL9
- STRING:   A6UQL9
- GeneID:   5326215
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_0886
- eggNOG:   arNOG04128
- HOGENOM:   HBG649839
- OMA:   NTSRSFI
- ProtClustDB:   CLSK876517
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 41298; Mature: 41298

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 20-20 BINDING 120-120 BINDING 167-167 BINDING 337-337

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFREKLKRELQGIKDENLYRKLRNQDDFILNFSTNDYLGLSKNEEVILAYNEGLKDGAGS
CCHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCEECCCCCCCEEEEECCCCCCCCCC
TGSRLTSGNFKLHEKLEGVISEFKETEKSLVYSSGYAANVGVISALAKKGDLVLSDELNH
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCEEEECCCCC
ASIIDGIRLSRADKLIYRHSDVQNLIEILEKNKYYENIIVVTDSVFSMDGDVSPIDKIAK
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHH
IIDEYNAVLIIDDAHGTGVLGQGKGTLKHFKVKASDNIIQIGTLSKAIGTSGGFVSGIEE
HHHCCCEEEEEECCCCCCEEECCCCCEEEEEEECCCCEEEEECCHHHHCCCCCHHHHHHH
LIDYLINNSRSFIYSTSLPPAVISASIKSFELVEKERLSKNLEKNIICANKLFKNHGFIK
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHCCCCEE
CESITPIYPFVFGEKSIDISKGLINHGIFGVPIRYPTVKKGMERIRISITSKHEKNDFKY
ECCCCCCCCEEECCCCCCHHHHHHHCCEEECEECCCHHHHHHHHEEEEEECCCCCCHHHH
LCEKIDKLTI
HHHHHHHCCC
>Mature Secondary Structure
MFREKLKRELQGIKDENLYRKLRNQDDFILNFSTNDYLGLSKNEEVILAYNEGLKDGAGS
CCHHHHHHHHCCCCCHHHHHHHCCCCCEEEEECCCCEECCCCCCCEEEEECCCCCCCCCC
TGSRLTSGNFKLHEKLEGVISEFKETEKSLVYSSGYAANVGVISALAKKGDLVLSDELNH
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCEEEECCCCC
ASIIDGIRLSRADKLIYRHSDVQNLIEILEKNKYYENIIVVTDSVFSMDGDVSPIDKIAK
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHH
IIDEYNAVLIIDDAHGTGVLGQGKGTLKHFKVKASDNIIQIGTLSKAIGTSGGFVSGIEE
HHHCCCEEEEEECCCCCCEEECCCCCEEEEEEECCCCEEEEECCHHHHCCCCCHHHHHHH
LIDYLINNSRSFIYSTSLPPAVISASIKSFELVEKERLSKNLEKNIICANKLFKNHGFIK
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHCCCCEE
CESITPIYPFVFGEKSIDISKGLINHGIFGVPIRYPTVKKGMERIRISITSKHEKNDFKY
ECCCCCCCCEEECCCCCCHHHHHHHCCEEECEECCCHHHHHHHHEEEEEECCCCCCHHHH
LCEKIDKLTI
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA