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The map label for this gene is ths [H]

Identifier: 150399579

GI number: 150399579

Start: 858080

End: 859711

Strand: Reverse

Name: ths [H]

Synonym: Mevan_0828

Alternate gene names: 150399579

Gene position: 859711-858080 (Counterclockwise)

Preceding gene: 150399580

Following gene: 150399576

Centisome position: 49.98

GC content: 39.58

Gene sequence:

>1632_bases
ATGGCACAACCAGGAGTTTTACCTGAAAACATGAAAAGGTATATGGGAAGAGATGCTCAGAGAATGAACATTTTAGCAGG
AAGGATTATCGCAGAAACCGTAAGATCAACACTCGGCCCAAAAGGAATGGACAAAATGTTAGTTGACGATTTAGGTGACG
TTGTTGTTACAAACGACGGAGTTACAATCTTAAGAGAAATGAGTGTAGAACACCCTGCAGCTAAAATGTTAATTGAAGTT
GCAAAAACCCAAGAAAAAGAAGTAGGAGATGGTACAACAACCGCAGTTGTACTTGCTGGGGAATTGTTAAGAAAAGCTGA
AGAATTATTGGACCAAAACGTACACCCAACAATCGTTGTTAAGGGTTACCAAATGGCTGCACAAAAGGCACAAGAAATTT
TAAAAGAAGTTGCATGTGACGTTAGTGCACAAGATAAAGAACTTTTAATAAAAATTGCAATGACATCAATCACCGGAAAG
GGTGCTGAAAAAGCTAAAGAACAATTAGCTGAAATTATCGTTGACGCAGTTTCAGCAGTTGTTGACGAAGATGGAAAAGT
TGACAAAGACTTAATCAAAATCGAGAAAAAGCAAGGCGCATCAATTGACGACACTGAATTAATCAAAGGTGTTTTGGTTG
ACAAAGAAAGAGTAAGCGCTCAAATGCCTAAAAAAGTTGTTAACGCAAAAATTGCACTCTTAAACTGTGCAATTGAAATC
AAAGAAACCGAAACCGATGCAGAAATTAGAATTACTGACCCTGCAAAATTAATGGAATTCATTGAACAAGAAGAAAAAAT
GTTAAAAGACATGGTCAATGAAATCAAAGCAAGCGGTGCAAACGTAGTATTCTGTCAAAAAGGAATTGACGACTTAGCAC
AACACTTCTTAGCTAAAGAAGGAATCGTTGCTGCAAGAAGAGTTAAAAAATCCGACATGGAAAAACTCGCAAAAGCAACC
GGTGCAACCGTAATTAATAACATTAAAGACTTAAGCGCTGCTGATTTAGGGGACGCTGGAATCGTTGAAGAGAAGAAAAT
CTCAGGAGACGCAATGATTTTCGTTGAAGAATGCAAACTTCCAAAAGCAGTTACAATGCTTATCAGGGGTACAACTGAAC
ATGTAATCGAAGAAGTTGCAAGAGCAGTTGACGACGCTGTTGGTGTAGTTGCATGTACAATTGAAGATGGAAAAATCGTA
TCAGGTGGGGGTTCAACAGAAGTTGAATTATCCTTAAGATTAAGAGAATACGCAGAAGGAATCAGCGGAAGAGAACAACT
CGCAGTTAGGGCATTTGCAGATGCTTTAGAGGTAATTCCTAGAACTTTAGCTGAAAACGCAGGACTTGATGCAATCGAAA
TCCTCGTTAAAGTTAGGGCAGCACACGCAAGCAACGGTAACAAGTGCGCAGGTTTAAACGTATTCACAGGAAACGTTGAA
GATATGTGTGCAAACGGCGTTGTTGAACCATTAAGAGTTAAAACTCAAGCAGTTCAATCAGCAGCAGAATCAACAGAAAT
GTTACTCAGAATCGATGACGTAATTGCTGCAGAAAAATTAAGAGGTGGCGCACCTGACATGGGCGACATGGGCGGAATGG
GAGGTATGGGCGGAATGGGAGGAATGATGTAA

Upstream 100 bases:

>100_bases
CAAAAAAATCAAATCGAAATAGTTATATATACCTTCATAGTCATATACATACCGAAGCAGTACATTTTAAAACCAAACAT
ATTAAAAATGAGGTGTAGTT

Downstream 100 bases:

>100_bases
TTTCCCTTCCCCTTTTTTATTTTCAAAAAAATATTTATAAATTTAGATATATTATATTTAAGTTTTCGGTTTTTCAGATA
AAGTGTAAATATAATTTTAA

Product: thermosome

Products: NA

Alternate protein names: Chaperonin subunit [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MAQPGVLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHPAAKMLIEV
AKTQEKEVGDGTTTAVVLAGELLRKAEELLDQNVHPTIVVKGYQMAAQKAQEILKEVACDVSAQDKELLIKIAMTSITGK
GAEKAKEQLAEIIVDAVSAVVDEDGKVDKDLIKIEKKQGASIDDTELIKGVLVDKERVSAQMPKKVVNAKIALLNCAIEI
KETETDAEIRITDPAKLMEFIEQEEKMLKDMVNEIKASGANVVFCQKGIDDLAQHFLAKEGIVAARRVKKSDMEKLAKAT
GATVINNIKDLSAADLGDAGIVEEKKISGDAMIFVEECKLPKAVTMLIRGTTEHVIEEVARAVDDAVGVVACTIEDGKIV
SGGGSTEVELSLRLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGNVE
DMCANGVVEPLRVKTQAVQSAAESTEMLLRIDDVIAAEKLRGGAPDMGDMGGMGGMGGMGGMM

Sequences:

>Translated_543_residues
MAQPGVLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHPAAKMLIEV
AKTQEKEVGDGTTTAVVLAGELLRKAEELLDQNVHPTIVVKGYQMAAQKAQEILKEVACDVSAQDKELLIKIAMTSITGK
GAEKAKEQLAEIIVDAVSAVVDEDGKVDKDLIKIEKKQGASIDDTELIKGVLVDKERVSAQMPKKVVNAKIALLNCAIEI
KETETDAEIRITDPAKLMEFIEQEEKMLKDMVNEIKASGANVVFCQKGIDDLAQHFLAKEGIVAARRVKKSDMEKLAKAT
GATVINNIKDLSAADLGDAGIVEEKKISGDAMIFVEECKLPKAVTMLIRGTTEHVIEEVARAVDDAVGVVACTIEDGKIV
SGGGSTEVELSLRLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGNVE
DMCANGVVEPLRVKTQAVQSAAESTEMLLRIDDVIAAEKLRGGAPDMGDMGGMGGMGGMGGMM
>Mature_542_residues
AQPGVLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHPAAKMLIEVA
KTQEKEVGDGTTTAVVLAGELLRKAEELLDQNVHPTIVVKGYQMAAQKAQEILKEVACDVSAQDKELLIKIAMTSITGKG
AEKAKEQLAEIIVDAVSAVVDEDGKVDKDLIKIEKKQGASIDDTELIKGVLVDKERVSAQMPKKVVNAKIALLNCAIEIK
ETETDAEIRITDPAKLMEFIEQEEKMLKDMVNEIKASGANVVFCQKGIDDLAQHFLAKEGIVAARRVKKSDMEKLAKATG
ATVINNIKDLSAADLGDAGIVEEKKISGDAMIFVEECKLPKAVTMLIRGTTEHVIEEVARAVDDAVGVVACTIEDGKIVS
GGGSTEVELSLRLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGNVED
MCANGVVEPLRVKTQAVQSAAESTEMLLRIDDVIAAEKLRGGAPDMGDMGGMGGMGGMGGMM

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI63162572, Length=535, Percent_Identity=39.2523364485981, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI24307939, Length=507, Percent_Identity=41.4201183431953, Blast_Score=381, Evalue=1e-105,
Organism=Homo sapiens, GI38455427, Length=515, Percent_Identity=40.1941747572816, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI5453607, Length=510, Percent_Identity=37.4509803921569, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI57863257, Length=521, Percent_Identity=38.0038387715931, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI58761484, Length=475, Percent_Identity=37.2631578947368, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI261399877, Length=490, Percent_Identity=36.3265306122449, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI4502643, Length=507, Percent_Identity=36.2919132149901, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI58331173, Length=506, Percent_Identity=35.5731225296443, Blast_Score=295, Evalue=1e-79,
Organism=Homo sapiens, GI5453603, Length=513, Percent_Identity=34.307992202729, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI302058290, Length=500, Percent_Identity=34.6, Blast_Score=266, Evalue=5e-71,
Organism=Homo sapiens, GI261399875, Length=445, Percent_Identity=34.8314606741573, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI48762932, Length=537, Percent_Identity=35.0093109869646, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI58331171, Length=507, Percent_Identity=32.9388560157791, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI302058292, Length=506, Percent_Identity=32.2134387351779, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI57863259, Length=364, Percent_Identity=34.6153846153846, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI58331185, Length=325, Percent_Identity=35.0769230769231, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI7657253, Length=498, Percent_Identity=26.7068273092369, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI25914754, Length=467, Percent_Identity=22.0556745182013, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI9055272, Length=467, Percent_Identity=22.0556745182013, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI41399285, Length=539, Percent_Identity=23.191094619666, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI31542947, Length=539, Percent_Identity=23.191094619666, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790586, Length=542, Percent_Identity=24.9077490774908, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25144674, Length=527, Percent_Identity=39.4686907020873, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17532603, Length=504, Percent_Identity=40.0793650793651, Blast_Score=354, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI17532601, Length=538, Percent_Identity=38.2899628252788, Blast_Score=345, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI25148561, Length=521, Percent_Identity=36.6602687140115, Blast_Score=331, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI17564182, Length=518, Percent_Identity=34.5559845559846, Blast_Score=327, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI25147750, Length=517, Percent_Identity=34.6228239845261, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI25144678, Length=524, Percent_Identity=33.969465648855, Blast_Score=284, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI32566944, Length=421, Percent_Identity=33.9667458432304, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI25144680, Length=403, Percent_Identity=33.7468982630273, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71998178, Length=561, Percent_Identity=29.0552584670232, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71981457, Length=335, Percent_Identity=37.0149253731343, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17555558, Length=559, Percent_Identity=22.8980322003578, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322446, Length=519, Percent_Identity=37.7649325626204, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322524, Length=535, Percent_Identity=36.2616822429907, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6322350, Length=516, Percent_Identity=36.6279069767442, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6320058, Length=508, Percent_Identity=36.4173228346457, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6320418, Length=527, Percent_Identity=35.1043643263757, Blast_Score=315, Evalue=8e-87,
Organism=Saccharomyces cerevisiae, GI6322049, Length=505, Percent_Identity=33.8613861386139, Blast_Score=273, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6320393, Length=524, Percent_Identity=32.2519083969466, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6322452, Length=554, Percent_Identity=29.7833935018051, Blast_Score=243, Evalue=5e-65,
Organism=Drosophila melanogaster, GI17647245, Length=511, Percent_Identity=40.7045009784736, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24647512, Length=528, Percent_Identity=38.6363636363636, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24647510, Length=528, Percent_Identity=38.6363636363636, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652903, Length=500, Percent_Identity=40.6, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24649027, Length=521, Percent_Identity=38.9635316698656, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24649029, Length=521, Percent_Identity=38.9635316698656, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24583944, Length=506, Percent_Identity=37.7470355731225, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24645179, Length=526, Percent_Identity=36.3117870722433, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI18858175, Length=516, Percent_Identity=34.8837209302326, Blast_Score=295, Evalue=7e-80,
Organism=Drosophila melanogaster, GI28571140, Length=516, Percent_Identity=34.8837209302326, Blast_Score=295, Evalue=8e-80,
Organism=Drosophila melanogaster, GI18859933, Length=521, Percent_Identity=35.5086372360845, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI19921848, Length=541, Percent_Identity=33.456561922366, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24641193, Length=547, Percent_Identity=23.0347349177331, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24641191, Length=547, Percent_Identity=23.0347349177331, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45550936, Length=530, Percent_Identity=22.2641509433962, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550132, Length=530, Percent_Identity=22.2641509433962, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550935, Length=530, Percent_Identity=22.2641509433962, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17864606, Length=577, Percent_Identity=23.3968804159445, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58044; Mature: 57913

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00750 TCP1_1 ; PS00751 TCP1_2 ; PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPGVLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDG
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCC
VTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVLAGELLRKAEELLDQNVHPTIVV
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
KGYQMAAQKAQEILKEVACDVSAQDKELLIKIAMTSITGKGAEKAKEQLAEIIVDAVSAV
ECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VDEDGKVDKDLIKIEKKQGASIDDTELIKGVLVDKERVSAQMPKKVVNAKIALLNCAIEI
HCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEEEEE
KETETDAEIRITDPAKLMEFIEQEEKMLKDMVNEIKASGANVVFCQKGIDDLAQHFLAKE
EECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHC
GIVAARRVKKSDMEKLAKATGATVINNIKDLSAADLGDAGIVEEKKISGDAMIFVEECKL
CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCHHCCCCCEEEEEECCCC
PKAVTMLIRGTTEHVIEEVARAVDDAVGVVACTIEDGKIVSGGGSTEVELSLRLREYAEG
CHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCCEEEEEEHHHHHHCC
ISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGNVE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCHH
DMCANGVVEPLRVKTQAVQSAAESTEMLLRIDDVIAAEKLRGGAPDMGDMGGMGGMGGMG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GMM
CCC
>Mature Secondary Structure 
AQPGVLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDG
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEECCC
VTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVLAGELLRKAEELLDQNVHPTIVV
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
KGYQMAAQKAQEILKEVACDVSAQDKELLIKIAMTSITGKGAEKAKEQLAEIIVDAVSAV
ECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VDEDGKVDKDLIKIEKKQGASIDDTELIKGVLVDKERVSAQMPKKVVNAKIALLNCAIEI
HCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEEEEEE
KETETDAEIRITDPAKLMEFIEQEEKMLKDMVNEIKASGANVVFCQKGIDDLAQHFLAKE
EECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHC
GIVAARRVKKSDMEKLAKATGATVINNIKDLSAADLGDAGIVEEKKISGDAMIFVEECKL
CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCHHCCCCCEEEEEECCCC
PKAVTMLIRGTTEHVIEEVARAVDDAVGVVACTIEDGKIVSGGGSTEVELSLRLREYAEG
CHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCCEEEEEEHHHHHHCC
ISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGNVE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCHH
DMCANGVVEPLRVKTQAVQSAAESTEMLLRIDDVIAAEKLRGGAPDMGDMGGMGGMGGMG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GMM
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9774467 [H]