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The map label for this gene is hemB [H]

Identifier: 150399323

GI number: 150399323

Start: 621199

End: 622167

Strand: Reverse

Name: hemB [H]

Synonym: Mevan_0571

Alternate gene names: 150399323

Gene position: 622167-621199 (Counterclockwise)

Preceding gene: 150399324

Following gene: 150399309

Centisome position: 36.17

GC content: 35.09

Gene sequence:

>969_bases
ATGATAATGCGACCAAGAAGACTTAGAAAGAGTGAAAAAATAAGGAATTTAGTTAGGGAAACCACCCTTACAAAAAATGA
TTTAATAATGCCTATTTTTATTGATGAAAATTTAAATGAAAACGAGAAAACTCCAATATCTTCAATGCCTGGCCAATTTA
GATTTGGAATTAGTGCTGCAATTTTGGAGTGCATTGAAATTTCAAATTTGGGTGTCTTAGCAGTTATTTTATTTGGGATT
CCAAAAGAAAAAGATCCTTTTGCACTTTCGGCATTTGATGAAAATGGAGGGGTTCAAAAAGTTATTCGGGCAGTGAAAAA
GAAACTTGGAGATAGTCTTTTAGTAATTGCAGATGTTTGTATGTGCGAATACACTTCTCACGGTCACTGCGGTATTGTTA
GCAACAATGAAGTATTAAATGACGAAACTTTGGAAGTTTTAGCAGATATTGCTCTTTCCTATGCAAAAGCAGGTGTGGAT
ATTGTAGCACCGTCTGATATGATGGATGGAAGAGTTTTAAAAATTCGAAAAACTTTAGATGAAAATGAATTCGAAAATGT
TTCAATAATGAGTTATGCGGCAAAATACGCATCCGCATTCTATGGGCCGTTTAGGGAAGCTGCTGAAAGTACGCCTCAAT
TTGGAGATAGGAAAACTTACCAGATGGATAGTGGAAATTCAAGAGAAGCTTTAAAAGAAATACAAATGGATGTATTAGAA
GGTGCAGATATGATACTTGTAAAACCTGCACTCTCTTACTTGGACATAATAAAAACTGCAAAAGAAAATACCCTTATTCC
CGTTGGAGGATACAGCGTAAGTGGCGAATATGCAATGATCGAATCTGCAGCAGAAAAAGGCTGGATTGACAGGGAAAAAG
CAATTTTTGAAGCACTTTTGAGCATAAAACGGGCAGGTGCAGATTTTATAATAACTTATTGGGCAAAAGAAATATCAAAA
AAGCTTTAA

Upstream 100 bases:

>100_bases
AAATTTATTATACTATAGTAATACAAGCTTTTAAATTTGTATTATTAAACTTATTAACCATATTAAAATAGGGTATAATT
ATTATTTTACAGGGGATTAA

Downstream 100 bases:

>100_bases
GTTTTTTAGAATACTAAAATTTTAAACTCAGACCTTTTAAATACCATTCAGGCACTTTTCTTTTGGACCATTTACAGAAT
TTCGATTTTTCAAGAATATA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MIMRPRRLRKSEKIRNLVRETTLTKNDLIMPIFIDENLNENEKTPISSMPGQFRFGISAAILECIEISNLGVLAVILFGI
PKEKDPFALSAFDENGGVQKVIRAVKKKLGDSLLVIADVCMCEYTSHGHCGIVSNNEVLNDETLEVLADIALSYAKAGVD
IVAPSDMMDGRVLKIRKTLDENEFENVSIMSYAAKYASAFYGPFREAAESTPQFGDRKTYQMDSGNSREALKEIQMDVLE
GADMILVKPALSYLDIIKTAKENTLIPVGGYSVSGEYAMIESAAEKGWIDREKAIFEALLSIKRAGADFIITYWAKEISK
KL

Sequences:

>Translated_322_residues
MIMRPRRLRKSEKIRNLVRETTLTKNDLIMPIFIDENLNENEKTPISSMPGQFRFGISAAILECIEISNLGVLAVILFGI
PKEKDPFALSAFDENGGVQKVIRAVKKKLGDSLLVIADVCMCEYTSHGHCGIVSNNEVLNDETLEVLADIALSYAKAGVD
IVAPSDMMDGRVLKIRKTLDENEFENVSIMSYAAKYASAFYGPFREAAESTPQFGDRKTYQMDSGNSREALKEIQMDVLE
GADMILVKPALSYLDIIKTAKENTLIPVGGYSVSGEYAMIESAAEKGWIDREKAIFEALLSIKRAGADFIITYWAKEISK
KL
>Mature_322_residues
MIMRPRRLRKSEKIRNLVRETTLTKNDLIMPIFIDENLNENEKTPISSMPGQFRFGISAAILECIEISNLGVLAVILFGI
PKEKDPFALSAFDENGGVQKVIRAVKKKLGDSLLVIADVCMCEYTSHGHCGIVSNNEVLNDETLEVLADIALSYAKAGVD
IVAPSDMMDGRVLKIRKTLDENEFENVSIMSYAAKYASAFYGPFREAAESTPQFGDRKTYQMDSGNSREALKEIQMDVLE
GADMILVKPALSYLDIIKTAKENTLIPVGGYSVSGEYAMIESAAEKGWIDREKAIFEALLSIKRAGADFIITYWAKEISK
KL

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=330, Percent_Identity=42.1212121212121, Blast_Score=259, Evalue=2e-69,
Organism=Escherichia coli, GI87081728, Length=321, Percent_Identity=47.3520249221184, Blast_Score=293, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6321398, Length=311, Percent_Identity=43.0868167202572, Blast_Score=235, Evalue=8e-63,
Organism=Drosophila melanogaster, GI21358291, Length=298, Percent_Identity=43.2885906040268, Blast_Score=248, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35755; Mature: 35755

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMRPRRLRKSEKIRNLVRETTLTKNDLIMPIFIDENLNENEKTPISSMPGQFRFGISAA
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
ILECIEISNLGVLAVILFGIPKEKDPFALSAFDENGGVQKVIRAVKKKLGDSLLVIADVC
HHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHH
MCEYTSHGHCGIVSNNEVLNDETLEVLADIALSYAKAGVDIVAPSDMMDGRVLKIRKTLD
HHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEHHHHCC
ENEFENVSIMSYAAKYASAFYGPFREAAESTPQFGDRKTYQMDSGNSREALKEIQMDVLE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
GADMILVKPALSYLDIIKTAKENTLIPVGGYSVSGEYAMIESAAEKGWIDREKAIFEALL
CCCEEEEHHHHHHHHHHHHHCCCCEEEECCEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
SIKRAGADFIITYWAKEISKKL
HHHHCCCCEEHHHHHHHHHHCC
>Mature Secondary Structure
MIMRPRRLRKSEKIRNLVRETTLTKNDLIMPIFIDENLNENEKTPISSMPGQFRFGISAA
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
ILECIEISNLGVLAVILFGIPKEKDPFALSAFDENGGVQKVIRAVKKKLGDSLLVIADVC
HHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHH
MCEYTSHGHCGIVSNNEVLNDETLEVLADIALSYAKAGVDIVAPSDMMDGRVLKIRKTLD
HHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEHHHHCC
ENEFENVSIMSYAAKYASAFYGPFREAAESTPQFGDRKTYQMDSGNSREALKEIQMDVLE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
GADMILVKPALSYLDIIKTAKENTLIPVGGYSVSGEYAMIESAAEKGWIDREKAIFEALL
CCCEEEEHHHHHHHHHHHHHCCCCEEEECCEECCCCHHHHHHHHHCCCCHHHHHHHHHHH
SIKRAGADFIITYWAKEISKKL
HHHHCCCCEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]