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The map label for this gene is glmU [C]

Identifier: 150399152

GI number: 150399152

Start: 451815

End: 453059

Strand: Reverse

Name: glmU [C]

Synonym: Mevan_0399

Alternate gene names: 150399152

Gene position: 453059-451815 (Counterclockwise)

Preceding gene: 150399153

Following gene: 150399151

Centisome position: 26.34

GC content: 29.88

Gene sequence:

>1245_bases
ATGGATGCAGTAATATTATGTGCCGGAAGTGGAACAAGACTTTATCCTATAACCGAAAATCGTCCAAAACCAATGATCCC
AATTGCGGGAAAACCAATACTTGAACATATTATTGAAAAAATTGAAAATCACGTTGAAAAAATATACTTGGTAGTTGGTT
TTGAAAAAGAAAAAATAATAGATTATTTTTACGGGAATGAAAAAATAGAATTTATAGTTCAAGAAAAACAGCTTGGAACG
GGGCATGCTGTATTAATGGCTAAAAACTACATAAAAGGAGATTTTTTAGTCTTAAATGGGGATGTAATTTTTGAAAGCGA
TATTTTGGAATTTTTAAATTATGAAAATGCTGTTGGCTTATCAAAAGTAGATAATCCTGAAAATTTTGGAGTAATTGAGC
TTGGATACGATAATAAAGTTATAAATTTACTTGAAAAACCAAATGAAGATGAAATAAAATCAAAATTTACATCAAATTTG
ATAAATGCTGGAATTTATAAACTGGAAAATTTTGTTTTTGAAATTTTGGAAAATCTGCTTCCTTCAGAACGGGGGGAAAT
TGAATTAACCGATGCCTTAAAAAAACTAATTGAAAGCAGTAAACTTTATGGAATTGAATTAAACGGGTACTGGAACGATA
TTGGGAGGCCTTGGGACGTTTTAAGTGCAAATAATTATTTTTTAAAAAATATAATGCCAAAAATTTCTGGAAATATTGAA
AATAATGTAACAATCACAGGAAATGTTATTATTGAAGAAGGAGTAACTGTAAAATCAAATTCAGTAATTGAAGGGCCAGT
AATTATAAAATCAGGTGCATTTATTGGGCCTTTAGCATATATAAGGCCAAATACTGTTTTAATGGAAGATACTTTTGTTG
GAAATTCTTCTGAGATTAAAGGGAGTATTATAATGAAAAATACTAAAATACCGCATCTTTCGTATGTTGGGGATAGTATT
ATCGGTTCAGACTGTAATTTTGGATGTAACACGATAACCGCAAATTTAAGGTTTGATGACGAACCAGTTACTCTAAATAT
TAAGGGTACGAAGGTAAAAAGTGTCAGGAAATTTGGTGCAGTTATCGGCGACAATGTAAAAACAGGAATTCAAGTTTCAT
TAATGCCTGGCGTTAAAGTTGGGAGTAATTCAATTATTGGTGCAAATTGCCTAGTTGATAAAGATATTGAAAAAGAAAGC
TTTGTTTATAAAAAAGACGAATTAATAATTAAAAAGAGGAATTAA

Upstream 100 bases:

>100_bases
AGAGTTAGAGTTGAAGCAAAAGATGAAACGTTTGCAAATGAACTGTTAAATAACGGAATTTCGCTTGTAAATAACGGAAT
TTTGAAATAAGGGGGAAAAT

Downstream 100 bases:

>100_bases
AATGATTATTGGTCCAAATATTTCAAAAGAATTTTTATCCGATTTAAAAGAAGGCCAGCTTCAACAGTGTGGGATTGACT
TAAAACTTGATAAAATCTAT

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDAVILCAGSGTRLYPITENRPKPMIPIAGKPILEHIIEKIENHVEKIYLVVGFEKEKIIDYFYGNEKIEFIVQEKQLGT
GHAVLMAKNYIKGDFLVLNGDVIFESDILEFLNYENAVGLSKVDNPENFGVIELGYDNKVINLLEKPNEDEIKSKFTSNL
INAGIYKLENFVFEILENLLPSERGEIELTDALKKLIESSKLYGIELNGYWNDIGRPWDVLSANNYFLKNIMPKISGNIE
NNVTITGNVIIEEGVTVKSNSVIEGPVIIKSGAFIGPLAYIRPNTVLMEDTFVGNSSEIKGSIIMKNTKIPHLSYVGDSI
IGSDCNFGCNTITANLRFDDEPVTLNIKGTKVKSVRKFGAVIGDNVKTGIQVSLMPGVKVGSNSIIGANCLVDKDIEKES
FVYKKDELIIKKRN

Sequences:

>Translated_414_residues
MDAVILCAGSGTRLYPITENRPKPMIPIAGKPILEHIIEKIENHVEKIYLVVGFEKEKIIDYFYGNEKIEFIVQEKQLGT
GHAVLMAKNYIKGDFLVLNGDVIFESDILEFLNYENAVGLSKVDNPENFGVIELGYDNKVINLLEKPNEDEIKSKFTSNL
INAGIYKLENFVFEILENLLPSERGEIELTDALKKLIESSKLYGIELNGYWNDIGRPWDVLSANNYFLKNIMPKISGNIE
NNVTITGNVIIEEGVTVKSNSVIEGPVIIKSGAFIGPLAYIRPNTVLMEDTFVGNSSEIKGSIIMKNTKIPHLSYVGDSI
IGSDCNFGCNTITANLRFDDEPVTLNIKGTKVKSVRKFGAVIGDNVKTGIQVSLMPGVKVGSNSIIGANCLVDKDIEKES
FVYKKDELIIKKRN
>Mature_414_residues
MDAVILCAGSGTRLYPITENRPKPMIPIAGKPILEHIIEKIENHVEKIYLVVGFEKEKIIDYFYGNEKIEFIVQEKQLGT
GHAVLMAKNYIKGDFLVLNGDVIFESDILEFLNYENAVGLSKVDNPENFGVIELGYDNKVINLLEKPNEDEIKSKFTSNL
INAGIYKLENFVFEILENLLPSERGEIELTDALKKLIESSKLYGIELNGYWNDIGRPWDVLSANNYFLKNIMPKISGNIE
NNVTITGNVIIEEGVTVKSNSVIEGPVIIKSGAFIGPLAYIRPNTVLMEDTFVGNSSEIKGSIIMKNTKIPHLSYVGDSI
IGSDCNFGCNTITANLRFDDEPVTLNIKGTKVKSVRKFGAVIGDNVKTGIQVSLMPGVKVGSNSIIGANCLVDKDIEKES
FVYKKDELIIKKRN

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Homo sapiens, GI11761621, Length=344, Percent_Identity=27.906976744186, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI11761619, Length=344, Percent_Identity=27.3255813953488, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790168, Length=461, Percent_Identity=26.0303687635575, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1788351, Length=240, Percent_Identity=28.75, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790224, Length=243, Percent_Identity=27.5720164609054, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788355, Length=282, Percent_Identity=24.468085106383, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787488, Length=262, Percent_Identity=28.2442748091603, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=356, Percent_Identity=30.0561797752809, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17509979, Length=343, Percent_Identity=27.1137026239067, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17509981, Length=332, Percent_Identity=26.5060240963855, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=345, Percent_Identity=31.5942028985507, Blast_Score=139, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21355443, Length=341, Percent_Identity=28.4457478005865, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24644084, Length=341, Percent_Identity=28.4457478005865, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_METVS (A6UP85)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001322919.1
- ProteinModelPortal:   A6UP85
- SMR:   A6UP85
- STRING:   A6UP85
- GeneID:   5325640
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_0399
- eggNOG:   arNOG04117
- HOGENOM:   HBG688195
- OMA:   GPNCFIR
- ProtClustDB:   CLSK876450
- InterPro:   IPR005835
- InterPro:   IPR011004

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 45990; Mature: 45990

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 312-312 BINDING 74-74 BINDING 79-79 BINDING 80-80 BINDING 130-130 BINDING 142-142 BINDING 162-162 BINDING 388-388 BINDING 405-405

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAVILCAGSGTRLYPITENRPKPMIPIAGKPILEHIIEKIENHVEKIYLVVGFEKEKII
CCEEEEECCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHEEEEEEEECCHHHEE
DYFYGNEKIEFIVQEKQLGTGHAVLMAKNYIKGDFLVLNGDVIFESDILEFLNYENAVGL
EEEECCCEEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCEEEHHHHHHHHCCCCCCCC
SKVDNPENFGVIELGYDNKVINLLEKPNEDEIKSKFTSNLINAGIYKLENFVFEILENLL
CCCCCCCCCCEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSERGEIELTDALKKLIESSKLYGIELNGYWNDIGRPWDVLSANNYFLKNIMPKISGNIE
CCCCCCEEHHHHHHHHHCCCCEEEEEECCEECCCCCCEEEECCCCEEHHHHHHHHCCCCC
NNVTITGNVIIEEGVTVKSNSVIEGPVIIKSGAFIGPLAYIRPNTVLMEDTFVGNSSEIK
CCEEEEEEEEEECCEEEECCCEEECCEEEECCCCCCCEEEECCCEEEEEEEECCCCCCCC
GSIIMKNTKIPHLSYVGDSIIGSDCNFGCNTITANLRFDDEPVTLNIKGTKVKSVRKFGA
EEEEEECCCCCEEECCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHH
VIGDNVKTGIQVSLMPGVKVGSNSIIGANCLVDKDIEKESFVYKKDELIIKKRN
HHCCCCCCCEEEEEECCEEECCCCEEEEEEEECCCCCCCCEEEECCEEEEEECC
>Mature Secondary Structure
MDAVILCAGSGTRLYPITENRPKPMIPIAGKPILEHIIEKIENHVEKIYLVVGFEKEKII
CCEEEEECCCCCEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHEEEEEEEECCHHHEE
DYFYGNEKIEFIVQEKQLGTGHAVLMAKNYIKGDFLVLNGDVIFESDILEFLNYENAVGL
EEEECCCEEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCEEEHHHHHHHHCCCCCCCC
SKVDNPENFGVIELGYDNKVINLLEKPNEDEIKSKFTSNLINAGIYKLENFVFEILENLL
CCCCCCCCCCEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSERGEIELTDALKKLIESSKLYGIELNGYWNDIGRPWDVLSANNYFLKNIMPKISGNIE
CCCCCCEEHHHHHHHHHCCCCEEEEEECCEECCCCCCEEEECCCCEEHHHHHHHHCCCCC
NNVTITGNVIIEEGVTVKSNSVIEGPVIIKSGAFIGPLAYIRPNTVLMEDTFVGNSSEIK
CCEEEEEEEEEECCEEEECCCEEECCEEEECCCCCCCEEEECCCEEEEEEEECCCCCCCC
GSIIMKNTKIPHLSYVGDSIIGSDCNFGCNTITANLRFDDEPVTLNIKGTKVKSVRKFGA
EEEEEECCCCCEEECCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHH
VIGDNVKTGIQVSLMPGVKVGSNSIIGANCLVDKDIEKESFVYKKDELIIKKRN
HHCCCCCCCEEEEEECCEEECCCCEEEEEEEECCCCCCCCEEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA