Click here to switch to the map view.

The map label for this gene is lhr [C]

Identifier: 150398790

GI number: 150398790

Start: 27367

End: 29622

Strand: Reverse

Name: lhr [C]

Synonym: Mevan_0030

Alternate gene names: 150398790

Gene position: 29622-27367 (Counterclockwise)

Preceding gene: 150398798

Following gene: 150398789

Centisome position: 1.72

GC content: 29.39

Gene sequence:

>2256_bases
ATGACAAATGTACTAAACTTACTTAATGAAATTGGAATTGAAGAACTAAGGCCGCCTCAAAAAAAGGTAATTGAAGAAGG
CTTACTTGATAAATCCAAAAATTTTTTAATATGTATACCAACAGCAAGTGGTAAAACACTAATTGGCGAAATGGCACTAT
TAAATCATGTTTTGGACGAAAATTATAATTTAACTGGAAAAAAAGGACTTTTTATAGTGCCTCTAAAAGCATTAGCAAGT
GAAAAATTTGATGAATTTCAAAAAAAGTATGAAACGTATGGGATAAAAGTTGGAATGTCTATTGGGGACTATGATACAAA
GGAAGACCTTTCAAAATATAATATAATTATTACAACGTCTGAAAAATTGGATTCATTAATGAGGCACAATATTGAATGGA
TAAAAGACTTATCACTTGCAGTAATCGATGAAATTCATTTAATAGGCGATAATGAACGTGGCGGAACTTTAGAAGTAATT
TTAACAAAATTAAAAAACATTAATGCACAAATAGTTGGCCTTTCAGCAACTGTTGGAAACCCAGAAGAAATTGCAAATTG
GTTAAATGCAAAATTAGTAACGGATGAATGGCGACCTGTCGAATTAAAAAAAGGAATTTACCTTGAAAATGAAATAAATT
ATATAAATAATCAAGATTCTCAAAAAAAATCATTTAAGGCCGTTAAATCGATTTCTAGAAATAACTTAACTGATTTAATA
GTGGATTCAGTAAATGAGAAGGGTTCTTGTTTAATATTTTGTAATTCAAAAAGAAATGCAGTTGGGGAATCTAAAAAACA
TAATTTAACAAAATATCTCTCAAAAGCAGAGTTAAACGATCTAAATTCCATTTCTGAAGAAATATTATCTATTTTAGAAA
CCCCAACTGAAACATGTAAATCACTTTCAGAATGTATAAAAAAAGGAGTCGCATTTCACCATGCAGGGCTTACGTACCAG
CATAGAAAAGCTGTAGAAGAAGGATTTAGGAATAAAGTTATAAAAGTAATCTGTTGTACTCCTACACTTTCAGCAGGATT
AAATTTACCTTGTAGAAGGGCAATTATTCGAGATATCAGGCGTTACAGTCAAAACGGTCTTATAGATATTCCAAAATTAG
AAATTCATCAGTGTATCGGGCGAGCTGGAAGGCCGGGCCTTGACCCGTATGGTGAAGGAATAATCCTTGCAAAAAATGAA
AAAGACGTTGAAAAAGCATTTTTAGCTTTAACTGGACCTTTGGAAAATATTTATTCAAAATTATCAAACCAAAAAGTACT
CCGTGTTCATATATTGGGACTTATCGCTACGTTGGAAATAAAAAGTACTTCTGAATTAATTAATTTTATAAAAAATACAT
TTTATGCACACCAATATGGAAATTTGCATGGAGTTTTAACGAATGTTTCAAAGGTTGTGGAATTTTTAGAAAAAAACAAA
TTTATAGAAACATTAGATGATGATTTTACTCCAAAAAAAAACCGTGTTTTAGAATTAACGCTTGATAATTCAAATAATTT
AGTTTTAGATTCAAAAAGAAGGATGGATACATTAACAAATTTATCATTCAAACCTACAAATCTTGGAAAACGTGTTTCCG
AATTATATATTGACCCATTAAGTTCTGAAATAATAATTGAAGGGTTAAATGAACTAAAAGAAAAAATTAACGATATGGAT
AGGTCAAACATAGACCAGTATATATTTTACATAATTTCAAAGGCTACTGAAATGAGGCCCCTTTTAAGGGTTAAAATGGA
TGAAGAACTTGAGTTAATACAAGAAATGGATAAGTTAAAAATATCCGACTATTCAATTGAAAACATTGAAGCATTTAAAA
ATTCAAAAATGTTTCTTGACTGGATAAATGAAACTCCTGAAGAAGTAATTCTTGAAAAATATGGAATTGAGCCGGGAATT
TTAAGATACAAGGTAGACCAAGCTAGATGGATGACTTATTCTTCAAAAGAAATTGCAAAACTTGTAAAGTTAAATAATGA
TAAAATTTACAAGGCACTTTTAGAAATGGAATTTAGGATTGAATATGGTGCAAAAGAAGAGTTGATTGAACTTTTAAAAA
TTAAAAATATTGGTCGAGTAAGAGCTAGACGACTTTTTAACATTGGAATAAAATCAAAAATGGATATTTTAAAAAATCCT
GAAAAAATTATTTCTACTTTTGGAGATAAAGTCGGTAAAAAAATACTAGACGAATTTGGGTTAAAATACGGTCAACAAAA
ATTATCCGGCTTTTAG

Upstream 100 bases:

>100_bases
GAAGTTCACTTTTGAATATTAAGAGTTATATAAAATTATAGGGGTATTTTTTAAACTAGATAACTAGTAAATTATAAGAG
TAATTAAAACGTTGGAAAAC

Downstream 100 bases:

>100_bases
AAGCAATTATTGAAGAAAATGCTGTTTAATATTAAAAAAGATATGCTCAGCTGTCCCCGTTGTCTTCATCGAACGAATTC
TCAGTGAAGTCGGCACTCAT

Product: DEAD/DEAH box helicase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 751; Mature: 750

Protein sequence:

>751_residues
MTNVLNLLNEIGIEELRPPQKKVIEEGLLDKSKNFLICIPTASGKTLIGEMALLNHVLDENYNLTGKKGLFIVPLKALAS
EKFDEFQKKYETYGIKVGMSIGDYDTKEDLSKYNIIITTSEKLDSLMRHNIEWIKDLSLAVIDEIHLIGDNERGGTLEVI
LTKLKNINAQIVGLSATVGNPEEIANWLNAKLVTDEWRPVELKKGIYLENEINYINNQDSQKKSFKAVKSISRNNLTDLI
VDSVNEKGSCLIFCNSKRNAVGESKKHNLTKYLSKAELNDLNSISEEILSILETPTETCKSLSECIKKGVAFHHAGLTYQ
HRKAVEEGFRNKVIKVICCTPTLSAGLNLPCRRAIIRDIRRYSQNGLIDIPKLEIHQCIGRAGRPGLDPYGEGIILAKNE
KDVEKAFLALTGPLENIYSKLSNQKVLRVHILGLIATLEIKSTSELINFIKNTFYAHQYGNLHGVLTNVSKVVEFLEKNK
FIETLDDDFTPKKNRVLELTLDNSNNLVLDSKRRMDTLTNLSFKPTNLGKRVSELYIDPLSSEIIIEGLNELKEKINDMD
RSNIDQYIFYIISKATEMRPLLRVKMDEELELIQEMDKLKISDYSIENIEAFKNSKMFLDWINETPEEVILEKYGIEPGI
LRYKVDQARWMTYSSKEIAKLVKLNNDKIYKALLEMEFRIEYGAKEELIELLKIKNIGRVRARRLFNIGIKSKMDILKNP
EKIISTFGDKVGKKILDEFGLKYGQQKLSGF

Sequences:

>Translated_751_residues
MTNVLNLLNEIGIEELRPPQKKVIEEGLLDKSKNFLICIPTASGKTLIGEMALLNHVLDENYNLTGKKGLFIVPLKALAS
EKFDEFQKKYETYGIKVGMSIGDYDTKEDLSKYNIIITTSEKLDSLMRHNIEWIKDLSLAVIDEIHLIGDNERGGTLEVI
LTKLKNINAQIVGLSATVGNPEEIANWLNAKLVTDEWRPVELKKGIYLENEINYINNQDSQKKSFKAVKSISRNNLTDLI
VDSVNEKGSCLIFCNSKRNAVGESKKHNLTKYLSKAELNDLNSISEEILSILETPTETCKSLSECIKKGVAFHHAGLTYQ
HRKAVEEGFRNKVIKVICCTPTLSAGLNLPCRRAIIRDIRRYSQNGLIDIPKLEIHQCIGRAGRPGLDPYGEGIILAKNE
KDVEKAFLALTGPLENIYSKLSNQKVLRVHILGLIATLEIKSTSELINFIKNTFYAHQYGNLHGVLTNVSKVVEFLEKNK
FIETLDDDFTPKKNRVLELTLDNSNNLVLDSKRRMDTLTNLSFKPTNLGKRVSELYIDPLSSEIIIEGLNELKEKINDMD
RSNIDQYIFYIISKATEMRPLLRVKMDEELELIQEMDKLKISDYSIENIEAFKNSKMFLDWINETPEEVILEKYGIEPGI
LRYKVDQARWMTYSSKEIAKLVKLNNDKIYKALLEMEFRIEYGAKEELIELLKIKNIGRVRARRLFNIGIKSKMDILKNP
EKIISTFGDKVGKKILDEFGLKYGQQKLSGF
>Mature_750_residues
TNVLNLLNEIGIEELRPPQKKVIEEGLLDKSKNFLICIPTASGKTLIGEMALLNHVLDENYNLTGKKGLFIVPLKALASE
KFDEFQKKYETYGIKVGMSIGDYDTKEDLSKYNIIITTSEKLDSLMRHNIEWIKDLSLAVIDEIHLIGDNERGGTLEVIL
TKLKNINAQIVGLSATVGNPEEIANWLNAKLVTDEWRPVELKKGIYLENEINYINNQDSQKKSFKAVKSISRNNLTDLIV
DSVNEKGSCLIFCNSKRNAVGESKKHNLTKYLSKAELNDLNSISEEILSILETPTETCKSLSECIKKGVAFHHAGLTYQH
RKAVEEGFRNKVIKVICCTPTLSAGLNLPCRRAIIRDIRRYSQNGLIDIPKLEIHQCIGRAGRPGLDPYGEGIILAKNEK
DVEKAFLALTGPLENIYSKLSNQKVLRVHILGLIATLEIKSTSELINFIKNTFYAHQYGNLHGVLTNVSKVVEFLEKNKF
IETLDDDFTPKKNRVLELTLDNSNNLVLDSKRRMDTLTNLSFKPTNLGKRVSELYIDPLSSEIIIEGLNELKEKINDMDR
SNIDQYIFYIISKATEMRPLLRVKMDEELELIQEMDKLKISDYSIENIEAFKNSKMFLDWINETPEEVILEKYGIEPGIL
RYKVDQARWMTYSSKEIAKLVKLNNDKIYKALLEMEFRIEYGAKEELIELLKIKNIGRVRARRLFNIGIKSKMDILKNPE
KIISTFGDKVGKKILDEFGLKYGQQKLSGF

Specific function: Unknown

COG id: COG1204

COG function: function code R; Superfamily II helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain

Homologues:

Organism=Homo sapiens, GI139394648, Length=793, Percent_Identity=25.7250945775536, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI110556640, Length=471, Percent_Identity=32.2717622080679, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI76880486, Length=458, Percent_Identity=31.2227074235808, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI40217847, Length=398, Percent_Identity=30.9045226130653, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI169218225, Length=609, Percent_Identity=27.5862068965517, Blast_Score=167, Evalue=5e-41,
Organism=Homo sapiens, GI130484567, Length=554, Percent_Identity=27.2563176895307, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI193211480, Length=425, Percent_Identity=24.2352941176471, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI67782311, Length=188, Percent_Identity=29.7872340425532, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI1787942, Length=431, Percent_Identity=22.969837587007, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71995032, Length=747, Percent_Identity=26.6398929049531, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17537127, Length=617, Percent_Identity=28.2009724473258, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17537519, Length=561, Percent_Identity=27.6292335115865, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI86563272, Length=810, Percent_Identity=24.0740740740741, Blast_Score=150, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17542826, Length=478, Percent_Identity=23.0125523012552, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71995036, Length=449, Percent_Identity=27.8396436525612, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI133930973, Length=185, Percent_Identity=30.8108108108108, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI9755332, Length=469, Percent_Identity=29.8507462686567, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6321020, Length=624, Percent_Identity=27.724358974359, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321710, Length=494, Percent_Identity=29.3522267206478, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322411, Length=444, Percent_Identity=26.3513513513513, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323430, Length=200, Percent_Identity=29, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24660651, Length=783, Percent_Identity=26.4367816091954, Blast_Score=212, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24647182, Length=457, Percent_Identity=30.1969365426696, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI28574898, Length=605, Percent_Identity=26.7768595041322, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI17933644, Length=450, Percent_Identity=29.7777777777778, Blast_Score=161, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17864608, Length=432, Percent_Identity=25.462962962963, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17933658, Length=473, Percent_Identity=22.8329809725159, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HELS_METVS (A6UN73)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001322557.1
- ProteinModelPortal:   A6UN73
- SMR:   A6UN73
- STRING:   A6UN73
- GeneID:   5325697
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_0030
- eggNOG:   arNOG04277
- HOGENOM:   HBG496908
- OMA:   RIEYGAK
- ProtClustDB:   CLSK926269
- HAMAP:   MF_00442
- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022965
- InterPro:   IPR003583
- SMART:   SM00487
- SMART:   SM00490
- SMART:   SM00278

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C

EC number: 3.6.1.-

Molecular weight: Translated: 85592; Mature: 85461

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNVLNLLNEIGIEELRPPQKKVIEEGLLDKSKNFLICIPTASGKTLIGEMALLNHVLDE
CCHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
NYNLTGKKGLFIVPLKALASEKFDEFQKKYETYGIKVGMSIGDYDTKEDLSKYNIIITTS
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHEEEEEEEH
EKLDSLMRHNIEWIKDLSLAVIDEIHLIGDNERGGTLEVILTKLKNINAQIVGLSATVGN
HHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCC
PEEIANWLNAKLVTDEWRPVELKKGIYLENEINYINNQDSQKKSFKAVKSISRNNLTDLI
HHHHHHHHCCEEECCCCCCEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHH
VDSVNEKGSCLIFCNSKRNAVGESKKHNLTKYLSKAELNDLNSISEEILSILETPTETCK
HHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SLSECIKKGVAFHHAGLTYQHRKAVEEGFRNKVIKVICCTPTLSAGLNLPCRRAIIRDIR
HHHHHHHHCCEEHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
RYSQNGLIDIPKLEIHQCIGRAGRPGLDPYGEGIILAKNEKDVEKAFLALTGPLENIYSK
HHCCCCCEECCHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHH
LSNQKVLRVHILGLIATLEIKSTSELINFIKNTFYAHQYGNLHGVLTNVSKVVEFLEKNK
HCCCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
FIETLDDDFTPKKNRVLELTLDNSNNLVLDSKRRMDTLTNLSFKPTNLGKRVSELYIDPL
HHHHHCCCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
SSEIIIEGLNELKEKINDMDRSNIDQYIFYIISKATEMRPLLRVKMDEELELIQEMDKLK
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHCC
ISDYSIENIEAFKNSKMFLDWINETPEEVILEKYGIEPGILRYKVDQARWMTYSSKEIAK
CCCCCHHHHHHHCCCCCEEEHHCCCHHHHHHHHHCCCCCEEEEEECHHHHEECCHHHHHH
LVKLNNDKIYKALLEMEFRIEYGAKEELIELLKIKNIGRVRARRLFNIGIKSKMDILKNP
HHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCH
EKIISTFGDKVGKKILDEFGLKYGQQKLSGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNVLNLLNEIGIEELRPPQKKVIEEGLLDKSKNFLICIPTASGKTLIGEMALLNHVLDE
CHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
NYNLTGKKGLFIVPLKALASEKFDEFQKKYETYGIKVGMSIGDYDTKEDLSKYNIIITTS
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHEEEEEEEH
EKLDSLMRHNIEWIKDLSLAVIDEIHLIGDNERGGTLEVILTKLKNINAQIVGLSATVGN
HHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCC
PEEIANWLNAKLVTDEWRPVELKKGIYLENEINYINNQDSQKKSFKAVKSISRNNLTDLI
HHHHHHHHCCEEECCCCCCEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHH
VDSVNEKGSCLIFCNSKRNAVGESKKHNLTKYLSKAELNDLNSISEEILSILETPTETCK
HHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SLSECIKKGVAFHHAGLTYQHRKAVEEGFRNKVIKVICCTPTLSAGLNLPCRRAIIRDIR
HHHHHHHHCCEEHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
RYSQNGLIDIPKLEIHQCIGRAGRPGLDPYGEGIILAKNEKDVEKAFLALTGPLENIYSK
HHCCCCCEECCHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHH
LSNQKVLRVHILGLIATLEIKSTSELINFIKNTFYAHQYGNLHGVLTNVSKVVEFLEKNK
HCCCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
FIETLDDDFTPKKNRVLELTLDNSNNLVLDSKRRMDTLTNLSFKPTNLGKRVSELYIDPL
HHHHHCCCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
SSEIIIEGLNELKEKINDMDRSNIDQYIFYIISKATEMRPLLRVKMDEELELIQEMDKLK
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHCC
ISDYSIENIEAFKNSKMFLDWINETPEEVILEKYGIEPGILRYKVDQARWMTYSSKEIAK
CCCCCHHHHHHHCCCCCEEEHHCCCHHHHHHHHHCCCCCEEEEEECHHHHEECCHHHHHH
LVKLNNDKIYKALLEMEFRIEYGAKEELIELLKIKNIGRVRARRLFNIGIKSKMDILKNP
HHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCH
EKIISTFGDKVGKKILDEFGLKYGQQKLSGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA