Click here to switch to the map view.

The map label for this gene is hssS

Identifier: 150394869

GI number: 150394869

Start: 2518710

End: 2520083

Strand: Direct

Name: hssS

Synonym: SaurJH1_2432

Alternate gene names: 150394869

Gene position: 2518710-2520083 (Clockwise)

Preceding gene: 150394868

Following gene: 150394870

Centisome position: 86.66

GC content: 31.3

Gene sequence:

>1374_bases
ATGTTTAAAACACTCTATGCTAGAATTGCGATTTATTCCATTACGGTTATTTTATTTAGTGCATTAATAAGTTTTGTATT
AACAAATGTTTACTATCATTATAATTTAAAAGCATCTAATGACGCGAAAATCATGAAGACACTTAAAGAAGCAAGACAAT
ATGAACAATCAGCTAAACCAACGCACATTCAACAATATTTCAAACATTTAGGGCAAATGAATTACCAAATAATGACCGTT
GATCAAAAAGGTCATAAGACATTTTATGGGGAGCCATTTAGAGAAGATACTTTATCACAAAATGCTATTAACAACGTATT
AAATAATAAAGATTACCATGGTATTAAAGATAAACCATTCGCATTATTCGTAACTGGATTTTTCGACAATGTAACAGATA
ATACTGTTGGTATTAACTTTAAGACAAAAGACGGTTCAATAGCAGTATTCATGCGTCCAGATATTGGAGAAACATTTAGC
GAGTTTAGAACATTCTTAGCCGTCTTGTTAATGTTGTTATTATTTATCTCGATTTCATTAGTTATCGCATCAACCTATTC
AATCATTCGTCCAGTAAAAAAGTTAAAGCTAGCGACCGAACGCTTAATTGATGGTGATTTTGAAACACCTATCAAACAAA
CACGCAAAGATGAAATTGGAACATTACAGTATCACTTTAATAAGATGAGAGAGTCATTGGGACAAGTTGATCAAATGAGG
CAGCATTTTGTACAAAATGTATCTCATGAAATCAAAACACCATTAACACATATTCATCATTTATTAAGCGAGTTACAACA
AACTTCTGATAAAACATTAAGACAACAATATATAAATGATATTTATACCATTACAACGCAGCTGAGCGGATTAACAACTG
AATTGTTACTCTTATCCGAATTAGATAATCACCAACATTTATTATTCGATGATAAGATTCAAGTCGATCAACTCATTAAA
GATATCATTCGACATGAACAATTTGCTGCTGATGAAAAGTCGTTAATCATTTTAGCTGACCTAGAATCAATCAATTTCCT
AGGAAATCAACGTTTGTTACATCAAGCATTGAGTAATTTATTAATAAATGCTATTAAGTATACAGATGTTGGTGGTGCCA
TTGACATCGCTTTGCAACATAGTCACAACAATATCATTTTCACAATAAGTAATGATGGTTCACCAATTAGTCCACAAGCT
GAAGCACGTTTATTTGAACGTTTTTATAAAGTGAGCAAACATGATAATAGCAATGGTTTAGGTCTTGCAATTACAAAATC
CATCATTGAATTGCATCATGGTACAATCCAATTCACACAAAGTAACGAGTATGTAACCACCTTTACTATTACACTGCCAA
ATAATTCACATTAA

Upstream 100 bases:

>100_bases
GTTGACGTTCATATTAAGCGACTACGCCAAAGATTAAAAAAATTAAATGCCACACTTACAATTGAAACAGTAAGAGGACA
AGGCTATAAGGTGGAGAATC

Downstream 100 bases:

>100_bases
TCTCTACCTCCTGAAAAAACATTTCTGTTTTTATTTCAGGAGGTATCTTTTATATTGATTAGCGCTTTCTAGCCACTTAA
CATTTAATTTCTACCATTCA

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTV
DQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFS
EFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIQVDQLIK
DIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQA
EARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSH

Sequences:

>Translated_457_residues
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTV
DQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFS
EFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIQVDQLIK
DIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQA
EARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSH
>Mature_457_residues
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTV
DQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFS
EFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIQVDQLIK
DIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQA
EARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSH

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=30.9859154929577, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786783, Length=296, Percent_Identity=27.7027027027027, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790346, Length=294, Percent_Identity=25.5102040816327, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790861, Length=288, Percent_Identity=25.6944444444444, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788279, Length=296, Percent_Identity=27.027027027027, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787894, Length=290, Percent_Identity=25.5172413793103, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=23.2142857142857, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1789403, Length=358, Percent_Identity=26.536312849162, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=23.8095238095238, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=28.8537549407115, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=25.7918552036199, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=24.7967479674797, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789149, Length=394, Percent_Identity=21.3197969543147, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=24.3362831858407, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSSS_STAA1 (A7X5Y6)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442936.1
- ProteinModelPortal:   A7X5Y6
- SMR:   A7X5Y6
- STRING:   A7X5Y6
- EnsemblBacteria:   EBSTAT00000002881
- GeneID:   5561488
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2346
- eggNOG:   COG0642
- GeneTree:   EBGT00050000023863
- HOGENOM:   HBG334875
- OMA:   MAKIFER
- ProtClustDB:   CLSK2460869
- BioCyc:   SAUR418127:SAHV_2346-MONOMER
- GO:   GO:0009405
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 52387; Mature: 52387

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x188d89ac)-; HASH(0x1850821c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCC
THIQQYFKHLGQMNYQIMTVDQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPF
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCE
ALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISL
EEEEEEHHCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LDNHQHLLFDDKIQVDQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNL
CCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHH
LINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGL
HHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSH
CHHHHHHHHHHHCCEEEEEECCCEEEEEEEECCCCCH
>Mature Secondary Structure
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCC
THIQQYFKHLGQMNYQIMTVDQKGHKTFYGEPFREDTLSQNAINNVLNNKDYHGIKDKPF
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCE
ALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISL
EEEEEEHHCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LDNHQHLLFDDKIQVDQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNL
CCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHH
LINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGL
HHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSH
CHHHHHHHHHHHCCEEEEEECCCEEEEEEEECCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA