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The map label for this gene is hssR

Identifier: 150394868

GI number: 150394868

Start: 2518043

End: 2518717

Strand: Direct

Name: hssR

Synonym: SaurJH1_2431

Alternate gene names: 150394868

Gene position: 2518043-2518717 (Clockwise)

Preceding gene: 150394865

Following gene: 150394869

Centisome position: 86.63

GC content: 35.26

Gene sequence:

>675_bases
ATGGTGCAATGTCTTGTTGTCGATGACGATCCTCGAATCCTAAATTATATAGCTAGCCATTTACAAACAGAGCACATTGA
TGCATACACACAACCAAGTGGTGAAGCTGCATTAAAACTTTTAGAAAAACAGCGTGTCGATATTGCAGTGGTAGATATTA
TGATGGATGGTATGGACGGCTTTCAATTATGTAATACATTAAAAAATGATTATGATATACCAGTTATTATGTTAACAGCG
CGGGATGCACTTAGTGACAAAGAGCGTGCGTTTATAAGTGGTACTGACGATTATGTAACCAAACCCTTTGAGGTTAAGGA
ACTTATTTTTAGAATTCGTGCGGTATTACGTCGATATAATATCAATTCAAATTCAGAAATGACTATTGGCAACTTAACGC
TAAACCAATCCTATTTGGAACTCCAAGTATCTAATAAAACGATGACGTTACCGAACAAGGAATTTCAATTATTATTTATG
CTTGCAGCACGTCCTAAGCAAATCTTTACTCGTGAACAAATAATAGAAAAAATTTGGGGCTATGATTATGAAGGAGATGA
ACGAACAGTTGACGTTCATATTAAGCGACTACGCCAAAGATTAAAAAAATTAAATGCCACACTTACAATTGAAACAGTAA
GAGGACAAGGCTATAAGGTGGAGAATCATGTTTAA

Upstream 100 bases:

>100_bases
AGTATAAGGTTGAAATATGAACTCAATATGAACAATTGTTTTTTTACGCAAAAATATTTTACATGTATAATAAATGAAAA
AGATAAGGGAGTTTATAGCT

Downstream 100 bases:

>100_bases
AACACTCTATGCTAGAATTGCGATTTATTCCATTACGGTTATTTTATTTAGTGCATTAATAAGTTTTGTATTAACAAATG
TTTACTATCATTATAATTTA

Product: response regulator receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDGFQLCNTLKNDYDIPVIMLTA
RDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYNINSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFM
LAARPKQIFTREQIIEKIWGYDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV

Sequences:

>Translated_224_residues
MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDGFQLCNTLKNDYDIPVIMLTA
RDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYNINSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFM
LAARPKQIFTREQIIEKIWGYDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
>Mature_224_residues
MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDGFQLCNTLKNDYDIPVIMLTA
RDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYNINSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFM
LAARPKQIFTREQIIEKIWGYDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=37.2727272727273, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=33.4841628959276, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=35.3211009174312, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32.8888888888889, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=32.1266968325792, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=32.15859030837, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=31.3636363636364, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=27.7533039647577, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=26.5765765765766, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=26.6968325791855, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=27.4261603375527, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=28.3783783783784, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786911, Length=205, Percent_Identity=24.8780487804878, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1788905, Length=104, Percent_Identity=35.5769230769231, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): HSSR_STAA1 (A7X5Y5)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442935.1
- ProteinModelPortal:   A7X5Y5
- SMR:   A7X5Y5
- STRING:   A7X5Y5
- EnsemblBacteria:   EBSTAT00000005324
- GeneID:   5559368
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2345
- eggNOG:   COG0745
- GeneTree:   EBGT00050000024053
- HOGENOM:   HBG753323
- OMA:   TEHIDAF
- ProtClustDB:   CLSK885926
- BioCyc:   SAUR418127:SAHV_2345-MONOMER
- GO:   GO:0005737
- GO:   GO:0009405
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 25946; Mature: 25946

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50110 RESPONSE_REGULATORY; PS00230 MAP1B_NEURAXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDG
CEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCH
FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
HHHHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHHHHCC
INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWG
CCCCCCEEEEEEEECCEEEEEEECCCEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCC
YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
CCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCCC
>Mature Secondary Structure
MVQCLVVDDDPRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVVDIMMDGMDG
CEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCH
FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
HHHHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHHHHCC
INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLAARPKQIFTREQIIEKIWG
CCCCCCEEEEEEEECCEEEEEEECCCEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCC
YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
CCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA