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The map label for this gene is mutS [H]

Identifier: 150394563

GI number: 150394563

Start: 2198819

End: 2200429

Strand: Direct

Name: mutS [H]

Synonym: SaurJH1_2122

Alternate gene names: 150394563

Gene position: 2198819-2200429 (Clockwise)

Preceding gene: 150394562

Following gene: 150394568

Centisome position: 75.65

GC content: 30.42

Gene sequence:

>1611_bases
ATGAGCACAAATCAAACATTTTTAATATTTGTTATAGCAATTATTCTACTTACATCTGTAATAGGAATTGTTGGACGATA
CATGAGTCGTCAACGTCTATTAAAATCTATGGAAACATTATGGCAAACGATTTCTCCATTAGAAGCTTTTATCAGACCGA
ACTCACATTTCGACTATGAGTATAAGCTCTACAAGGAAAAATTTGAATCACATTCATTAGTTGATGATAAAACTTGGTCC
GACTTAAATATGAATGCAATTTTTCATAAGATGAATTATAATTTAACAGCTATTGGTGAAATGAAGCTATATGCCTGTTT
ACGTGGAATGCTTTCAATTACGAACAAATCATTACTTAGTTTATTTAATGATAATGCTGAATTTAGAAAAAACGTAACAT
ATCATTTAGCTTTGATTGGTAAAACTGTTTATCCAACATTTCCAGACCAAATCACACCGGTAAAACGTCAAAATATATTG
TTTCTATGCCCGTTTTTACCAGTTATCTCATTTGCAGTTATATTTATTAATTCACAAGTTGGTATTTTATTATTTCTTAT
GAGTTGCCTATTTAATATCATTTTATCAGCAACTTTAAAGCGTACATATGAGGATGACTTAAAATCTATCTTTTATGCAT
CCAATGTTTTAAAACAAGGCTATACTATCTCAAAAATTAAACATGCTCCACAACCTGAAGTCAATTTTAAGCAATTTAGA
ACAGCACGTCATTTAACGAGTGTTTTAGCTGAAGTTAATGATGAAGATATCGGAGCTATGGTAATTAAACTAGTTAAACT
TATTTTCATGCTTGATTATGTTTTATTTCATTCAATTCAAAAAAGCTATACAACACATATGAATGAGCTTAAAAATTGTT
TCGATTACATAGCTGAATTAGATAATCATTATGCATTAGCAATGTATCGTAGAACGCTAGAATGTTATACTGAACCACAA
ATTGATGATACAAATGATGGCATAGTATTCTCTGAGTTAACACATCCACTCATAGCAGATGCAGTAGCCAATGATTTCTC
ACTTTCACAAAATATACTGTTAACTGGGTCTAATGCTTCGGGTAAATCAACATTTATGAAATCCATAGCAATAAACATTA
TTCTTGCATCGGCTATACAAACAGTTACCGCAAGCAAATTTGTATATCAACCTGGAATTGTGTTCACGTCAATGGCAAAT
GCCGATGATGTGTTATCAGGCGATAGTTATTTTATGGCTGAATTAAAATCTATTAAGCGTATTGTTGAAATTCCAGATAA
TCAAAAAATATACTGCTTTATCGATGAAATTTTTAAAGGTACCAACACAACTGAACGAATTGCCGCTTCAGAATCAGTAC
TATCATTTTTACATGAAAAATCTAACTTTAGAGTTATTGCAGCAACACATGATATTGAGTTAGCTGAACTCTTAAAACAA
CGTTATGAAAATTATCATTTCAATGAGGTAATAGAAAATAATAACATACATTTTGATTACAAAATTAAGCCTGGCAAAGC
AAATACTCGTAATGCCATCGAATTATTAAAAATCACTTCATTTCCAGCAAAAATATATGAACGAGCAAAAGATAATGTTT
CCAATGGTTAG

Upstream 100 bases:

>100_bases
TGTTTTTATCAAAATTCATTGTTAAGACACTTTCTTTATGAAATAATAATATTATTGAAGTATATTTTTATTATTATTAA
AAATAAATAAGGAGATACTT

Downstream 100 bases:

>100_bases
CATGAATCTTGAACATCAATCAATGTTCAAGTCGCAACATTGTTATATTGACAGTCTTTGACTAAATGAAAATACGCTTG
TAATAAGTTTTTTCAATACT

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSTNQTFLIFVIAIILLTSVIGIVGRYMSRQRLLKSMETLWQTISPLEAFIRPNSHFDYEYKLYKEKFESHSLVDDKTWS
DLNMNAIFHKMNYNLTAIGEMKLYACLRGMLSITNKSLLSLFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNIL
FLCPFLPVISFAVIFINSQVGILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFR
TARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAELDNHYALAMYRRTLECYTEPQ
IDDTNDGIVFSELTHPLIADAVANDFSLSQNILLTGSNASGKSTFMKSIAINIILASAIQTVTASKFVYQPGIVFTSMAN
ADDVLSGDSYFMAELKSIKRIVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQ
RYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG

Sequences:

>Translated_536_residues
MSTNQTFLIFVIAIILLTSVIGIVGRYMSRQRLLKSMETLWQTISPLEAFIRPNSHFDYEYKLYKEKFESHSLVDDKTWS
DLNMNAIFHKMNYNLTAIGEMKLYACLRGMLSITNKSLLSLFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNIL
FLCPFLPVISFAVIFINSQVGILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFR
TARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAELDNHYALAMYRRTLECYTEPQ
IDDTNDGIVFSELTHPLIADAVANDFSLSQNILLTGSNASGKSTFMKSIAINIILASAIQTVTASKFVYQPGIVFTSMAN
ADDVLSGDSYFMAELKSIKRIVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQ
RYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG
>Mature_535_residues
STNQTFLIFVIAIILLTSVIGIVGRYMSRQRLLKSMETLWQTISPLEAFIRPNSHFDYEYKLYKEKFESHSLVDDKTWSD
LNMNAIFHKMNYNLTAIGEMKLYACLRGMLSITNKSLLSLFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNILF
LCPFLPVISFAVIFINSQVGILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFRT
ARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAELDNHYALAMYRRTLECYTEPQI
DDTNDGIVFSELTHPLIADAVANDFSLSQNILLTGSNASGKSTFMKSIAINIILASAIQTVTASKFVYQPGIVFTSMANA
DDVLSGDSYFMAELKSIKRIVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQR
YENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=285, Percent_Identity=27.719298245614, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI284813531, Length=280, Percent_Identity=25, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789089, Length=261, Percent_Identity=28.3524904214559, Blast_Score=89, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17508445, Length=245, Percent_Identity=27.7551020408163, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321912, Length=277, Percent_Identity=26.7148014440433, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319935, Length=232, Percent_Identity=26.2931034482759, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320302, Length=142, Percent_Identity=30.2816901408451, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24664545, Length=297, Percent_Identity=26.9360269360269, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24584320, Length=249, Percent_Identity=21.285140562249, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 61257; Mature: 61125

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNQTFLIFVIAIILLTSVIGIVGRYMSRQRLLKSMETLWQTISPLEAFIRPNSHFDYE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
YKLYKEKFESHSLVDDKTWSDLNMNAIFHKMNYNLTAIGEMKLYACLRGMLSITNKSLLS
HHHHHHHHHCCCCCCCCCCCCCCHHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNILFLCPFLPVISFAVIFINSQV
HHCCCHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCH
GILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHH
TARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAEL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNHYALAMYRRTLECYTEPQIDDTNDGIVFSELTHPLIADAVANDFSLSQNILLTGSNAS
CCCHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
GKSTFMKSIAINIILASAIQTVTASKFVYQPGIVFTSMANADDVLSGDSYFMAELKSIKR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
IVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQ
HHCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHH
RYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG
HHHCCCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STNQTFLIFVIAIILLTSVIGIVGRYMSRQRLLKSMETLWQTISPLEAFIRPNSHFDYE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
YKLYKEKFESHSLVDDKTWSDLNMNAIFHKMNYNLTAIGEMKLYACLRGMLSITNKSLLS
HHHHHHHHHCCCCCCCCCCCCCCHHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNILFLCPFLPVISFAVIFINSQV
HHCCCHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCH
GILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHH
TARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAEL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNHYALAMYRRTLECYTEPQIDDTNDGIVFSELTHPLIADAVANDFSLSQNILLTGSNAS
CCCHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
GKSTFMKSIAINIILASAIQTVTASKFVYQPGIVFTSMANADDVLSGDSYFMAELKSIKR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
IVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQ
HHCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHH
RYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG
HHHCCCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]