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The map label for this gene is hmrM [H]

Identifier: 150010483

GI number: 150010483

Start: 4755184

End: 4756476

Strand: Direct

Name: hmrM [H]

Synonym: BDI_3924

Alternate gene names: 150010483

Gene position: 4755184-4756476 (Clockwise)

Preceding gene: 150010482

Following gene: 150010487

Centisome position: 98.83

GC content: 36.81

Gene sequence:

>1293_bases
ATGAATTATACATATAAACAAATATGGCTCATCAACTTTCCTGTAATGATGAGCATCTTAATGGAACAATTAATCAATAT
TACGGATGCTGTTTTCTTAGGCCACGTTGGAGAGATAGAATTAGGAGCGTCCGCTATCGCCGGAATTTATTATTTAGCGA
TTTATATGCTTGGTTTTGGATTTAGCATTGGGTTGCAAGTAATGGTAGCTCGAAGGAATGGAGAGCAAGATTACAAGGAA
ACCGGCAAGACCTTTTTTCAAGGCTTATTTTTCCTTTTGGGATTGGCTATCTTTCTTTACCTTCTCATTCATACGGTTTC
CCCATTTATACTAAAGAAGCTGATCGTTTCCTCGGATATTTATCGAGCGGTAATTCTATACTTGGATTGGCGTAGCTTTG
GATTGTTGTTTTCATTCCCATTTTTAGCGATACGTTCTTTTTTAGTGGGGATAACGCATACAAAAGCTCTATCTTGGGCT
GCTGCCATAGCGGTATTAATCAATATTCCTTTAAATTTTTATTTGATATTCACTAGGGAATTAGGAATCTCGGGGGCGGC
AATTGCCTCTTCTTTGGCAGAGATGGGCTCCTTTATGATGCTTTCCTTCTATATGTGGATACGATTGGATAAAGAAAAAT
ATGGGTTAAGGCCGGTCTATAATGGTAATTTACTTATAAAAGTCTTGAAGTTATCAACATGGAGTATGCTTCATGCGCTT
ATTAGTGTAGCCCCTTGGTTCTTGTTTTTCGTTTCAATTGAACATTTGGGAAAAATAGAGTTAGCGATTTCCAATATAAC
CCGGAGCGTATCGGCTATATTTTTTGTGATAGCGAATTCTTTTGCGCTTACAACAGGCTCATTAGTCAGTAATGCGATTG
GTGCGGGAGAAGGGAAGACACTATTTTCAATCTGTAGTAAAATTCTGAAATTAGGTTATACCATAGGATTTCCCTTGGTT
GCGATTGCTTTATTGTGTAATCGATGGATTATTGGTTTTTATACGAGTAATGAACTATTGATACAATTAGCTTTTGCCCC
TTTTGTTGTAATGTTGTTGAATTACACTTTCGCTTTACCGGGTTATGTATATTTGAATGCTGTCGGAGGAACAGGAAAGA
CACAAATGACTTTCCTTTTTCAAGTTACGACAACAGCCATATATTTGGTTTATCTTTATTGGTTATGTCGCTACACGCAA
GCTCCTCTCGCAATCTATTTAACAGCGGAATACGTCTTTGTAATTCTGTTGGCTACACAATCTATTTTTTATTTGAAAAA
GAAACATTACTAA

Upstream 100 bases:

>100_bases
TATTTGTCACGGAGATTTTATATCCTTTTATTTTATGGATTACGAAATAACATACTGCATAAAAGCGGTATGTTGTATCG
CACTATTATACAGTTGAGCA

Downstream 100 bases:

>100_bases
AAAACGAAGAAAGATGATGACTAAAATATATCCACGTACGGGAAATAAACAAACCGTATATCTAAATACCATTATACAAG
ATCCTCAAATAGTGGGATTG

Product: BexA cation effux pump

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter; Na(+)/drug antiporter [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASAIAGIYYLAIYMLGFGFSIGLQVMVARRNGEQDYKE
TGKTFFQGLFFLLGLAIFLYLLIHTVSPFILKKLIVSSDIYRAVILYLDWRSFGLLFSFPFLAIRSFLVGITHTKALSWA
AAIAVLINIPLNFYLIFTRELGISGAAIASSLAEMGSFMMLSFYMWIRLDKEKYGLRPVYNGNLLIKVLKLSTWSMLHAL
ISVAPWFLFFVSIEHLGKIELAISNITRSVSAIFFVIANSFALTTGSLVSNAIGAGEGKTLFSICSKILKLGYTIGFPLV
AIALLCNRWIIGFYTSNELLIQLAFAPFVVMLLNYTFALPGYVYLNAVGGTGKTQMTFLFQVTTTAIYLVYLYWLCRYTQ
APLAIYLTAEYVFVILLATQSIFYLKKKHY

Sequences:

>Translated_430_residues
MNYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASAIAGIYYLAIYMLGFGFSIGLQVMVARRNGEQDYKE
TGKTFFQGLFFLLGLAIFLYLLIHTVSPFILKKLIVSSDIYRAVILYLDWRSFGLLFSFPFLAIRSFLVGITHTKALSWA
AAIAVLINIPLNFYLIFTRELGISGAAIASSLAEMGSFMMLSFYMWIRLDKEKYGLRPVYNGNLLIKVLKLSTWSMLHAL
ISVAPWFLFFVSIEHLGKIELAISNITRSVSAIFFVIANSFALTTGSLVSNAIGAGEGKTLFSICSKILKLGYTIGFPLV
AIALLCNRWIIGFYTSNELLIQLAFAPFVVMLLNYTFALPGYVYLNAVGGTGKTQMTFLFQVTTTAIYLVYLYWLCRYTQ
APLAIYLTAEYVFVILLATQSIFYLKKKHY
>Mature_430_residues
MNYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASAIAGIYYLAIYMLGFGFSIGLQVMVARRNGEQDYKE
TGKTFFQGLFFLLGLAIFLYLLIHTVSPFILKKLIVSSDIYRAVILYLDWRSFGLLFSFPFLAIRSFLVGITHTKALSWA
AAIAVLINIPLNFYLIFTRELGISGAAIASSLAEMGSFMMLSFYMWIRLDKEKYGLRPVYNGNLLIKVLKLSTWSMLHAL
ISVAPWFLFFVSIEHLGKIELAISNITRSVSAIFFVIANSFALTTGSLVSNAIGAGEGKTLFSICSKILKLGYTIGFPLV
AIALLCNRWIIGFYTSNELLIQLAFAPFVVMLLNYTFALPGYVYLNAVGGTGKTQMTFLFQVTTTAIYLVYLYWLCRYTQ
APLAIYLTAEYVFVILLATQSIFYLKKKHY

Specific function: Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to norfloxacin, acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48402; Mature: 48402

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASAIAGIYYLAIYMLGFG
CCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHC
FSIGLQVMVARRNGEQDYKETGKTFFQGLFFLLGLAIFLYLLIHTVSPFILKKLIVSSDI
HHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRAVILYLDWRSFGLLFSFPFLAIRSFLVGITHTKALSWAAAIAVLINIPLNFYLIFTRE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
LGISGAAIASSLAEMGSFMMLSFYMWIRLDKEKYGLRPVYNGNLLIKVLKLSTWSMLHAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHCCCCCEECCCEEEEEEHHHHHHHHHHH
ISVAPWFLFFVSIEHLGKIELAISNITRSVSAIFFVIANSFALTTGSLVSNAIGAGEGKT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCH
LFSICSKILKLGYTIGFPLVAIALLCNRWIIGFYTSNELLIQLAFAPFVVMLLNYTFALP
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
GYVYLNAVGGTGKTQMTFLFQVTTTAIYLVYLYWLCRYTQAPLAIYLTAEYVFVILLATQ
CEEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHH
SIFYLKKKHY
HHHHHHHCCC
>Mature Secondary Structure
MNYTYKQIWLINFPVMMSILMEQLINITDAVFLGHVGEIELGASAIAGIYYLAIYMLGFG
CCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHC
FSIGLQVMVARRNGEQDYKETGKTFFQGLFFLLGLAIFLYLLIHTVSPFILKKLIVSSDI
HHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRAVILYLDWRSFGLLFSFPFLAIRSFLVGITHTKALSWAAAIAVLINIPLNFYLIFTRE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
LGISGAAIASSLAEMGSFMMLSFYMWIRLDKEKYGLRPVYNGNLLIKVLKLSTWSMLHAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHCCCCCEECCCEEEEEEHHHHHHHHHHH
ISVAPWFLFFVSIEHLGKIELAISNITRSVSAIFFVIANSFALTTGSLVSNAIGAGEGKT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCH
LFSICSKILKLGYTIGFPLVAIALLCNRWIIGFYTSNELLIQLAFAPFVVMLLNYTFALP
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
GYVYLNAVGGTGKTQMTFLFQVTTTAIYLVYLYWLCRYTQAPLAIYLTAEYVFVILLATQ
CEEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHH
SIFYLKKKHY
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]