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The map label for this gene is zraS [H]

Identifier: 150010171

GI number: 150010171

Start: 4404596

End: 4405726

Strand: Direct

Name: zraS [H]

Synonym: BDI_3594

Alternate gene names: 150010171

Gene position: 4404596-4405726 (Clockwise)

Preceding gene: 150010170

Following gene: 150010172

Centisome position: 91.55

GC content: 44.65

Gene sequence:

>1131_bases
ATGATACAGGATTTACATACCGAGATCGATCGGTTAAAAAGGCGGATTAAACTTTGCGAGCGGGTTACGCTGGGTAGCTT
GGTCGGTATTTGTGTATCTGTGAAGTTCGGTCATCAAGAATGGATCGGATTGCTTTTCTTGATTCTGTTTTGCCAGATCT
CTAAGTTGGTTTTCAAGCGGAAACTCAAACAAAAAGAGTATTTGGTAAAAGAGGTAGAGGAGCGTACGCAGGAGATCCGT
TCGGAGAAAGACGCGATCCAAGAGGAATCCGAGAAATTGGCGGCCGCTTTGAAAGCCTTGGGTGAGGCGCAGGACGAGCT
GGTCCGTAAGGAACGGATGGCTACCGTAGGACAATTGACTCAAGGTTTGGTGGACCGCATTTTGAACCCTCTGAATTATA
TCAATAACTTTGCGAATTTGACATCGGGGCTGGCCAAGGATCTCCGGGAAAATCTGGATAGTCAGAAAGAGCATCTGAAA
CCGGATGTGTATGATGACTCGGTAGATTTGCTGAATATGATGACCAGTAATTTGGAGAAGATCTCCGAGCATGGTTTCAA
TACGGTCCGTATCGTTAAGGCGATGGAGGAATTGCTGAAAGACCGAAGAGGTAATCTTACGCTTACCAACATAAACGGAT
TATGCCGGATTGCCTTGGATAAATTGAAGAAAACGTATGAGCAGGATATTCAAGAGAAGAATATCCGGATTGTTTTCGAT
AATTTGACGCTGTCTTTGATGATGGAGGTAAACGTGGAGCAGTTCAGTAAGGTTCTGGCCGGGATATTGAAAAATTCCAT
GTATGCCCTGTTGAAGAAATCGGAGACTGTGACTTTTAGTCCGGAGATATTCCTTGGATTGAAAGTCAATAAGGATATGC
TGGAAATAACGATCCGGGATAATGGGTCCGGTATCGACGAGAATATAAAAGATAAGATATTCGCTCCTTTCTTCACGACA
AAGACAACGGGGGAAGCGGCCGGCGTAGGGCTTTACCTATGTCGTGAGATCGTGCAAAACCATCGGGGAACCATCGAGGT
GGAGAGTAAGAAAGGAGAATATACCCAGTTTCTAATTACGATCCCTGTATATCAACCGAAAACAATTACACCGCCTAAAG
AGGAGGAATAG

Upstream 100 bases:

>100_bases
GTTGAACCATAAGGGTACGATCGCTATCGAGTCGGAGAAAGATAAATATACGGAAGTTACGATTACGTTGCCTATTTATA
GTTAGGAAAGGAGGTTCATC

Downstream 100 bases:

>100_bases
ATATGGAAGACCAGAGTAAGGAAATAGAACGGCTACGTTTGCAAGTGAAGAACTTAGAGAAATTATCTTCTTTAGGTATG
TTGAGTGCCGGGATCGCGCA

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MIQDLHTEIDRLKRRIKLCERVTLGSLVGICVSVKFGHQEWIGLLFLILFCQISKLVFKRKLKQKEYLVKEVEERTQEIR
SEKDAIQEESEKLAAALKALGEAQDELVRKERMATVGQLTQGLVDRILNPLNYINNFANLTSGLAKDLRENLDSQKEHLK
PDVYDDSVDLLNMMTSNLEKISEHGFNTVRIVKAMEELLKDRRGNLTLTNINGLCRIALDKLKKTYEQDIQEKNIRIVFD
NLTLSLMMEVNVEQFSKVLAGILKNSMYALLKKSETVTFSPEIFLGLKVNKDMLEITIRDNGSGIDENIKDKIFAPFFTT
KTTGEAAGVGLYLCREIVQNHRGTIEVESKKGEYTQFLITIPVYQPKTITPPKEEE

Sequences:

>Translated_376_residues
MIQDLHTEIDRLKRRIKLCERVTLGSLVGICVSVKFGHQEWIGLLFLILFCQISKLVFKRKLKQKEYLVKEVEERTQEIR
SEKDAIQEESEKLAAALKALGEAQDELVRKERMATVGQLTQGLVDRILNPLNYINNFANLTSGLAKDLRENLDSQKEHLK
PDVYDDSVDLLNMMTSNLEKISEHGFNTVRIVKAMEELLKDRRGNLTLTNINGLCRIALDKLKKTYEQDIQEKNIRIVFD
NLTLSLMMEVNVEQFSKVLAGILKNSMYALLKKSETVTFSPEIFLGLKVNKDMLEITIRDNGSGIDENIKDKIFAPFFTT
KTTGEAAGVGLYLCREIVQNHRGTIEVESKKGEYTQFLITIPVYQPKTITPPKEEE
>Mature_376_residues
MIQDLHTEIDRLKRRIKLCERVTLGSLVGICVSVKFGHQEWIGLLFLILFCQISKLVFKRKLKQKEYLVKEVEERTQEIR
SEKDAIQEESEKLAAALKALGEAQDELVRKERMATVGQLTQGLVDRILNPLNYINNFANLTSGLAKDLRENLDSQKEHLK
PDVYDDSVDLLNMMTSNLEKISEHGFNTVRIVKAMEELLKDRRGNLTLTNINGLCRIALDKLKKTYEQDIQEKNIRIVFD
NLTLSLMMEVNVEQFSKVLAGILKNSMYALLKKSETVTFSPEIFLGLKVNKDMLEITIRDNGSGIDENIKDKIFAPFFTT
KTTGEAAGVGLYLCREIVQNHRGTIEVESKKGEYTQFLITIPVYQPKTITPPKEEE

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=262, Percent_Identity=29.3893129770992, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788549, Length=346, Percent_Identity=23.4104046242775, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42999; Mature: 42999

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQDLHTEIDRLKRRIKLCERVTLGSLVGICVSVKFGHQEWIGLLFLILFCQISKLVFKR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
KLKQKEYLVKEVEERTQEIRSEKDAIQEESEKLAAALKALGEAQDELVRKERMATVGQLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLVDRILNPLNYINNFANLTSGLAKDLRENLDSQKEHLKPDVYDDSVDLLNMMTSNLEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHH
ISEHGFNTVRIVKAMEELLKDRRGNLTLTNINGLCRIALDKLKKTYEQDIQEKNIRIVFD
HHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
NLTLSLMMEVNVEQFSKVLAGILKNSMYALLKKSETVTFSPEIFLGLKVNKDMLEITIRD
CCEEEHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEECCCEEEEEEEC
NGSGIDENIKDKIFAPFFTTKTTGEAAGVGLYLCREIVQNHRGTIEVESKKGEYTQFLIT
CCCCCCCCHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEE
IPVYQPKTITPPKEEE
EECCCCCCCCCCCCCC
>Mature Secondary Structure
MIQDLHTEIDRLKRRIKLCERVTLGSLVGICVSVKFGHQEWIGLLFLILFCQISKLVFKR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
KLKQKEYLVKEVEERTQEIRSEKDAIQEESEKLAAALKALGEAQDELVRKERMATVGQLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLVDRILNPLNYINNFANLTSGLAKDLRENLDSQKEHLKPDVYDDSVDLLNMMTSNLEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHH
ISEHGFNTVRIVKAMEELLKDRRGNLTLTNINGLCRIALDKLKKTYEQDIQEKNIRIVFD
HHHCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEE
NLTLSLMMEVNVEQFSKVLAGILKNSMYALLKKSETVTFSPEIFLGLKVNKDMLEITIRD
CCEEEHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEECCCEEEEEEEC
NGSGIDENIKDKIFAPFFTTKTTGEAAGVGLYLCREIVQNHRGTIEVESKKGEYTQFLIT
CCCCCCCCHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEE
IPVYQPKTITPPKEEE
EECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]