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The map label for this gene is zraS [H]

Identifier: 150010172

GI number: 150010172

Start: 4405729

End: 4406580

Strand: Direct

Name: zraS [H]

Synonym: BDI_3595

Alternate gene names: 150010172

Gene position: 4405729-4406580 (Clockwise)

Preceding gene: 150010171

Following gene: 150010173

Centisome position: 91.57

GC content: 45.42

Gene sequence:

>852_bases
ATGGAAGACCAGAGTAAGGAAATAGAACGGCTACGTTTGCAAGTGAAGAACTTAGAGAAATTATCTTCTTTAGGTATGTT
GAGTGCCGGGATCGCGCATGAGATCCAGAATCCGCTCAACTTTGTCATCAATTTCAGTAAGCTGTCCTCTAAGTTAGTGG
ATGACTTGGAAGATATATTAGAAGAAGAGAAAGATGTCTTGCCTCCGGAATCTTGGGAGAAGCTGACCGCCTTGCATGAG
GAGTTTAGCGAGATCGTTAACGATTTGCATGGTAACTTGAAGAAGATCGAGGAACATGGAAACCGGGCGACAAGTATCAT
CCGGGGTATCTTGCTTTATTCCAGAGGGAAGGATGACGAGTACATCCCTACGGATATCAAGAATCTGGTGAAGGAATATG
TTTGGCTGGCTTATCATTCGATGCGAGCGAACTATAAAGGTTTCAATATTGCGATCCGGGAGCATTACGAGGAGGGGCTT
CCGATGCTGAAAGTGATCCCGCAGGATTTGAGCCGTGCGGTATTGAATGTCATGAATAACGCTTGCTATGCGGTCTATAG
TAAATCCAAGCTCTCGCCGATCGGGTATGAGCCGGTTATATCCGTGGATCTACGGAAGGAGGGAGATTCTTTAAGATTAA
GTATCGAGGATAATGGTATCGGTATGCCGGAGAATATCCGGGAGCAGATATTCTCCGCGTTTTTTACCACGAAACCGGTG
GGAGAGGGAACTGGCTTGGGGCTATCTATCACTCGATCCATTATAGAGGAGAAGCATGACGGGAAGATAGAGGTGGAATC
GAAAGAGGGTGAGTTTACCCGTTTCATATTCCTTATTCCATTAACGAAATAA

Upstream 100 bases:

>100_bases
TCGAGGTGGAGAGTAAGAAAGGAGAATATACCCAGTTTCTAATTACGATCCCTGTATATCAACCGAAAACAATTACACCG
CCTAAAGAGGAGGAATAGAT

Downstream 100 bases:

>100_bases
ACAGAAGAATTATGGCGATCAAGATATTAAGCGTAGACGACGAACAGGATCTGGAAGCGTTGCTAACCCAATATTTCCGT
CGGAAGATCCGTAAGGGAGA

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MEDQSKEIERLRLQVKNLEKLSSLGMLSAGIAHEIQNPLNFVINFSKLSSKLVDDLEDILEEEKDVLPPESWEKLTALHE
EFSEIVNDLHGNLKKIEEHGNRATSIIRGILLYSRGKDDEYIPTDIKNLVKEYVWLAYHSMRANYKGFNIAIREHYEEGL
PMLKVIPQDLSRAVLNVMNNACYAVYSKSKLSPIGYEPVISVDLRKEGDSLRLSIEDNGIGMPENIREQIFSAFFTTKPV
GEGTGLGLSITRSIIEEKHDGKIEVESKEGEFTRFIFLIPLTK

Sequences:

>Translated_283_residues
MEDQSKEIERLRLQVKNLEKLSSLGMLSAGIAHEIQNPLNFVINFSKLSSKLVDDLEDILEEEKDVLPPESWEKLTALHE
EFSEIVNDLHGNLKKIEEHGNRATSIIRGILLYSRGKDDEYIPTDIKNLVKEYVWLAYHSMRANYKGFNIAIREHYEEGL
PMLKVIPQDLSRAVLNVMNNACYAVYSKSKLSPIGYEPVISVDLRKEGDSLRLSIEDNGIGMPENIREQIFSAFFTTKPV
GEGTGLGLSITRSIIEEKHDGKIEVESKEGEFTRFIFLIPLTK
>Mature_283_residues
MEDQSKEIERLRLQVKNLEKLSSLGMLSAGIAHEIQNPLNFVINFSKLSSKLVDDLEDILEEEKDVLPPESWEKLTALHE
EFSEIVNDLHGNLKKIEEHGNRATSIIRGILLYSRGKDDEYIPTDIKNLVKEYVWLAYHSMRANYKGFNIAIREHYEEGL
PMLKVIPQDLSRAVLNVMNNACYAVYSKSKLSPIGYEPVISVDLRKEGDSLRLSIEDNGIGMPENIREQIFSAFFTTKPV
GEGTGLGLSITRSIIEEKHDGKIEVESKEGEFTRFIFLIPLTK

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=277, Percent_Identity=28.5198555956679, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788549, Length=277, Percent_Identity=27.7978339350181, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790300, Length=265, Percent_Identity=27.9245283018868, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 32209; Mature: 32209

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDQSKEIERLRLQVKNLEKLSSLGMLSAGIAHEIQNPLNFVINFSKLSSKLVDDLEDIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHH
EEEKDVLPPESWEKLTALHEEFSEIVNDLHGNLKKIEEHGNRATSIIRGILLYSRGKDDE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
YIPTDIKNLVKEYVWLAYHSMRANYKGFNIAIREHYEEGLPMLKVIPQDLSRAVLNVMNN
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
ACYAVYSKSKLSPIGYEPVISVDLRKEGDSLRLSIEDNGIGMPENIREQIFSAFFTTKPV
HHEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
GEGTGLGLSITRSIIEEKHDGKIEVESKEGEFTRFIFLIPLTK
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCC
>Mature Secondary Structure
MEDQSKEIERLRLQVKNLEKLSSLGMLSAGIAHEIQNPLNFVINFSKLSSKLVDDLEDIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHH
EEEKDVLPPESWEKLTALHEEFSEIVNDLHGNLKKIEEHGNRATSIIRGILLYSRGKDDE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
YIPTDIKNLVKEYVWLAYHSMRANYKGFNIAIREHYEEGLPMLKVIPQDLSRAVLNVMNN
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
ACYAVYSKSKLSPIGYEPVISVDLRKEGDSLRLSIEDNGIGMPENIREQIFSAFFTTKPV
HHEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
GEGTGLGLSITRSIIEEKHDGKIEVESKEGEFTRFIFLIPLTK
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]