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The map label for this gene is pyrH

Identifier: 150009953

GI number: 150009953

Start: 4088279

End: 4088989

Strand: Direct

Name: pyrH

Synonym: BDI_3371

Alternate gene names: 150009953

Gene position: 4088279-4088989 (Clockwise)

Preceding gene: 150009952

Following gene: 150009954

Centisome position: 84.97

GC content: 48.95

Gene sequence:

>711_bases
ATGGCTCAATACAAACGTATCTTATTAAAATTAAGCGGGGAGTCGCTGATGGGTGGTAAACAATATGGGATCGATGAGGT
CCGCTTGAATGAATATGCGGCACAGATCAAGGAGATCGCCGAGATGGGCGTACAGATCGGTATCGTGATTGGTGGCGGTA
ATATTTTCCGTGGATTGAGTGGCGCTTCCAAAGGTTTCGATCGGGTAAAAGGAGACCAAATGGGTATGCTGGCGACGGTA
ATCAATAGCTTGGCGCTTAGCTCCGCATTGGTCGCTCAAGGCGTGAATGCGAAGGTTTTGACCGCTATCCGTATGGAACC
GATCGGCGAGTTCTATAATAAATGGCGTGCGATCGAGTTGCTGGAACAAGGTAACGTGGTCATCATGTCCGGCGGTACGG
GTAATCCGTTCTTTACTACGGATACCGGATCTTCCTTGAGAGGTATCGAGATCGAGGCGGATGTCATGCTGAAAGGTACC
CGTGTGGACGGTATTTACACCGCTGATCCGGAGAAAGATCCTACGGCTACCAAGTTCTCCGATATTACGTATGATGAGAT
CTATACCCGGGGCCTGAAGGTAATGGACTTGACCGCTACCACGATGTGTAAAGAGAACAACCTCCCGATCATCGTATTCG
ATATGGATACCAACGGCAACTTGAAGAAAGTGATGAGCGGAGAGAATATCGGGACACTGGTGCATAATTAG

Upstream 100 bases:

>100_bases
GTGTTTAGATCGCCCCGACACCGGTTGGGGCGATCTTTTTTATGCGAATATCGGATTATTCGTTACTTTTGCGGAATTAC
ATATTAAATATATACAAAAC

Downstream 100 bases:

>100_bases
TGCCATTAACCGATGACACGGCAGTGCCATGCTGGTGGTACTGTCGTGCCACAGGCATGGCAAGGTTGTGCCAGCCCTGT
GGCAAATACGTTAGACCTTT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MAQYKRILLKLSGESLMGGKQYGIDEVRLNEYAAQIKEIAEMGVQIGIVIGGGNIFRGLSGASKGFDRVKGDQMGMLATV
INSLALSSALVAQGVNAKVLTAIRMEPIGEFYNKWRAIELLEQGNVVIMSGGTGNPFFTTDTGSSLRGIEIEADVMLKGT
RVDGIYTADPEKDPTATKFSDITYDEIYTRGLKVMDLTATTMCKENNLPIIVFDMDTNGNLKKVMSGENIGTLVHN

Sequences:

>Translated_236_residues
MAQYKRILLKLSGESLMGGKQYGIDEVRLNEYAAQIKEIAEMGVQIGIVIGGGNIFRGLSGASKGFDRVKGDQMGMLATV
INSLALSSALVAQGVNAKVLTAIRMEPIGEFYNKWRAIELLEQGNVVIMSGGTGNPFFTTDTGSSLRGIEIEADVMLKGT
RVDGIYTADPEKDPTATKFSDITYDEIYTRGLKVMDLTATTMCKENNLPIIVFDMDTNGNLKKVMSGENIGTLVHN
>Mature_235_residues
AQYKRILLKLSGESLMGGKQYGIDEVRLNEYAAQIKEIAEMGVQIGIVIGGGNIFRGLSGASKGFDRVKGDQMGMLATVI
NSLALSSALVAQGVNAKVLTAIRMEPIGEFYNKWRAIELLEQGNVVIMSGGTGNPFFTTDTGSSLRGIEIEADVMLKGTR
VDGIYTADPEKDPTATKFSDITYDEIYTRGLKVMDLTATTMCKENNLPIIVFDMDTNGNLKKVMSGENIGTLVHN

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=54.978354978355, Blast_Score=260, Evalue=7e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PARD8 (A6LHB0)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001304696.1
- ProteinModelPortal:   A6LHB0
- SMR:   A6LHB0
- STRING:   A6LHB0
- GeneID:   5308520
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_3371
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   PDIS435591:BDI_3371-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25543; Mature: 25412

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 53-53 BINDING 57-57 BINDING 72-72 BINDING 160-160 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQYKRILLKLSGESLMGGKQYGIDEVRLNEYAAQIKEIAEMGVQIGIVIGGGNIFRGLS
CCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHCCC
GASKGFDRVKGDQMGMLATVINSLALSSALVAQGVNAKVLTAIRMEPIGEFYNKWRAIEL
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHEEE
LEQGNVVIMSGGTGNPFFTTDTGSSLRGIEIEADVMLKGTRVDGIYTADPEKDPTATKFS
ECCCCEEEEECCCCCCCEEECCCCCEEEEEEEEEEEEEEEEECCEEECCCCCCCCCCEEC
DITYDEIYTRGLKVMDLTATTMCKENNLPIIVFDMDTNGNLKKVMSGENIGTLVHN
CCCHHHHHHCCCEEEEEEEHHEECCCCCEEEEEEECCCCCHHHHCCCCCCEEECCC
>Mature Secondary Structure 
AQYKRILLKLSGESLMGGKQYGIDEVRLNEYAAQIKEIAEMGVQIGIVIGGGNIFRGLS
CHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHCCC
GASKGFDRVKGDQMGMLATVINSLALSSALVAQGVNAKVLTAIRMEPIGEFYNKWRAIEL
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHEEE
LEQGNVVIMSGGTGNPFFTTDTGSSLRGIEIEADVMLKGTRVDGIYTADPEKDPTATKFS
ECCCCEEEEECCCCCCCEEECCCCCEEEEEEEEEEEEEEEEECCEEECCCCCCCCCCEEC
DITYDEIYTRGLKVMDLTATTMCKENNLPIIVFDMDTNGNLKKVMSGENIGTLVHN
CCCHHHHHHCCCEEEEEEEHHEECCCCCEEEEEEECCCCCHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA